BEFORE you use COMBIVIR talk to your doctor or pharmacist if:

• You ever had to stop taking this or another medication for this illness because you were allergic to them or they caused problems.

• You had, or do you have, any diseases of the kidney.

• You had, or do you have, any diseases of the liver, particularly hepatitis B or C infection.

• You had, or you have, very low red blood cell count (severe anemia), very low white blood cell count (neutropenia) or any type of blood disorder.

• You are taking ribavirin as it could cause or worsen anemia (symptoms of tiredness, shortness of breath).

  Your doctor will advise whether you should stop taking COMBIVIR.

• You are taking interferon.

Remember that treatment with COMBIVIR does not reduce the risk of passing the infection onto others. You will still be able to pass HIV by sexual contact or by blood transfusion and you should use appropriate precautions, for example:

• Use a condom when you have oral or penetrative sex.

• Don’t risk blood transfer—for example, don’t share needles.

While taking COMBIVIR or any other therapy for HIV disease, you may continue to develop other infections and other complications of HIV infection. Therefore, you should keep in regular contact with the doctor who is treating your condition.

Your doctor will arrange regular blood tests to check for side effects. See Side Effects and What to Do About Them: for more details.

Tell your doctor about all your medicines, including vitamin supplements, herbal remedies or homeopathic remedies, including those you have bought yourself. COMBIVIR should not be taken with stavudine, emtricitabine, zalcitabine, ribavirin, lamivudine or zidovudine.

It is important that you tell your doctor if you are taking any of the medicines below:

• phenytoin, valproic acid

• oxazepam, lorazepam

• codeine, morphine, methadone

• acetylsalicylic acid, indomethacin, ketoprofen, naproxen

• rifampicin, co-trimoxazole (trimethoprim and sulfamethoxazole), dapsone, pentamidine

• ganciclovir, fluconazole, amphotericin, flucytosine

• vincristine, vinblastine, doxorubicin

• cimetidine

• probenecid

• clofibrate

• atovaquone, pyrimethamine

• interferon

• isoprinosine

• clarithromycin to be taken 2 hours before or 2 hours after taking COMBIVIR

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not take COLOCORT by mouth. It is for use only in your rectum.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. You may need to use this medication for up to 8 weeks.

Wash your hands before and after using this medicine.

Try to empty your bowel and bladder just before using the COLOCORT.

Use only the applicator provided with the medication to insert it into your rectum.

For best results from the enema, lie down on your left side for at least 30 minutes after using the foam or enema to allow the liquid to distribute throughout your intestines. Try to hold in the enema for at least 1 hour, or all night if possible. Avoid using the bathroom during this time.

Call your doctor if your symptoms do not improve or if they get worse after using this medicine for a few days.

Store at room temperature away from moisture and heat.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

•feeling short of breath, even with mild exertion;

•swelling of your ankles or feet;

•muscle weakness;

•rapid weight gain, especially in your face and midsection;

•severe rectal pain or burning;

•bleeding from your rectum;

•severe stomach pain;

•sudden and severe headache or pain behind your eyes; or

•seizure (convulsions).

Less serious side effects may include:

•mild rectal pain or burning;

•acne;

•changes in your menstrual periods;

•increased sweating; or

•increased facial or body hair growth.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

•congestive heart failure;

•a history of tuberculosis;

•stomach ulcer or diverticulitis;

•a colostomy or ileostomy;

•fever or any type of infection;

•kidney disease;

•high blood pressure; or

•myasthenia gravis.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

FDA pregnancy category C. It is not known whether COLOCORT will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether hydrocortisone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Before using COLOCORT, tell your doctor if you also use insulin or take oral diabetes medication.

There may be other drugs that can interact with COLOCORT Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Usual adult dose:

Side effects may include:

• new or worsened constipation

• worsened haemorrhoids and bleeding from haemorrhoids

• raised liver enzymes levels in your blood

• gas, heartburn, vomiting, loss of appetite

• hives

• headache, anxiety, vertigo, drowsiness

• fatigue, weakness

BEFORE you use COLESTID talk to your doctor or pharmacist if:

• You have or have had in the past any health problems as some conditions can affect your cholesterol level and should be treated before you take COLESTID.

• You have dysproteinemia (an abnormality in protein content of the blood, usually in the content of immunoglobulins), diabetes, thyroid, gallbladder, kidney or liver disease.

• You have a deficiency of vitamins A, D, or K.

• You are pregnant, if you become pregnant or if you are breastfeeding your baby.

• You are taking other medicines, even medicine without prescription.

• You have irritable bowel syndrome, diverticulosis and diverticulitis, as these conditions can be influenced by the nonmedicinal ingredient colloidal silicon present in these products.

COLESTID can reduce the effect of other medications taken at the same time. Take other medications at least 1 hour before or, wait 4 hours after you take COLESTID before taking other medications.

Drugs that may interact with COLESTID include:

• Antibiotics

• Beta-blockers (used to decrease blood pressure)

• Digoxin or digitoxin

• Diuretics (water pills)

• Warfarin (anticoagulant)

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

COLAZAL can be taken with or without food.

To make swallowing easier, you may open the COLAZAL capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away. Do not save the mixture for later use. The yellow-orange medicine from the capsule may stain your teeth or tongue when you use this method.

Call your doctor if your symptoms do not improve, or if they get worse while using COLAZAL.

COLAZAL is usually taken only for a short time (8 to 12 weeks). Follow your doctor's dosing instructions very carefully.

Store at room temperature away from moisture and heat.Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

COLAZAL can be taken with or without food.

To make swallowing easier, you may open the COLAZAL capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away. Do not save the mixture for later use. The yellow-orange medicine from the capsule may stain your teeth or tongue when you use this method.

Call your doctor if your symptoms do not improve, or if they get worse while using COLAZAL.

COLAZAL is usually taken only for a short time (8 to 12 weeks). Follow your doctor's dosing instructions very carefully.

Store at room temperature away from moisture and heat.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

•worsening colitis symptoms--fever, stomach pain, cramps, or bloody diarrhea;

•kidney problems--little or no urinating, swelling, rapid weight gain;

•liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

•pain or burning when you urinate; or

•anemia (low red blood cells)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating.

Common side effects may include:

•headache;

•mild or occasional nausea, vomiting, stomach pain, diarrhea;

•joint pain; or

•cold symptoms such as stuffy nose, sneezing, sore throat.

You should not use this medicine if you are allergic to COLAZAL or mesalamine, or to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others).

To make sure COLAZAL is safe for you, tell your doctor if you have:

•kidney disease;

•liver disease;

•a stomach condition called pyloric stenosis.

COLAZAL tablets contain sodium. Talk to your doctor before using this form of COLAZAL if you are on a low salt diet.

FDA pregnancy category B. COLAZAL is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether COLAZAL passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

COLAZAL capsules should not be given to a child younger than 5 years old. COLAZAL tablets should not be given to anyone under 18 years old.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may interact with COLAZAL, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Doses will vary depending on the patient. The following is a typical dosing schedule:

For oral dosage form (tablets):

For Idiopathic Parkinsonism:

Adults: Start with 0.5-1 milligrams (mg) at bedtime. Your doctor may increase your dose as needed. The dose is usually not more than 6 mg.

Children age 3 years and older: Dosing schedule will be determined by your doctor.

Children under age 3: Use is not recommended.

For Parkinson-like symptoms caused by other medicines:

Adults: Start with 1-4 mg, once or twice a day. Your doctor may increase your dose as needed.

Children age 3 and older: Dosing schedule will be determined by your doctor.

Children under age 3: Use is not recommended.

For Postencephalitic Parkinsonism:

Adults: Start with 0.5-2 mg at bedtime. Your doctor may increase your dose as needed. The dose is usually not more than 6 mg.

Children age 3 and older: Dosing schedule will be determined by your doctor.

Children under age 3: Use is not recommended.

Common Side Effects of COGENTINE

•Drowsiness

•Dry mouth

•Difficulty urinating

•Constipation

You should tell your doctor if any of these symptoms become severe or do not subside.

Serious Side Effects of COGENTINE

Call your doctor immediately if you experience any of the following symptoms:

•Skin rash

•Fast, irregular, or pounding heartbeat

•Fever

•Confusion

•Hallucinations or delusions

•Depression

•Eye pain

This medication may make you drowsy. You should exercise caution while driving or operating machinery until you know how COGENTINE will affect you.

COGENTINE may cause an upset stomach, so you should take it with food or milk.

Before taking this drug, you should tell your doctor if you have ever had the following conditions:

•Kidney or liver disease

•Glaucoma

•Heart or blood pressure issues

•Myasthenia gravis

•Problems with your prostate, urinary system, or stomach

•Bleeding problems

•Esophageal achalasia

•Intestinal or urinary blockage

•Ulcerative colitis

You should tell your physician if you are taking COGENTINE before having any type of surgery, including dental surgery.

Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding while taking COGENTINE.

This medicine is not recommended for use in children younger than 3 years of age.

COGENTINE may cause weakness or the inability to move particular muscle groups, especially in large doses.

Mental confusion and excitement may also occur in large doses. Visual hallucinations have been occasionally reported.

This medicine should be administered with caution during hot weather as it may cause anhidrosis, which is the inability to sweat normally. This can lead to heat exhaustion.

You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking, especially:

•Potassium

•Morphine

•Morphine Sulfate Liposome (DepoDur)

•Oxymorphone (Opana)

•Umeclidinium

•Betel Nut

•Chlorpromazine (Thorazine)

•Haloperidol (Haldol)

•Amantadine (Symadine)

•Digoxin (Lanoxin)

•Levodopa (Sinemet)

•Pramlintide (Symlin)

•Tranquilizers

You should also refrain from taking diarrhea medicines or antacids containing aluminum or magnesium within two hours of COGENTINE.

COGENTINE and Alcohol

Alcohol can enhance the effects of drowsiness while taking COGENTINE. You should limit your intake of alcoholic beverages.

COGENTINE and Other Interactions

You should also avoid unnecessary or prolonged exposure to hot weather or other situations of excessive heat such as exercise, as COGENTINE may keep you from sweating enough.

Usual dose:

At the beginning of treatment, Clopixol may make you feel drowsy and dizzy so you should not drive a car or use any tools or machines until you are sure Clopixol does not affect your mental alertness.

Side-effects that have been reported by patients taking Clopixol include: muscle spasm, stiffness, shaking or uncontrolled body movements. These can happen in different parts of the body, such as the tongue, face, mouth, jaw, eyes, hands, arms and legs. Contact your doctor if this happens to you.

Other possible side-effects include dry mouth, dizziness, blurred or altered vision (difficulty reading small print), constipation, excessive salivation or sweating, trouble passing urine. Decreases in blood pressure, increases in heart rate, weight changes, skin rash, decreased sexual interest or function, and changes in your monthly cycle (if you are female).

In addition, blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If you notice any of these symptoms seek medical advice immediately.

Your doctor should check your body weight before starting Clopixol and continue to monitor it for as long as you are being treated.

Your doctor should take blood tests before starting Clopixol. They will monitor blood sugar, and the number of infection fighting white blood cells. Your doctor should continue to monitor your blood for as long as you are being treated.

If you have high levels of prolactin (measured with a blood test) and a condition called hypogonadism you may be at increased risk of breaking a bone due to osteoporosis. This occurs in both men and women.

Tell your doctor or pharmacist if you think you have any of these or other effects while taking Clopixol.

Any fever (increased temperature) or soreness of the mouth, gums, or throat that happens while you are taking Clopixol should be reported to your doctor immediately.

BEFORE you use Clopixol talk to your doctor or pharmacist if:

Drugs that may interact with Clopixol include:

Like all medications, CLOMIPHENE can cause side effects, although not everybody gets them.

The more common side effects include hot flashes, abdominal-pelvic discomfort (distention, bloating, pain, or soreness), ovarian enlargement, and visual blurring. The symptoms resembling menopausal “hot flashes” are not usually severe and disappear promptly after treatment is discontinued. Abdominal symptoms may be most often related to ovulatory or premenstrual phenomena, or to swollen ovaries.

Other less frequently reported symptoms during CLOMIPHENE (clomiphene citrate) therapy have included nausea or vomiting, appetite increase, constipation, diarrhea, increased nervous tension, depression, fatigue, dizziness or lightheadedness, insomnia, headache, breast soreness, abnormal uterine bleeding, heavier menses, intermenstrual spotting, vaginal dryness, urticaria or allergic dermatitis, vertigo, weight gain, and increased urinary frequency or volume. Moderate, reversible hair loss has been reported in a few patients, primarily on prolonged continuous therapy. Birth defects have been reported.

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days:

• Increased pain with periods, heavy periods or bleeding between periods

• Pain in the lower part of the stomach. This could be a sign of endometriosis or worsening of endometriosis, ovarian cancer or enlarged ovaries

• Pain in the upper middle or upper left part of the abdomen. This could be a sign of hypertriglyceridemia (excess of fats in the blood)-induced pancreatitis (inflammation of the pancreas).

• Cloudy lenses in the eye (cataracts)

• Feeling tired or difficulty in sleeping (insomnia), depression or change in moods or behaviour

• Skin rash or itching

• Flushing of the skin

• Swelling of the face, around the eyes, lips or tongue

• Painful breasts

• Heart palpitations (sensation of rapid, pounding, or irregular heartbeat)

There have been rare reports of ovarian cancer with fertility drugs. Some studies suggest that prolonged use of clomiphene may increase this risk. Therefore the recommended duration of treatment should not be exceeded.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medications. This includes medications you buy without a prescription, including herbal medicines. This is because CLOMIPHENE can affect the way some other medicines work. Also some medicines can affect the way CLOMIPHENE works.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Take sulindac with food.

If you use this medicine long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using CLINORIL and call your doctor at once if you have:

• changes in your vision;
• shortness of breath (even with mild exertion), swelling, rapid weight gain;
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• pancreas problems--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
• kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
• low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• nausea, vomiting, stomach pain, indigestion, loss of appetite;
• diarrhea, constipation, gas;
• headache, dizziness, nervousness;
• itching, rash; or
• ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

CLINORIL can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

CLINORIL may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using CLINORIL, especially in older adults.

CLINORIL can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

CLINORIL may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using CLINORIL, especially in older adults.

You should not use CLINORIL if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure CLINORIL is safe for you, tell your doctor if you have:

• heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
• a history of heart attack, stroke, or blood clot;
• a history of stomach ulcers or bleeding;
• kidney disease or a history of kidney stones;
• liver disease;
• a pancreas disorder;
• asthma;
• fluid retention; or
• a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, or lupus.

Taking CLINORIL during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using CLINORIL.

It is not known whether CLINORIL passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

CLINORIL is not approved for use by anyone younger than 18 years old.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin or other NSAIDs while you are taking CLINORIL.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to CLINORIL. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Ask your doctor before using CLINORIL if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines and any you start or stop using, especially:

• cyclosporine;
• lithium;
• methotrexate;
• a blood thinner (warfarin, Coumadin, Jantoven);
• heart or blood pressure medication, including a diuretic or "water pill";
• oral diabetes medication; or
• steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with CLINORIL, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.