Use MACRODANTIN as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take MACRODANTIN by mouth with food.
• Do not take an antacid that has magnesium trisilicate in it while you are taking MACRODANTIN. Check with your pharmacist if you are unsure which antacids have magnesium trisilicate in them.
• Drinking extra fluids while you are taking MACRODANTIN is recommended. Check with your doctor for instructions.
• To clear up your infection completely, take MACRODANTIN for the full course of treatment. Keep taking it even if you feel better in a few days.
• If you miss a dose of MACRODANTIN, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use MACRODANTIN.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

• Gas; headache; loss of appetite; mild diarrhea; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

• Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bluish skin or nails; blurred vision or other vision changes (eg, vision loss); butterfly-shaped rash on the nose and cheeks; confusion; eye pain; joint or muscle pain; mood or mental changes (eg, depression); persistent feeling of being unwell; red, swollen, blistered, or peeling skin; severe or persistent diarrhea; severe or persistent headache; severe stomach pain or cramps; symptoms of liver problems (eg, yellowing of the eyes or skin, dark urine, pale stools, severe or persistent nausea or loss of appetite, stomach pain); symptoms of lung problems (eg, fever, chills, chest pain, shortness of breath, unusual or persistent cough); tingling, numbness, or burning of the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Do NOT use MACRODANTIN if:

• you are allergic to any ingredient in MACRODANTIN
• you are pregnant and at term (38 to 42 weeks pregnant), you are about to go into labor, or you are in labor
• you have decreased kidney function or decreased urination, or if you are unable to urinate
• you have a history of liver problems or yellowing of the skin or eyes after taking any form of MACRODANTIN
• the patient is younger than 1 month old

Contact your doctor or health care provider right away if any of these apply to you.

Before using MACRODANTIN:

Some medical conditions may interact with MACRODANTIN. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have anemia, diabetes, blood electrolyte problems, glucose-6-phosphate dehydrogenase (G6PD) deficiency, kidney problems, liver problems, nerve problems (eg, peripheral neuropathy), porphyria (a certain blood problem), or low levels of vitamin B in your blood
• if you have a history of lung problems (eg, diffuse interstitial pneumonitis, pulmonary fibrosis)
• if you have very poor health

Important safety information:

• MACRODANTIN may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use MACRODANTIN with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• MACRODANTIN may rarely cause severe and sometimes fatal lung problems. If this occurs, it is usually in patients who take MACRODANTIN for 6 months or longer. These problems may occur without warning signs. If you will be using MACRODANTIN for a long period of time, your doctor may perform lung function tests to check for side effects. Tell your doctor right away if you develop fever, chills, chest pain, unusual cough, trouble breathing (especially while you are being active), other breathing problems, or persistent feeling of being unwell.
• MACRODANTIN may rarely cause severe and sometimes fatal liver problems. Tell your doctor right away if you develop yellowing of the skin or eyes; pale stools; or severe or persistent nausea, loss of appetite, or stomach pain.
• MACRODANTIN may rarely cause severe and sometimes fatal nerve problems. The risk may be greater in patients who have decreased kidney function, anemia, diabetes, electrolyte problems, or low blood vitamin B levels. Tell your doctor right away if you develop numbness, burning, or tingling in the hands or feet.
• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
• Long-term or repeated use of MACRODANTIN may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• MACRODANTIN only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use MACRODANTIN for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• MACRODANTIN may discolor the urine. This is normal and not a cause for concern.
• Diabetes patients - MACRODANTIN may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
• Lab tests, including liver function, kidney function, and lung function, may be performed while you use MACRODANTIN. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use MACRODANTIN with caution in the ELDERLY; they may be more sensitive to its effects, especially lung or liver problems.
• MACRODANTIN should not be used in CHILDREN younger than 1 month old; the risk of anemia may be greater in these children.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using MACRODANTIN while you are pregnant. Do NOT take MACRODANTIN if you are at term (38 to 42 weeks pregnant), if you are about to go into labor, or if you are in labor. MACRODANTIN is found in breast milk. Do not breast-feed infants younger than 1 month old while you are taking MACRODANTIN. If your child is older than 1 month, check with your doctor. Discuss any possible risks to your baby.

Some MEDICINES MAY INTERACT with MACRODANTIN. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Probenecid or sulfinpyrazone because they may increase the risk of MACRODANTIN's side effects or decrease MACRODANTIN's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if MACRODANTIN may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

In 2009, the FDA approved a label change for MACROBID, adding a warning that the drug should not be taken by those who had jaundice (a yellowing of the skin) or liver problems.

You shouldn’t take MACROBID if you have severe kidney problems or have trouble passing urine.

If you take MACROBID for six months or longer, your doctor should monitor you closely for any potential lung problems, because the drug has been linked to pulmonary fibrosis, a scarring disease of the lungs

Pregnancy and MACROBID

The FDA classifies MACROBID as a Pregnancy Category B drug. That means that animal studies have not found evidence of harm to the developing fetus, though no adequate studies have been done in pregnant women.

For that reason, the drug should be used during pregnancy only if the benefits outweigh the potential risks.

If you are breastfeeding, research suggests that MACROBID poses minimal risk to the infant. Talk to your doctor about breastfeeding while on MACROBID.

Infants under one month of age should not be given MACROBID.

Common Side Effects of MACROBID

Diarrhea, gas, nausea, and headache are common side effects. These usually do not need medical attention. However, if they are severe, check in with your doctor.

Severe Side Effects of MACROBID

If you have any of these symptoms while taking MACROBID, check with your doctor right away. Some of them could indicate liver problems.

• Stomach pain, tenderness
• Stools the color of clay or urine that is dark
• No appetite or lower appetite
• Nausea, vomiting
• Yellowing of skin, eyes
• Weakness, fatigue
• Feet or leg swelling

Other side effects that warrant an immediate call to the doctor include:

• Chills, cough, fever
• Hives, itching, shortness of breath, skin rash
• Pain in joints or muscles

Rare Side Effects of MACROBID

Some of the rare side effects of MACROBID are:

• Confusion
• Light-colored stools
• Color blindness
• Vomiting blood
• Scaly skin

The recommended dose of MACROBID is different depending on whether it is being used to treat a urinary tract infection or prevent one.

In general, here are the ranges of oral doses given:

• 50 to 100 milligrams (mg) at bedtime for adults and teens to prevent infections.
• 50 to 100 mg every six hours for adults and teens to treat infections.
• Doses are based on body weight for children and infants one month and older.
• For the extended-release capsules, 100 mg every 12 hours for 7 days for adults, teens and children ages 12 and older. The dose is individualized for children under age 12.

MACROBID Overdose

Overdosing on MACROBID can cause vomiting. Call your doctor if you think you have taken too much MACROBID.

Missed Dose of MACROBID

Take a missed dose of MACROBID as soon as possible when you remember. However, if it is nearly time for your next dose, resume your regular schedule. Don't double up on doses.

If you are taking MACROBID, avoid antacids that contain magnesium trisilicate. Taking both together will reduce how well and how quickly the antibiotic is absorbed.

Taking MACROBID while you are on the antifungal drug Diflucan (fluconazole) is not recommended. If it is necessary, your doctor may change the dose of each medicine or how often you take them.

Tell your doctor if you are on Probalan (probenecid) or Anturane (sulfinpyrazone), used to treat gout. They can affect the way the MACROBID works.

If you have diabetes while taking MACROBID, you may have a false-positive result on urine tests.

You should always tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs, herbal remedies, nutritional and dietary supplements, and all other drugs and treatments you’re taking.

MACROBID and Alcohol

Your doctor may tell you to avoid alcohol while on MACROBID. Combining alcohol and MACROBID can intensify any side effects

You may receive your first few doses of LYSODREN in a hospital setting where you can be monitored in case the medication causes serious side effects.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Always wear rubber gloves when handling LYSODREN tablets. Do not crush or break a tablet and do not use a broken pill. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.

You may need to take steroid medication along with LYSODREN, especially if you have a serious injury or medical emergency. Do not change your doses or medication schedule without advice from your doctor.

You may need to stop taking LYSODREN for a short time if you have a serious injury or medical emergency. Your doctor will determine when you can start taking this medicine again.

While using LYSODREN, you may need frequent medical tests. Your nerve and muscle function may also need to be checked. You may not notice any change in your symptoms, but your blood work will help your doctor determine how long to treat you with LYSODREN.

You must remain under the care of a doctor while taking LYSODREN.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• blurred or double vision;
• confusion, problems with speech, balance, or walking;
• a light-headed feeling, like you might pass out;
• easy bruising or bleeding (nosebleeds, bleeding gums); or
• any bleeding that will not stop.

Common side effects may include:

• nausea, vomiting, loss of appetite;
• diarrhea;
• drowsiness;
• depressed mood, weakness, lack of energy;
• dizziness, spinning sensation; or
• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You may need to stop taking LYSODREN for a short time if you have a serious injury or medical emergency. Your doctor will determine when you can start taking this medicine again. You may need to take steroid medication along with LYSODREN, especially if you have a serious injury or medical emergency. Do not change your doses or medication schedule without advice from your doctor.

You must remain under the care of a doctor while taking LYSODREN.

You should not use this medicine if you are allergic to LYSODREN.

To make sure LYSODREN is safe for you, tell your doctor if you have:

• recent infection, surgery, or trauma;
• liver disease; or
• if you take a blood thinner (warfarin, Coumadin, Jantoven).

Do not use LYSODREN if you are pregnant. This medicine could harm the unborn baby or cause miscarriage or premature birth. Use effective birth control to avoid pregnancy during your treatment with LYSODREN. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.

LYSODREN can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Other drugs may interact with LYSODREN, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Overdose:

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

The effects of an overdose of LUVERIS are unknown, nevertheless there is a possibility that ovarian hyperstimulation syndrome may occur. If you inject more medication at one time that you were prescribed, you should contact your doctor.

Missed dose:

If you forget to take LUVERIS, do not take a double dose. In the case of a forgotten dose, please contact your doctor.

As with any drug, you may experience side effects when taking LUVERIS. In clinical trials, the most common side effects (experienced by more than 2% of patients) were headache, pelvic and abdominal pain, nausea, OHSS, breast pain, ovarian cysts, flatulence, injection site reactions, general pain, constipation, fatigue, painful menstruation, ovarian disorder, diarrhea and upper respiratory tract infections.

When taking LUVERIS, there is a risk of developing ovarian hyperstimulation syndrome (OHSS). The early warning signs of development of OHSS are severe abdominal pain, nausea, vomiting and weight gain. Since OHSS develops rapidly, if you experience any of these symptoms, contact your doctor immediately.

It is important to regularly tell your health care professional how you are feeling and if you have developed any new symptoms while taking LUVERIS.

Serious Side Effects, How Often They Happen and What to Do About Them:

The most serious side effect associated with LUVERIS is ovarian hyperstimulation syndrome (OHSS). If you experience the early warning signs of OHSS, including severe abdominal pain, nausea, vomiting and weight gain, contact your doctor as soon as possible.

This is not a complete list of side effects. For any unexpected effects while taking LUVERIS, contact your doctor or pharmacist.

BEFORE you use LUVERIS talk to your doctor or pharmacist if:

• You have sex hormone-dependent tumours of the reproductive tract and accessory organs
• You have active, untreated tumours of the hypothalamus or pituitary gland
• You are pregnant or are breast-feeding your baby
• You have ovarian failure
• You have abnormal uterine bleeding of unknown origin
• You have hypersensitivity to gonadotropins or to any of the nonmedicinal ingredients

Compared with natural conception, the incidence of multiple pregnancies (mainly twins) and births is increased in patients undergoing this type of treatment. However, this can be minimized by using the recommended dose and schedule of administration.

Miscarriages are higher than in the normal population, but comparable with the rates found in women with fertility problems.

Women with a history of tubal disease are at a risk of ectopic pregnancy (pregnancy where the embryo is implanted outside the womb), whether the pregnancy is obtained by spontaneous conception or with fertility treatments.

There have been reports of tumours of the ovary and other reproductive organs, both benign and malignant, in women who have undergone multiple drug regimens for infertility treatment.

If you are at risk of thromboembolic events (formation of a blood clot in vein or artery), because of your personal or family history, treatment with gonadotropins, like pregnancy itself, may further increase the risk. If you think you may have such a risk, please ask your doctor.

Birth defects after ART (Assisted Reproduction Techniques) may be slightly higher than after spontaneous conceptions, although this is not confirmed. This could be due to differences in parental factors like maternal age, genetics, as well as the ART procedures and multiple pregnancies.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

LUVERIS has not been shown to affect the activity of co-administered GONAL-F.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not use LUDIOMIL if you have a seizure disorder, or if you have used an MAO inhibitor within the past 14 days. Serious, life-threatening side effects can occur if you take LUDIOMIL before the MAO inhibitor has cleared from your body.

Before taking LUDIOMIL, tell your doctor if you have liver or kidney disease, seizures, heart disease, a thyroid disorder, if you receive electroshock therapy, or if you have a history of heart attack, stroke, drug abuse, or suicidal thoughts.

It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.

Avoid drinking alcohol. It can increase some of the side effects of LUDIOMIL.

LUDIOMIL can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

You should not take this medication if you are allergic to LUDIOMIL, or if you have a seizure disorder.

Do not use LUDIOMIL if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take LUDIOMIL before the MAO inhibitor has cleared from your body.

Before taking LUDIOMIL, tell your doctor if you are allergic to any drugs, or if you have:

• liver or kidney disease;
• if you are receiving electroshock therapy;
• seizures or epilepsy;
• a thyroid disorder;
• heart disease, heart rhythm disorder;
• a history of heart attack or stroke; or
• a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may not be able to use LUDIOMIL, or you may need a dosage adjustment or special tests during treatment.

This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

LUDIOMIL can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• seizure (convulsions);
• fast or pounding heart rate;
• confusion, hallucinations;
• unusual thoughts or behavior; or
• feeling like you might pass out.

Less serious side effects include:

• drowsiness, dizziness;
• loss of balance or coordination;
• numbness or tingling;
• blurred vision;
• ringing in your ears;
• nausea, stomach pain;
• constipation;
• dry mouth; or
• thirst.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by LUDIOMIL. Tell your doctor if you need to use any of these other medicines while you are taking LUDIOMIL.

Avoid drinking alcohol. It can increase some of the side effects of LUDIOMIL.

LUDIOMIL can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

The following drugs can interact with LUDIOMIL. Tell your doctor if you are using any of these:

• guanethidine (Ismelin);
• medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), mesoridazine (Serentil), or thioridazine (Mellaril);
• a sedative such as Valium;
• cimetidine (Tagamet); or
• phenytoin (Dilantin).

This list is not complete and there may be other drugs that can interact with LUDIOMIL. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Take the regular tablet form of LUDIOMIL with water.

LUDIOMIL is usually taken once a day at bedtime. Follow your doctor's instructions.

It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.

Store LUDIOMIL at room temperature, away from moisture and heat.

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include extreme drowsiness, fast heart rate, confusion, vomiting, blue lips or fingernails, and seizure (convulsions).

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

LOZOL comes as a tablet to take by mouth, typically once daily in the morning.

Your dose will depend on your medical condition and response to treatment.

You can take this medicine with or without food.

At first, LOZOL may make you urinate more often.

You may want to take your dose before 6 p.m. to avoid disturbing your sleep with the need to urinate.

Follow the instructions on your prescription label carefully. Don't take more or less LOZOL than is recommended.

Continue to take LOZOL even if you feel well. Don't stop your treatment without first talking to your doctor.

LOZOL Overdose

Symptoms of an LOZOL overdose may include:

• Vomiting
• Nausea
• Weakness

If you suspect an overdose, contact a poison control center or emergency room immediately.

Missed Dose of LOZOL

If you miss a dose of LOZOL, take it as soon as you remember.

But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.

Don't take extra medicine to make up for a missed dose.

Before taking LOZOL, tell your doctor if you have, or have ever had, any of the following:

• Diabetes
• Gout (a type of arthritis caused by a buildup of uric acid crystals in the joints)
• Any type of heart problem
• Kidney disease
• Liver disease
• Problems urinating
• Lupus (a chronic inflammatory condition)
• Thyroid or parathyroid disease
• Low levels of sodium or potassium in the blood
• Persistent vomiting
• A neurosurgical procedure known as a sympathectomy
• Allergies to any medication

LOZOL may affect your blood sugar levels. If you have diabetes, monitor your condition carefully while using this medicine.

Let your doctor know you're taking LOZOL before having any type of medical or dental procedure.

Also, tell your doctor if you're currently on a low-salt diet.

Your doctor may recommend that you adopt a specific diet and exercise plan while taking LOZOL. Follow these instructions carefully.

Try to avoid becoming dehydrated while using LOZOL. Ask your doctor how much fluid you should consume throughout the day.

This medicine may make your skin more sensitive to sunlight. Avoid unnecessary exposure to the sun and tanning booths, and wear sunscreen and protective clothing while outdoors.

Your doctor will want to perform frequent tests to check your body's response to LOZOL.

Keep all appointments with your doctor and laboratory.

Pregnancy and LOZOL

LOZOL should only be taken during pregnancy when it's clearly needed.

Tell your doctor if you become pregnant while using this medicine. You'll need to discuss the benefits and risks of taking LOZOL during pregnancy.

It's not known whether this drug passes into breast milk. Don't breastfeed a baby while using LOZOL.

Common Side Effects of LOZOL

Tell your doctor if any of the following side effects become severe or don't go away:

• Frequent urination (this symptom should decrease after a few weeks of treatment)
• Mild dizziness or lightheadedness (especially when standing or sitting up)
• Back pain
• Constipation
• Mild diarrhea
• Drowsiness
• Headache
• Nausea
• Runny nose
• Nervousness
• Trouble sleeping
• Upset stomach
• Weakness
• Vomiting
• Decreased sexual ability

Serious Side Effects of LOZOL

Tell your doctor right away if you experience any of the following serious side effects:

• Chest pain
• Blurred vision
• Jaundice
• Dark-colored urine
• Decreased urination or problems with urination
• Pale-colored stools
• Dry mouth
• Fainting
• Fast or irregular heartbeat
• Fatigue
• Fever, chills, cough, or sore throat
• Increased thirst
• Loss of appetite
• Numbness of the hands or feet
• Severe dizziness, drowsiness, or lightheadedness
• Severe stomach pain
• Red, swollen, peeling, or blistered skin
• Swelling of the hands, ankles, or feet
• Muscle pain, weakness, or cramping
• Confusion
• Mental or mood changes
• Seizures
• Unusual sluggishness, tiredness, or weakness
• Unusual bruising or bleeding
• Signs of anaphylaxis, which may include rash, hives, itching, difficulty breathing, chest tightness, or swelling of the face, mouth, lips, or tongue

Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

• Other medication for high blood pressure
• Corticosteroids, such as prednisone
• Lanoxin (digoxin)
• Indocin (indomethacin)
• Lithobid (lithium)
• Benemid (probenecid)
• Vitamins

LOZOL and Other Interactions

LOZOL may make you drowsy.

Don't drive or perform activities that require alertness until you know how this medicine affects you.

LOZOL and Alcohol

Alcohol may worsen certain side effects of LOZOL.

Avoid drinking alcoholic beverages while using this medicine.

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If you take this drug too close to bedtime, you may need to wake up to urinate. It is best to take this medication at least 4 hours before your bedtime.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick. It may take up to several weeks before you get the full benefit of this drug.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take indapamide at least 4 hours before or at least 4 hours after these medications.

Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase).

Dizziness or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Indapamide may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps/weakness, fast/irregular heartbeat, confusion, decreased urination.

Tell your doctor right away if you have any serious side effects, including: decrease in vision, eye pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Before taking indapamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, kidney problems, liver disease, lupus.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Severe sweating, diarrhea, or vomiting can increase the risk for a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.

If you have diabetes, this product may increase your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may decrease your level of potassium in the blood. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skinblisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: dofetilide, lithium.

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

This medication may interfere with certain lab tests (including parathyroid function), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take LOXITANE with a full glass of water.

You may not start feeling better right away when you start taking LOXITANE . Call your doctor if your symptoms do not improve, or if they get worse while using LOXITANE.

Store at room temperature away from moisture, heat, and light.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using LOXITANE and call your doctor at once if you have:

• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• confusion, slurred speech;
• seizure (convulsions);
• sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough;
• little or no urinating;
• severe constipation; or
• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

• dizziness or drowsiness;
• problems with balance or walking;
• blurred vision;
• feeling restless or agitated;
• constipation;
• dry mouth, stuffy nose; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

LOXITANE is not approved for use in psychotic conditions related to dementia. LOXITANE may increase the risk of death in older adults with dementia-related conditions.

You should not use LOXITANE if you have decreased alertness caused by taking certain medications or drinking alcohol.

You should not use this medicine if you are allergic to LOXITANE , or if you have decreased alertness caused by taking certain medications or drinking alcohol.

LOXITANE is not approved for use in psychotic conditions related to dementia. LOXITANE may increase the risk of death in older adults with dementia-related conditions.

Long-term use of LOXITANE can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take LOXITANE , the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults.

To make sure LOXITANE is safe for you, tell your doctor if you have:

• epilepsy or other seizure disorder;
• a history of low white blood cell (WBC) counts;
• glaucoma;
• urination problems;
• Parkinson's disease;
• heart disease; or
• a history of breast cancer.

Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking LOXITANE, do not stop taking it without your doctor's advice.

It is not known whether LOXITANE passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

LOXITANE may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. You should not take LOXITANE if you are under the effects of alcohol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. LOXITANE can decrease perspiration and you may be more prone to heat stroke.

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking LOXITANE with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with LOXITANE, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.