Clinoril (Sulindac)

(℞) Prescription Required

    Clinoril (Sulindac) Dosage and Side Effects

    CLINORIL is used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout.

    Proper Use of this medication

    Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

    Take sulindac with food.

    If you use this medicine long-term, you may need frequent medical tests.

    Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

    Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

    Seek emergency medical attention or call the Poison Help line.

    Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

    Side Effects

    Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

    Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

    Stop using CLINORIL and call your doctor at once if you have:

    • changes in your vision;
    • shortness of breath (even with mild exertion), swelling, rapid weight gain;
    • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
    • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
    • pancreas problems--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
    • kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
    • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
    • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

    Common side effects may include:

    • nausea, vomiting, stomach pain, indigestion, loss of appetite;
    • diarrhea, constipation, gas;
    • headache, dizziness, nervousness;
    • itching, rash; or
    • ringing in your ears.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

    Warnings and Precautions

    CLINORIL can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

    CLINORIL may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using CLINORIL, especially in older adults.

    CLINORIL can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

    Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

    CLINORIL may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using CLINORIL, especially in older adults.

    You should not use CLINORIL if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

    To make sure CLINORIL is safe for you, tell your doctor if you have:

    • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
    • a history of heart attack, stroke, or blood clot;
    • a history of stomach ulcers or bleeding;
    • kidney disease or a history of kidney stones;
    • liver disease;
    • a pancreas disorder;
    • asthma;
    • fluid retention; or
    • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, or lupus.

    Taking CLINORIL during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using CLINORIL.

    It is not known whether CLINORIL passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

    CLINORIL is not approved for use by anyone younger than 18 years old.

    Interactions with this medication

    Avoid drinking alcohol. It may increase your risk of stomach bleeding.

    Avoid taking aspirin or other NSAIDs while you are taking CLINORIL.

    Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to CLINORIL. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

    Ask your doctor before using CLINORIL if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

    Tell your doctor about all your current medicines and any you start or stop using, especially:

    • cyclosporine;
    • lithium;
    • methotrexate;
    • a blood thinner (warfarin, Coumadin, Jantoven);
    • heart or blood pressure medication, including a diuretic or "water pill";
    • oral diabetes medication; or
    • steroid medicine (such as prednisone).

    This list is not complete. Other drugs may interact with CLINORIL, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

    Other related products

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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