Premarin Vaginal Cream (Conjugated Estrogens)

(℞) Prescription Required

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Premarin Vaginal Cream 0.625mg

Product of Canada
Manufactured by: Pfizer Inc
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Premarin Vaginal Cream 0.625mg
Product of Canada
Manufactured by Pfizer Inc
Top Brand Choice
Top Generic Choice

Premarin Vaginal Cream 0.625mg

Product of India
Manufactured by: Pfizer Inc
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Premarin Vaginal Cream 0.625mg
Product of India
Manufactured by Pfizer Inc
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Premarin Vaginal Cream

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Premarin Cream

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Premarin Vaginal Cream Cost & Discount Savings Available

This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment. Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).

To buy Premarin Cream with our certified Canadian Pharmacy, a prescription is required to process your order. The active medicinal ingredient is conjugated equine estrogen, which is manufactured by Pfizer. Premarin Cream is available in tubes of 14 grams with 1 applicator or 30 grams with 2 applicators whereby each gram consists of 0.625mg of active ingredient. The find the lowest Premarin Cream cost, click on the "CHECK PRICES" icon above to find options available to order.

You can save up to 80% on your prescription price when you order with PricePro Pharmacy. Premarin vaginal cream cost for one one 14 gram tube is as low as $29.00.

We currently do not have a Premarin Cream coupon on our Rx Coupons page and there is no generic alternative available on the market.

For more prescribing information and details on this medication, click on the blue boxes below for more information.

Premarin Vaginal Cream (Conjugated Estrogens) Medication Information


Premarin Vaginal Cream (conjugated estrogens) is a vaginal cream prescribed to treat menopausal changes in and around the vagina.  It’s also prescribed to treat painful intercourse caused by menopausal changes of the vagina.

When a woman’s body makes less estrogen due to menopause, the vaginal walls may become thin, dry, and inflamed.  These changes can make sexual intercourse painful and can also cause urinary discomforts.

Premarin Vaginal Cream is a cream that comes with a special applicator to apply the cream directly to the vagina.  The cream contains a mixture of estrogen hormones that can help rebuild vaginal tissue. 


Premarin Vaginal Cream comes in a 30-gram tube.  Each gram contains 0.625 mg of conjugated estrogens.  The tube comes with a vaginal applicator used to apply up to 2 grams of cream.  

Your doctor will explain when to use Premarin Vaginal Cream, depending on your condition.  They’ll advise you to use it either twice per week or once per day for 3 weeks, then take 1 week off.  Be sure to follow your doctor’s directions exactly.


Premarin Vaginal Cream contains estrogen hormones, which may have serious health risks.

Premarin Vaginal Cream may not be safe for women with the following medical history or conditions:

  • Unusual vaginal bleeding
  • Stroke or heart attack
  • Cancer
  • Blood clots
  • Liver problems
  • Bleeding problems
  • Previous allergic reaction to Premarin or any of its ingredients
  • Pregnancy or breastfeeding

Side Effects

Premarin Vaginal Cream can cause mild side effects and may cause serious, but less common, side effects.

Common but usually mild side effects may include:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach pain or bloating
  • Nausea or vomiting
  • Hair loss
  • Swelling in your legs or feet
  • Vaginal yeast infection
  • Vaginal burning, itching, or irritation after inserting cream with applicator

Less common but serious side effects may include:

  • Heart attack
  • Stroke
  • Blood clots
  • Dementia
  • Breast, uterine, or ovarian cancer
  • High blood pressure
  • High blood sugar
  • Gallbladder or liver problems 
  • Thyroid hormone changes
  • Uterus fibroids 
  • Severe allergic reaction

For more side effect information, talk with your doctor or pharmacist. 


No drug interaction studies were done with Premarin Vaginal Cream, but some medications are likely to interact due to its estrogen ingredients.  Some drug interactions are known to happen with estrogen, such as:

  • Clarithromycin
  • Ketoconazole
  • Ritonavir

Grapefruit and grapefruit juice can also increase the risk of side effects with estrogens and should be avoided.

Talk with your doctor or pharmacist before taking any other medications or herbal supplements with Premarin Vaginal Cream.


Store Premarin Vaginal Cream at room temperature between 68°F and 77°F (20°C and 25°C).

Pharmacists Tips

  • How to Apply: Detailed instructions for applying Premarin Vaginal Cream are included in the product packaging.  You can also view a helpful instructional video on the manufacturer’s website.
  • After each use, wash the applicator with mild soap in warm water.
  • Premarin Vaginal Cream may not be safe for long-term use.  Check with your doctor every 6 months to discuss if it’s safe for you to continue using Premarin Vaginal Cream.  

Premarin Vaginal Cream FAQs

How long does it take for Premarin Vaginal Cream to work to relieve painful sexual intercourse?

In clinical trials, women who had moderate to severe pain with sexual intercourse noticed an improvement after 3 months, on average.  If your symptoms don’t improve in 3 to 4 months, talk with your doctor. 


I accidentally threw away the applicator for my Premarin Vaginal Cream.  Is there a way to get extra applicators?

Yes, you can get extra applicators for free by calling 1-866-298-8486 or visiting the manufacturer’s website.  Next time, be sure to wash the applicator with mild soap in warm water after use.  Don’t use hot water or boil the applicator.  Let air dry.

Related Drugs


  1. Premarin Vaginal Cream Prescribing Information.  Philadelphia, PA: Pfizer; 2018.  Accessed January 24, 2021.
  2. Bleibel B, Nguyen H. Vaginal Atrophy. Treasure Island, FL: StatPearls Publishing; 2020. Accessed January 24, 2021.

PharmD Medical Writer

Author: Dr. Patricia Weiser, PharmD

Patricia Weiser, PharmD, is a licensed pharmacist and medical writer.  She has clinical experience in community and hospital pharmacy.  Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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