Divigel (Estradiol)

Divigel (Estradiol) Medication Information

Uses

Divigel is an estrogen containing product that is used to treat symptoms of menopause. 

Dosage

The gel is available in several different strengths:

• 0.25 mg
• 0.5 mg
• 1 mg

Side Effects

The most common side effects of Divigel include:

• Nasopharyngitis
• Upper respiratory infection
• Vaginal mycosis
• Breast tenderness

Speak with your doctor for a full list of side effects that apply to you if you are taking Divigel.

Precautions

In women who have not had a hysterectomy, it is important to add progestin to Divigel treatment. 

Women can experience an increase in blood pressure and triglycerides with the addition of Divigel. 

There is an increased risk of ovarian cancer with Divigel use. 

Interactions

A common drug interaction with Divigel includes:

• Ketoconazole
• Clarithromycin
• Ritonavir
• Grapefruit juice
• Phenobarbital
• Carbamazepine 

Speak with your doctor for more information and before starting a new medication with Divigel. 

Storage

Store at room temperature (66-77 ºF). 

Pharmacist Tips

• Divigel is for women who have already gone through menopause.
• The symptoms that Divigel is used to treat are hot flashes.
• Divigel should be used for the shortest time possible to reduce your risk for serious complications. 

Estradiol FAQs

How long does it take for Divigel to work?

It can take up to 4 weeks to see effect with Divigel, and the maximum effect can take up to 12 weeks. 

How long after I apply the gel before I can shower?

You should wait at least an hour after applying Divigel before showering.

Can I use Divigel every day?

Divigel is applied once a day to the skin.

Where do you apply Divigel?

Divigel should be applied to the right or left upper thigh.

What are the side effects of Divigel?

Some common side effects of Divigel are nausea, vomiting, acne, swollen breasts, vaginal pain, and decreased sex drive.

Related Drugs

• Climara
• Estring
• Estrogel
• Premarin
• Premarin Vaginal Cream
• Provera
• Vagifem
• Vivelle Dot

Reference:

Divigel {package insert}. Minneapolis, MN: Upsher-Smith Laboratories, Inc.; 2007.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022038lbl.pdf