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Onglyza or Saxagliptin is an oral tablet for diabetic people. It is designed for those suffering from Type 2 diabetes. This medication helps regulates blood sugar levels.
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This medication is manufactured by AstraZeneca and Bristol-Myers Squibb and we offer it in these doses: 2.5mg and 5mg. There currently is no generic available on the market. Lastly, click our dosage boxes shown above to view our low prices.
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Onglyza (Saxagliptin) Medication Information
Onglyza is a prescription medication for type 2 diabetes that contains the active ingredient saxagliptin.
Onglyza is prescribed, along with a healthy diet and exercise, to improve blood sugar levels in adults with type 2 diabetes.
Insulin is a hormone made by the pancreas that normally helps sugar get into your cells. But, if your body doesn’t recognize insulin properly, too much sugar stays in your blood. Over time, high blood sugar levels can lead to many other health problems and increase your risk of having a heart attack or stroke.
The good news is you can take control of your diabetes by eating healthy foods, exercising, and taking your medications as prescribed.
Onglyza (saxagliptin) is an oral tablet that comes as 2.5 milligrams (mg) and 5 mg.
Take Onglyza once daily, around the same time each day. You can take with or without food.
Your doctor will decide the dosage that is best for you.
Onglyza may not be safe for people with the following medical history or conditions:
- Pancreatitis or other pancreas problems
- Heart disease
- Kidney problems
- Pregnant or plan to become pregnant
- Type 1 diabetes or diabetic ketoacidosis
- History of an allergic reaction to saxagliptin (Onglyza)
Like all medications, Onglyza may cause side effects. The most common side effects of Onglyza are mild, but severe side effects are also possible.
Common side effects may include:
- Upper respiratory tract infections
- Urinary tract infections
- Hypoglycemia (low blood sugar)
- Peripheral edema (swelling in your feet, ankles, or hands)
Serious side effects can rarely occur with Onglyza. These side effects require emergency medical care and may include:
- Pancreatitis (inflammation of the pancreas)
- Heart failure (heart does not pump blood very well)
- Allergic reaction
- Joint pain
- Skin reaction
Your doctor will prescribe Onglyza if the benefits for your health outweigh your risk of severe side effects. For more information about the side effects of Onglyza, talk with your doctor or pharmacist.
Some potentially harmful drug interactions can happen with Onglyza. A few examples include:
- Insulin or other medicines that lower blood sugar
Talk with your doctor or pharmacist before taking any other medications or herbal supplements with Onglyza
Store at room temperature between 68°F and 77°F (20°C and 25°C).
- Swallow Onglyza tablets whole; Don’t crush, chew, or cut in half.
- If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Don’t take two doses of Onglyza at the same time.
How does Onglyza work in the body?
Onglyza enhances the body’s natural ability to maintain healthy blood sugar levels. Saxagliptin helps the body increase the effects of insulin after meals. It also reduces the amount of sugar released overnight by the liver, resulting in lower blood sugar and A1C.
What is A1C, and how does Onglyza affect it?
Your doctor will check your A1C using a simple blood test. This test indicates your average blood sugar level over the past two to three months. In clinical trials, Onglyza helped to lower A1C when combined with exercise and a healthy diet. The lower your A1C, the lower your risk for developing complications of diabetes, such as heart attack or stroke.
- Onglyza Prescribing Information. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2019. https://www.azpicentral.com/onglyza/onglyza.pdf Accessed November 20, 2020.
- Goyal R, Jialal I. Diabetes Mellitus Type 2. Treasure Island, FL: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK513253/ Accessed November 20, 2020.
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Author: Dr. Patricia Weiser, PharmD
Patricia Weiser, PharmD, is a licensed pharmacist and medical writer. She has clinical experience in community and hospital pharmacy. Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.