Requip (Ropinirole)

Author , posted on July 5, 2017

Category:


Requip

Ropinirole Hydrochloride
Select Quantity:
Select Quantity:
Select Quantity:
Select Quantity:
Select Quantity:

Requip

Ropinirole Hydrochloride
Select Quantity:

Ropinirole (Generic)

Ropinirole Hydrochloride
Select Quantity:

Ropinirole (Generic)

Ropinirole Hydrochloride
Select Quantity:
Select Quantity:
Select Quantity:
Select Quantity:

Ropinirole (Generic)

Ropinirole Hydrochloride
Select Quantity:

Requip (Ropinirole) Dosage and Side Effects

REQUIP, also known as ropinirole, is used to treat the signs and symptoms of Parkinson's disease.  You may receive REQUIP on its own but it may also be given with another drug used to treat Parkinson's disease.

Proper Use of this medication

 Usual dose:

Follow the doctor's instructions about how and when you should take your tablets. Your doctor will decide how many tablets you need to take each day and you should always follow his/her instructions. When you first start taking REQUIP, the amount you take will be increased gradually.

Your doctor may adjust the amount that you are taking. You will usually be told to take REQUIP three times a day. You should not change the dose or discontinue treatment with REQUIP without the recommendation of your doctor.

If you are taking other medicines for Parkinson's disease, the doctor may adjust the dose of these medicines while you are taking REQUIP.

You should swallow the tablets whole with water. Do not chew. REQUIP can be taken with or without food.

You should continue to take your medicine even if you do not feel better, as it may take a number of weeks for the medicine to work.

REMEMBER: THIS MEDICINE IS FOR THE PERSON NAMED BY THE DOCTOR. DO NOT GIVE IT TO ANYBODY ELSE.

Overdose:

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

If you or someone you know have taken too many tablets all at once, you should get medical help immediately, either by calling your doctor, the Regional Poison Control Centre, or the nearest hospital (do not drive yourself). Always take the labelled medicine container with you even if there are no tablets left.

Missed dose:

If you have forgotten to take REQUIP, do not take extra doses to make up for forgotten individual doses. When you do remember to take REQUIP, take your next dose of REQUIP at the usual time. If you have missed taking REQUIP for one day or more consult your doctor for advice on restarting REQUIP.

Side Effects

Like all medications, REQUIP tablets can cause some side effects. You may not experience any of them. For most patients these side effects are likely to be minor and temporary. However, some may be serious. Consult your doctor if you experience these or other side effects.

Some of the most commonly reported side effects of REQUIP tablets are:

  • Feeling or being sick
  • Stomach ache
  • Dizziness or light-headedness, fainting
  • Sleepiness
  • Headache
  • Some leg swelling
  • Tiredness
  • Viral infection
  • Feeling full and bloated or experiencing heartburn

Warnings and Precautions

You are warned of a sudden onset of sleep condition which may occur without warning, while taking REQUIP. You should not operate machinery or engage in activities that require alertness, as you may put yourself and others at risk of serious injury or death. This sudden onset of sleep condition has also been reported in patients taking other similar anti-Parkinson drugs.

What should I know before taking REQUIP:

Studies of people with Parkinson's disease show that they may be at an increased risk of developing melanoma, a form of skin cancer, when compared to people without Parkinson's disease. It is not known if this problem is associated with Parkinson's disease or the drugs used to treat Parkinson's disease. REQUIP is one of the drugs used to treat Parkinson's disease, therefore, patients treated with REQUIP should have periodic skin examinations.

Drop in Blood Pressure:

While taking REQUIP, you may experience a drop in blood pressure that may make you feel dizzy or faint especially when standing up from a sitting or lying position.

Neurological Disorder:

Symptoms resembling a neurological disorder (Neuroleptic Malignant Syndrome) characterized by fever, muscle stiffness, stupor and unstable involuntary actions have been reported in relation to changes in treatment, reduction of treatment dose and stopping treatment.

REQUIP taken with L-dopa:

REQUIP may amplify the side effects of L-dopa (also called levodopa) and may cause or worsen pre-existing uncontrolled jerky movements (dyskinesia). Tell your doctor if this happens as the dose of your medicines may need adjusting.

Eye Disorders:

If you have albinism (lack of pigmentation in skin or hair), you may have an increased risk of eye disorders while taking REQUIP compared to people without albinism. Therefore, you should take REQUIP only under an ophthalmologist’s (doctor who specializes in eye disorders) care.

Hallucinations:

While taking REQUIP, you may experience hallucinations, such as seeing or hearing things that aren’t really there.

Psychiatric Disorders:

Impulse control symptoms including compulsive behaviours, e.g. feeling an urge to gamble, hypersexuality, compulsive shopping, or binge eating, as well as aggression have been reported with the use of REQUIP.

BEFORE you use REQUIP talk to your doctor or pharmacist if you:

  • have any health problem, especially any heart, liver or kidney condition.
  • have previously taken REQUIP and became unwell.
  • have any allergies or reactions to foods or drugs.
  • are pregnant or think you may be pregnant, or if you are breast feeding. You should not be taking REQUIP if you are pregnant or breast feeding.
  • are taking any other medications, including any drugs you can buy without a prescription.
  • have experienced any unusual urges and/or behaviours (such as excessive gambling or excessive sexual behaviour).

Interactions with this medication

Other medications may be affected by REQUIP or may affect how REQUIP works. Do not take any other medication, including any drugs or herbal products you can buy without a prescription. Tell any other doctor, dentist or pharmacist that you talk to that you are taking REQUIP.

Drug-drug Interaction:

Drugs that may interact with REQUIP include:

  • a drug used to help with breathing difficulties called theophylline
  • an antibiotic called ciprofloxacin
  • any hormone replacement therapy (HRT)
  • other dopamine agonists, e.g. L-dopa: REQUIP may make some of the side effects of L-dopa worse, e.g. jerky movement
  • certain medicines called neuroleptics used to treat schizophrenia and other serious mental illnesses
  • digoxin, a heart medicine that is used to treat congestive heart failure or certain heartbeat irregularities

Drug-lifestyle Interaction:

  • REQUIP may affect your ability to remain alert while doing normal daily activities. You should refrain yourself from doing activities such as driving a car, doing physical tasks or using hazardous machinery until you know how REQUIP affects you.
  • Because REQUIP can make you feel sleepy, tell your doctor or pharmacist if you are planning to drink alcohol.

Before making any change to other medications you are taking, or stopping them, talk to your doctor first.

Other related products

Estrogel Gel (Estrogel)

Author , posted on July 5, 2017

Category:


Estrogel

Estradiol
Select Quantity:

Estrogel

Estradiol
Select Quantity:

Estrogel Gel (Estradiol) Dosage and Side Effects

ESTROGEL is used for a replacement of estrogen in menopausal women with symptoms of menopause, which may include hot flushes, disturbed sleep and vaginal dryness.

Proper Use of this medication

 Do not apply ESTROGEL on the breasts since this may cause unwanted effects and discomfort. Do not apply ESTROGEL to the face or to irritated or damaged skin.

Usual dose:

The recommended dosage of ESTROGEL is two pump pressures (2.5 g) per day on a cyclic schedule from day 1 to day 25 of each calendar month or from day 1 to day 21 of a 28-day cycle. ESTROGEL may be applied either in the morning or evening after washing, but preferably about the same time each day. If your periods have stopped, or are irregular, you can start using ESTROGEL at any time.

Under the supervision of your doctor, the dose of ESTROGEL can be adjusted to meet your individual needs. Attempts to adjust the necessary dosage should be made after two months of treatment. Breast tenderness and/or unexpected bleeding are generally signs that the dose is too high and needs to be lowered. However, if the selected dose fails to control your menopausal symptoms, a higher dose may be prescribed.

You and your doctor should talk regularly about whether you still need treatment with estrogen.

How and When To Apply ESTROGEL:

ESTROGEL Pump:

  • Remove the large pump cover. When you open a new pump, press on the pump once or twice in order to prime the pump and discard these doses.

  • Press firmly on the pump once, collect the gel in your hand and apply the gel on one arm, as illustrated. Repeat and apply the gel on the opposite arm.

  • ESTROGEL should be applied using clean hands onto clean, dry skin. The gel should be spread over a large area of skin (at least 2000 cm2), which corresponds to approximately 4 times the size of your hand. It is recommended to apply ESTROGEL to both arms, as illustrated. Other recommended areas of application are the abdomen or the inner thighs, as illustrated. It is not necessary to rotate the site of administration. Do not apply ESTROGEL on the breasts since this may cause unwanted effects and discomfort. Do not apply ESTROGEL to the face or to irritated or damaged skin.

  • Allow the gel to dry for 2 minutes before covering with clothes. ESTROGEL does not stain and does not smell.

  • The pump contains enough gel for approximately 1 month's use (i.e. 64 metered-doses) at the recommended dose of two pumps/per day (2.5 g). After that, the amount of gel delivered may be lower and thus, it is recommended to change the pump.

  • Always replace the small protective cap back in the tip of the pump as well as the large pump cover after each use, as illustrated.

Overdose:

For management of a suspected drug overdose, contact your regional Poison Control Centre.

When someone accidentally takes too much ESTROGEL, the following symptoms may arise: nausea (urge to vomit), breast discomfort, fluid retention, abdominal cramps, headache, dizziness, bloating or vaginal bleeding in women.

In case of accidental overdosage or ingestion of ESTROGEL, contact your doctor and/or your local Poison Control Centre.

Missed dose:

If a dose of this medication has been missed, it should be taken as soon as possible. However if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not double dose. If you are in doubt, contact your healthcare provider.

Side Effects

 Very rarely, skin irritation can occur with ESTROGEL. Depending on the dosage of estrogen and the sensitivity of the patient, the following side effects are possible:

  • genital bleeding or spotting (minor vaginal bleeding) in between the normal periods;

  • headaches or depressive mood;

  • breast tenderness/swelling;

  • water retention (bloating, swelling);

  • endometrial hyperplasia (overgrowth of the lining of the uterus);

  • nausea (urge to vomit), abdominal discomfort (cramps, pressure, pain);

  • gallbladder disorder, impaired liver function;

  • menstrual cramps;

  • vaginal itching/discharge;

  • pain during sexual intercourse;

  • pain on urination or difficulty urinating;

  • premenstrual syndrome (PMS);

  • inflammation of the bladder;

  • brown, blotchy spots on exposed skin (pregnancy mask);

  • skin rash, tender red lumps or nodules or other skin reactions;

  • loss of hair, hairiness;

  • acne;

  • palpitations (unpleasant sensation of irregular and/or forceful beating of the heart);

  • worsening of varicose veins (visible and bulging veins);

  • nervousness;

  • fatigue (tiredness);

  • irritability;

  • intolerance to contact lenses;

  • changes in appetite and body weight;

  • change in sexual drive;

  • pain in the joints and muscles, usually lasting only 3-6 weeks.

For any unexpected effects while taking ESTROGEL, contact your doctor or pharmacist.

Warnings and Precautions

Serious Warnings and Precautions

The Women's Health Initiative (WHI) trial is a large clinical study that assessed the benefits and risks of oral combined estrogen plus progestin therapy and oral estrogen-alone therapy compared with placebo (a pill with no active ingredients) in post-menopausal women.

The WHI trial indicated an increased risk of myocardial infarction (heart attack), stroke, breast cancer, pulmonary emboli (blood clots in the lungs) and deep vein thrombosis (blood clots in the large veins) in post-menopausal women taking oral combined estrogen plus progestin.

The WHI trial indicated an increased risk of stroke and deep vein thrombosis in post-menopausal women with prior hysterectomy (surgical removal of the uterus) taking oral estrogen-alone.

Therefore you should highly consider the following:

  • There is an increased risk of developing invasive breast cancer, heart attack, stroke and blood clots in both lungs and large veins with the use of estrogen plus progestin therapy.

  • There is an increased risk of stroke and blood clots in the large veins with the use of estrogen-alone therapy.

  • Estrogens with or without progestins should not be used to prevention of heart disease or stroke.

  • Estrogens with or without progestins should be used at the lowest effective dose and for the shortest period of time possible. Regular medical follow-up is advised.

Breast Cancer:

The results of the WHI trial indicated an increased risk of breast cancer in post-menopausal women taking combined estrogen plus progestin compared to women taking placebo.

The results of the WHI trial indicated no difference in the risk of breast cancer in post-menopausal women with prior hysterectomy taking estrogen-alone compared to women taking placebo.

Estrogens should not be taken by women who have a personal history of breast cancer.

In addition, women with a family history of breast cancer or women with a history of breast lumps, breast biopsies or abnormal mammograms (breast x-rays) should consult with their doctor before starting HRT.

Women should have a mammogram before starting HRT and at regular intervals during treatment as recommended by their doctor.

Regular breast examinations by a doctor and regular breast self-examinations are recommended for all women. You should review technique for breast self-examination with your doctor.

Overgrowth of the lining of the uterus and cancer of the uterus:

The use of estrogen-alone therapy by post-menopausal women who still have a uterus increases the risk of developing endometrial hyperplasia (overgrowth of the lining of the uterus), which increases the risk of endometrial cancer (cancer of the lining of the uterus).

If you still have your uterus, you should take a progestin medication (another hormone drug) regularly for a certain number of days of each month to reduce the risk of endometrial hyperplasia.

You should discuss progestin therapy and risk factors for endometrial hyperplasia and endometrial carcinoma with your doctor. You should also report any unexpected or unusual vaginal bleeding to your doctor.

If you have had your uterus removed, you are not at risk of developing endometrial hyperplasia or endometrial carcinoma. Progestin therapy is therefore not generally required in women who have had a hysterectomy.

Ovarian Cancer:

In some studies the use of estrogen-alone therapy and estrogen plus progestin therapies for 5 or more years has been associated with an increased risk of ovarian cancer.

Heart Disease and Stroke:

The results of the WHI trial indicated an increased risk of stroke and coronary heart disease in post-menopausal women taking combined estrogen plus progestin compared to women taking placebo.

The results of the WHI trial indicated an increased risk of stroke, but no difference in the risk of coronary heart disease in post-menopausal women with prior hysterectomy taking estrogen alone compared to women taking placebo.

Abnormal Blood Clotting:

The results of the WHI trial indicated an increased risk of blood clots in the lungs and large veins in post-menopausal women taking combined estrogen plus progestin compared to women taking placebo. The results of the WHI trial indicated an increased risk of blood clots in the large veins, but no difference in the risk of blood clots in the lungs in post-menopausal women with prior hysterectomy taking estrogen-alone compared to women taking placebo.

The risk of blood clots also increases with age, if you or a family member has had blood clots, if you smoke or if you are severely overweight. The risk of blood clots is also temporarily increased if you are immobilized for long periods of time and following major surgery. You should discuss risk factors for blood clots with your doctor since blood clots can be life-threatening or cause serious disability.

Gallbladder Disease:

The use of estrogen therapy by post-menopausal women has been associated with an increased risk of gallbladder disease requiring surgery.

Dementia (loss of memory and intellectual function): The Women's Health Initiative Memory Study (WHIMS) was a substudy of the WHI trial and indicated an increased risk of dementia (loss of memory and intellectual function) in post-menopausal women age 65 and over taking oral combined estrogen plus progestin compared to women taking placebo. The WHIMS indicated no difference in the risk of dementia in post-menopausal women age 65 and over with prior hysterectomy taking oral estrogen-alone compared to women taking placebo.

Contact Sensitization:

Products applied onto the skin may result in sensitization. Although it is extremely rare, skin sensitization may evolve into severe hypersensitivity reaction with continued use of the gel.

BEFORE you use ESTROGEL talk to your doctor or pharmacist if you:

  • have a history of liver disease, liver tumours, or jaundice (yellowing of the eyes and/or skin) or itching related to estrogen use or during pregnancy;

  • have a personal history of breast disease (including breast lumps) and/or breast biopsies, or a family history of breast cancer;

  • have a history of endometrial hyperplasia (overgrowth of the lining of the uterus);

  • have experienced undiagnosed or unusual vaginal bleeding;

  • have experienced pressure or pain in your abdomen or pelvis;

  • have a history of uterine fibroids (abnormally thick tissue in the uterus) or endometriosis (disorder of the uterine lining);

  • have a history of heart disease or stroke or family history of blood clots;

  • have a history of migraine headaches;

  • have a personal history of active thrombophlebitis (inflammation of veins);

  • have had a partial or complete loss of vision due to blood vessel disease of the eye;

  • are pregnant or may be pregnant;

  • have a history of allergy or intolerance to ESTROGEL or any of its ingredients, or to any medications or other substances;

  • smoke;

  • have a history of high blood pressure;

  • have history of kidney disease, asthma or epilepsy (seizures);

  • have a history of bone disease (this includes certain metabolic conditions or cancers that can affect blood levels of calcium and phosphorus);

  • have been diagnosed with diabetes;

  • have been diagnosed with porphyria (disease of blood pigments);

  • have a history of high cholesterol or high triglycerides (a type of fat in the blood);

  • have a history of depression;

  • have had a hysterectomy (surgical removal of the uterus);

  • have been told that you have a condition called hereditary angioedema or if you have had episodes of rapid swelling of the hands, feet, face, lips, eyes, tongue, throat (airway blockage), or digestive tract;

  • have been diagnosed with lupus;

  • have been diagnosed with hearing loss due to otosclerosis;

  • breastfeeding.

Interactions with this medication

Drugs that may interact with ESTROGEL include:

Barbiturates, hydantoins, carbamazepine, meprobamate, phenylbutazone or rifampin, atorvastatin, antibiotics, aminoglutethimide, some herbal products (e.g. St. John's wort), phenobarbital, phenytoin, troglitazone, ascorbic acid, acetaminophen, oral contraceptives containing ethinyl estradiol, progestin.

Estrogens may diminish the effectiveness of anticoagulant (substance that prevents coagulation), antidiabetic (drugs treating diabetes mellitus) and antihypertensive agents (drugs treating high blood pressure).

Tell your doctor or pharmacist if you are taking any other medications, including prescription medications, over-the-counter medications, vitamins or herbal products.

Other related products

 
 

Condylox (Podofilox)

Author , posted on July 5, 2017

Category:


Condyline Solution

Podofilox
Select Quantity:

Condylox (Podofilox) Dosage and Side Effects

CONDYLOX topical (for the skin) is used to treat genital warts that appear on the outside of the body, but this medicine is not a cure for genital warts.

Proper Use of this medication

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your healthcare provider may show you how to apply this medicine at home.

Using more of this medication will not make it work better, and may increase side effects.

Wash your hands before applying CONDYLOX topical. Also wash the skin area to be treated, and allow it to dry completely before applying the medicine.

Apply the medication using the cotton applicator provided or with your finger. Apply CONDYLOX only to the wart tissue and avoid getting it on healthy skin. If the genital wart is in a skin fold, spread the skin apart and apply the medicine. Allow the treated skin to dry before releasing the skin fold.

This medication is usually applied in the morning and evening for 3 days in a row, followed by 4 days of not using the medicine. This 7-day treatment cycle should be repeated up to 4 times, or until you can no longer see any signs of wart tissue.

Wash your hands again after applying CONDYLOX topical.

Call your doctor if your symptoms do not improve after 4 treatment cycles.

CONDYLOX topical is not a cure for genital warts and it may not keep you from spreading this condition to others through vaginal, anal, or oral sex. You may develop new lesions during treatment with CONDYLOX topical. For best results, keep using the medicine for the entire length of time prescribed by your doctor.

Store at room temperature away from moisture and heat. Do not freeze.

This medication is flammable. Do not use it near high heat or open flame, or while you are smoking.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Wash off the medicine and call your doctor at once if you have a serious skin reaction such as severe itching, burning, oozing, bleeding, or skin changes where the medicine is applied.

Less serious side effects may include:

•mild skin irritation, tenderness, bleeding, dryness, peeling, tingling, scarring, blistering, crusting, or swelling of the skin where the medicine was applied;

•sleep problems (insomnia);

•unpleasant skin odor;

•nausea, vomiting; or

•pain during sex.

Warnings and Precautions

Do not use this medication on any warts or skin growths that have not been checked by your doctor.

Using more of this medication will not make it work better, and may increase side effects.

Avoid getting this medication in your eyes. If this does happen, rinse with water and call your doctor. Do not place the gel or solution in your rectum, vagina, or urethra. If it does get into any of these areas, rinse with water.

Avoid having unprotected sex. CONDYLOX is not a cure for genital warts, and it will not protect against sexually transmitted diseases such as chlamydia, gonorrhea, herpes, HIV, syphilis, and trichomoniasis. Talk with your doctor about safe ways to prevent transmission during sex.

Wash your hands before and after applying CONDYLOX topical.

You should not use CONDYLOX topical if you are allergic to it.

Do not use this medication on any warts or skin growths that have not been checked by your doctor.

FDA pregnancy category C. It is not known whether CONDYLOX topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication..

It is not known whether CONDYLOX topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Interactions with this medication

Do not have sex on the days you apply CONDYLOX topical.

Avoid getting this medication in your eyes. If this does happen, rinse with water and call your doctor. Do not place the gel or solution in your rectum, vagina, or urethra. If it does get into any of these areas, rinse with water.

Avoid having unprotected sex. CONDYLOX is not a cure for genital warts, and it will not protect against sexually transmitted diseases such as chlamydia, gonorrhea, herpes, HIV, syphilis, and trichomoniasis. Talk with your doctor about safe ways to prevent transmission during sex.

It is not likely that other drugs you take orally or inject will have an effect on topically applied CONDYLOX. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Other related products

CeeNU (Lomustine)

Author , posted on July 5, 2017

Category:


CeeNU

Lomustine
Select Quantity:
Select Quantity:

Lomustine (Generic)

Lomustine
Select Quantity:

CeeNU (Lomustine) Medication Information

Uses

CeeNU has been shown to be useful as a single agent in addition to other treatment modalities, or in established combination therapy with other approved chemotherapeutic agents in the following:

  • Brain tumor
  • Hodgkin’s disease

Dosage

There are oral capsules available in several different strengths:

  • 10 mg
  • 40 mg
  • 100 mg

Side Effects

The most common side effects of CeeNU include:

  • Hematologic toxicity
  • Pulmonary toxicity
  • Nausea/vomiting
  • Hepatotoxicity
  • Nephrotoxicity
  • Stomatitis
  • Alopecia
  • Lethargy
  • Ataxia 

Speak with your doctor or pharmacist for a full list of side effects that applies to you.

Precautions

In all instances where the use of CeeNU is considered for chemotherapy, the physician must evaluate the need and usefulness of the drug against the risks of toxic effects or adverse reactions. Most such adverse reactions are reversible if detected early. When such effects or reactions do occur, the drug should be reduced in dosage or discontinued and appropriate corrective measures should be taken according to the clinical judgment of the physician. Reinstitution of CeeNU therapy should be carried out with caution and with adequate consideration of the further need for the drug and alertness as to possible recurrence of toxicity.

CeeNU is carcinogenic in rats and mice, producing a marked increase in tumor incidence in doses approximating those employed clinically. Nitrosourea therapy does have carcinogenic potential in humans. CeeNU also affects fertility in male rats at doses somewhat higher than the human dose.

Interactions

Some of the common drug interactions with CeeNU:

  • Chloramphenicol
  • Clozapine
  • Denosumab
  • Fingolimod
  • Leflunomide
  • Ocrelizumab
  • Vaccines

Speak with your doctor or pharmacist for more information. 

Storage

Store at controlled room temperature (77ºF). 

Pharmacist Tips

  • CeeNU is an anticancer drug and belongs to the group of medicines known as alkylating agents.
  • there may be 2 or more different types and colors of capsules in the container dispensed by the pharmacist.
  • Wear gloves when handling CeeNU Capsules.
  • If any of the following reactions occur, notify the physician: fever, chills, sore throat, unusual bleeding or bruising, shortness of breath, dry cough, swelling of feet or lower legs, mental confusion, or yellowing of eyes and skin.

CeeNU FAQs

Can I take this if I am pregnant?

CeeNU can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking (receiving) this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.

 

Can I take this while breastfeeding?

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from CeeNU, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

 

How is CeeNU given?

CeeNU is given as a single oral dose and will not be repeated for at least 6 weeks.

 

How long does the nausea/vomiting last?

Nausea and vomiting usually last less than 24 hours, although loss of appetite may last for several days.

 

How often should blood be monitored?

Due to delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose.

 

Can the capsules be opened?

Capsules should not be broken.

Related Drugs

  • Gleostine
  • Procarbazine
  • Vincristine

Reference:

CeeNU {package insert}. Princeton, NJ: Bristol-Myers Squibb Company; 2010.

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

Estring Vaginal Ring (Estradiol)

Author , posted on July 4, 2017

Category:


Estring Vaginal Ring

Estradiol Hemihydrate
Select Quantity:

Estring Vaginal Ring

Estradiol Hemihydrate
Select Quantity:

Estring Coupon

Estring Coupon Code

Get $10 Discount

Apply Estring coupon code EST10 at checkout.

With this bonus offer you can buy Estring starting at $89.

*Coupon codes cannot be combined and are for one-time use only

Buy Estring Online

Estring is the brand name of a 90-day vaginal ring, containing the active ingredient Estradiol, a form of estrogen found in the body. It is often prescribed to relieve the symptoms of vaginal atrophy such as dryness, burning, itching, painful and frequent urination. If you are suffering from a similar condition and your doctor prescribes Estring to you, do not worry about the costs. PricePro Pharmacy is here, committed to providing you cheap, affordable, and convenient options for your prescription drugs.

Take advantage of lower drug prices in Canada, by placing an order of Estring online. You can also talk or chat live with our healthcare experts if you have any questions regarding the medicine or ordering system.

Simply browse our website or call our toll-free number at 1-855-776-0079 to order your Estring Vaginal Ring prescription online and request to talk with a customer care representative.

Please note in order to process your order, we’d need a valid doctor's prescription. Make sure to either email, fax, or upload the Rx to your online pharmacy account, before placing an order.

Estring Vaginal Ring Product Overview

The brand Estring Vaginal Ring is available from the United Kingdom and Canada. Both products are and manufactured by Pfizer Inc.

The available options at PricePro Pharmacy are Estring Vaginal Ring 2mg (7.5mcg/24hr), which contains a total of 2mg of Estradiol and releases 7.5mcg of the drug to your bloodstreams every 24 hours.

The product is available as a single pack and each pack contains 1 slightly opaque with a whitish core Estring Vaginal Ring. To know about the price, click on "Check Prices" above.

A generic alternative may have reduced your expenses, but unfortunately, Estring does not have one in the market.

Available Products

prescription drugs

The following doses are available at PricePro Pharmacy,

  • Estring Vaginal Ring 2mg (7.5mcg/24hr)

This product comes in single pack size, containing one “90-day” ring insert for vaginal delivery of Estradiol to the bloodstreams.

Each ring delivers 7.5mcg of the active ingredient Estradiol every 24hr, for a total of 3 months.

The medical product Estring is manufactured by Pfizer both in the UK and Canada.

Estring Vaginal Ring Price Comparison

save money on prescription drugs

The average retail price of  Estring 2mg Vaginal ring, at your local US pharmacy is:

  • $604.96 for 1 ring

While at PricePro Pharmacy, we set the price at

  • $99.00 for 1 ring (Product of UK)

If you compare this price with the price at your local pharmacy, you will observe a massive 84% savings. What’s more, you do not need to search for other Rx coupons or vouchers to buy Estring at this price.

As an extra bonus, we are offering a one-time Estring Coupon for a $10 discount. Apply the code “EST10” during checkout and have the price reduced to an even more exciting 89$ per single pack.

At PricePro pharmacy, we are committed to addressing your health needs by providing you affordable and competitive prices at all times.

Shipping Times

prescription delivery

The approximate delivery times for your purchase will differ depending on the product you have chosen.

  • Product of the United Kingdom and Canada – delivered within 7 to 10 business days

The regular shipping price for all orders is $9.95.

An email update with the tracking information will be sent to you, as soon as the product has been dispensed and shipped from the approved and licensed pharmacy.

Estring Prescription Refill

online prescription refill

PricePro Pharmacy is always striving to make your online shopping experience simple, easy, and affordable for you and your family.

In tandem with this goal, we offer a special service of notifying you when it is time for a new refill. Part of our prescription refill service is to alert patients, via emails or phone calls,  when they need to replenish their medication supply.

Moreover, you can sign in directly to your online account and add a reorder there, if you have an active prescription on file.

Save Money on Estring Vaginal Ring Now

At PricePro Pharmacy, our priority is you and your well-being. We pride ourselves on our excellent care and customer service at PricePro Pharmacy. We are available through emails, telephones, and live chat services.

Our healthcare experts are always ready with tips and techniques to manage your condition and help you select and order the appropriate medicine you need. Call 1-855-776-0079 and schedule a meeting with our licensed pharmacists to discuss any particular questions you might have, related to your condition or prescription.

Providing you with friendly, quick, competent, and quality services is what we aim for every day. So, do not wait any longer.  Get your individualized and personalized healthcare at your fingertips now.

Estring (Estradiol Vaginal Ring) Medication Information

Uses

Estring (estradiol vaginal ring) is a vaginal ring prescribed after menopause to treat moderate to severe vaginal atrophy.  Estring is a ring that is inserted into the vagina and stays in place for 90 days.  Estring contains estradiol, a form of estrogen.

What is Vaginal Atrophy?

When a woman’s body has less estrogen after menopause, the walls of the vagina may become thin, dry, and inflamed.  Vaginal atrophy can make sexual intercourse painful and also leads to urinary discomforts.

Dosage

Estring vaginal ring contains 2 mg of estradiol (a form of estrogen), which gradually releases over 90 days.  

Precautions

Estring contains a form of estrogen, which may have serious health risks.

Estring may not be safe for women with the following medical history or conditions:

  • Unusual vaginal bleeding
  • Stroke or heart attack
  • Cancer
  • Blood clots
  • Liver problems
  • Bleeding problems
  • Previous allergic reaction to Estring or any of its ingredients
  • Pregnancy or breastfeeding

Side Effects

Estring, like all estrogen-replacement medications, has the potential for common, mild side effects but also could cause rare, serious side effects.

Common, but usually mild side effects may include:

  • Increased vaginal moisture
  • Headache
  • Breast pain
  • Vaginal bleeding or spotting
  • Stomach pain or bloating
  • Nausea and vomiting
  • Vaginal yeast infection

Rare, serious side effects may include:

  • Heart attack
  • Stroke
  • Blood clots
  • Dementia
  • Breast, uterine, or ovarian cancer
  • High blood pressure
  • High blood sugar
  • Gallbladder or liver problems 
  • Thyroid hormone changes
  • Uterus fibroids 

For more side effect information, talk with your doctor or pharmacist. 

Interactions

Some drug interactions can happen with Estring which can increase the risk of side effects. A few examples include:

  • Clarithromycin
  • Ketoconazole
  • Ritonavir

Grapefruit and grapefruit juice can also increase the risk of side effects with Estring and should be avoided.

Talk with your doctor or pharmacist before taking any other medications or herbal supplements with Estring.

Storage

Store Estring at room temperature between 68°F and 77°F (20°C and 25°C). 

Pharmacists Tips

  • The most common side effect of Estring is increased vaginal secretions (moisture). This vaginal moisture is similar to what naturally occurs before menopause, and it’s a sign that Estring is working.
  • Estring is not safe for life-long use after menopause.  Talk with your healthcare provider every 3 to 6 months to discuss if it is safe for you to continue using Estring.  

Estring FAQs

How long does it take for Estring to work?

It typically takes 2 to 3 weeks for Estring to relieve your symptoms. If your symptoms don’t improve within a few weeks, talk with your healthcare provider. 

Will my partner feel Estring during sex?

You and your partner will probably not notice Estring during intercourse.  If you do, and it causes you or your partner any discomfort, you can remove Estring before sex.  Make sure to reinsert Estring as soon as possible.  Instructions to insert, remove, or reinsert the ring are included with Estring’s packaging.

What should I do if Estring falls out?

It is rare but possible for Estring to fall out.  If this occurs, rinse Estring with warm (not hot) water and reinsert it.  Instructions to insert, remove, or reinsert the ring are included with Estring’s packaging.

Related Products

References

  1. ESTRING Prescribing Information.  New York, NY: Pfizer; 2017. http://labeling.pfizer.com/ShowLabeling.aspx?id=567 Accessed November 14, 2020.
  2. Bleibel B, Nguyen H. Vaginal Atrophy. Treasure Island, FL: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK559297/ Accessed November 14, 2020.

PharmD Medical Writer

Author: Dr. Patricia Weiser, PharmD

Patricia Weiser, PharmD, is a licensed pharmacist and medical writer.  She has clinical experience in community and hospital pharmacy.  Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters.

View Linkedin profile

Xyzal (Levocetirizine)

Author , posted on July 4, 2017

Category:


Xyzal

Levocetirizine Dihydrochloride
Select Quantity:

Xyzal Oral Solution

Levocetirizine Dihydrochloride
Select Quantity:

Levocetirizine (Generic)

Levocetirizine Dihydrochloride
Select Quantity:

Xyzal (Levocetirizine) Dosage and Side Effects

XYZAL is used to treat year-round or seasonal allergies. The medicine can treat allergy symptoms, such as runny nose; sneezing; or red, itchy, and watery eyes. The drug may also be used to treat the itching and swelling that occur with hives.

Proper Use of this medication

XYZAL comes as a tablet and liquid to take by mouth. It's typically taken once a day in the evening with or without food.

Your dosage will be based on your age, medical condition, and response to treatment.

Follow the instructions on your prescription label carefully when taking this medication. Don't take more or less than your doctor prescribes.

XYZAL Overdose

Symptoms of overdose include the following:

  • Drowsiness in adults
  • Restlessness followed by drowsiness in children

If you suspect an overdose, you should contact a poison control center or emergency room immediately.

Missed Dose of XYZAL

If you miss a dose of XYZAL, take it as soon as you remember.

However, if it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Don't take extra medicine to make up for a missed dose.

Side Effects

Common Side Effects of XYZAL

You should tell your doctor if any of the following side effects become severe or don't go away:

  • Sleepiness or tiredness
  • Weakness
  • Sore throat
  • Stuffy nose
  • Cough
  • Dry mouth
  • Vomiting
  • Diarrhea or constipation

XYZAL and Weight Gain

Weight gain is not a common side effect of XYZAL, but some patients do report it. You can prevent weight gain by following a healthy diet and exercise plan.

Serious Side Effects of XYZAL

You should call your doctor immediately if you experience any of the following serious side effects:

  • Rash, hives, or itching
  • Swelling of your hands, arms, feet, ankles, or lower legs
  • Feeling as if you might pass out
  • Nosebleed (especially in children)
  • Hearing problems or pain in your ears
  • Depression, agitation, hallucinations, or aggression
  • Yellowing of your skin or eyes
  • Painful or difficult urination
  • Dark-colored urine
  • Foul-smelling stools
  • Numbness or tingling around your lips or mouth
  • Fever
  • Stomachache or loss of appetite

Warnings and Precautions

It's important not to give a child more of this medication than is the doctor prescribes. A child's body absorbs twice as much of the same dose of XYZAL as an adult's body does.

You shouldn't give this medication to an infant who is younger than 6 months old.

Don't use XYZAL if you are allergic to levocetirizine or cetirizine (Zyrtec).

Before taking XYZAL, you should tell your doctor if you have or have ever had:

  • Liver disease
  • Kidney disease
  • An enlarged prostate
  • Problems with urination
  • Gallbladder problems

You shouldn't take this drug if you have end-stage kidney disease or are on dialysis. Children younger than age 12 with kidney disease shouldn't take XYZAL.

Call your doctor if your symptoms don't improve or worsen or you also have a fever.

Tell your doctor you are taking XYZAL before having any laboratory exams, as the medication can interfere with the results of certain tests.

Pregnancy and XYZAL

XYZAL is a Pregnancy Category B drug, which means it's not expected to harm an unborn baby. You should tell your doctor if you are pregnant or plan to become pregnant while taking this medicine.

The drug can pass into breast milk and may harm a breastfeeding baby. You shouldn't breastfeed while taking XYZAL.

Interactions with this medication

You should always tell your doctor about any prescription, non-prescription, illegal, and recreational drugs; herbal remedies; and nutritional and dietary supplements you're taking, especially:

  • Antidepressants
  • Drugs for anxiety, mental illness, or seizures
  • Ritonavir (Norvir, in Kaletra)
  • Sedatives
  • Sleeping pills
  • Theophylline (Theochron, Theolair, and others)
  • Tranquilizers
  • Other antihistamines

XYZAL and Alcohol

Consuming alcohol while taking XYZAL may increase your risk of side effects, especially drowsiness. You should talk to your doctor about how much alcohol is safe to drink while taking this drug.

XYZAL and Other Interactions

XYZAL may make you drowsy. You shouldn't drive or operate machinery until you know how this medicine affects you.

Other related products

Estraderm (Estradiol)

Author , posted on July 4, 2017

Category:


Estraderm MX

Estradiol
Select Quantity:
Select Quantity:
Select Quantity:
Select Quantity:

Estraderm MX

Estradiol
Select Quantity:
Select Quantity:
Select Quantity:

Estraderm (estradiol) Dosage and Side Effects

ESTRADERM is used to treat and prevent hot flushes in women experiencing menopause. ESTRADERM gel is also used to treat vaginal dryness, itching, and burning in menopausal women. The medicine may also be used to prevent osteoporosis, replace estrogen in women with ovarian failure, or as part of a cancer treatment regimen.

Warnings and Precautions

ESTRADERM can increase the risk that you will develop endometrial cancer (cancer of the lining of the uterus). If you have not had a hysterectomy, you should take progestin along with ESTRADERM to decrease this risk.

However, before taking these two medicines together, talk with your doctor about your risk for other health problems.

In one study, women who took estrogens (such as ESTRADERM) by mouth with progestin had a higher risk of heart attacks, stroke, blood clots, breast cancer, and dementia.

Women who use topical ESTRADERM alone or with progestin may also have a higher risk of developing these conditions.

Using topical ESTRADERM may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks.

Before taking ESTRADERM, tell your doctor if you have or have ever had:

  • A heart attack or stroke
  • Heart disease
  • Blood clots
  • Any type of cancer
  • Abnormal vaginal bleeding
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Asthma
  • Gallbladder disease
  • A thyroid disorder
  • Epilepsy or another seizure disorder
  • Liver disease
  • Lupus
  • Breast lumps or abnormal mammogram results
  • Uterine fibroids
  • Yellowing of the skin or eyes (jaundice)
  • Migraine headaches
  • Endometriosis (a condition where the type of tissue that lines the uterus grows in other areas of the body, usually the abdomen or pelvis)
  • Low levels of calcium in your blood
  • Porphyria (a condition where abnormal substances build up in the blood)

Also, tell your doctor if you smoke or use tobacco products.

You should use the lowest dose of ESTRADERM for the shortest time possible to control your symptoms.

Talk with your doctor every three to six months to determine if you should lower your dose or stop using this medicine.

You should conduct a breast self-exam every month and have a mammogram and clinical breast exam (a breast exam by a health professional) every year to help detect breast cancer.

Tell your doctor if you are having surgery or will be on bed rest while taking ESTRADERM. Your doctor may tell you to stop taking the medication to decrease the risk of blood clots.

The topical medicine may harm other people who touch your skin. You should not let anyone else touch the skin where you applied ESTRADERM for one hour after application.

If someone does touch the area, he or she should wash his or her hands with soap and water immediately.

Pregnancy and ESTRADERM

ESTRADERM can harm an unborn baby or cause birth defects. You should not use this medication while pregnant.

Tell your doctor right away if you become pregnant or might become pregnant while taking this drug.

Since ESTRADERM can also pass into breast milk, talk to your doctor before breastfeeding while taking the drug.

Side Effects

Common Side Effects of ESTRADERM

You should tell your doctor if any of the following symptoms are severe or do not go away:

  • Breast pain or tenderness
  • Headache
  • Diarrhea
  • Gas
  • Constipation
  • Heartburn
  • Mood changes or depression
  • Nervousness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose, cough, or flu-like symptoms
  • Hair loss or unwanted hair growth
  • Darkening of facial skin
  • Difficulty wearing contact lenses
  • Vaginal discharge
  • Swelling, redness, burning, irritation, or itching of the vagina
  • Redness or irritation at the site of application

ESTRADERM and Weight Gain

Water retention that increases your weight is a common side effect.

Talk to your doctor about adjusting your dose of ESTRADERM if weight gain becomes a problem.

Serious Side Effects of ESTRADERM

Contact your doctor immediately if you experience any of the following serious side effects:

  • Sudden, severe headache
  • Sudden, severe vomiting
  • Speech problems
  • Dizziness or fainting
  • Sudden, complete or partial loss of vision or double vision
  • Weakness or numbness of an arm or leg
  • Crushing chest pain or chest heaviness
  • Coughing up blood
  • Sudden shortness of breath or difficulty breathing
  • Breast lumps or other breast changes
  • Nipple discharge
  • Difficulty thinking clearly or remembering
  • Pain, tenderness, or redness in one leg
  • Bulging eyes
  • Yellowing of the skin or eyes
  • Loss of appetite
  • Fever
  • Joint pain
  • Itching
  • Stomach tenderness, pain, or swelling
  • Hives, rash, or blisters
  • Movements that are difficult to control
  • Hoarseness
  • Wheezing
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • Difficulty swallowing

Interactions with this medication

You should tell your doctor about all prescription, non-prescription, over-the-counter (OTC), illegal or recreational drugs; herbal remedies; and nutritional or dietary supplements you're taking, especially:

  • Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • St. John's wort
  • Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
  • Clarithromycin (Biaxin)
  • Erythromycin (E.E.S, Erythrocin)
  • Lovastatin (Alticor, Altoprev, Mevacor)
  • Medications for thyroid disease
  • Phenobarbital
  • Rifampin (Rifadin, Rimactane, Rifamate)
  • Ritonavir (Norvir, in Kaletra)

ESTRADERM and Grapefruit

Grapefruit and grapefruit juice may interact with ESTRADERM and cause unwanted side effects.

You should talk to your doctor before consuming any grapefruit products while taking ESTRADERM.

ESTRADERM and Other Interactions

You should avoid unnecessary sun exposure while taking ESTRADERM, since the gel may make your skin more sensitive to sunlight.

Proper Use of this medication

Your dose of ESTRADERM will depend on the condition that is being treated.

ESTRADERM tablets in doses of 0.5 milligrams (mg), 1 mg, or 2 mg are typically given on a daily basis.

They can also be prescribed to be taken for three weeks, followed by one week of no medication.

The tablets can be taken more than once a day for some conditions.

The topical gel or emulsions are applied to the skin at the same time each day.

The vaginal ring is inserted in the vagina and left for three months at a time.

The patch should be applied to a dry, clean, hairless part of the trunk (but not the breasts). It should not be placed on irritated or damaged skin.

You should rotate the site of application, with at least one week between repeated applications to any one site.

ESTRADERM Overdose

Symptoms of an overdose include the following:

  • Nausea or vomiting
  • Heavy vaginal bleeding
  • Drowsiness
  • Tender breasts
  • Discolored urine
  • Headache

If you suspect an overdose, you should contact a poison control center or emergency room immediately.

Missed Dose of ESTRADERM

If you miss a dose of oral ESTRADERM, take it as soon as you remember.

However, if it's almost time for your next scheduled dose, skip the missed dose and continue on your regular schedule. Do not double up on doses.

If you forget a dose of ESTRADERM gel but remember more than 12 hours before your next scheduled dose, apply the missed dose immediately.

However, if you remember less than 12 hours before your next dose, skip the missed dose and continue on your regular dosing schedule.

Do not apply extra gel to make up for a missed one.

If you forget to apply ESTRADERM emulsion in the morning, apply it as soon as you remember.

Don't apply extra emulsion to make up for a missed dose.

Other related products

Estrace (Estradiol)

Author , posted on July 4, 2017

Category:


Estrace

Estradiol
Select Quantity:
Select Quantity:

Estrace

Estradiol
Select Quantity:

Estradiol (Generic)

Estradiol
Select Quantity:
Select Quantity:
Select Quantity:

Estrace Coupon

Estrace Coupon Code

Save $10 on Estrace Rx

Apply Estrace coupon code ESR10 at checkout.

You can qualify for this offer when you place an order with a minimum $50 value.

Browse our other Rx coupons for more discounts.

*Coupon codes cannot be combined and are for one-time use only

Estrace (Estradiol) Dosage and Side Effects

ESTRACE (estradiol) is an estrogen replacement hormone used to manage menopausal symptoms such as abnormal uterine bleeding, hot flashes, sweating, and chills.

Proper Use of this medication

Your dose of estradiol will depend on the condition that is being treated.

ESTRACE tablets in doses of 0.5 milligrams (mg), 1 mg, or 2 mg are typically given on a daily basis.

They can also be prescribed to be taken for three weeks, followed by one week of no medication.

The tablets can be taken more than once a day for some conditions.

The topical gel or emulsions are applied to the skin at the same time each day.

The vaginal ring is inserted in the vagina and left for three months at a time.

The patch should be applied to a dry, clean, hairless part of the trunk (but not the breasts). It should not be placed on irritated or damaged skin.

You should rotate the site of application, with at least one week between repeated applications to any one site.

Estradiol Overdose

Symptoms of an overdose include the following:

  • Nausea or vomiting
  • Heavy vaginal bleeding
  • Drowsiness
  • Tender breasts
  • Discolored urine
  • Headache

If you suspect an overdose, you should contact a poison control center or emergency room immediately.

Missed Dose of Estradiol

If you miss a dose of oral estradiol, take it as soon as you remember.

However, if it's almost time for your next scheduled dose, skip the missed dose and continue on your regular schedule. Do not double up on doses.

If you forget a dose of estradiol gel but remember more than 12 hours before your next scheduled dose, apply the missed dose immediately.

However, if you remember less than 12 hours before your next dose, skip the missed dose and continue on your regular dosing schedule.

Do not apply extra gel to make up for a missed one.

If you forget to apply estradiol emulsion in the morning, apply it as soon as you remember.

Don't apply extra emulsion to make up for a missed dose.

Side Effects

Common Side Effects of Estradiol

You should tell your doctor if any of the following symptoms are severe or do not go away:

  • Breast pain or tenderness
  • Headache
  • Diarrhea
  • Gas
  • Constipation
  • Heartburn
  • Mood changes or depression
  • Nervousness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose, cough, or flu-like symptoms
  • Hair loss or unwanted hair growth
  • Darkening of facial skin
  • Difficulty wearing contact lenses
  • Vaginal discharge
  • Swelling, redness, burning, irritation, or itching of the vagina
  • Redness or irritation at the site of application

Estradiol and Weight Gain

Water retention that increases your weight is a common side effect.

Talk to your doctor about adjusting your dose of estradiol if weight gain becomes a problem.

Serious Side Effects of Estradiol

Contact your doctor immediately if you experience any of the following serious side effects:

  • Sudden, severe headache
  • Sudden, severe vomiting
  • Speech problems
  • Dizziness or fainting
  • Sudden, complete or partial loss of vision or double vision
  • Weakness or numbness of an arm or leg
  • Crushing chest pain or chest heaviness
  • Coughing up blood
  • Sudden shortness of breath or difficulty breathing
  • Breast lumps or other breast changes
  • Nipple discharge
  • Difficulty thinking clearly or remembering
  • Pain, tenderness, or redness in one leg
  • Bulging eyes
  • Yellowing of the skin or eyes
  • Loss of appetite
  • Fever
  • Joint pain
  • Itching
  • Stomach tenderness, pain, or swelling
  • Hives, rash, or blisters
  • Movements that are difficult to control
  • Hoarseness
  • Wheezing
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • Difficulty swallowing

Warnings and Precautions

Estradiol can increase the risk that you will develop endometrial cancer (cancer of the lining of the uterus). If you have not had a hysterectomy, you should take progestin along with estradiol to decrease this risk.

However, before taking these two medicines together, talk with your doctor about your risk for other health problems.

In one study, women who took estrogens (such as estradiol) by mouth with progestin had a higher risk of heart attacks, stroke, blood clots, breast cancer, and dementia.

Women who use topical estradiol alone or with progestin may also have a higher risk of developing these conditions.

Using topical estradiol may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks.

Before taking estradiol, tell your doctor if you have or have ever had:

  • A heart attack or stroke
  • Heart disease
  • Blood clots
  • Any type of cancer
  • Abnormal vaginal bleeding
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Asthma
  • Gallbladder disease
  • A thyroid disorder
  • Epilepsy or another seizure disorder
  • Liver disease
  • Lupus
  • Breast lumps or abnormal mammogram results
  • Uterine fibroids
  • Yellowing of the skin or eyes (jaundice)
  • Migraine headaches
  • Endometriosis (a condition where the type of tissue that lines the uterus grows in other areas of the body, usually the abdomen or pelvis)
  • Low levels of calcium in your blood
  • Porphyria (a condition where abnormal substances build up in the blood)

Also, tell your doctor if you smoke or use tobacco products.

You should use the lowest dose of estradiol for the shortest time possible to control your symptoms.

Talk with your doctor every three to six months to determine if you should lower your dose or stop using this medicine.

You should conduct a breast self-exam every month and have a mammogram and clinical breast exam (a breast exam by a health professional) every year to help detect breast cancer.

Tell your doctor if you are having surgery or will be on bed rest while taking estradiol. Your doctor may tell you to stop taking the medication to decrease the risk of blood clots.

The topical medicine may harm other people who touch your skin. You should not let anyone else touch the skin where you applied estradiol for one hour after application.

If someone does touch the area, he or she should wash his or her hands with soap and water immediately.

Pregnancy and Estradiol

Estradiol can harm an unborn baby or cause birth defects. You should not use this medication while pregnant.

Tell your doctor right away if you become pregnant or might become pregnant while taking this drug.

Since estradiol can also pass into breast milk, talk to your doctor before breastfeeding while taking the drug.

Interactions with this medication

You should tell your doctor about all prescription, non-prescription, over-the-counter (OTC), illegal or recreational drugs; herbal remedies; and nutritional or dietary supplements you're taking, especially:

  • Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • St. John's wort
  • Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
  • Clarithromycin (Biaxin)
  • Erythromycin (E.E.S, Erythrocin)
  • Lovastatin (Alticor, Altoprev, Mevacor)
  • Medications for thyroid disease
  • Phenobarbital
  • Rifampin (Rifadin, Rimactane, Rifamate)
  • Ritonavir (Norvir, in Kaletra)

Estradiol and Grapefruit

Grapefruit and grapefruit juice may interact with estradiol and cause unwanted side effects.

You should talk to your doctor before consuming any grapefruit products while taking estradiol.

Estradiol and Other Interactions

You should avoid unnecessary sun exposure while taking estradiol, since the gel may make your skin more sensitive to sunlight.

Estalis Patches (Estradiol/Norethindrone)

Author , posted on July 4, 2017

Category:


Estalis

Estradiol, Norethindrone Acetate
Select Quantity:
Select Quantity:

Estalis Patches (Estradiol/Norethindrone) Dosage and Side Effects

Treatment with ESTALIS offers relief from menopausal symptoms for women with uteri. With ESTALIS used in a continuous regimen, you receive estradiol and norethindrone acetate (NETA), a progestin, throughout the entire 28-day cycle. The progestin provides important protection for your uterus.

Proper Use of this medication

Usual dose:

ESTALIS: ESTALIS packs contain 8 patches. ESTALIS (NETA/17β-estradiol) patches are available in two strengths, called ESTALIS 140/50 and ESTALIS 250/50, each containing and releasing different amounts of estradiol and norethindrone acetate, as follows:

  • ESTALIS 140/50: 9 cm2 patch, containing 0.620 mg estradiol and 2.70 mg NETA, and releasing around 50 µg estradiol and 140 µg NETA per day.

  • ESTALIS 250/50: 16 cm2 patch, containing 0.512 mg estradiol and 4.80 mg NETA, and releasing around 50 µg estradiol and 250 µg NETA per day.

    Your doctor will prescribe the patches in a continuous regimen.

Continuous regimen:

The ESTALIS patch is worn continuously for the 4 weeks of the cycle. The ESTALIS patches are applied twice weekly on the same days of each week. Each patch should be worn continuously for 3-4 days.

The next treatment cycle is started immediately after removal of the last ESTALIS patch. Irregular uterine bleeding may occur particularly in the first 6 months, but generally decreases with time.

It is important that you take your medication as your physician has prescribed. Do not discontinue or change your therapy without consulting your physician first.

How and where to apply ESTALIS:

It is recommended that you change the site of application each time the patch is applied. In other words, each time you apply a patch, place it on a different area of your abdomen or buttocks than used before. The same area should not be used again for at least one week. However, each time you apply a patch you should always apply it to the same area of your body (i.e., if the patch is applied to the buttocks, move the patch from right side to left side, twice a week or more if there is any redness under the patch).

Apply whole patches.

  1. Preparing the skin: In order for the patch to stick, the skin should be clean, dry, cool and free of any powder, moisturizer, lotions or oils. If you wish, you may use body lotion after the patch has been properly applied to the skin. The skin should not be irritated or broken, since this may alter the amount of hormone you get. Contact with water (bath, pool, or shower) should not affect the patch (see Helpful Hints:).

  2. Where to apply the ESTALIS patches: The patches may be applied to the buttocks or abdomen (see Figure 3). Change the site of application each time you put a patch on. A one week period should elapse before applying the patch to a previously used spot.

    Avoid areas of the skin where clothing may rub the patch off or areas where the skin is very hairy or folded. Also avoid areas where the patch is likely to be exposed to the sun since this may affect how the patch works.

    DO NOT APPLY THE PATCHES TO YOUR BREAST, since this may cause unwanted effects and discomfort.

  3. Opening the pouch: The patches contained in ESTALIS are individually sealed in a protective pouch. Tear open this pouch at the indented notch and remove the patch (see Figure 4). Do not use scissors, as you may accidentally cut and destroy the patch.

  4. Removing the liner: One side of the patch has the adhesive that sticks to your skin. The adhesive is covered by a protective liner that must be removed.

    To separate the patch from the liner, hold the patch with the protective liner facing you. Peel off one side of the protective backing and discard it (see Figure 5). Try to avoid touching the sticky side of the patch with your fingers.

    Using the other half of the backing as a handle, apply the sticky side of the system to a dry area of your abdomen or buttocks. Press the sticky side on the skin and smooth down.

    Fold back the remaining side of the patch. Grasp the straight edge of the protective backing and pull it off the patch (see Figure 6). Avoid touching the adhesive.

  5. Applying the ESTALIS patches: Apply the adhesive side to the spot you have chosen. Press it firmly in place with the palm of your hand for about 10 seconds, then run your finger around the edge, making sure there is good contact with the skin. Apply the patch soon after opening the pouch and removing the protective backing.

    ESTALIS should be worn continuously until it is time to replace it with a new patch. You may wish to experiment with different locations when applying a new patch, to find sites that are most comfortable for you, where clothing will not rub against the patch.

  6. When and how to remove the patch: Continuous regimen: The ESTALIS patch should be changed twice weekly. Always change it on the same 2 days of the week. If you forget to change it at the scheduled time, there is no cause for alarm. Just change it as soon as possible and continue to follow your usual schedule.

    After you remove the patch fold it in half with the adhesive sides inwards. Throw it away, safely out of the reach of children or pets.

    Any adhesive left on your skin should rub off easily. You can also use mineral oil, baby oil or rubbing alcohol to remove adhesive from the skin. Apply a new ESTALIS patch on a different spot of clean, dry skin.

    The drug in your patch is contained in the adhesive and not in a special reservoir.

Helpful Hints:

What to do if the patch falls off: Should a patch fall off in a very hot bath or shower, shake the water off the patch. Dry your skin completely and reapply the patch as soon as possible (to a different area of skin) and continue your regular schedule. Make sure you choose a clean, dry, lotion-free area of skin. If it still does not stick completely to your skin, then use a new patch. No matter what day this happens, go back to changing this patch on the same days as the initial schedule.

If hot baths, saunas or whirlpools are something you enjoy and you find that the patch is falling off, you may consider removing the patch temporarily while you are in the water. If you do remove the patch temporarily, the adhesive side of the patch should be placed on the protective liner that was removed when originally applying the patch. Wax paper may be used as an alternate to the liner. This prevents the contents of the patch from emptying by evaporation while you are not wearing it.

In addition to exposure to very hot water, there are some other causes for the patch failing to stick. If you are having patches fall off regularly, this could be happening as a result of:

  • using any type of bath oil

  • using soaps with a high cream content

  • using skin moisturizers before applying the patch

Patch adhesion may be improved if you avoid using these products, and by cleansing the site of application with rubbing alcohol before you apply the patch.

What to do if your skin becomes red or irritated under or around the patch: As with any product that covers the skin for a period of time (such as bandages), the ESTALIS patches can produce some skin irritation in some women. This varies according to the sensitivity of each woman.

Usually this redness does not pose any health concern to you, but to reduce this problem, you may change the site of application of the ESTALIS patches every time a new patch is applied.

Experience with another patch, VIVELLE, has shown that if you allow the patch to be exposed to the air for approximately 10 seconds after the protective liner has been removed, skin redness may not occur.

If redness and/or itching continues, you should consult your physician.

Always Remember:

Your doctor has prescribed ESTALIS for you after a careful review of your medical needs. Use it only as directed and do not give it to anyone else.

Use ESTALIS within 6 months of purchase or before the expiry date shown on the pack, whichever comes first.

Do not use any ESTALIS pack that is damaged or shows signs of tampering.

Do not expose the patch to direct sunlight.

Overdose:

Symptoms:

Overdosage with estrogen may cause nausea, breast discomfort, fluid retention, bloating or vaginal bleeding in women.

Progestin (norethindrone acetate) overdosage may cause depressed mood, tiredness, acne and hirsutism.

If you suspect an overdose, remove the patch, contact either your doctor, or emergency department of the nearest hospital, or your regional poison control center immediately.

Missed dose:

If you forget to change a patch, replace it with another patch as soon as you remember. No matter when this happens, go back to changing this patch on the day as specified on your initial schedule.

Side Effects

All medicines can have side effects. Sometimes they are serious, most of the time they are not.

Check with your doctor as soon as possible if any of the following occur:

Most Common Adverse Drug Reactions (≥1%):

  • back pain or menstrual period-like pain,

  • breast tenderness and excessive vaginal secretions (may be a sign that too much estrogen is taken), vaginal thrush (vaginal fungal infection with severe itching, vaginal discharge),

  • change in weight,

  • headache,

  • intolerable breast tenderness,

  • itching under the patch, reddening of the skin after the patch has been removed (signs of application site reaction includes bleeding, bruising, burning, discomfort, dryness, skin boils, edema, erythema, inflammation, irritation, pain, tiny solid skin bumps, rash, skin discolouration, skin pigmentation, swelling, hives, and blisters),

  • nervousness,

  • pain in extremity,

  • pelvic pain,

  • persistent or severe skin irritation,

  • rash, itching, acne, dryness

Less Common Adverse Drug Reactions (<1%):

  • breast cancer, abnormal tumour growth related to estrogens (e.g. cancer of the lining of the womb—endometrial cancer),

  • change in your sex drive,

  • gall bladder disease (tendency to form gall stones),

  • painful and/or heavy periods (may be signs of growth of fibroids in uterus),

  • or discoloration of the skin, purple skin patches,

  • swelling of the lower legs, ankles, fingers or abdomen due to fluid retention (oedema) persisting for more than 6 weeks,

  • tingling or numbness

Adverse Drug Reactions with unknown frequency:

  • tender, red nodules under the skin (most common on the shins),

  • spotty darkening of the skin, particularly on the face or abdomen (chloasma),

  • easy bruising,

  • excessive nose bleeds,

  • sudden contraction of the womb,

  • hair loss,

  • excessive hairiness,

  • decline of memory or mental ability,

  • rapid change in mood,

  • difficulty sleeping,

  • contact lens discomfort,

  • dry eyes,

  • hearing loss,

  • itchy rash

For any unexpected effects while taking ESTALIS contact your doctor or pharmacist.

Warnings and Precautions

Serious Warnings and Precautions

The Women's Health Initiative (WHI) trial is a large clinical study that assessed the benefits and risks of oral combined estrogen plus progestin therapy and oral estrogen-alone therapy compared with placebo (a pill with no active ingredients) in postmenopausal women.

The WHI trial indicated an increased risk of myocardial infarction (heart attack), stroke, breast cancer, pulmonary emboli (blood clots in the lungs) and deep vein thrombosis (blood clots in the large veins) in postmenopausal women taking oral combined estrogen plus progestin.

The WHI trial indicated an increased risk of stroke and deep vein thrombosis in postmenopausal women with prior hysterectomy (surgical removal of the uterus) taking oral estrogen-alone. Therefore, you should highly consider the following:

  • There is an increased risk of developing invasive breast cancer, heart attack, stroke and blood clots in both lungs and large veins with the use of estrogen plus progestin therapy.

  • There is an increased risk of stroke and blood clots in the large veins with the use of estrogen-alone therapy.

  • Estrogens with or without progestins should not be used for the prevention of heart disease or stroke.

  • Estrogens with or without progestins should be used at the lowest effective dose and for the shortest period of timepossible. Regular medical follow-up is advised.

  • Breast cancer

    The results of the WHI trial indicated an increased risk of breast cancer in post-menopausal women taking combined estrogen plus progestin compared to women taking placebo.

    The results of the WHI trial indicated no difference in the risk of breast cancer in postmenopausal women with prior hysterectomy taking estrogen-alone compared to women taking placebo.

    Estrogens with or without progestins should not be taken by women who have a personal history of breast cancer.

    In addition, women with a family history of breast cancer or women with a history of breast lumps, breast biopsies or abnormal mammograms (breast x-rays) should consult with their doctor before starting hormone replacement therapy.

    Women should have a mammogram before starting HRT and at regular intervals during treatment as recommended by their doctor.

    Regular breast examinations by a doctor and regular breast self-examinations are recommended for all women. You should review technique for breast self-examination with your doctor.

  • Overgrowth of the lining of the uterus and cancer of the uterus

    The use of estrogen-alone therapy by post menopausal women who still have a uterus increases the risk of developing endometrial hyperplasia (overgrowth of the lining of the uterus), which increases the risk of endometrial cancer (cancer of the lining of the uterus).

    The purpose of adding a progestin medication to estrogen therapy is to reduce the risk of endometrial hyperplasia.

    You should discuss progestin therapy and risk factors for endometrial hyperplasia and endometrial carcinoma with your doctor. You should also report any unexpected or unusual vaginal bleeding to your doctor.

    If you have had your uterus removed, you are not at risk of developing endometrial hyperplasia or endometrial carcinoma. Progestin therapy is therefore not generally required in women who have had a hysterectomy.

  • Ovarian cancer

    In some studies, the use of estrogen-alone and estrogen plus progestin therapies for 5 or more years has been associated with an increased risk of ovarian cancer.

  • Heart disease and stroke

    The results of the WHI trial indicated an increased risk of stroke and coronary heart disease in post-menopausal women taking combined estrogen plus progestin compared to women taking placebo.

    The results of the WHI trial indicated an increased risk of stroke, but no difference in the risk of coronary heart disease in post-menopausal women with prior hysterectomy taking estrogen alone compared to women taking placebo.

  • Abnormal blood clotting

    The results of the WHI trial indicated an increased risk of blood clots in the lungs and large veins in post menopausal women taking combined estrogen plus progestin compared to women taking placebo.

    The results of the WHI trial indicated an increased risk of blood clots in the large veins, but no difference in the risk of blood clots in the lungs in post-menopausal women with prior hysterectomy taking estrogen-alone compared to women taking placebo.

    The risk of blood clots increases with age, if you or a family member has had blood clots, if you smoke or if you are severely overweight. The risk of blood clots is also temporarily increased if you are immobilized for long periods of time and following major surgery. You should discuss risk factors for blood clots with your doctor since blood clots can be life-threatening or cause serious disability.

  • Gallbladder disease

    The use of estrogens by postmenopausal women has been associated with an increase risk of gallbladder disease requiring surgery.

  • Dementia

    The Women's Health Initiative Memory Study (WHIMS) was a substudy of the WHI trial and indicated an increased risk of dementia (loss of memory and intellectual function) in post-menopausal women age 65 and over taking oral combined estrogen plus progestin compared to women taking placebo.

    The WHIMS indicated no difference in the risk of dementia in post-menopausal women age 65 and over with prior hysterectomy taking oral estrogen-alone compared to women taking placebo.

Before you use ESTALIS talk to your doctor or pharmacist if you:

  • have a history of severe allergic reaction or intolerance to any medications or other substances

  • have been told that you have a condition called hereditary angioedema of if you have had episodes of rapid swelling of the hands, feet, face, lips, eyes, tongue, throat (airway blockage) or digestive tract

  • have a personal history of breast disease (including breast lumps) and/or breast biopsies, or a family history of breast cancer

  • have experienced any unusual or undiagnosed vaginal bleeding

  • have a history of uterine fibroids or endometriosis

  • have a history of liver disease or liver tumours, jaundice (yellowing of the eyes and/or skin) or itching related to estrogen use or during pregnancy

  • have a history of migraine headache

  • have a history of high blood pressure

  • have a personal or family history of blood clots, or a personal history of heart disease or stroke

  • phlebitis (inflamed varicose veins)

  • if you have had several miscarriages

  • have a history of kidney disease or asthma

  • have a history of bone disease (this includes certain metabolic conditions or cancers that can affect blood levels of calcium and phosphorus)

  • have been diagnosed with diabetes

  • have been diagnosed with porphyria (a disease of blood pigment)

  • have been diagnosed with lupus

  • gall bladder disease

  • depression

  • have been diagnosed with hearing loss due to otosclerosis

  • epilepsy (seizures) or other neurological disorders

  • have a history of high cholesterol or high triglycerides

  • are pregnant or may be pregnant

  • are breastfeeding

  • have had a hysterectomy (surgical removal of the uterus)

  • smoke

  • are undergoing surgery or need long bed rest

  • have been told that you have hypothyroidism (a condition in which your thyroid gland fails to produce enough thyroid hormone) and you are treated with thyroid hormone replacement therapy

Ask your doctor and pharmacist to answer any questions you may have.

Interactions with this medication

Tell your doctor or pharmacist if you are taking or have recently taken any other medications, including prescription medications, over-the-counter medications, vitamins or herbal products.

This particularly includes the following:

  • acetaminophen,

  • aminoglutethimide with medroxyprogesterone acetate (MPA),

  • anti-anxiety medicines (meprobamate, temazepam),

  • cyclosporin,

  • anti-epileptic medicines (e.g. phenobarbital, phenytoin or carbamazepine),

  • an anti-inflammatory medicine called phenylbutazone,

  • antibiotics and other anti-infective medicines (e.g. ketoconazole, erythromycin, rifampicin, rifabutin, nevirapine, efavirenz, ritonavir and nelfinavir), and

  • herbal medicines (e.g. St John's wort),

  • morphine,

  • prednisone,

  • salicylic acid,

  • theophylline,

  • vitamin C

These medicines may be affected by ESTALIS or, conversely, they may affect how well ESTALIS works. Your doctor may need to adjust the dose of your treatment.

Tell your doctor that you are on treatment with ESTALIS if you are going to have laboratory tests. Some laboratory tests, such as tests for glucose tolerance or thyroid function, may be affected by ESTALIS therapy.

Other related products

Atopica (Cylclosporin)

Author , posted on July 4, 2017

Category:


Atopica

Cyclosporine (Ciclosporin)
Select Quantity:
Select Quantity:
Select Quantity:
Select Quantity:

Atopica Solution

Cyclosporine (Ciclosporin)
Select Quantity:

Cyclosporine (Generic)

Cyclosporine (Ciclosporin)
Select Quantity:
Select Quantity:
Select Quantity:

Cyclosporine (Generic)

Cyclosporine (Ciclosporin)
Select Quantity:
Select Quantity:
Select Quantity:

Atopica (Cyclosporine) Pet Medication Information

Atopica is prescribed for dogs with atopic dermatitis. This condition is caused be an allergic reaction which could be brought on by one of many things including their food, the environment, or even the detergent used on their bedding.

Cyclosporine is the active ingredient in this medicine and is a cyclic polypeptide consisting of eleven amino acids. Atopica stops the helper T-lymphocytes from conveying chemical messages that end up cause your dog’s skin mast cells to release histamine. Without histamine, no inflammation can occur in the nerve endings of your dog’s skin and it will not experience severe itching. If your dog’s nerve endings are irritated, they can itch and hurt. Atopica is just the right medicine to buy for your dog if it has lost its hair and damaged its skin through constant scratching. Atopica is in the form of capsules that are taken orally, and  should only be prescribed if your dog  weighs at least 1.8 kilograms.

Buy Atopica Online

Atopica is manufactured by Novartis and we have it in 25 mg, 50 mg and 100 mg. These dosages are also available in the generic capsules, called Cyclosporin, and manufactured by different companies. Shipping to the United States would take approximately  2-3 weeks. Standard shipping charges are $9.95 per order.

We would need a copy of your pet's prescription from their vet. They could forward a copy to us by fax  to 1-855-776-0006.   If you are given a copy and need to send the prescription yourself, you can email a copy to [email protected], or upload a copy on our website.

Dosage

Initially, the dog being treated will receive 5mg per kg per day as one dose for the next thirty days. After the first treatment, the vet may recommend giving the dog its medicine every other day. It can even be twice every week. When the minimum amount is reached, the dog will be healed. When giving this medicine to your dog, ensure that it is either one hour prior to a meal or two hours after eating.

Should it miss one dose, administer the next planned dose. Atopica should be given only once per day, so don’t give your dog an overdose. The product label should show you the exact amount to give your dog based on its body weight. For instance, dogs weighing 2 to 2.9 kilograms should be given one 10mg capsule.

A huge dog weighing 36 to 55.9 kilograms should be given 2, 100mg capsules once per day. Make sure you follow the veterinary’s instructions well and read the product label.

Side Effects of Atopica

Several dogs that are treated with Atopica hardly experience any effects. However, there are about thirty percent of them that will vomit; lack of appetite, diarrhea or have GI upsets. The best way to treat your pet without risking it having side effects is to give it a smaller starting dose. If you give it a normal starting dose and the side effects occur, allow these to disappear on their own in about a week or two.

Occasionally, Atopica could trigger skin and gum irritation, and as a result, the affected dogs might develop thickened, swollen gums while others might endure red or tender ear flaps. Still, there are some dogs that might develop thickened foot pads. These as well as shedding of hair are normal side effects of Atopica.

Precautions

If you have a dog that is under six months old, then don’t give it Atopica. As well as this measure, consider the following:

  • Avoid giving Atopica to dogs that are pregnant or lactating
  • Discuss with your veterinarian about the risk of gastrointestinal problems, gingival hyperplasia and neoplastic and infectious conditions
  • If the animal has diabetes mellitus or develops it while being treated with Atopica, tell the veterinarian
  • If the pet is on medicines that affect the P450 enzyme system, let the vet know
  • Use with caution if your doctor has renal insufficiency

Related Products