You should not use CLINDAGEL if you have ulcerative colitis or enteritis (inflammation of your intestines), or if you have ever had severe diarrhea caused by antibiotic medicine.

You should not use this medicine if you are allergic to clindamycin or lincomycin, or if you have:

•inflammation of your intestines (also called enteritis);

•ulcerative colitis; or

•if you have ever had severe diarrhea caused by antibiotic medicine.

CLINDAGEL is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether CLINDAGEL passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not use this medication on a child younger than 12 years old without the advice of a doctor.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when CLINDAGEL is applied to the skin, side effects can occur if the medication is absorbed into your bloodstream.

Stop using CLINDAGEL and call your doctor at once if you have:

•severe redness, itching, or dryness of treated skin areas; or

•severe stomach pain, diarrhea that is watery or bloody.

Common side effects may include:

•mild burning or itching;

•oily skin;

•mild dryness of treated skin; or

•redness or other irritation.

It is not likely that other drugs you take orally or inject will have an effect on topically applied CLINDAGEL. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. CLINDAGEL topical is for use only on the skin. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.

CLINDAGEL topical is usually applied once per day. Follow your doctor's instructions.

CLEOCIN comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of CLEOCIN in a day, and that dose is normally only for people receiving CLEOCIN via injection into the thigh.

You can take CLEOCIN with or without food, but always with a full glass of water to help prevent it from bothering your throat.

It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.

Common Side Effects of CLEOCIN

Tell your doctor or seek immediate medical help if any of the following common side effects of CLEOCIN do not go away or become severe:

•Mild rash or itching

•Stomach pain, nausea

Serious Side Effects and Reactions

Contact your doctor immediately or seek emergency medical care if you have any of the following while taking CLEOCIN:

•Skin problems, such as hives, rash, red, shedding, or peeling skin

•Yellow appearance of the skin, nails, or whites of the eyes (jaundice)

•Vomiting, severe stomach pain, or diarrhea

•Signs of low blood pressure, ranging from dizziness to fainting

•Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)

•Vein irritation (if you are receiving injections of CLEOCIN)

•Fever or body aches

Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas

•Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth

•Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests

In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking CLEOCIN and call 911.

CLEOCIN has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

CLEOCIN changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking CLEOCIN, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take CLEOCIN for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe CLEOCIN for serious infections that other drugs won't treat.

If you are allergic to CLEOCIN or lincomycin, you should not take CLEOCIN.

Tell your doctor if you are taking erythromycin, because CLEOCIN and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking CLEOCIN:

•Rash

•Painful joints

•Any problems swallowing, including pain while swallowing

•Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)

•Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis

•Nausea

•Vomiting

•Heartburn

Before taking CLEOCIN, also let your doctor know if:

•You are allergic to CLEOCIN, lincomycin, or any of these drugs' ingredients

•You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines

•You have meningitis

Pregnancy and CLEOCIN

CLEOCIN falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

CLEOCIN is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs are known to interact with CLEOCIN:

•Botulinum toxin A (Botox)

•Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel

•Mycophenolate mofetil (Cellcept, Myfortic)

•Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)

•Sodium picosulfate

CLEOCIN and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking CLEOCIN.

Grapefruit juice decreases the body's ability to break down CLEOCIN, which could cause the drug to rise to dangerously high levels in your blood.

CLEOCIN and Other Interactions

You should not take CLEOCIN if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

CLEOCIN has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

CLEOCIN changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking CLEOCIN, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take CLEOCIN for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe CLEOCIN for serious infections that other drugs won't treat.

If you are allergic to CLEOCIN or lincomycin, you should not take CLEOCIN.

Tell your doctor if you are taking erythromycin, because CLEOCIN and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking CLEOCIN:

•Rash

•Painful joints

•Any problems swallowing, including pain while swallowing

•Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)

•Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis

•Nausea

•Vomiting

•Heartburn

Before taking CLEOCIN, also let your doctor know if:

•You are allergic to CLEOCIN, lincomycin, or any of these drugs' ingredients

•You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines

•You have meningitis

Pregnancy and CLEOCIN

CLEOCIN falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

CLEOCIN is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

Common Side Effects of CLEOCIN

Tell your doctor or seek immediate medical help if any of the following common side effects of CLEOCIN do not go away or become severe:

•Mild rash or itching

•Stomach pain, nausea

Serious Side Effects and Reactions

Contact your doctor immediately or seek emergency medical care if you have any of the following while taking CLEOCIN:

•Skin problems, such as hives, rash, red, shedding, or peeling skin

•Yellow appearance of the skin, nails, or whites of the eyes (jaundice)

•Vomiting, severe stomach pain, or diarrhea

•Signs of low blood pressure, ranging from dizziness to fainting

•Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)

•Vein irritation (if you are receiving injections of CLEOCIN)

•Fever or body aches

Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas

•Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth

•Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests

In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking CLEOCIN and call 911.

It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs are known to interact with CLEOCIN:

•Botulinum toxin A (Botox)

•Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel

•Mycophenolate mofetil (Cellcept, Myfortic)

•Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)

•Sodium picosulfate

CLEOCIN and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking CLEOCIN.

Grapefruit juice decreases the body's ability to break down CLEOCIN, which could cause the drug to rise to dangerously high levels in your blood.

CLEOCIN and Other Interactions

You should not take CLEOCIN if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

CLEOCIN comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of CLEOCIN in a day, and that dose is normally only for people receiving CLEOCIN via injection into the thigh.

You can take CLEOCIN with or without food, but always with a full glass of water to help prevent it from bothering your throat.

It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.

CLEOCIN comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of CLEOCIN in a day, and that dose is normally only for people receiving CLEOCIN via injection into the thigh.

You can take CLEOCIN with or without food, but always with a full glass of water to help prevent it from bothering your throat.

It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.

Common Side Effects of CLEOCIN

Tell your doctor or seek immediate medical help if any of the following common side effects of CLEOCIN do not go away or become severe:

•Mild rash or itching

•Stomach pain, nausea

Serious Side Effects and Reactions

Contact your doctor immediately or seek emergency medical care if you have any of the following while taking CLEOCIN:

•Skin problems, such as hives, rash, red, shedding, or peeling skin

•Yellow appearance of the skin, nails, or whites of the eyes (jaundice)

•Vomiting, severe stomach pain, or diarrhea

•Signs of low blood pressure, ranging from dizziness to fainting

•Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)

•Vein irritation (if you are receiving injections of CLEOCIN)

•Fever or body aches

Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas

•Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth

•Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests

In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking CLEOCIN and call 911.

CLEOCIN has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

CLEOCIN changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking CLEOCIN, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take CLEOCIN for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe CLEOCIN for serious infections that other drugs won't treat.

If you are allergic to CLEOCIN or lincomycin, you should not take CLEOCIN.

Tell your doctor if you are taking erythromycin, because CLEOCIN and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking CLEOCIN:

•Rash

•Painful joints

•Any problems swallowing, including pain while swallowing

•Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)

•Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis

•Nausea

•Vomiting

•Heartburn

Before taking CLEOCIN, also let your doctor know if:

•You are allergic to CLEOCIN, lincomycin, or any of these drugs' ingredients

•You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines

•You have meningitis

Pregnancy and CLEOCIN

CLEOCIN falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

CLEOCIN is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs are known to interact with CLEOCIN:

•Botulinum toxin A (Botox)

•Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel

•Mycophenolate mofetil (Cellcept, Myfortic)

•Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)

•Sodium picosulfate

CLEOCIN and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking CLEOCIN.

Grapefruit juice decreases the body's ability to break down CLEOCIN, which could cause the drug to rise to dangerously high levels in your blood.

CLEOCIN and Other Interactions

You should not take CLEOCIN if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

CLEOCIN has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

CLEOCIN changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking CLEOCIN, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take CLEOCIN for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe CLEOCIN for serious infections that other drugs won't treat.

If you are allergic to CLEOCIN or lincomycin, you should not take CLEOCIN.

Tell your doctor if you are taking erythromycin, because CLEOCIN and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking CLEOCIN:

•Rash

•Painful joints

•Any problems swallowing, including pain while swallowing

•Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)

•Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis

•Nausea

•Vomiting

•Heartburn

Before taking CLEOCIN, also let your doctor know if:

•You are allergic to CLEOCIN, lincomycin, or any of these drugs' ingredients

•You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines

•You have meningitis

Pregnancy and CLEOCIN

CLEOCIN falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

CLEOCIN is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

Common Side Effects of CLEOCIN

Tell your doctor or seek immediate medical help if any of the following common side effects of CLEOCIN do not go away or become severe:

•Mild rash or itching

•Stomach pain, nausea

Serious Side Effects and Reactions

Contact your doctor immediately or seek emergency medical care if you have any of the following while taking CLEOCIN:

•Skin problems, such as hives, rash, red, shedding, or peeling skin

•Yellow appearance of the skin, nails, or whites of the eyes (jaundice)

•Vomiting, severe stomach pain, or diarrhea

•Signs of low blood pressure, ranging from dizziness to fainting

•Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)

•Vein irritation (if you are receiving injections of CLEOCIN)

•Fever or body aches

Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas

•Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth

•Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests

In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking CLEOCIN and call 911.

It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs are known to interact with CLEOCIN:

•Botulinum toxin A (Botox)

•Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel

•Mycophenolate mofetil (Cellcept, Myfortic)

•Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)

•Sodium picosulfate

CLEOCIN and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking CLEOCIN.

Grapefruit juice decreases the body's ability to break down CLEOCIN, which could cause the drug to rise to dangerously high levels in your blood.

CLEOCIN and Other Interactions

You should not take CLEOCIN if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

CLEOCIN comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of CLEOCIN in a day, and that dose is normally only for people receiving CLEOCIN via injection into the thigh.

You can take CLEOCIN with or without food, but always with a full glass of water to help prevent it from bothering your throat.

It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.

Your dose of CIPRO will depend on the type of bacterial infection you have.

CIPRO comes in regular and extended-release tablets and as a liquid.

Take regular tablets or the liquid twice a day (morning and evening) at about the same time each day, and take extended-release tablets once a day.

Swallow all tablets whole. Don’t crush, split, or chew them.

Regular tablets come in 250, 500, and 750 milligrams (mg).

Some typical doses for common infections using regular tablets include:

•Uncomplicated gonorrhea infection: 250 mg, single dose

•Uncomplicated urinary tract infection: 250 mg every 12 hours for three days

•Bacterial diarrhea: 500 mg every 12 hours for five to seven days

•Acute sinusitis: 500 mg every 12 hours for 10 days

•Severe pneumonia: 750 mg every 12 hours for seven to 14 days

•Chronic bacterial prostatitis: 500 mg every 12 hours for 28 days

•Moderate bone or joint infection: 500 mg every 12 hours for four to six weeks

The most common side effects of CIPRO are nausea, diarrhea, vomiting, and rash. Let your doctor know if you have any side effects.

Less common side effects include:

•Headache

•Stomachache

•Heartburn

•Body aches

•Itching

•Skin sensitivity to sunlight

•Loss of appetite

Serious side effects can also occur. If you have any of these side effects, stop taking CIPRO and call your doctor right away or call 911:

•Seizure

•Unusual thoughts or hallucinations

•Dizziness

•Confusion

•Depression or suicidal thoughts

•Tremors

•Numbness, tingling, or weakness

•Swelling or pain near a joint

•Chest pain

•Severe or bloody diarrhea

•Skin rash, hives, or blistering of the skin

•Difficulty breathing or swallowing

•Swelling of the face, throat, or body

•Decreased ability to pass urine

•Loss of consciousness

•Unusual bruising or bleeding

•Yellowing of skin or eyes (jaundice) or dark-colored urine

CIPRO may increase the risk for swelling and tearing of tendons, such as those that attach muscles to bones in the hands, shoulders, and ankles.

The likelihood of tendon damage is greater if you also take a steroid medication or if you're older than 60. If you experience pain, swelling, or stiffness while taking CIPRO, let your doctor know.

In some people, CIPRO may cause changes in brain activity. This affects people with a history of seizures.

Possible symptoms of these changes include dizziness, hallucinations, tremors, seizures, confusion, depression, and suicidal thoughts.

If you have any of these symptoms while on CIPRO, let your doctor know right away.

CIPRO may cause a severe reaction called anaphylaxis if you are allergic to it.

This allergic reaction, which can be life-threatening, may include hives, swelling of the throat, and difficulty breathing. 

It's important to know that once you start a course of CIPRO, you should finish the whole course.

Do not stop taking CIPRO, even if you feel better, until all of the medication is gone.

If you don’t take an antibiotic long enough, your infection can come back stronger. And stopping CIPRO too soon can lead to bacteria becoming resistant to it.

You may not be able to take CIPRO if you have a condition called myasthenia gravis. CIPRO may increase muscle weakness caused by this condition.

You should also take CIPRO with caution if you have certain conditions. Tell your doctor if you have:

•Heartburn or reflux

•Depression

•Seizures

•Asthma

•Tendon injury

•Heart condition

•Liver disease

•Kidney disease

CIPRO and Pregnancy

Before taking CIPRO, women should let their doctor know if they are or may be pregnant or if they're breastfeeding.

It’s unknown whether CIPRO is safe to take during pregnancy.

Experts do know that CIPRO passes through breast milk, so it is not safe to take if you are breastfeeding.

Except for children with a few specific and serious infections, no one younger than 18 should take CIPRO.

Some drugs may affect the way CIPRO works, and CIPRO may affect other drugs you are taking.

It’s very important to let your doctor know about all drugs you take, including over-the-counter (OTC) antacids, vitamins, and supplements.

Many antacids, vitamins, and supplements that contain magnesium, calcium, aluminum, iron, or zinc can interfere with CIPRO.

Other OTC drugs, including such pain and fever medications as Advil, Aleve, and Motrin, may also interact with CIPRO.

CIPRO may increase the effects of caffeine.

If you drink caffeinated drinks or take OTC medications that contain caffeine while taking CIPRO, you may have some caffeine side effects such as nervousness, sleeplessness, or anxiety.

You may not be able to take CIPRO if you are also taking the drug theophylline to treat asthma and wheezing (brand names include Elixophyllin, Uniphyl, and Theo-24). 

Serious reactions, including heart attack, decreased ability to breathe, and seizures, have happened when people took these medications together.

Other medications that interact with CIPRO include:

•Blood thinners, such as warfarin (Coumadin, Jantoven)

•Anti-seizure medication, including phenytoin (Dilantin, Phenytek)

•Certain antidepressants and medications to treat mental illness, such as clozapine (Clozaril, FazaClo)

•Medications that contain caffeine, including Excedrin, NoDoz, and Vivarin

•The immunosuppressant cyclosporine (Gengraf, Neoral, Sandimmune)

•The muscle relaxant tizanidine (Zanaflex)

•Diuretics (water pills)

•Certain drugs for irregular heartbeat, such as amiodarone (Cordarone), disopyramide (Norpace), and procainamide (Procanbid)

•The arthritis drug methotrexate (Rheumatrex, Trexall)

•A drug used to treat nausea, vomiting, heartburn, and reflux called metoclopramide (Reglan)

•The type 2 diabetes drug glyburide (DiaBeta, Glucovance, Micronase)

•Some non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn)

Other CIPRO Interactions

CIPRO can cause drowsiness and confusion. Don’t drive or participate in any dangerous activities until you know how CIPRO affects you.

CIPRO can make your skin more sensitive to sun exposure.

Don’t use a tanning bed, and avoid long exposure to sunlight while taking it. Protect your skin in the sun with clothing or sunscreen.

You can take CIPRO with or without food.

Don’t take CIPRO with only dairy products or with only calcium-fortified juice because calcium can interfere with absorption of CIPRO.

You can, however, take CIPRO with a meal that includes dairy or calcium-fortified juice.

Your dose of CIPRO will depend on the type of bacterial infection you have.

CIPRO comes in regular and extended-release tablets and as a liquid.

Take regular tablets or the liquid twice a day (morning and evening) at about the same time each day, and take extended-release tablets once a day.

Swallow all tablets whole. Don’t crush, split, or chew them.

Regular tablets come in 250, 500, and 750 milligrams (mg).

Some typical doses for common infections using regular tablets include:

•Uncomplicated gonorrhea infection: 250 mg, single dose

•Uncomplicated urinary tract infection: 250 mg every 12 hours for three days

•Bacterial diarrhea: 500 mg every 12 hours for five to seven days

•Acute sinusitis: 500 mg every 12 hours for 10 days

•Severe pneumonia: 750 mg every 12 hours for seven to 14 days

•Chronic bacterial prostatitis: 500 mg every 12 hours for 28 days

•Moderate bone or joint infection: 500 mg every 12 hours for four to six weeks

The most common side effects of CIPRO are nausea, diarrhea, vomiting, and rash. Let your doctor know if you have any side effects.

Less common side effects include:

•Headache

•Stomachache

•Heartburn

•Body aches

•Itching

•Skin sensitivity to sunlight

•Loss of appetite

Serious side effects can also occur. If you have any of these side effects, stop taking CIPRO and call your doctor right away or call 911:

•Seizure

•Unusual thoughts or hallucinations

•Dizziness

•Confusion

•Depression or suicidal thoughts

•Tremors

•Numbness, tingling, or weakness

•Swelling or pain near a joint

•Chest pain

•Severe or bloody diarrhea

•Skin rash, hives, or blistering of the skin

•Difficulty breathing or swallowing

•Swelling of the face, throat, or body

•Decreased ability to pass urine

•Loss of consciousness

•Unusual bruising or bleeding

•Yellowing of skin or eyes (jaundice) or dark-colored urine

CIPRO may increase the risk for swelling and tearing of tendons, such as those that attach muscles to bones in the hands, shoulders, and ankles.

The likelihood of tendon damage is greater if you also take a steroid medication or if you're older than 60. If you experience pain, swelling, or stiffness while taking CIPRO, let your doctor know.

In some people, CIPRO may cause changes in brain activity. This affects people with a history of seizures.

Possible symptoms of these changes include dizziness, hallucinations, tremors, seizures, confusion, depression, and suicidal thoughts.

If you have any of these symptoms while on CIPRO, let your doctor know right away.

CIPRO may cause a severe reaction called anaphylaxis if you are allergic to it.

This allergic reaction, which can be life-threatening, may include hives, swelling of the throat, and difficulty breathing. 

It's important to know that once you start a course of CIPRO, you should finish the whole course.

Do not stop taking CIPRO, even if you feel better, until all of the medication is gone.

If you don’t take an antibiotic long enough, your infection can come back stronger. And stopping CIPRO too soon can lead to bacteria becoming resistant to it.

You may not be able to take CIPRO if you have a condition called myasthenia gravis. CIPRO may increase muscle weakness caused by this condition.

You should also take CIPRO with caution if you have certain conditions. Tell your doctor if you have:

•Heartburn or reflux

•Depression

•Seizures

•Asthma

•Tendon injury

•Heart condition

•Liver disease

•Kidney disease

CIPRO and Pregnancy

Before taking CIPRO, women should let their doctor know if they are or may be pregnant or if they're breastfeeding.

It’s unknown whether CIPRO is safe to take during pregnancy.

Experts do know that CIPRO passes through breast milk, so it is not safe to take if you are breastfeeding.

Except for children with a few specific and serious infections, no one younger than 18 should take CIPRO.

Some drugs may affect the way CIPRO works, and CIPRO may affect other drugs you are taking.

It’s very important to let your doctor know about all drugs you take, including over-the-counter (OTC) antacids, vitamins, and supplements.

Many antacids, vitamins, and supplements that contain magnesium, calcium, aluminum, iron, or zinc can interfere with CIPRO.

Other OTC drugs, including such pain and fever medications as Advil, Aleve, and Motrin, may also interact with CIPRO.

CIPRO may increase the effects of caffeine.

If you drink caffeinated drinks or take OTC medications that contain caffeine while taking CIPRO, you may have some caffeine side effects such as nervousness, sleeplessness, or anxiety.

You may not be able to take CIPRO if you are also taking the drug theophylline to treat asthma and wheezing (brand names include Elixophyllin, Uniphyl, and Theo-24). 

Serious reactions, including heart attack, decreased ability to breathe, and seizures, have happened when people took these medications together.

Other medications that interact with CIPRO include:

•Blood thinners, such as warfarin (Coumadin, Jantoven)

•Anti-seizure medication, including phenytoin (Dilantin, Phenytek)

•Certain antidepressants and medications to treat mental illness, such as clozapine (Clozaril, FazaClo)

•Medications that contain caffeine, including Excedrin, NoDoz, and Vivarin

•The immunosuppressant cyclosporine (Gengraf, Neoral, Sandimmune)

•The muscle relaxant tizanidine (Zanaflex)

•Diuretics (water pills)

•Certain drugs for irregular heartbeat, such as amiodarone (Cordarone), disopyramide (Norpace), and procainamide (Procanbid)

•The arthritis drug methotrexate (Rheumatrex, Trexall)

•A drug used to treat nausea, vomiting, heartburn, and reflux called metoclopramide (Reglan)

•The type 2 diabetes drug glyburide (DiaBeta, Glucovance, Micronase)

•Some non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn)

Other CIPRO Interactions

CIPRO can cause drowsiness and confusion. Don’t drive or participate in any dangerous activities until you know how CIPRO affects you.

CIPRO can make your skin more sensitive to sun exposure.

Don’t use a tanning bed, and avoid long exposure to sunlight while taking it. Protect your skin in the sun with clothing or sunscreen.

You can take CIPRO with or without food.

Don’t take CIPRO with only dairy products or with only calcium-fortified juice because calcium can interfere with absorption of CIPRO.

You can, however, take CIPRO with a meal that includes dairy or calcium-fortified juice.

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

While treating a corneal ulcer, you may notice a whitish buildup in your eye. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
• Use only the number of drops your doctor has prescribed.
• Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

If you are using this medication to treat a corneal ulcer, you may need to use the eye drops every 15 to 30 minutes for the first day, and then every 1 to 4 hours for the rest of your treatment. Follow your doctor's instructions.

To apply the ointment:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.
• Squeeze out a ribbon of ointment 1/2-inch long into the lower eyelid pocket without touching the tip of the tube to your eye. Look down and close your eyes for a few minutes. Rolling your eyes around gently will help spread the ointment evenly.
• After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.

Do not allow the tip of the tube or dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Store this medicine at room temperature away from moisture and heat. Keep the bottle or tube tightly closed when not in use.

You may rinse the eyes with warm water if you think you have used too much of this medicine. An overdose of CILOXAN ophthalmic is not likely to cause life-threatening symptoms.

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; slow heart rate, weak pulse, fainting; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

•severe swelling, itching, burning, redness, or discomfort in or around your eye;

•eye pain, vision changes, increased sensitivity of your eyes to light;

•signs of new infection, such as drainage, crusting, or oozing of your eyes or eyelids;

•the first sign of any skin rash, no matter how mild.

Less serious side effects may include:

•mild itching, burning, redness, or irritation;

•blurred vision, dry or watery eyes;

•puffy eyelids;

•feeling like something is in your eye;

•a white-colored buildup in your eye (if you are being treated for corneal ulcer); or

•nausea, unpleasant taste in your mouth after using the drops.

You should not use this medication if you allergic to CILOXAN (Cipro) or similar medications such as levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

Avoid wearing contact lenses while you still have active symptoms of the eye infection you are treating. Do not use other eye drops or medications during treatment unless otherwise directed by your doctor.

Do not allow the tip of the tube or dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

While treating a corneal ulcer, you may notice a whitish buildup in your eye. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

CILOXAN ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Call your doctor at once if you have a serious side effect such as severe swelling, itching, burning, redness, or discomfort, eye pain or vision changes, signs of new eye infection (drainage, crusting, or oozing), or the first sign of any skin rash, no matter how mild.

You should not use this medication if you allergic to CILOXAN (Cipro) or similar medications such as levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

FDA pregnancy category C. It is not known whether CILOXAN ophthalmic is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether CILOXAN ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use CILOXAN eye drops in a child younger than 1 year old. Do not use CILOXAN eye ointment in a child younger than 2 years old.

You should not wear contact lenses while you still have active symptoms of the eye infection you are treating.

Do not use other eye drops or medications during treatment unless otherwise directed by your doctor.

Avoid caffeine while you are using CILOXAN, because the medication can make the effects of caffeine stronger.

CILOXAN ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

It is not likely that other drugs you take orally or inject will have an effect on CILOXAN used in the eyes. But many drugs can interact with each other. Tell your doctor about all other medications you use, especially:

•theophylline (Elixophyllin, Theo-24, Uniphyl);

•a blood thinner such as warfarin (Coumadin); or

•cyclosporine used in the eyes (Restasis) or taken by mouth (Neoral, Sandimmune, Gengraf).

This list is not complete and there may be other drugs that can interact with CILOXAN ophthalmic. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

While treating a corneal ulcer, you may notice a whitish buildup in your eye. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
• Use only the number of drops your doctor has prescribed.
• Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

If you are using this medication to treat a corneal ulcer, you may need to use the eye drops every 15 to 30 minutes for the first day, and then every 1 to 4 hours for the rest of your treatment. Follow your doctor's instructions.

To apply the ointment:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.
• Squeeze out a ribbon of ointment 1/2-inch long into the lower eyelid pocket without touching the tip of the tube to your eye. Look down and close your eyes for a few minutes. Rolling your eyes around gently will help spread the ointment evenly.
• After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.

Do not allow the tip of the tube or dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Store this medicine at room temperature away from moisture and heat. Keep the bottle or tube tightly closed when not in use.

You may rinse the eyes with warm water if you think you have used too much of this medicine. An overdose of CILOXAN ophthalmic is not likely to cause life-threatening symptoms.

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; slow heart rate, weak pulse, fainting; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

•severe swelling, itching, burning, redness, or discomfort in or around your eye;

•eye pain, vision changes, increased sensitivity of your eyes to light;

•signs of new infection, such as drainage, crusting, or oozing of your eyes or eyelids;

•the first sign of any skin rash, no matter how mild.

Less serious side effects may include:

•mild itching, burning, redness, or irritation;

•blurred vision, dry or watery eyes;

•puffy eyelids;

•feeling like something is in your eye;

•a white-colored buildup in your eye (if you are being treated for corneal ulcer); or

•nausea, unpleasant taste in your mouth after using the drops.

You should not use this medication if you allergic to CILOXAN (Cipro) or similar medications such as levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

Avoid wearing contact lenses while you still have active symptoms of the eye infection you are treating. Do not use other eye drops or medications during treatment unless otherwise directed by your doctor.

Do not allow the tip of the tube or dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

While treating a corneal ulcer, you may notice a whitish buildup in your eye. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

CILOXAN ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Call your doctor at once if you have a serious side effect such as severe swelling, itching, burning, redness, or discomfort, eye pain or vision changes, signs of new eye infection (drainage, crusting, or oozing), or the first sign of any skin rash, no matter how mild.

You should not use this medication if you allergic to CILOXAN (Cipro) or similar medications such as levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

FDA pregnancy category C. It is not known whether CILOXAN ophthalmic is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether CILOXAN ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use CILOXAN eye drops in a child younger than 1 year old. Do not use CILOXAN eye ointment in a child younger than 2 years old.

You should not wear contact lenses while you still have active symptoms of the eye infection you are treating.

Do not use other eye drops or medications during treatment unless otherwise directed by your doctor.

Avoid caffeine while you are using CILOXAN, because the medication can make the effects of caffeine stronger.

CILOXAN ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

It is not likely that other drugs you take orally or inject will have an effect on CILOXAN used in the eyes. But many drugs can interact with each other. Tell your doctor about all other medications you use, especially:

•theophylline (Elixophyllin, Theo-24, Uniphyl);

•a blood thinner such as warfarin (Coumadin); or

•cyclosporine used in the eyes (Restasis) or taken by mouth (Neoral, Sandimmune, Gengraf).

This list is not complete and there may be other drugs that can interact with CILOXAN ophthalmic. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.