Check with your doctor or pharmacist before taking any other drugs, including non-prescription drugs (for colds, nausea, etc.). ZOLADEXmight interfere with some medicines used to treat heart rhythm problems or might increase the risk of heart rhythm problems when used with some other drugs that can cause heart rhythm abnormalities.

Before taking ZONEGRAN, tell your doctor if you have, or have ever had:

• Liver disease
• Kidney problems or kidney stones
• Lung or breathing difficulties
• High blood acid levels
• A mental illness, such as depression
• A history of status epilepticus (long periods of continuous seizures, or a series of seizures without a return to consciousness)
• Allergies to medications

Also, let your doctor know if you're on a high-fat, low-carbohydrate diet (ketogenic diet) to control your seizures.

ZONEGRAN can make it harder for your body to cool down when it gets hot. Avoid exposure to extreme heat, and tell your doctor immediately if you have a fever or aren't sweating as you usually do.

Let your healthcare provider know if you have diarrhea any time before or during your treatment.

Your mental health may change in unexpected ways while taking ZONEGRAN. In clinical studies, a small number of people who took anticonvulsants such as ZONEGRAN became suicidal.

Tell your doctor right away if you experience any of the following symptoms:

• New or worsening depression, anxiety, or irritability
• Violent, aggressive, or angry behavior
• Thoughts of harming yourself
• Agitation or restlessness
• Panic attacks
• Difficulty falling asleep or staying asleep
• An abnormally excited mood
• Withdrawal from family and friends
• A preoccupation with death
• Any other changes in behavior or mood

Your doctor will probably tell you to drink six to eight glasses of water every day while taking ZONEGRAN. Follow these instructions carefully.

Some people who take medicines like ZONEGRAN develop a severe, and sometimes fatal, reaction. Tell your doctor right away if you experience:

• Fever, chills, cough, or sore throat
• Rash
• Swollen, blistered, or peeling skin
• Red or irritated eyes
• Sores in the mouth, throat, nose, or eyes
• Unusual bleeding or bruising
• Extreme fatigue
• Pale skin
• Severe stomach pain
• Loss of appetite
• Dark-colored urine or pale-colored stools

Be sure to tell your healthcare provider you're taking this medicine before having any type of surgery, including a dental procedure.

ZONEGRAN may cause a condition called metabolic acidosis (high blood acid levels). Talk to your doctor about this risk.

This medicine shouldn't be taken by children younger than 16. Children may be at higher risk for side effects such as kidney stones, heatstroke, reduced growth, and metabolic acidosis.

Continue to take ZONEGRAN even if you feel well. Don't stop taking this drug without first talking to your doctor.

If you stop taking this medicine suddenly, your seizures may worsen. Your doctor will probably tell you to stop taking ZONEGRAN gradually if the drug is no longer helpful or needed.

Your doctor will want to order frequent tests to check your body's response to ZONEGRAN. Keep all appointments with your doctor's office and laboratory.

Pregnancy and ZONEGRAN

ZONEGRAN can harm a fetus, so don't take it if you're pregnant. Contact your doctor right away if you become pregnant while taking this medicine.

Use an effective form of birth control while taking ZONEGRAN.

ZONEGRAN passes into breast milk. Don't breastfeed while taking this medicine.

Common Side Effects of ZONEGRAN

Tell your doctor if any of the following side effects become severe or don't go away:

• Nausea or vomiting
• Heartburn
• Constipation
• Weight loss
• Changes in taste
• Dry mouth
• Dizziness or drowsiness
• Headache

Serious Side Effects of ZONEGRAN

Tell your doctor if you experience any of the symptoms listed in the ZONEGRAN Warnings section above, or any of the following serious side effects:

• Worsening or longer-lasting seizures
• Sudden back pain
• Bone pain
• Painful urination
• Difficulty thinking of words, or trouble speaking
• Confusion or memory problems
• Difficulty concentrating
• Lack of coordination
• Difficulty walking
• Severe weakness or muscle pain
• Shallow, fast breathing
• Irregular heartbeat
• Loss of consciousness
• Pain, burning, numbness, or tingling in the hands or feet
• Uncontrollable eye movements or double vision

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

• Cordarone or Pacerone (amiodarone)
• Antifungals, such as Sporanox (itraconazole) or Nizoral (ketoconazole)
• Carbonic anhydrase inhibitors, such as Diamox (acetazolamide) or Neptazane (methazolamide)
• Biaxin (clarithromycin) or Prevpac (lansoprazole, amoxicillin, and clarithromycin)
• Cardizem, Dilacor, or Tiazac (diltiazem)
• E.E.S., E-Mycin, or Erythrocin (erythromycin)
• Luvox (fluvoxamine)
• HIV protease inhibitors, such as Crixivan (indinavir), Viracept (nelfinavir), Norvir (ritonavir), or Kaletra (lopinavir and ritonavir)
• Medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems
• Other medications for seizures, such as Carbatrol, Epitol, or Tegretol (carbamazepine), Luminal or Solfoton (phenobarbital), Dilantin or Phenytek (phenytoin), or Depakene or Depakote (valproic acid)
• Serzone (nefazodone)
• Hormonal contraceptives (birth control pills, patches, rings, and injections)
• Actos (pioglitazone), Actoplus MET (pioglitazone and metformin), or Duetact (pioglitazone and glimepiride)
• Mycobutin (rifabutin)
• Rifadin or Rimactane (rifampin)
• St. John's wort
• Calan, Covera, Isoptin, or Verelan (verapamil)
• TAO (troleandomycin — not available in the United States)

ZONEGRAN and Other Interactions

ZONEGRAN may cause drowsiness, dizziness, or vision problems. Don't drive or perform any activity that requires alertness until you know how this medicine affects you.

ZONEGRAN and Alcohol

Alcohol may worsen certain side effects of ZONEGRAN. Talk to your doctor before drinking alcohol while taking this medicine.

ZONEGRAN and Grapefruit

Grapefruit and grapefruit juice may interact with the way ZONEGRAN is absorbed in the body.

Talk to your doctor about this potential interaction.

ZONEGRAN comes as a capsule. It's typically taken once or twice a day, with or without food.

Try to take ZONEGRAN around the same time each day.

Follow the instructions on your prescription label carefully. Don't use more or less ZONEGRAN than is recommended.

Don't chew, split, or crush the capsules. Swallow them whole.

Your doctor will probably start you on a low dose of ZONEGRAN and gradually increase it.

ZONEGRAN Overdose

Symptoms of a ZONEGRAN overdose may include:

• Slowed breathing or a slow heartbeat
• Dizziness
• Fainting
• Coma

If you suspect an overdose, contact a poison control center or emergency room immediately.

Missed Dose of ZONEGRAN

If you miss a dose of ZONEGRAN, take it as soon as you remember.

But if it's almost time for your next dose, skip the missed dose and continue with your regular medication schedule.

Don't take extra medicine to make up for a missed dose.

Warning info here....

Side Effects info...

interactions info....

proper use info...

Whether you are taking medication to stop smoking or not, the following are symptoms you may feel: depressed, short-tempered, frustrated or angry, nervous, impatient; have difficulty concentrating. Your appetite may increase, and you may gain some weight.

Like all medications, ZYBAN can cause some side effects, although not everybody gets them.

The common side effects are mostly mild to moderate and these usually occur in the first weeks of treatment.

Common side effects of ZYBAN can include:

• difficulty sleeping

• dry mouth

• stuffy or runny nose

• dizziness

• nausea

• constipation

• disturbed concentration

• feeling anxious

• joint aches

If you think you have these side effects, it is important that you seek medical advice from your doctor straight away.

You should tell your doctor if you are taking or have recently taken any medications (prescription, non-prescription or natural herbal) especially:

• medicines for Parkinson’s disease such as levodopa, amantadine or orphenadrine

• medicines used for epilepsy (such as carbamazepine, phenytoin, or phenobarbitone)

• the antipsychotic thioridazine

• other medications for mental illness such as haloperidol and risperidone

• antidepressants such as citalopram, paroxetine, venlafaxine

• cyclophosphamide or ifosfamide, drugs mainly used to treat cancer

• drugs called beta blockers to treat heart conditions

• medicines to regulate heart rhythm

• clopidogrel or ticlopidine, drugs used to reduce blood clots

• tamoxifen, a drug to treat breast cancer

• ritonavir or efavirenz, drugs to treat HIV infection

• sedatives or tranquilizers

• digoxin used to treat congestive heart failure and a fast heart rate or irregular heart rhythm such as atrial fibrillation sometimes called “a-fib”.

In general, drinking alcoholic beverages should be kept to a minimum or avoided completely while taking ZYBAN. Alcohol may trigger or worsen the allergic reactions. Be sure to discuss your use of alcohol with your doctor before you begin taking ZYBAN.

Warnings: Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks. When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Get medical help right away if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat.Precautions: Before taking metoprolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (such as atenolol, propranolol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as a slow heartbeat, sick sinus syndrome, second- or third-degree atrioventricular block), breathing problems (such as asthma, chronic bronchitis, emphysema), liver disease, serious allergic reactions, including those needing treatment with epinephrine, blood circulation problems (such as Raynaud's disease, peripheral vascular disease), mental/mood disorders (such as depression), a certain muscle disease (myasthenia gravis). If you have diabetes, this product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness and sweating, are unaffected by this drug. This product may also make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. This drug passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.

Drowsiness, dizziness, tiredness, diarrhea, and slow heartbeat may occur. Decreased sexual ability has been reported infrequently. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: very slow heartbeat, severe dizziness, fainting, blue fingers/toes, trouble breathing, new or worsening symptoms of heart failure (such as swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain), mental/mood changes (such as confusion, mood swings, depression). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: fingolimod. Other medications can affect the removal of metoprolol from your body, which may affect how metoprolol works. Examples include lumefantrine, propafenone, quinidine, SSRI antidepressants (such as fluoxetine, paroxetine), St. John's wort, among others. Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure/heart rate or worsen your heart failure. Ask your pharmacist for more details.

See also Warning section. Take this medication by mouth, with or right after a meal, as directed by your doctor, usually once or twice a day. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Do not suddenly stop taking this medication without consulting your doctor. Your condition may become worse when the drug is suddenly stopped. For the treatment of high blood pressure, it may take several weeks before you get the full benefit of this drug. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. To prevent chest pain, a second heart attack, or migraine headaches, it is very important to take this medication regularly as prescribed. This drug should not be used to treat chest pain or migraines when they occur. Use other medications to relieve sudden attacks as directed by your doctor (for example, nitroglycerin tablets placed under the tongue for chest pain, "triptan" drugs such as sumatriptan for migraines). Consult your doctor or pharmacist for details. Tell your doctor if your condition does not improve or if it worsens (for example, if your routine blood pressure readings remain high or increase if your chest pain or migraines occur more often).

• ZYCLARA should not be used in patients under 18 years of age

• Avoid exposure to sunlight, sunlamp or tanning-bed during the treatment with ZYCLARA. Wear protective clothing and hat if you go outside during daylight

• ZYCLARA may cause severe skin reactions

• ZYCLARA may also cause flu-like symptoms before or during local skin reactions

BEFORE you use ZYCLARA talk to your doctor or pharmacist if:

• you have or had other skin cancers or other growths on your body

• you are immunocompromised (have weak immune system)

• you have or have had any other treatment for your actinic keratosis, such as freezing or surgery

• you are pregnant or planning to become pregnant

• you are breastfeeding or planning to breastfeed

ZYCLARA treatment is not recommended on areas larger than either the face or balding scalp.

Possible side effects in the treatment area observed in studies of ZYCLARA include:

Actinic keratoses that were not seen before may appear during treatment.

Very common: redness, scabbing or crusting, flaking or dry skin, swelling, small open sores, drainage; itching, irritation, pain; Uncommon: abnormal sensation, scarring; Very rare: bleeding.

The side effects may go outside of the area where ZYCLARA Cream was applied.

During treatment and until the skin has healed, your skin in the treatment area is likely to appear noticeably different from normal skin. If your skin breaks down, if sores develop during the first week of treatment, or if you get any skin reactions that affect your daily activities or do not go away, stop ZYCLARA Cream right away and call your healthcare provider.

Sometimes, ZYCLARA Cream must be stopped for a while to allow your skin to heal.

Other possible side effects observed in studies of ZYCLARA Cream include:

Common: headache, tiredness, nausea, fever, loss of appetite, dizziness, herpes outbreak, pain, diarrhea, swollen lymph nodes, joint aches , skin irritation, difficulty sleeping; Uncommon: chills, influenza-like symptoms, muscle aches, lack of energy, and itching; Very rare: lip cracking, low blood counts.

If flu-like symptoms (fatigue, fever, muscle and joint pain, chills) develop after beginning treatment with ZYCLARA Cream, contact your healthcare provider.

Tell your doctor or pharmacist about all the medicines you take or have taken, including prescription and non-prescription medicines, vitamins and herbal supplements. It is not known if ZYCLARA Cream and other medicines can affect each other.