Renvela (Sevelamer)

Usual starting dose:

Dosage is individualized. Your doctor will determine your dosage.

RENVELA should be taken immediately prior to or with meals.

The total daily dose should be divided according to meal portions during the day.

Average maintenance dose is approximately 7-8 tablets of 800 mg each day. Always follow your physician’s dosage instructions.

Overdose:

In case of an overdose, contact your doctor or regional poison control center immediately.

Missed dose:

If a dose is forgotten, it should be skipped. Double dosing is not advisable.

Although RENVELA is generally well tolerated, some patients may experience side effects, including: nausea, vomiting, diarrhea, indigestion, constipation, abdominal pain, rash, itch, and flatulence (gas). Tell your doctor if you have new onset or worsening of constipation.

Serious Warnings and Precautions

Renvela may cause serious side effects that may require hospitalization and surgery. Tell your doctor or go to the hospital right away if you have difficulty swallowing, bowel obstruction, or bowel perforation.

RENVELA tablets should be swallowed whole and should not be crushed, chewed, or broken into pieces.

BEFORE you use RENVELA talk to your doctor or pharmacist if you:

• have difficulty swallowing (swallowing disorders or problems with your esophagus).
• have an intestinal disorder such as, conditions that slow down the passage of food through the intestine and lead to blockage.
• have had surgery on your intestines.
• have severe or worsening constipation.
• have low phosphorus levels in your blood.
• have low calcium levels in your blood.
• are pregnant, plan to become pregnant or are nursing.
• have any allergies to this drug or its ingredients or components of the container.

RENVELA may affect the way other medicines work. Please tell your doctor or pharmacist what medicine you have recently taken, are taking or intend to take including those available without prescription and herbal remedies. These medicines may need to be taken one hour before or three hours after RENVELA. Remember, RENVELAmust always be taken with food.

If you see another doctor or a dentist while you are using RENVELA, you should tell them that you are using RENVELA.

Drugs that may interact with RENVELA include: ciprofloxacin and levothyroxine. Your doctor may order blood tests to more closely monitor the thyroid hormones in your blood if you are taking levothyroxine and RENVELA.

RENVELA may also interact with drugs that are used to prevent the rejection of a transplanted organ, such as cyclosporin, mycophenolate and tacrolimus.