Janumet XR (Sitagliptin/Metformin)

(℞) Prescription Required

Top Brand Choice
Top Generic Choice

Janumet XR 50mg/1000mg

Product of Australia
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Select Quantity
Janumet XR 50mg/1000mg
Product of Australia
Manufactured by Merck Sharp & Dohme
Top Brand Choice
Top Generic Choice

Janumet XR 100mg/1000mg

Product of Australia
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Select Quantity
Janumet XR 100mg/1000mg
Product of Australia
Manufactured by Merck Sharp & Dohme
Top Brand Choice
Top Generic Choice

Janumet XR 50mg/500mg

Product of Canada
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Select Quantity
Janumet XR 50mg/500mg
Product of Canada
Manufactured by Merck Sharp & Dohme
Top Brand Choice
Top Generic Choice

Janumet XR 50mg/1000mg

Product of Canada
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
**Med currently on backorder ETA mid-October 2023**
Select Quantity
Janumet XR 50mg/1000mg
Product of Canada
Manufactured by Merck Sharp & Dohme
Top Brand Choice
Top Generic Choice

Janumet XR 100mg/1000mg

Product of Canada
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Select Quantity
Janumet XR 100mg/1000mg
Product of Canada
Manufactured by Merck Sharp & Dohme
Select your dosage

Janumet XR Coupon

Free Janumet XR Coupon

Get $15 Discount with Janumet XR Coupon Code JXR15

Lower the price of Janumet XR by $15 with coupon code JXR15.

Simply enter the Janumet XR coupon code at checkout for savings.

This Rx coupon code can be applied to all dosages.

View all of our special offers and Rx coupons for more deals.

*Coupon codes cannot be combined and are for one-time use only

Buy Canadian Pharmacy Janumet XR (Sitagliptin/Metformin)

To buy Janumet XR online, go to PricePro Pharmacy website and either place your order online, by the phone, or through our live chat support. We do require a valid prescription to process your order and this can be provided directly from your doctor's office as a faxed copy or email.

Doctors commonly prescribe this diabetes medication for people who have type-2 diabetes and can be treated safely with sitagliptin and metformin extended-release drug. Sitagliptin helps to break down incretin hormones that make the pancreas release insulin when a patient eats. On the other hand, Metformin works to lower blood sugar levels.

If you are suffering from type-2 diabetes and your doctor prescribes this medication for you, do not fear the cost. PricePro Pharmacy is here with a commitment to provide you your prescribed drugs at affordable prices.

Once you place your order and provide the prescription, it then will take 1-2 business days to process and review your order before the medication is dispensed and shipped from the pharmacy.

We offer this medication from Australia and our Canadian pharmacy with an estimated shipping time of 10-18 business days from Australia and 7-10 business days from Canada.

There currently is no generic Janumet XR available on the market. However, to help lower the cost of your prescription you can redeem our free Janumet XR coupon at checkout.

We are proud to offer prescription medication at affordable prices. For instance, view the savings when you order Janumet XR 50mg/100mg from our Canadian pharmacy at $175 for 60 tablets compared to $568 for 60 tablets from your local American pharmacy.

To view Janumet XR prices and more details click on the dosage box above to start saving today.

Janumet XR Product Overview

The brand name product is manufactured by Merck both in Canada and Australia.

The available options for Janumet XR at PricePro Pharmacy are 50mg/1000mg, 50mg/500mg and 100mg/1000mg. The pack size differs from one dose to another. You should click on "CHECK PRICES" if you want to know about the pack size and prices.

The lowest price at PricePro Pharmacy is $125 for 56 tabs (50mg/1000mg dose). This is far lower than any price you will get at your local US pharmacy So, make your decision - pay more? Or pay less?

Available Products

prescription drugs

The following dosages are available at PricePro Pharmacy:

  • 50mg/1000mg (Sitagliptin 50mg and Metformin 1000mg)
  • 50mg/500mg (Sitagliptin 50mg and Metformin 500mg)
  • 100mg/1000mg (Sitagliptin 1000mg and Metformin 1000mg)

They are available in packsize of 28 tablets, 30 tablets, 56 tablets, and 60 tablets depending the dose selected.

The two product choices available are sourced from Australia and Canada.

Janumet XR Cost Comparison

save money on prescription drugs

In the United States, the average retail price of Janumet XR 50mg/1000mg is:

  • $581.04 for 60 tablets

While at PricePro Pharmacy, we focus on providing more affordable prescription prices:

  • $165.00 for 60 tablets

If you make a comparison between our PricePro Pharmacy price and local US pharmacy price, you can see an almost 72% savings. Don't worry about insurance as our prices are available to you without any insurance coverage required. However, be sure to upload your prescription to avoid delays in the processing of your order.

Free Janumet XR Coupon Available

The example of the low prices above clearly show how ordering from PricePro Pharmacy can save you money. To make things even better, we have a free Janumet XR coupon that can be applied to any dosage.

Shipping Times

prescription delivery

Once you place your order and provide your prescription a verification process takes place, which takes about 1-2 business days to process and review. Following that, your order is dispensed and shipped from our licensed pharmacies.

The estimated delivery times will depend on the medication source selected:

  • Product of Australia - 10 to 18 business days for delivery
  • Product of Canada - 7 to 10 business days for delivery

The shipping cost for all orders from PricePro Pharmacy is $9.95. 

We will send you an email with all tracking information, as soon your order ships.

Prescription Refill

online prescription refill

PricePro Pharmacy is always determined to make your online shopping experience easy and affordable for you and your loved ones.  

To make it possible, we provide a special notification service for you when it is time for a new refill. Part of our prescription refill service is to notify our customers via emails or phone calls when it is time to reorder the prescribed medicines based on previous prescription information. 

In addition, if you have an active prescription on file. you may sign in directly to your PricePro Pharmacy online account and make reorder easily.

Janumet XR (Sitagliptin and Metformin Hydrochloride Extended-Release) Medication Information



Janumet XR is a tablet that combines two prescription diabetes medications: sitagliptin (Januvia) and metformin extended-release. Janumet XR is used to lower blood sugar in adults with type 2 diabetes, along with a healthy diet and physical exercise.

In diabetes, blood sugar (glucose) becomes too high.  Insulin, a hormone made by the pancreas, helps sugar move from the bloodstream into your cells. If your body doesn’t make enough insulin or use it properly, too much sugar stays in your blood.  

Over time, having high blood sugar can lead to many health problems.  Uncontrolled blood sugar levels can increase your risk of having a heart attack or stroke. 

The good news: you can prevent type 2 diabetes from getting worse.  You can control your blood sugar by eating a healthy diet, exercising, and taking prescription medications.


Janumet XR (sitagliptin and metformin extended-release) tablets are available in three strengths: 50 mg/500 mg, 50 mg/1,000 mg, and 100 mg/1,000 mg.  Your doctor will decide the strength that is best for you.

It should be taken once daily with a meal, preferably in the evening.


Janumet XR may not be safe for people with the following medical history or conditions:

  • Kidney disease
  • Pancreas problems
  • Pregnant or plan to become pregnant
  • Breastfeeding
  • Type 1 diabetes
  • History of an allergic reaction to Janumet XR, sitagliptin (Januvia), or metformin

Side Effects

Like all medications, Janumet XR may cause side effects.  The most common side effects of Janumet XR are mild, but severe side effects are also possible.  

The most common but usually mild side effects include:

  • Diarrhea
  • Stomach upset: bloating, gas, nausea, or vomiting
  • Stuffy or runny nose and sore throat
  • Upper respiratory infection
  • Hypoglycemia (low blood sugar)
  • Headache
  • Weakness

Serious side effects can rarely occur, including:

  • Lactic acidosis (build-up of acid in the blood)
  • Pancreatitis (inflammation of the pancreas)
  • Heart failure (heart doesn’t pump blood well)
  • Kidney damage
  • Dehydration
  • Joint pain
  • Allergic reaction

Your doctor will prescribe Janumet XR if its benefits outweigh your risks for serious side effects.  For more information about the side effects of Janumet XR, talk with your doctor or pharmacist.


Some potentially harmful drug interactions can happen with Janumet XR. A few examples include:

  • Acetazolamide
  • Cimetidine
  • Digoxin
  • Diuretics (water pills)
  • Insulin or other medicines that lower blood sugar
  • Ranolazine 
  • Topiramate
  • Zonisamide

This is not a complete list of all drug interactions.  Talk with your doctor or pharmacist before taking any new medications or herbal supplements with Janumet XR.


Store Janumet XR at room temperature between 68°F and 77°F (20°C and 25°C).  Don’t keep in high-moisture areas like the bathroom.

Pharmacist Tips

  • Take Janumet XR with food to reduce stomach-related side effects like diarrhea.  
  • Swallow Janumet XR tablets whole; don’t split, crush, or chew.

Janumet XR FAQs

What should I do if I get diarrhea or other stomach side effects from Janumet XR?

When starting or increasing the dose of Janumet XR, diarrhea and stomach upset are very common.  These side effects should go away within one to two weeks once your body gets used to the medication.  

Until then, the best way to reduce these side effects is to take Janumet XR every day, not skipping any doses, and taking it with a meal, preferably in the evening.  If these side effects don’t go away within two weeks, talk to your doctor.

Can I drink alcohol with Janumet XR?

Drinking excessive amounts of alcohol can increase the risk of a dangerous side effect called lactic acidosis.  Talk with your doctor about drinking alcohol while taking Janumet XR.

Related Drugs


  1. Janumet XR Prescribing Information.  Whitehouse Station, NJ: Merck Sharp & Dohme Corp; 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202270s020lbl.pdf  Accessed November 16, 2020.
  2. Goyal R, Jialal I. Diabetes Mellitus Type 2. Treasure Island, FL: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK513253/ Accessed November 16, 2020.

PharmD Medical Writer

Author: Dr. Patricia Weiser, PharmD

Patricia Weiser, PharmD, is a licensed pharmacist and medical writer.  She has clinical experience in community and hospital pharmacy.  Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters.

View Linkedin profile

Sign up to receive exclusive discounts & offers, medication updates, & health news delivered to your inbox.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Back to top