Premarin (Conjugated Estrogens)

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    This medication is a female hormone (ie estrogen pills).

    It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

    Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer.

    These medications should be considered for use before estrogen treatment.

    Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).

    Talk to your physician about the benefit of using Premarin (Conjugated Estrogens), as well as discuss the risk associated with it. Your doctor will determine which treatment is best for the symptoms you are experiencing.  

     

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    Premarin Dosage

    Premarin (Conjugated Estrogens): An Overview

    The active ingredient in Premarin is conjugated equine estrogen, which is manufactured by Pfizer. The dosage forms available are: 0.3 mg,  0.625 mg, and 1.25 mg.

    The Premarin 0.3mg tablets are green color available in blister strips of 28 tablets. The Premarin 0.625mg tablets are maroon color available in blister strips of 28 quantity, and the 1.25mg tablets are yellow color in a pack size of 84 tablets.

    Looking for more information of how to take this medication and common side effects, then check out the drug information below for helpful tips.

    Premarin Dosage

    Follow the direction of your doctor when taking Premarin (Conjugated Estrogens). It is important to take this medication exactly the way it was prescribed. Do not change the way in which you take it or your schedule unless you have discussed the changes in treatment with your doctor. The aim is to take the lowest dose of this medication that will provide help for your condition. Do not share your medication with others, as it can be detrimental to their health.  

     If you expect an overdose, get immediate medical assistance. Symptoms of an overdose include breast discomfort, vomiting, nausea, fluid retention, bloating and vaginal bleeding. There is a risk of amenorrhea in the case of an overdose. It may also lead to irregular menses for a number of future cycles.  

     

    Side Effects of Premarin

    Some of these side effects include:  

    • Rash 
    • Itching  
    • Hives 
    • Tender red nodules on the shins and legs 
    • Acne  
    • Nausea, vomiting, bloating, abdominal pain or diarrhea  
    • Mood disturbances, irritability or problems sleeping  
    • Joint pain, leg pain Inflammation of the vagina, vaginal itching or discharge  
    • Headache (including migraine)  
    • Hair loss  
    • Dizziness  
    • Changes in weight (increase or decrease)  
    • Changes in libido  
    • Breast pain, leaking of milk from the nipple  
    • Breakthrough bleeding, spotting, changes in menstrual flow or painful periods 

     If you experience any of these common side effects and they become severe, contact your doctor or pharmacist to see how to modify your treatment.  

    Warnings and Precautions

    Talk to your doctor about the risks versus the benefits of taking this medication. A clinical study by the Women’s Health Initiative has shown risks of heart attack, breast cancer, stroke and blood clots in the lungs and deep veins associated with menopausal women who take oral combined with estrogen plus progestin. Women who have had a previous hysterectomy and are postmenopausal have an increased risk of stroke and blood clots in the deep veins when alone oral estrogen. 

    Interactions with this Medication

    Some of the possible interactions come from the following medications:  

    • Theophylline (medication used to treat breathing problems such as asthma)  
    • Temazepam (medication used to treat insomnia)  
    • Salicylic acid  
    • Rifampicin (medication used in the treatment of tuberculosis)  
    • Oral contraceptives (birth control pills) and other medicines containing estrogen  
    • Morphine  
    • Ketoconazole, itraconazole (medications to treat fungal infections)  
    • Herbal products containing St. John’s Wort  
    • Grapefruit juice  
    • Erythromycin, clarithromycin (antibiotic medications to treat infections) 
    • Dexamethasone, prednisolone (corticosteroids used to treat joint pain and swelling)  
    • Cyclosporin (medication used in suppressing the immune system) 
    • Cimetidine (medication generally used to treat stomach problems) 
    • Carbamazepine, phenytoin, or phenobarbital (medications to prevent epilepsy or seizures)  
    • Atorvastatin, clofibric acid (medication to lower cholesterol)  
    • Ascorbic acid (such as vitamin c)  
    • Antiviral medications (such as, ritonavir)  
    • Antihypertensives (for high blood pressure)  
    • Antidiabetic medications (e.g. Troglitazone 
    • Anticoagulant medications used to thin the blood acetaminophen used to treat pain and fever.

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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