Vagifem (Estradiol)

(℞) Prescription Required

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Estradiol 10mcg

Product of United Kingdom
Manufactured by: UK Various Generics
*Product image for reference use only.
**1 applicator for multiple uses**
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Estradiol 10mcg
Product of United Kingdom
Manufactured by UK Various Generics
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Vagifem 10mcg

Product of unknown
Manufactured by: Novo Nordisk
*Product image for reference use only.
**Single use applicator for each tablet**
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Vagifem 10mcg
Product of unknown
Manufactured by Novo Nordisk
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Estradiol 10mcg

Product of Australia
Manufactured by: Aspen Pharmacare
*Product image for reference use only.
**6 applicators per 18 tabs**
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Estradiol 10mcg
Product of Australia
Manufactured by Aspen Pharmacare
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Vagifem 10mcg

Product of Canada
Manufactured by: Novo Nordisk
*Product image for reference use only.
**Single use applicator for each tablet**
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Vagifem 10mcg
Product of Canada
Manufactured by Novo Nordisk
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Vagifem 10mcg

Product of Turkey
Manufactured by: Novo Nordisk
*Product image for reference use only.
**Single use applicator for each tablet**
Select Quantity
Vagifem 10mcg
Product of Turkey
Manufactured by Novo Nordisk
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Check Vagifem Cost and Buy Online at PricePro Pharmacy

Vagifem (Estradiol) is used as local estrogen replacement therapy to help patients experiencing vaginal atrophy due to low estrogen in the body during menopause.

Are you tired of spending a significant portion of your savings towards filling your medicine cabinet every month? Do you wish to ease up a bit on the spending and still get the same high-quality prescription medicines? If yes, you have come to the right place. 

Get the same brand and generic drugs at prices 70-90% lower than what you would usually pay at your local pharmacy. 

Simply visit our user-friendly website, browse through our massive catalog of medicines and select the one you need. Feel free to communicate with our friendly customer care agents using our live chat feature or calling us (toll-free) at 1-855-776-0079.

Please note a Vagifem prescription is required to be submitted in order to process your order. 

PricePro Pharmacy operates like your local pharmacy and thus requires a valid Rx from your licensed physician to process orders of prescription drugs. You can upload your Rx before check-out or email it to us at [email protected]. We also offer fax option at 1-855-776-006. If you are having trouble with any of these options, we can also contact your doctor on your behalf and ask them to forward your Rx to us. In that case, you will need to provide the contact details of your physician with your order.

Vagifem 10mcg box by Novo Nordisk


prescription drugs

Vagifem Dosage

The following dosage is available to order:

  • Vagifem 10mcg

This medication is manufactured by Novo Nordisk in Canada, United Kingdom, and Turkey.

The active ingredient is called Estradiol.

You can select the dosage box above to view more product details.

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Cost of Vagifem

At PricePro Pharmacy, the low cost of Vagifem is:

  • $59.00 for 18 tablets

While the average retail price of Vagifem 10mcg in the United States is:

  • $487.98 for 18 tablets

You can save up to 88% ($428.98) when you order your Vagifem medication from PricePro Pharmacy.

You can get this price without any coupon codes or insurance coverage.

Canadian Pharmacy Coupon

Vagifem Coupon Code

At the moment, we are not offering any coupons specific to Vagifem. 

However, there is a special offer for our new customers.

New customers can get special discounts which can be applied at checkout as follows:

  • PRICE10 - Save $10 on your first order (minimum $50 order value)
  • PRICE20 - Save $20 on your first order (minimum $100 order value)

The above coupons are for single-use only and cannot be combined with other coupons.


Generic Drug Bottle

Generic for Vagifem

The generic alternative of Vagifem, Estradiol 10mcg, is available here at PricePro pharmacy. 

Generic drugs are copies of brand-name drugs with the exact dosage, intended use, effects, side effects, administration route, risks, safety, and strength as the original drug. However, they are allowed for sale after the patents on the original drugs expire. Hence, generic drugs are priced lower than their brand-name counterparts.

  • Generic Estradiol 10mcg cost $59 for 24 tabs at PricePro Pharmacy
  • You will have to pay $505 on average for the same generic drug at your local drugstore

Buy from PricePro Pharmacy and save $446!


prescription delivery

Delivery Times

The estimated shipping time for your order is:

  • 7 to 12 business days (Product of Canada and UK)
  • 10-18 business days (Product of Turkey)

The standard shipping fee is $9.95 per order. 

Once your medication ships, an email will be sent to you with your order’s shipping details.

We ship all across the United States.


online prescription refill

Refill Rx

Have you ever been feeling that you have forgotten something and cannot remember it anyhow, only to find out later you missed refilling that essential medicine? With PricePro’s prescription refill service, you won't have to face such situations anymore. 

We offer a prescription refill reminder service where we send you an email or call you, informing you about the optimal time of placing a new order, all while taking into account shipping times.

You can access your order history online. To reorder online, just sign in to your online customer account and click reorder. You do not have to submit a new prescription if the current one is already available and valid. If not, we will need a newly issued Rx to process your order.

If you have any questions, please use our live chat or call us toll-free at 1-855-776-0079.

Vagifem (Estradiol) Medication Information


Vagifem is a vaginal estradiol tablet that can be prescribed for treating atrophic vaginitis (vaginal dryness) due to menopause.

As women age, their levels of hormones, like estrogen, decrease. Estrogen contributes to the maintenance of the vaginal environment, so when it decreases due to menopause, atrophic vaginitis can develop.

Vagifem helps to restore previous levels of estrogen to the vagina and treat atrophic vaginitis.  


Insert 1 tablet into the vagina daily for two weeks, followed by 1 tablet twice weekly for as long as directed by your healthcare provider.

Vagifem is available in 10 mcg and 25 mcg doses.

Side Effects

The most common side effects from Vagifem may include:

  • Abdominal pain
  • Back pain
  • Diarrhea
  • Genital pruritus
  • Headache
  • Moniliasis
  • Upper respiratory tract infection
  • Vulvovaginal mycotic infection


Tell your doctor if you have a history of cancer or clot-related disorders. Estrogen therapy can increase the risk for certain types of cancer, including endometrial cancer and breast cancer. It can also increase the risk of embolic disorders like stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE).

Do not use Vagifem if you are pregnant or planning to become pregnant.

Tell your doctor if you have a history of liver problems. 

Estrogen replacement can increase the risk of gallbladder disease.

Your doctor should monitor your thyroid function while using Vagifem.

Do not use Vagifem if you have hypersensitivity to any inactive ingredients, including hypromellose, lactose monohydrate, maize starch, and magnesium stearate.


In general, drug-drug interactions with Vagifem are rare because it does not absorb into the bloodstream to a significant extent. However, possible interactions with estrogen therapy may include:

  • Apalutamide
  • Atazanavir
  • Carbamazepine
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Enzalutamide
  • Fosphenytoin
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lonafarnib
  • Lopinavir
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Mifepristone
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Ombitasvir-paritaprevir-ritonavir
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Rifampin (rifampicin)
  • Ritonavir and ritonavir-containing coformulations
  • Saquinavir
  • Telithromycin
  • Tucatinib
  • Voriconazole

Tell your doctor and pharmacist about all medications you are taking, including over-the-counter (OTC) drugs, herbal medications, and supplements.


Vagifem should be stored close to room temperature close to 25ºC (77ºF) and between 15ºC-30ºC (59ºF-86ºF). Do not store in the refrigerator.

Pharmacist Tips

  • Use the included applicator to insert Vagifem tablets into the vagina. In some people, it may cause vaginal abrasion.
  • Each tablet for the brand name Vagifem medication will come with its own single-use applicator. Do not reuse applicators from dose to dose.
  • Do not use Vagifem if you notice abnormal vaginal bleeding.

Vagifem FAQs

What position should I be in for the correct application of Vagifem tablets?

The manufacturer recommends lying on your back or standing, using one hand to guide the applicator through the vaginal opening and the other hand holding the applicator.


What time of day should I take Vagifem?

Vagifem can be taken at any time of the day.


How long should I take Vagifem?

Meet with your doctor every three to six months to determine if you still need Vagifem. Estrogen products should be used for the shortest amount of time possible.


Related Products


  1. Vagifem [package insert]. Princeton, NJ: Novo Nordisk; 2009.

Medication Review by a Clinical Pharmacist - PharmD

Author: Dr. Conor Sheehy, PharmD, BCPS

Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics.  He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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