Lialda (Mesalamine)

(℞) Prescription Required

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Lialda 1200mg

Product of United Kingdom
Manufactured by: Shire Pharmaceuticals
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Lialda is also marketed as Mezavant XL
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Lialda 1200mg
Product of United Kingdom
Manufactured by Shire Pharmaceuticals
Top Brand Choice
Top Generic Choice

Lialda 1200mg

Product of Canada
Manufactured by: Shire Biochem Inc.
*Product image for reference use only.
Lialda is also marketed as Mezavant XL
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Lialda 1200mg
Product of Canada
Manufactured by Shire Biochem Inc.
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Top Generic Choice

Mesalamine DR 1200mg

Product of India
Manufactured by: Sun Pharmaceuticals Ltd
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Mesalamine DR 1200mg
Product of India
Manufactured by Sun Pharmaceuticals Ltd
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We do not currently offer a Lialda coupon. But, we can assure you the Lialda cost you'll pay is better than any you've found at local pharmacies and on other sites. We strive to provide our customers with the best options for their lialda medication needs, so rest assured you're getting fair and affordable options.

About Lialda (Mesalamine)

Lialda is a prescription medication for treating inflammation of the colon—ulcerative colitis. Brand name Lialda is manufactured by Shire Pharmaceuticals and is available in one dose of 1200mg.  This is an extended-release tablet and is known as Mezavant XL in Canada and in the United Kingdom.

The active chemical ingredient is called mesalamine and we also provide a generic alternative for this medication.

Lialda (Mesalamine) Medication Information


Lialda is prescribed to treat ulcerative colitis, a disease of the large intestine. 

Ulcerative colitis (UC) is a chronic condition where the bowels become inflamed and ulcers form. The inflammation and ulcers affect the inner lining of the large intestine. Symptoms may include blood in the stool, diarrhea, and abdominal pain.

Inflammation is a normal immune system process of the body. However, in some people, the immune system is overactive and causes inflammation when it is not needed. This overactive immune reaction is part of what causes UC.

Lialda works by reducing inflammation in the large intestine. The exact mechanism is unknown, but it appears to modify the chemical signals involved in immune system reactions. Lialda reduces inflammation and is used for induction of remission and maintenance of remission.


Lialda is made in 1.2 g tablets.

Your doctor will prescribe different doses based on whether your UC is in remission or not.

To induce remission, the normal dose of Lialda is two to four tablets by mouth once daily with food.

Once remission is achieved, the dosage is two tablets by mouth once daily with food.

Side Effects

Common side effects of Lialda may include:

  • Abdominal pain
  • Flatulence
  • Headache
  • Liver function test abnormalities
  • Ulcerative colitis


Do not take Lialda if you have an allergy to aspirin or similar medications.

Tell your doctor if you have a history of kidney problems. Mesalamine can worsen kidney function while taking it. Do not take NSAIDs while you are taking Lialda.

Tell your doctor if you have a history of liver problems. 


Tell your doctor and pharmacist about all medications you are taking before you start Lialda. Common drug interactions with Mesalamine include:

  • 6-Mercaptopurine
  • Azathioprine
  • H2 receptor blockers
  • Antacids
  • Proton pump inhibitors
  • Varicella-containing vaccines

Avoid medications that are used as “antacids” because they will reduce the absorption of Lialda.


Store at room temperature 15 °C to 25 °C (59 °F to 77 °F).

Pharmacist Tips

  • Take Lialda whole and do not crush or chew it. Lialda has a delayed-release coating that helps it reach the large intestine without being digested.
  • Lialda must be taken with food.
  • Use skin protection while taking Lialda, including sunscreen and protective clothing. Avoid prolonged exposure to the sun and ultraviolet light.

Mesalamine FAQs

How long does it take Mesalamine to work?

For most people, it takes about four weeks for Lialda to start working.


Can I take Lialda while pregnant or breastfeeding?

Lialda is probably safe to take while pregnant, but you should talk to your doctor before taking anything while pregnant. Lialda passes through breast milk to a small extent, but it is unknown if this is harmful to the baby.


Is it safe to take Lialda if I am 65 or older?

Yes, but you may be at a higher risk of blood problems. Your doctor should monitor the levels of your blood cells while you are taking Lialda.


Related Products


  1. Lialda [package insert]. Wayne, PA: Shire; 2014.

Medication Review by a Clinical Pharmacist - PharmD

Author: Dr. Conor Sheehy, PharmD, BCPS

Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics.  He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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