Latuda (Lurasidone)

(℞) Prescription Required

    Latuda (Lurasidone) Dosage and Side Effects

    LATUDA is used to treat the symptoms of schizophrenia.

    Warnings and Precautions

    Serious Warnings and Precautions

    Various medicines of the group to which LATUDA belongs have been associated with an increased rate of death when used in elderly patients with dementia. LATUDA is not indicated in elderly patients with dementia.

    BEFORE you use LATUDA, talk to your doctor or pharmacist if you:

    • are taking any other medicines (prescriptions or over the counter medicines)
    • are pregnant, think you are pregnant, or plan to become pregnant
    • are breastfeeding or plan to breastfeed
    • are an elderly patient suffering from dementia (loss of memory and other mental abilities)
    • exercise vigorously or work in hot or sunny places
    • have high blood sugar or a history of diabetes
    • have a history of kidney or liver problems
    • have involuntary, irregular muscle movements, especially in the face or tongue
    • suffer from abnormal (high) blood pressure or have rapid heartbeat and a drop in pressure when getting up
    • suffer from heart disease or have a family history of heart disease, stroke, or "mini" stroke
    • have a history of any problems with the way your heart beats (arrhythmias) or if you are taking any medicines that may have an impact on the way your heart beats; or have a condition known as QT prolongation
    • have risk factors for developing blood clots such as: a family history of blood clots, age over 65, smoking, obesity, recent major surgery (such as hip or knee replacement), immobility due to air travel or other reason, take oral contraceptives ("The Pill")
    • have or have had breast cancer
    • have pituitary tumours
    • drink alcohol or use street drugs
    • have ever had fainting, blackouts, or seizures
    • work with hazardous machinery or drive a motorized vehicle
    • have a history of low blood cell counts

    Effects on Newborns:

    In some cases, babies born to a mother taking LATUDA during pregnancy have experienced symptoms that are severe and require the newborn to be hospitalized. Sometimes, the symptoms may resolve on their own. Be prepared to seek immediate emergency medical attention for your newborn if they have difficulty breathing, are overly sleepy, have muscle stiffness, or floppy muscles (like a rag doll), are shaking, or are having difficulty feeding.

    Other cautions:

    Because some people experience drowsiness, you should not drive or operate machinery until you are reasonably certain that LATUDA does not affect your ability to carry out these activities.

    Some people may faint, or experience symptoms such as lightheadedness and dizziness, especially when getting up from a lying or sitting position. This is more likely to happen if you are elderly and also in the early stages of treatment or following dose increases. This will usually pass on its own but if it does not, tell your doctor.

    Since medications of this type may interfere with the ability of the body to adjust to heat, it is best to avoid becoming overheated or dehydrated (for example, with vigorous exercise or exposure to extreme heat) while taking LATUDA.

    Side Effects

    The most common side effects of LATUDA in patients with schizophrenia are:

    • drowsiness/sleepiness
    • feeling of restlessness (akathisia)
    • abnormal movements, tremor, muscle stiffness, slowing of movement
    • nausea

    The most common side effects of LATUDA in patients with depression associated with bipolar disorder are:

    • feeling of restlessness (akathisia)
    • abnormal movements, tremor, muscle stiffness, slowing of movement.

    The following other side effects may also happen in some people who take LATUDA:

    • Symptoms of an allergic reaction including rash, itching, flushing, and/or inflammation of the mouth and/or skin (see also Serious Side Effects, How Often They Happen and What to Do About Them).
    • Increase in the amount of sugar (glucose) in the blood (hyperglycemia). Symptoms of high blood sugar can include feeling very thirsty and/or hungry, needing to urinate more than usual, feeling weak or tired, feeling sick to your stomach, feeling confused, fruity smelling breath.
    • Decreased blood pressure. Symptoms of decreased blood pressure can include lightheadedness or fainting when rising too quickly from a sitting or lying position.

    The following may also occur with LATUDA, and may be seen in routine blood testing:

    • decrease in the amount of white blood cells
    • increase in the amount of hormone prolactin in the blood which:
      • in women, may lead to swelling of breasts and unexpected production of breast milk and changes in the regularity of monthly periods; and
      • in men, may lead to diminished sexual function and breast enlargement

    If you have high levels of prolactin (measured with a blood test) and a condition called hypogonadism you may be at an increased risk of breaking a bone due to osteoporosis. This occurs in both men and women.

    Your doctor should check your body weight before starting LATUDA and continue to monitor it for as long as you are being treated.

    Your doctor should take blood tests before starting LATUDA. They will monitor blood sugar and the number of infection fighting white blood cells. Your doctor should continue to monitor your blood for as long as you are being treated.

    Interactions with this medication

    Tell all doctors, dentists, and pharmacists who are treating you that you are taking LATUDA.

    As well, be sure to tell them about any other medications—prescription, non-prescription, or alternative—that you are taking or plan to take.

    Inform your doctor if you start or stop taking any of the following medications:

    • ketoconazole, itraconazole, ritonavir, and other medicines that may increase the level of LATUDA in your blood and should not be taken while you are receiving LATUDA
    • rifampin, phenobarbital, phenytoin, and other medicines that may decrease the effect of LATUDA and should not be used while you are receiving LATUDA
    • diltiazem, erythromycin, fluconazole, verapamil, and other medicines that may increase the level of LATUDA in your blood as your doctor may have to change your dose of LATUDA
    • medicines used to treat problems with your heart beat (antiarrhythmics) or medicines that can cause an imbalance in electrolytes (low levels of potassium or magnesium) such as diuretics (water pills) or certain antibiotics (drugs to treat infections)

    The effects of alcohol could be made worse while taking LATUDA. It is recommended that you do not drink alcohol while taking LATUDA.

    You should avoid consuming grapefruit, grapefruit juice, or products containing grapefruit extract while receiving LATUDA.

    Proper Use of this medication

    Usual dose:

    Schizophrenia:

    The usual starting dose is 40 mg once a day.

    Depression Associated with Bipolar Disorder:

    The usual starting dose is 20 mg once a day alone or in combination with lithium or valproate.

    The most important thing about taking LATUDA is to take it exactly the way your doctor has prescribed it, every day. You should check with your doctor or pharmacist if you are not sure. Your doctor has decided on the best dosage for you based on your individual situation. Your doctor may increase or decrease your dose depending on your response.

    LATUDA should be taken with food (at least 350 calories independent of fat content) and swallowed whole with water. It is best to take LATUDA at the same time each day.

    If you have moderate liver problems, your daily dose of LATUDA should not be more than 80 mg. If you have severe liver problems, your daily dose of LATUDA should not be more than 40 mg.

    If you have moderate or severe kidney problems, your daily dose of LATUDA should not be more than 80 mg.

    Do not give LATUDA to anyone else. Your doctor has prescribed it for you and your condition. LATUDA is not for use in children under 18 years of age.

    Overdose:

    If you have taken more LATUDA tablets than your doctor has recommended (or if someone else has taken some of your LATUDA tablets), contact your regional Poison Control Centre and talk to your doctor right away or go to your nearest hospital emergency department. Take the medication package with you.

    Missed dose:

    If you miss a dose by a few hours, take it as soon as possible. If most of the day has passed, skip that dose and wait to take your next scheduled dose at the regular time. DO NOT DOUBLE THE DOSE PRESCRIBED TO YOU TO MAKE UP FOR A MISSED DOSE.

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    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.