Janumet (Sitagliptin/Metformin)

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    Along with diet and exercise, the prescription drug Janumet (Sitagliptin/Metformin) is given to patients with Type 2 diabetes to improve blood sugar levels. 

    On this page, you'll find information about this medication including Janumet dosage, side effects, and interactions. 

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    Proper Use

    Do not deviate from how your medical health professional has directed that you take Janumet (Sitagliptin/Metformin). Your doctor will check your blood sugar to determine the right dosage for treatment. In most cases, Janumet (Sitagliptin/Metformin) is taken twice a day with food to help avoid an upset stomach.  

     The tablets should be taken whole. If you have difficulty swallowing this medication, talk to your doctor and pharmacist about options. Janumet (Sitagliptin/Metformin) tablets should not be cut, chewed or crushed.  

     If you experience the following, contact your doctor to find out what you should do: 

    • Need to get a contrast agent for an x-ray procedure 
    • Have a planned surgery 
    • Experiencing dehydration or a condition that causes a large loss of bodily fluids 

    If you miss a dose, take the next dose with food as soon as you realize you missed it; however, do not take two doses at the same time.  

    Side Effects

    The most common side effects of Janumet (Sitagliptin/Metformin) are a runny nose and sore throat, along with the following: 

    • Nausea 
    • Diarrhea 
    • Abdominal pain 
    • Bloating 
    • Upset stomach 
    • Loss of appetite 
    • Gas 

     Serious side effect that may occur while taking Janumet (Sitagliptin/Metformin) include:  

    • Lactic acidosis, which is due to lactic acid build up in the blood.  
    • Low blood sugar when taking sulfonylurea or insulin. Some of the signs of low blood sugar include: 
    • Fast heartbeat 
    • Sweating 
    • Jittery feeling 
    • Hunger 
    • Headache 
    • Weakness 
    • Confusion 
    • Drowsiness 
    • Irritability

    Allergic reactions may include: 

    • Rash 
    • Swelling (lips, throat, tongue or face) 
    • Hives 
    • Difficulty breathing or swallowing

    Additional side effects of Janumet (Sitagliptin/Metformin) include: 

    • Vomiting 
    • Headache 
    • Constipation 
    • Inflammation of the pancreas 
    • Blisters 
    • Back pain 
    • Itching 
    • Join pain 
    • Muscle aches 
    • Arm or leg pain

    Warnings and Precautions

    Janumet (Sitagliptin/Metformin) may cause lactic acidosis, which needs to be treated in a hospital. Symptoms of lactic acidosis include:  

    • Weak and tired 
    • Dizziness and lightheadedness  
    • Unusual muscle pain 
    • Feeling cold 
    • Stomach pain with nausea, vomiting or diarrhea 
    • Difficulty breathing 
    • Irregular heartbeat 
    • Changes in medical condition

    You may have a higher chance of lactic acidosis if you have the following conditions: 

    • Kidney problems 
    • 80 years of age or older  
    • Congestive heart failure 
    • Heart attack, severe infection or stroke 
    • Drink alcohol 
    • X-rays with contrast agents or injectable dyes 
    • Dehydration 
    • Surgery

    Patients taking Janumet (Sitagliptin/Metformin) may have an increased risk of pancreatitis.  

     Do not take Janumet (Sitagliptin/Metformin) without talking to your doctor, if you have experienced the following:  

    • You have pancreatitis or have had it in the past 
    • Liver problems 
    • Aged 80 years or older 
    • Taking insulin for hypoglycemia 
    • Kidney problems 
    • Allergic reaction to sitagliptin, metformin or Janumet (Sitagliptin/Metformin) 
    • Heart problems 
    • Breastfeeding or plan to breastfeed 
    • Pregnant or plan to become pregnant 

    Children under the age of 18 years of age should not take Janumet (Sitagliptin/Metformin). 

    Interactions with this medication

    To avoid interactions with Janumet (Sitagliptin/Metformin), tell your doctor and pharmacist about all of the medications you are taking, especially the following: 

    • Nifedipine 
    • Cationic drugs 
    • Other diabetes drugs 
    • Furosemide 
    • Ace inhibitor drugs 
    • Other drugs that may cause hyperglycemia, which includes: 
      • Thyroid products 
      • Corticosteroids 
      • Thiazide 
      • Estrogens 
      • Phenothiazines 
      • Oral contraceptives  
      • Beta-2-agonists 
      • Phenytoin 
      • Isoniazid 
      • Nicotinic acid 
      • Calcium channel blockers 
      • Sympathomimetics 

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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