THEO-DUR can also worsen some conditions, so you shouldn't use it if you have:

• Ulcers
• Seizure disorders
• Some forms of cardiac arrhythmias (abnormal heart rate)

Under certain conditions, the drug can remain in your body longer than normal and build up to unsafe levels, resulting in fatal toxic reactions.

In these cases, you should not take THEO-DUR unless the benefits clearly outweigh the risk, and then your doctor will have to carefully decide on your dosage and monitor your blood for levels of the drug.

The conditions that can lead to a deadly toxic reaction include:

• Being younger than 1 year old, or older than 60 years
• Congestive heart failure and right-sided heart failure (cor pulmonale) that typically arises from high blood pressure
• A buildup of fluid in the lungs (acute pulmonary edema)
• Liver disease, acute hepatitis, or cirrhosis (scarring of the liver)
• Reduced kidney function
• Cystic fibrosis
• A fever of 102 Fahrenheit or more that lasts 24 hours, or a low fever that lasts longer than a day
• A high-carbohydrate, low-protein diet
• Thyroid disease
• A state of physical shutdown called shock
• Sepsis (blood infection) with multi-organ failure
• The flu
• Tobacco and marijuana smoking
• Stopping smoking
• Taking or stopping certain drugs while on THEO-DUR

You need to be very careful about other drugs you are on or stop taking because of the same potentially fatal toxic reaction.

Pregnancy and THEO-DUR

Studies in animals have shown that the drug can cause birth defects, but no adequate and well-controlled studies have been conducted in pregnant women.

THEO-DUR should only be used during pregnancy if the potential benefits to the mother outweigh the risks to her unborn child.

THEO-DUR is excreted in breast milk, potentially causing irritability and other signs of mild toxicity in breastfeeding infants.

It's not likely to cause serious side effects in infants unless the breastfeeding mother has very high concentrations of the drug in her body.

Nonetheless, if you are breastfeeding your child, you shouldn't take THEO-DUR unless the potential benefits outweigh the risks, and then only under the guidance of your doctor.

Common Side Effects of THEO-DUR

Although these effects are common, they can be serious and are likely to mean your doctor should change your dosage.

Tell your doctor if you experience any of the following, and if the effect becomes severe, get immediate medical help:

• Nausea and vomiting
• Headache
• Upset stomach
• Loss of appetite
• Fast, strong heartbeat
• Irregular heartbeat (arrhythmia): usually there are no symptoms, but it can cause a fluttering feeling, dizziness, shortness of breath, chest pain, heartbeats that feel too fast or slow, or fainting
• Symptoms similar to how you feel when you've had too much coffee, such as trouble falling asleep (insomnia), restlessness, and irritability.
• Skin rash

Severe Side Effects of THEO-DUR

You need immediate emergency medical treatment if you are experiencing:

• Seizures

Rare Side Effects of THEO-DUR

Tell your doctor right away or get emergency medical help if you experience any of the following more rare side effects:

• Stomach pain
• Anxiety
• Diarrhea
• Dizziness
• Tremors
• Urination issues, including frequent or infrequent urination and hyperuricemia (high levels of uric acid)
• Allergic reaction
• Reflux

Some drugs can affect your body's ability to process THEO-DUR, potentially causing it to build up to unsafe levels and become toxic.

In addition, THEO-DUR interacts with a wide variety of other drugs, so it's especially important to tell your doctor about any medications, illegal or recreational drugs, herbal remedies, and supplements you're taking, even if you are smoking tobacco.

The following drugs are especially important to tell your doctor about before you take THEO-DUR:

• Adenosine (Adenoscan)
• Allopurinol (Zyloprim)
• Aminoglutethimide (Cytadren)
• Carbamazepine (Tegretol)
• Cimetidine
• Ciprofloxacin (Cipro)
• Clarithromycin (Biaxin)
• Diazepam (Valium)
• Disulfiram (Antabuse)
• Enoxacin
• Ephedrine
• Erythromycin (Ery-tab)
• Estrogen-containing oral contraceptives
• Flurazepam (Dalmane)
• Fluvoxamine (Luvox)
• Halothane (Fluothane)
• Interferon
• Isoproterenol (Isuprel)
• Ketamine (Ketalar)
• Lithium
• Lorazepam (Ativan)
• Methotrexate (Trexall)
• Mexiletine (Mexitil)
• Midazolam
• Moricizine
• Pancuronium (Pavulon)
• Pentoxifylline (Trenal)
• Phenobarbital
• Phenytoin (Dilantin)
• Propafenone (Rythmol)
• Propranolol (Inderal)
• Rifampin (Rifadin)
• Ritonavir
• Roflumilast (Daliresp)
• St. John's wort
• Sulfinpyrazone (Anturane)
• Tacrine (Cognex)
• Thiabendazole (Mintezol)
• Ticlopidine (Ticlid)
• Troleandomycin (Tao)
• Verapamil (Calan)

THEO-DUR and Alcohol

Drinking alcohol while taking THEO-DUR may cause the drug to remain in your body for up to 30 percent longer, which can lead to serious toxic effects.

Therefore, you should not drink alcohol when taking THEO-DUR.

A sudden overdose from taking too much THEO-DUR all at once is rare.

A chronic overdose, however, is not rare, especially if you have been taking a dose that is a little too high for a long time, or if your dose has recently been increased.

An overdose of THEO-DUR may cause slow heart rate, abnormal heart rate, seizures, circulatory system failure, and death.

If you suspect an overdose, you should contact a poison-control center or emergency room immediately.

Missed Dose of THEO-DUR

Missing a dose of THEO-DUR may cause your asthma or bronchitis symptoms to reappear.

If you remember your missed dose within 6 hours of your regular dosing time, take your missed dose immediately.

Take half a dose if you remember the missed dose between 6 and 18 hours after your regular time.

If more than 18 hours have passed since your missed dose, skip it and take your next dose at your regular dosing time.

Never double-up a dose of THEO-DUR.

You should not take TICLID if you have any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury), or a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).

TICLID can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

You will need frequent blood tests to check your blood cell levels.

You should not use this medicine if you are allergic to TICLID, or if you have:

• severe liver disease;
• any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury); or
• a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).

To make sure TICLID is safe for you, tell your doctor if you have:

• high cholesterol or triglycerides;
• a stomach ulcer;
• stomach or intestinal bleeding;
• a history of surgery, injury, or medical emergency;
• liver disease; or
• kidney disease.

TICLID is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with TICLID, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether TICLID passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some of the side effects of TICLID can occur in the first few days of taking this medicine, or after several weeks of treatment.

Call your doctor at once if you have:

• any bleeding that will not stop;
• severe or ongoing diarrhea;
• pink or brown urine;
• low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
• liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
• signs of a serious blood-clotting problem--pale skin, purple spots under your skin or on your mouth, problems with speech, weakness, seizures (convulsions), dark urine, jaundice.

Common side effects may include:

• low blood cell counts;
• diarrhea, nausea, vomiting;
• upset stomach; or
• rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and others. Using an NSAID with TICLID may cause you to bruise or bleed easily.

Taking TICLID with certain other drugs can increase your risk of bleeding. Tell your doctor about all your current medicines and any you start or stop using, especially:

• any other medicines to treat or prevent blood clots, including heparin or warfarin (Coumadin, Jantoven); or
• NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Tell your doctor about all other medications you use, especially:

• antacids or cimetidine (Tagamet);
• phenytoin; or
• theophylline.

This list is not complete. Other drugs may interact with TICLID, including prescription and over-the-counter medicines, vitamins, and herbal products.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

TICLID may be taken with food if it upsets your stomach.

If you were switched to TICLID from another medicine to prevent blood clots, you should stop using the other medicine first. Do not take the medicines together unless your doctor has told you to.

While using TICLID, you will need frequent blood tests to check your blood cell levels and liver function.

Because this medicine keeps your blood from coagulating (clotting) to prevent unwanted blood clots, TICLID can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using TICLID. You may need to stop using the medicine for 10 to 14 days before surgery to prevent excessive bleeding.

Store at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

The recommended dosage for adult and pediatric patients 6 years of age and older is two inhalations four times a day at regular intervals, which provides a dose of 14 mg per day. In patients whose asthma is well controlled on this dosage (e.g., patients who only need occasional inhaled or oral beta2-agonists and who are not experiencing serious exacerbations), less frequent administration may be effective.

Each Tilade (nedocromil inhalation aerosol) Inhaler canister must be primed with 3 actuations prior to the first use. If a canister remains unused for more than 7 days, then it should be reprimed with 3 actuations. Tilade (nedocromil inhalation aerosol) Inhaler may be added to the patient's existing treatment regimen (e.g., bronchodilators). When a clinical response to Tilade (nedocromil inhalation aerosol) Inhaler is evident and if the patient's asthma is under good control, an attempt may be made to decrease concomitant medication usage gradually. Proper inhalational technique is essential (see Patient Instructions for Use). Patients should be advised that the optimal effect of Tilade (nedocromil inhalation aerosol) therapydepends upon its administration at regular intervals, even during symptom-free periods.

WARNINGS

Tilade® Inhaler (nedocromil inhalation aerosol) (nedocromil sodium inhalation aerosol) is not a bronchodilator and, therefore, should not be used for the reversal of acute bronchospasm, particularly status asthmaticus. Tilade (nedocromil inhalation aerosol) should ordinarily be continued during acute exacerbations unless the patient becomes intolerant to the use of inhaled dosage forms.

As with other inhaled asthma medications, bronchospasm, which can be life-threatening, may occur immediately after administration. If this occurs, Tilade (nedocromil inhalation aerosol) should be discontinued and alternative therapy instituted.

PRECAUTIONS

General: The role of Tilade (nedocromil inhalation aerosol) as a corticosteroid-sparing agent in patients receiving oral or inhaled corticosteroids remains to be defined. If systemic or inhaled corticosteroid therapy is reduced in patients receiving Tilade (nedocromil inhalation aerosol) , careful monitoring is necessary.

Information for Patients: Patients should be told that:

• Tilade (nedocromil inhalation aerosol) must be taken regularly to achieve benefit, even during symptom-free periods.

• Tilade (nedocromil inhalation aerosol) is not meant to relieve acute asthma symptoms. If symptoms do not improve or the patient's condition worsens, the patient should not increase the dosage but should notify the physician immediately.

• They should not decrease the dose without the physician's knowledge. The recommended dose should not be exceeded.

• The full therapeutic effect of Tilade (nedocromil inhalation aerosol) may not be obtained for 1 week or longer after initiating treatment.

• Because the therapeutic effect depends upon local delivery to the lungs, it is essential that patients be properly instructed in the correct method of use (see Patient Instructions for Use).

• An illustrated leaflet for the patient is included in each Tilade (nedocromil inhalation aerosol) Inhaler pack.

Tilade (nedocromil inhalation aerosol) is generally well tolerated. Adverse event information was derived from 6,469 patients receiving Tilade (nedocromil inhalation aerosol) in controlled and open-label clinical trials of 1-52 weeks in duration. A total of 4,400 patients received two inhalations four times a day. An additional 2,069 patients received two inhalations twice daily or another dose regimen. Seventy-seven percent of patients were treated with Tilade (nedocromil inhalation aerosol) for eight weeks or longer.

Of the 4,400 patients who received two inhalations of Tilade (nedocromil inhalation aerosol) four times a day, 2,632 were in placebo-controlled, parallel trials and of these 6.0% withdrew from the trials due to adverse events, compared to 5.7% of the 2,446 patients who received placebo.

The reasons for withdrawal were generally similar in the Tilade (nedocromil inhalation aerosol) and placebo-treated groups, except that patients withdrew due to bad taste statistically more frequently on Tilade (nedocromil inhalation aerosol) than on placebo. Headache reported as severe or very severe, some with nausea and ill feeling, was experienced by 1.0% of Tilade (nedocromil inhalation aerosol) patients and 0.7% of placebo patients.

The events reported with a frequency of 1% or greater across all placebo-controlled studies are displayed for all patients ages 6 years and older who received Tilade (nedocromil inhalation aerosol) or placebo at two inhalations four times daily.

The adverse event profile observed in children ages 6 through 11 was similar to that observed in adults.

In clinical studies, Tilade (nedocromil inhalation aerosol) has been co-administered with other anti-asthma medications, including inhaled and oral bronchodilators, and inhaled corticosteroids, with no evidence of increased frequency of adverse events or laboratory abnormalities. No formal drug-drug interaction studies, however, have been conducted.

Your doctor may have suggested this medication for conditions other than those listed in this drug information. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

Do not use this medication if you:

• are allergic to the medication or any ingredient of the medication
• are in overt heart failure or cardiogenic shock (shock due to heart-related causes)
• have an extremely slow heart rate or serious heart block
• have asthma or severe chronic obstructive pulmonary disease (e.g., emphysema, chronic bronchitis)

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Contact lenses: There are preservatives present in both formulations of TIMOPTIC eye drops. These preservatives may be absorbed by soft contact lenses. Contact lenses should be removed before using TIMOPTIC drops and not re-inserted until at least 15 minutes after use.

Diabetes: Beta-blockers such as TIMOPTIC may mask the signs and symptoms of acute hypoglycemia (low blood sugar). People with diabetes prone to hypoglycemia or who are receiving insulin or hypoglycemic medications should monitor blood glucose regularly.

General: As with other topically applied eye drops, this medication may be absorbed into the blood circulation. The same side effects reported with oral medications from the family known as beta-blockers (e.g., timolol, propranolol, metoprolol) may occur with the eye drops.

Heart failure: People with heart failure should be carefully monitored by their doctors while using TIMOPTIC eye drops.

Overactive thyroid: TIMOPTIC may mask the signs of overactive thyroid. People who have this condition or are prone to developing it should be carefully monitored by their doctors.

Pregnancy: TIMOPTIC has not been studied for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: TIMOPTIC eye drops are not currently recommended for use by children.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• blurred vision (temporary) after putting in the eye drop
• decreased night vision
• double vision
• dry, red eyes
• stinging of eye or other eye irritation (when medication is applied)

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• low blood pressure
• shortness of breath or any difficulty breathing
• signs of an allergy such as swelling of the mouth, shortness of breath, hives, severe itching, and rash
• slow heartbeat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

There may be an interaction between TIMOPTIC and any of the following:

• calcium channel blockers (e.g., diltiazem, nifedipine, verapamil)
• clonidine
• epinephrine
• ergot alkaloids (e.g., dihydroergotamine, ergotamine, methysergide)
• guanethidine
• insulin
• metformin
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., ibuprofen, naproxen, indomethacin)
• other beta-blockers (e.g., betaxolol, levobunolol)
• prazosin
• quinidine
• reserpine
• terazosin
• theophylline

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The usual starting dose is one drop of TIMOPTIC 0.25% solution in the affected eye(s) twice daily. If the response to the drops is not adequate, your doctor may change the dose to one drop of TIMOPTIC 0.5% solution in each of the affected eye twice daily.

Before each use, invert the closed container and shake once. Avoid allowing the tip of the dispensing container to touch the eye or around the eye. Eye solutions, if handled improperly, can become contaminated by common bacteria known to cause eye infections. Serious damage to the eye and loss of vision may result from using contaminated solutions.

If more than one type of eye drop is being used, the different eye drops should be administered at least 10 minutes apart.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not instill a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and keep it out of the reach of children. The contents should not be used for more than one month after the date on which the container is first opened.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Your doctor may have suggested this medication for conditions other than those listed in this drug information. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

Do not use this medication if you:

• are allergic to the medication or any ingredient of the medication
• are in overt heart failure or cardiogenic shock (shock due to heart-related causes)
• have an extremely slow heart rate or serious heart block
• have asthma or severe chronic obstructive pulmonary disease (e.g., emphysema, chronic bronchitis)

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Contact lenses: There are preservatives present in both formulations of TIMOPTIC eye drops. These preservatives may be absorbed by soft contact lenses. Contact lenses should be removed before using TIMOPTIC drops and not re-inserted until at least 15 minutes after use.

Diabetes: Beta-blockers such as TIMOPTIC may mask the signs and symptoms of acute hypoglycemia (low blood sugar). People with diabetes prone to hypoglycemia or who are receiving insulin or hypoglycemic medications should monitor blood glucose regularly.

General: As with other topically applied eye drops, this medication may be absorbed into the blood circulation. The same side effects reported with oral medications from the family known as beta-blockers (e.g., timolol, propranolol, metoprolol) may occur with the eye drops.

Heart failure: People with heart failure should be carefully monitored by their doctors while using TIMOPTIC eye drops.

Overactive thyroid: TIMOPTIC may mask the signs of overactive thyroid. People who have this condition or are prone to developing it should be carefully monitored by their doctors.

Pregnancy: TIMOPTIC has not been studied for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: TIMOPTIC eye drops are not currently recommended for use by children.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• blurred vision (temporary) after putting in the eye drop
• decreased night vision
• double vision
• dry, red eyes
• stinging of eye or other eye irritation (when medication is applied)

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• low blood pressure
• shortness of breath or any difficulty breathing
• signs of an allergy such as swelling of the mouth, shortness of breath, hives, severe itching, and rash
• slow heartbeat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

There may be an interaction between TIMOPTIC and any of the following:

• calcium channel blockers (e.g., diltiazem, nifedipine, verapamil)
• clonidine
• epinephrine
• ergot alkaloids (e.g., dihydroergotamine, ergotamine, methysergide)
• guanethidine
• insulin
• metformin
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., ibuprofen, naproxen, indomethacin)
• other beta-blockers (e.g., betaxolol, levobunolol)
• prazosin
• quinidine
• reserpine
• terazosin
• theophylline

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The usual starting dose is one drop of TIMOPTIC 0.25% solution in the affected eye(s) twice daily. If the response to the drops is not adequate, your doctor may change the dose to one drop of TIMOPTIC 0.5% solution in each of the affected eye twice daily.

Before each use, invert the closed container and shake once. Avoid allowing the tip of the dispensing container to touch the eye or around the eye. Eye solutions, if handled improperly, can become contaminated by common bacteria known to cause eye infections. Serious damage to the eye and loss of vision may result from using contaminated solutions.

If more than one type of eye drop is being used, the different eye drops should be administered at least 10 minutes apart.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not instill a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and keep it out of the reach of children. The contents should not be used for more than one month after the date on which the container is first opened.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

You should not use this medication if you are allergic to TINDAMAX or metronidazole (Flagyl), or if you are in the first 3 months of pregnancy.

You should not breast-feed a baby while you are taking TINDAMAX. However, you may begin nursing again 3 days after you take the last dose. Do not keep any milk you collect with a breast pump while you are taking TINDAMAX.

Before you take TINDAMAX, tell your doctor if you have kidney disease (or if you are on dialysis), epilepsy or other seizure disorder, a blood cell disorder such as anemia or low platelets, or a weak immune system.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. TINDAMAX will not treat a viral infection such as the common cold or flu.

Do not drink alcohol while taking TINDAMAX and for at least 3 days after your treatment ends.

A medicine similar to TINDAMAX has caused cancer in laboratory animals. It is not known if TINDAMAX would have the same effect in animals, or in humans. Talk with your doctor about your individual risk.

You should not use this medication if you are allergic to TINDAMAX or metronidazole (Flagyl), or if you are in the first 3 months of pregnancy.

TINDAMAX can pass into breast milk and may harm a nursing baby. Do not breast-feed while you are taking TINDAMAX and for at least 3 days after your last dose.

You may begin nursing again 3 days after your last dose or TINDAMAX. If you use a breast pump during treatment, throw out any milk you collect while taking TINDAMAX. Do not feed it to your baby.

To make sure you can safely take TINDAMAX, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);
• epilepsy or other seizure disorder;
• a blood cell disorder such as anemia or low platelets; or
• a weak immune system.

Do not take TINDAMAX during the first 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

A medicine similar to TINDAMAX has caused cancer in laboratory animals. It is not known if TINDAMAX would have the same effect in animals, or in humans. Talk with your doctor about your individual risk.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• fever, chills, body aches, flu symptoms;
• numbness, burning pain, or tingly feeling; or
• seizure (convulsions).

Less serious side effects may include:

• vaginal itching or discharge;
• nausea, vomiting, loss of appetite, indigestion;
• constipation, diarrhea, stomach cramps;
• feeling weak or tired;
• headache, dizziness; or
• a metallic or bitter taste in your mouth;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Do not drink alcohol while taking TINDAMAX and for at least 3 days after your treatment ends. You may have unpleasant side effects such as fast heartbeats, severe nausea, vomiting, sweating, and warmth or tingling under your skin.

Check the label of the products and other medicines you use, such as mouthwash or cough and cold medicines. Alcohol in these products can also cause a reaction if you use them while taking TINDAMAX.

Tell your doctor about all other medicines you use, especially:

• any other antibiotic;
• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Gengraf, Neoral, Sandimmune);
• fluorouracil (Adrucil, Efudex, Carac, Flurorplex);
• isoniazid (for treating tuberculosis);
• lithium (Lithobid, Eskalith);
• St. John's wort;
• tacrolimus (Prograf);
• an antidepressant such as nefazodone;
• antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
• a barbiturate such as phenobarbital (Solfoton) and others;
• heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
• HIV medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir); or
• seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with TINDAMAX. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take TINDAMAX with food.

Some infections are treated with only one dose. Follow your doctor's instructions.

Do not share this medication with another person, even if they have the same symptoms you have.

If you are treating a sexually transmitted infection, make sure your sexual partner seeks medical attention to be treated also.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. TINDAMAX will not treat a viral infection such as the common cold or flu.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.