You may experience headaches, a feeling of warmness, flushing or constipation, while taking ZOFRAN. Although uncommon, low blood pressure and hiccups have also been reported.

There is no need to stop taking your medicine, but you should tell your doctor about these symptoms at your next visit.

If your nausea (feeling of sickness) or vomiting do not improve while taking ZOFRAN, consult your doctor for further advice.

If you feel unwell or have any symptoms that you do not understand, you should contact your doctor immediately.

BEFORE you use ZOFRAN or ZOFRAN ODT talk to your doctor or pharmacist if:

• you have a history of hypersensitivity (an allergic reaction) to any ingredient in ZOFRAN or ZOFRAN ODT.

• if you have had an allergic reaction to medicines similar to ZOFRAN or ZOFRAN ODT such as medicines containing granisetron or palonosetron.

• you are pregnant or likely to become pregnant.

• you are breast feeding.

• you have liver problems.

• you have signs of intestinal obstruction.

• you have a history of heart problems.

• you have a condition called phenylketonuria and were prescribed ZOFRAN ODT, because it contains aspartame.

If you experience wheezing and tightness of the chest, heart throbbing, swelling of eyelids, face or lips, or develop a skin rash, skin lumps or hives, contact your doctor immediately. Do not take anymore medicine unless your doctor tells you to do so.

Serotonin Syndrome is a rare but potentially life-threatening reaction that may occur if you take ZOFRAN or ZOFRAN ODT with certain other medications. It may cause serious changes in how your brain, muscles and digestive system work. Be sure to tell your healthcare professional all the medicines you are taking.

As with most medicines, interactions with other drugs are possible. To avoid potentially life-threatening reactions tell your healthcare professional about ALL the medications you take, including those prescribed by other doctors, vitamins, minerals, natural supplements or alternative medicines. It is important that your doctor know about all your medication so that you get the best possible treatment. Tell your doctor if you are taking carbamazepine, phenytoin, or rifampicin. If you are taking any medicines containing tramadol, ZOFRAN may decrease its effectiveness.

Also, make sure you tell your doctor or pharmacist if you are taking:

• Drugs used to treat heart rhythm disorders

• Other drugs that may disturb heart rhythm

• Antipsychotics

• Antidepressants

• Antibiotics or antifungals

• Opioid analgesics (painkillers)

• Other drugs to treat nausea and vomiting

• Asthma drugs

• Cancer drugs

• Diuretics

• Other drugs that affect serotonin including SSRIs^‡, SNRIs^§, triptans, MAOIs^¶ (including the antibiotic linezolid and methylene blue), drugs that contain tryptophan, or St. John’s Wort.

You may experience headaches, a feeling of warmness, flushing or constipation, while taking ZOFRAN. Although uncommon, low blood pressure and hiccups have also been reported.

There is no need to stop taking your medicine, but you should tell your doctor about these symptoms at your next visit.

If your nausea (feeling of sickness) or vomiting do not improve while taking ZOFRAN, consult your doctor for further advice.

If you feel unwell or have any symptoms that you do not understand, you should contact your doctor immediately.

BEFORE you use ZOFRAN or ZOFRAN ODT talk to your doctor or pharmacist if:

• you have a history of hypersensitivity (an allergic reaction) to any ingredient in ZOFRAN or ZOFRAN ODT.

• if you have had an allergic reaction to medicines similar to ZOFRAN or ZOFRAN ODT such as medicines containing granisetron or palonosetron.

• you are pregnant or likely to become pregnant.

• you are breast feeding.

• you have liver problems.

• you have signs of intestinal obstruction.

• you have a history of heart problems.

• you have a condition called phenylketonuria and were prescribed ZOFRAN ODT, because it contains aspartame.

If you experience wheezing and tightness of the chest, heart throbbing, swelling of eyelids, face or lips, or develop a skin rash, skin lumps or hives, contact your doctor immediately. Do not take anymore medicine unless your doctor tells you to do so.

Serotonin Syndrome is a rare but potentially life-threatening reaction that may occur if you take ZOFRAN or ZOFRAN ODT with certain other medications. It may cause serious changes in how your brain, muscles and digestive system work. Be sure to tell your healthcare professional all the medicines you are taking.

As with most medicines, interactions with other drugs are possible. To avoid potentially life-threatening reactions tell your healthcare professional about ALL the medications you take, including those prescribed by other doctors, vitamins, minerals, natural supplements or alternative medicines. It is important that your doctor know about all your medication so that you get the best possible treatment. Tell your doctor if you are taking carbamazepine, phenytoin, or rifampicin. If you are taking any medicines containing tramadol, ZOFRAN may decrease its effectiveness.

Also, make sure you tell your doctor or pharmacist if you are taking:

• Drugs used to treat heart rhythm disorders

• Other drugs that may disturb heart rhythm

• Antipsychotics

• Antidepressants

• Antibiotics or antifungals

• Opioid analgesics (painkillers)

• Other drugs to treat nausea and vomiting

• Asthma drugs

• Cancer drugs

• Diuretics

• Other drugs that affect serotonin including SSRIs^‡, SNRIs^§, triptans, MAOIs^¶ (including the antibiotic linezolid and methylene blue), drugs that contain tryptophan, or St. John’s Wort.

RENAGEL tablets should be swallowed whole and should not be crushed, chewed, dissolved or broken into pieces.

Usual starting dose:

Dosage is individualized. Your doctor will determine your dosage.

RENAGEL should be taken immediately prior to or with meals.

The total daily dose should be divided according to meal portions during the day.

Average Maintenance Dose: Approximately nine 800 mg tablets per day (equivalent to three 800 mg tablets per meal). Always follow your physician’s dosage instructions.

Overdose:

In case of an overdose, contact your doctor or poison control center immediately.

Missed dose:

If a dose is forgotten, it should be skipped. Double dosing is not advisable.

Although RENAGEL is generally well tolerated, some patients may experience side effects, including: nausea, vomiting, diarrhea, indigestion, constipation, rash and itch.

Serious Warnings and Precautions

Renagel may cause serious side effects that may require hospitalization and surgery. Tell your doctor or go to the hospital right away if you have difficulty swallowing, bowel obstruction, or bowel perforation.

RENAGEL tablets should be swallowed whole and should not be crushed, chewed, dissolved or broken into pieces.

BEFORE you use RENAGEL talk to your doctor or pharmacist if you:

• have difficulty swallowing (swallowing disorders or problems with your esophagus).
• have an intestinal disorder such as, conditions that slow down the passage of food through the intestine and lead to blockage.
• have had surgery on your intestines.
• have severe or worsening constipation.
• have low phosphorus levels in your blood.
• have low calcium levels in your blood.
• are pregnant, plan to become pregnant or are nursing.
• have any allergies to this drug or its ingredients or components of the container.

RENAGEL may affect the way other medicines work. Please tell your doctor or pharmacist what medicine you have recently taken, are taking or intend to take including those available without prescription and herbal remedies. These medicines may need to be taken one hour before or three hours after RENAGEL. Remember, RENAGEL must always be taken with food.

If you see another doctor or a dentist while you are using RENAGEL, you should tell them that you are using RENAGEL.

Drugs that may interact with RENAGEL include: ciprofloxacin and levothyroxine. Your doctor may order blood tests to more closely monitor the thyroid hormones in your blood if you are taking levothyroxine and RENAGEL.

RENAGEL may also interact with drugs that are used to prevent the rejection of a transplanted organ, such as cyclosporin, mycophenolate and tacrolimus.

How do I use FAMVIR?

You should take FAMVIR only as directed by your doctor. Do not take more of it, do not take it more often and do not take it for a longer period of time than your doctor ordered.

Be sure to take FAMVIR regularly as prescribed. Try to take your tablets at the same time each day. You should continue to take your medicine even if you do not feel better, as it may take a few days for your medicine to work.

If your kidneys are not working very well, your doctor will probably have you take this medicine less often, check with your doctor if you have kidney problems.

FAMVIR will work whether or not you take it with food. You should swallow the tablets whole, with water. Do not chew them.

How long do I use FAMVIR?

The usual adult dose is one FAMVIR tablet three times a day for shingles. Follow your doctor's instructions about how and when to take your tablets. Start taking them as soon as you can for the best effect.

Most people take one tablet when they get up in the morning, one in the middle of the afternoon and one before going to bed at night.

Finish all the tablets you have been given even if you start to feel better. The treatment lasts for seven days.

Treating an outbreak of recurrent genital herpes:

If you have had herpes infections of the genitals before (called recurrent genital herpes), your doctor may decide to treat the outbreak. You will likely be told to take 125 mg twice a day for 5 days or if you are HIV-positive, 500 mg twice a day for 7 days. Most people with recurrent genital herpes take one tablet when waking, and one tablet just before going to bed. FAMVIR should be taken as soon as possible after the early symptoms (pain, burning, blisters, itching, tingling) begin to appear.

Preventing outbreaks of recurrent genital herpes:

If you have had herpes infections of the genitals before (called recurrent genital herpes), then your doctor may decide to prevent future outbreaks. Your doctor will likely tell you that you should continually take 250 mg twice a day. Most people with recurrent genital herpes take one tablet when waking, and one tablet just before going to bed.

Overdose:

Warning:

In case of drug overdose, contact a healthcare practitioner (doctor), hospital emergency department or regional poison control centre, even if there are no symptoms, Bring your pack of tablets with you.

Taking too much of any type of medicine is risky.

Taking too much FAMVIR may affect the kidneys. In people who already have kidney problems it may, rarely, lead to kidney failure if their dose is not correctly lowered.

Important: Your doctor may give you different instructions better suited to your specific needs. If you need more information on how to take FAMVIR properly, double-check with your doctor or pharmacist.

Missed dose:

If you miss taking a FAMVIR tablet, don't worry. Take it as soon as you remember. Take your next tablet at the normal time. However, do not take two doses within a time interval of less than 1 hour, in that case you should skip the missed dose. Carry on as normal until you have finished all the tablets. It is important that you finish all the tablets you have been given, unless your doctor tells you to stop taking them. Do not double-dose.

Any medicine can cause side effects. With FAMVIR, some people may feel sick or get a headache, or experience confusion or dizziness. Other side effects include drowsiness (usually in older people), hallucinations (seeing or hearing things that are not really there), vomiting, yellowing of the skin and/or eyes, abnormal liver function test results, palpitations (signs of abnormal heart beat), skin rash, itching or blistering, diarrhea, tiredness and abdominal pain. If you get these or any other problems while you are taking FAMVIR, tell your doctor or pharmacist.

Before you take FAMVIR, talk to your doctor if:

• You have an intolerance to some sugars, galactose intolrance, a severe lactase deficiency or glucose-galactose malabsorption, then you should not take FAMVIR, as this product contains latose
• You have an allergy (including itching) or other unwanted (side) effects when previously taking FAMVIR
• You are pregnant, planning to become pregnant or breastfeeding when using FAMVIR
• You have a past history or current kidney disease
• You have severe liver problems
• You have other medical conditions

It is important to tell your doctor, dentist or pharmacist if you are taking other medication, as combining drugs can sometimes result in a change from the expected drug effects, or cause harmful effects.

You may experience headaches, a feeling of warmness, flushing or constipation, while taking ZOFRAN. Although uncommon, low blood pressure and hiccups have also been reported.

There is no need to stop taking your medicine, but you should tell your doctor about these symptoms at your next visit.

If your nausea (feeling of sickness) or vomiting do not improve while taking ZOFRAN, consult your doctor for further advice.

If you feel unwell or have any symptoms that you do not understand, you should contact your doctor immediately.

BEFORE you use ZOFRAN or ZOFRAN ODT talk to your doctor or pharmacist if:

• you have a history of hypersensitivity (an allergic reaction) to any ingredient in ZOFRAN or ZOFRAN ODT.

• if you have had an allergic reaction to medicines similar to ZOFRAN or ZOFRAN ODT such as medicines containing granisetron or palonosetron.

• you are pregnant or likely to become pregnant.

• you are breast feeding.

• you have liver problems.

• you have signs of intestinal obstruction.

• you have a history of heart problems.

• you have a condition called phenylketonuria and were prescribed ZOFRAN ODT, because it contains aspartame.

If you experience wheezing and tightness of the chest, heart throbbing, swelling of eyelids, face or lips, or develop a skin rash, skin lumps or hives, contact your doctor immediately. Do not take anymore medicine unless your doctor tells you to do so.

Serotonin Syndrome is a rare but potentially life-threatening reaction that may occur if you take ZOFRAN or ZOFRAN ODT with certain other medications. It may cause serious changes in how your brain, muscles and digestive system work. Be sure to tell your healthcare professional all the medicines you are taking.

As with most medicines, interactions with other drugs are possible. To avoid potentially life-threatening reactions tell your healthcare professional about ALL the medications you take, including those prescribed by other doctors, vitamins, minerals, natural supplements or alternative medicines. It is important that your doctor know about all your medication so that you get the best possible treatment. Tell your doctor if you are taking carbamazepine, phenytoin, or rifampicin. If you are taking any medicines containing tramadol, ZOFRAN may decrease its effectiveness.

Also, make sure you tell your doctor or pharmacist if you are taking:

• Drugs used to treat heart rhythm disorders

• Other drugs that may disturb heart rhythm

• Antipsychotics

• Antidepressants

• Antibiotics or antifungals

• Opioid analgesics (painkillers)

• Other drugs to treat nausea and vomiting

• Asthma drugs

• Cancer drugs

• Diuretics

• Other drugs that affect serotonin including SSRIs^‡, SNRIs^§, triptans, MAOIs^¶ (including the antibiotic linezolid and methylene blue), drugs that contain tryptophan, or St. John’s Wort.