Lialda (Mesalamine)

(℞) Prescription Required - Lialda is also marketed as Mezavant

    Lialda (Mesalamine) Dosage and Side Effects

    Doctors prescribe LIALDA to help control and prevent ulcerative colitis flare-ups. LIALDA belongs to a class of drugs called anti-inflammatory agents, which reduce inflammation by blocking production of an inflammatory chemical in the intestines called prostaglandin.

    Proper Use of this medication

    Dosages of LIALDA vary by brand and manufacturer.

    Apriso comes in extended-release capsules of 375 milligrams (mg), while Asacol HD comes in delayed-release tablets of 800 mg.

    Asacol delayed-release tablets of 400 mg were discontinued in 2013.

    Lialda comes in tablets of 1.2 grams (g), while Pentasa comes in extended-release capsules of 250 mg and 500 mg.

    Delzicol comes in delayed-release capsules of 400 mg.

    Canasa is a suppository of 1 g and Rowasa is a rectal solution (enema) containing 4 g of LIALDA per 60 milliliters (ml) of liquid.

    Always take LIALDA tablets and capsules with a full glass of water.

    Never break, crush, chew, or split delayed-release tablets or extended-release capsules containing LIALDA.

    Try to take Delzicol either on an empty stomach or a few hours after eating.

    Lialda, on the other hand, should always be taken with food.

    More studies are needed to determine the maximum dose of LIALDA you can safely take, and in what form.

    Yet some studies show that people can tolerate as much as 4.8 g of LIALDA by mouth, plus 4 g by enema daily, without adverse side effects.

    Work with your doctor to figure out what dose works best for you.

    LIALDA Overdose

    If you suspect an overdose of LIALDA, contact an emergency room or poison control center right away.

    Missed Dose of LIALDA

    If you miss a dose of LIALDA, take it as soon as you remember.

    But if it's almost time for your next dose, skip the missed dose and take your next dose at the regular time.

    Don't double up on doses to make up for a missed one.

    Side Effects

    Common Side Effects

    Tell your doctor if any of the following side effects are severe or don't go away:

    • Headache
    • Nausea or stomach pain
    • Infection or inflammation of the nose and throat
    • Flare-ups in bowel condition

    Serious Side Effects

    The following serious side effects require urgent medical attention:

    • Kidney disease, inflammation, or failure
    • Liver disease or failure
    • Infection or inflammation of the muscles or lining of the heart
    • Blood abnormalities
    • Allergic reactions
    • A severe reaction called acute intolerance syndrome, which may involve abdominal pain, fever, and severe or bloody diarrhea

    If you experience any symptoms of acute intolerance syndrome, stop taking LIALDA and contact your doctor right away.

    Warnings and Precautions

    You shouldn't take LIALDA if you are:

    • Allergic to LIALDA or any other ingredients in the medication
    • Allergic or sensitive to salicylates
    • Breastfeeding

    In addition, people who are allergic or sensitive to sulfites should not use the rectal solution (enema) form of LIALDA, called Rowasa.

    Never give LIALDA in any form to children who have chicken pox or who might have the flu.

    Lialda, one of the newer LIALDA-containing drugs on the market, may cause swelling of the face, lips, and mouth (angioedema), and severe skin reactions.

    Talk to your doctor before taking LIALDA if you:

    • Have had a peptic ulcer
    • Are 65 or older
    • Are taking lactulose
    • Have kidney or liver problems
    • Are allergic to Azulfidine (sulfasalazine)
    • Have a blockage in your stomach or small intestine

    LIALDA may lower the sperm count in some men.

    Pregnancy and LIALDA

    The effects of LIALDA on a pregnant woman's unborn child have not been studied.

    Talk to your doctor about the drug if you're pregnant or planning a pregnancy.

    It's unclear what effect LIALDA has on nursing babies, so talk to your doctor before taking the drug if you are breastfeeding.

    And remember that it's always a good idea to talk to your doctor about all of your medications if you're pregnant, planning a pregnancy, or breastfeeding.

    Interactions with this medication

    Tell your doctor(s) and pharmacist about all prescription, over-the-counter, illegal, recreational, herbal, nutritional, or vitamin-containing drugs and supplements you're taking.

    Don't take LIALDA if you're taking:

    • Zanosar (streptozocin)

    Other drugs that may have serious interactions with LIALDA include:

    • Aciphex (rabeprazole), Dexilant (dexlansoprazole), Nexium (esomeprazole), and Prevacid (lansoprazole)
    • Alternagel or Amphojel (aluminum hydroxide) and Milk of Magnesia (magnesium hydroxide)
    • Axid or Axid AR (nizatidine), Pepcid (famotidine), and Tagamet (cimetidine)
    • Baciim (bacitracin)
    • Live varicella vaccine
    • MMR II (live measles, mumps, and rubella vaccine)
    • Polymyxin B

    LIALDA and Alcohol

    Alcohol can irritate your stomach and intestines, and may potentially worsen your condition if you already have ulcerative colitis.

    If you can, avoid or at least limit drinking while taking LIALDA.

    LIALDA and Grapefruit Juice

    Avoid eating grapefruit and drinking grapefruit juice while taking LIALDA.

    Grapefruit slows down the body's breakdown of LIALDA, which could result in dangerously high levels of the drug in the bloodstream.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.