Januvia

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    Januvia (sitagliptin) Dosage and Side Effects

    JANUVIA can be used to improve blood sugar levels in adult patients with type 2 diabetes mellitus in addition to diet and exercise.

    Warnings and Precautions

    Cases of inflammation of the pancreas (pancreatitis) which may be severe and lead to death have been reported in patients taking JANUVIA.

    BEFORE you use JANUVIA talk to your physician or pharmacist if:

    • you have or have had pancreatitis (inflammation of the pancreas) or any risk factors for pancreatitis such as gallstones (solid particles that form in the gall bladder), a history of alcoholism, high triglyceride levels.
    • you have type 1 diabetes.
    • you have or have had diabetic ketoacidosis (increased ketones in the blood or urine).
    • you are taking a sulfonylurea. When JANUVIA is used in combination with a sulfonylurea and metformin, or in combination with insulin (with or without metformin), low blood sugar can occur. Your physician may consider lowering the dose of the sulfonylurea or insulin. Take precautions to avoid low blood sugar while driving or using machinery.
    • you have or have had an allergic reaction to JANUVIA.
    • you have congestive heart failure (a condition where your heart becomes weaker and less able to pump the blood that your body needs).
    • you have or have had kidney problems.
    • you have liver problems.
    • you are pregnant or plan to become pregnant. JANUVIA is not recommended for use during pregnancy.
    • you are breast-feeding or plan to breast-feed. It is not known if JANUVIA passes into breast milk.

    JANUVIA is not recommended for use in children under 18 years of age.

    Side Effects

    The most common side effects of JANUVIA include: stuffy or runny nose and sore throat.

    Tell your physician or pharmacist if you develop any unusual side effects, or any of the above side effects that do not go away or gets worse.

    When JANUVIA is used with metformin and a sulfonylurea medicine, or with insulin (with or without metformin), low blood sugar (hypoglycemia) can occur. Lower doses of the sulfonylurea medicine or insulin may be required while you use JANUVIA. The signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery. Discuss with your physician or pharmacist how to treat low blood sugar.

    Additional side effects have been reported in general use with JANUVIA:

    • Allergic reactions, which may be serious, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have an allergic reaction, stop taking JANUVIA and call your physician right away. Your physician may prescribe a medication to treat your allergic reaction and a different medication for your diabetes.
    • Inflammation of the pancreas
    • Kidney problems (sometimes requiring dialysis)
    • Vomiting
    • Constipation
    • Headache
    • Joint pain
    • Muscle aches
    • Arm or leg pain
    • Back pain
    • Itching
    • Blisters

    Interactions with this medication

    Tell your physician or pharmacist about all the medicines you take. This includes prescription and non-prescription medicines, and herbal supplements.

    Proper Use of this medication

    Take JANUVIA exactly as your physician has prescribed.

    Usual dose:

    100 mg once daily by mouth with or without food. The daily dose may be adjusted in patients with kidney problems.

    Overdose

    In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

    Missed dose:

    If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take a double dose of JANUVIA on the same day.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.