Cymbalta (Duloxetine)

(℞) Prescription Required - Cymbalta is also marketed as Yentreve

    Cymbalta (Duloxetine) Dosage and Side Effects

    CYMBALTA helps to relieve the emotional and physical symptoms of depression and anxiety.

    Proper Use of this medication

    Once each day, at about the same time every day

    • Swallow capsules whole with a drink of water.

    • Take with or without food. Taking it with food can reduce nausea at the start of treatment.

    • Take exactly as prescribed. Do NOT give it to anybody else. They may have unwanted side effects that may be serious.

    • Do NOT chew, crush or open the capsule. Do NOT mix with liquids or sprinkle on food or drink.

    • If you accidentally break or open the capsules, do NOT touch the powder. Wash away any loose powder right away with water. If you get powder in your eyes, rinse them with water right away and contact your healthcare professional.

    Usual dose:

    The usual adult dose is 60 mg once daily.

    Elderly patients with generalized anxiety:

    The starting dose is 30 mg once daily. After 2 weeks, your healthcare professional may increase the dose to 60 mg once daily.

    Your healthcare professional may adjust the dose during the course of your treatment. Only increase the amount of CYMBALTA you are taking if your healthcare professional tells you to.

    You should continue to take CYMBALTA for several months or longer, as directed by your healthcare professional.

    Stopping CYMBALTA:

    Do NOT stop taking CYMBALTA without discussing it with your healthcare professional. This may help you avoid discontinuation symptoms. Follow your healthcare professional’s instructions. They may gradually reduce the dose you are taking.

    Patients being treated for nerve pain caused by diabetes:

    Continue to see your healthcare professional regularly for the proper management of your diabetes. This will help to control your blood sugar levels and prevent further nerve damage. It is important that you continue to do daily foot examinations.

    Missed Dose:

    If you miss a dose of CYMBALTA by a few hours, take the dose when you remember. If most of the day has passed, wait until your next scheduled dose. Try not to miss any more. Do NOT take a double dose to make up for a missed dose.

    Side Effects

    These are not all the possible side effects you may feel when taking CYMBALTA. If you experience any side effects not listed here, contact your healthcare professional.

    Most side effects are minor and temporary. However, some may be serious.

    The most common side effects with CYMBALTA are:

    • Constipation

    • Diarrhea

    • Dizziness

    • Dry mouth

    • Erectile dysfunction (trouble getting or keeping an erection)

    • Feeling tired

    • Headache

    • Insomnia (trouble falling asleep and/or staying asleep)

    • Less appetite

    • More sweating

    • Nausea

    • Pain in the belly

    • Sleepiness

    • Vomiting (throwing up)

    These side effects have been shown to decrease with continued treatment.

    Tell your healthcare professional if:

    • any of the side effects discussed above affect you severely;

    • you experience other side effects not listed here.

    Some of these side effects may be related to the dose you are taking. Your healthcare professional will decide if your dose needs to be changed.

    Depression and anxiety may decrease your sexual desire, performance and satisfaction. This medication may further decrease sexual enjoyment.

    You may also have symptoms after you stop taking CYMBALTA:

    • Anxiety

    • Diarrhea

    • Dizziness

    • Feeling tired

    • Headache

    • Insomnia

    • Irritability

    • Muscle pain

    • Nausea

    • Nerve sensations (numbing, tingling, burning or prickling)

    • Nightmares

    • Sleepiness

    • Severe sweating

    • Vertigo (feeling of spinning when not moving)

    • Vomiting

    These symptoms usually go away without treatment. Tell your healthcare professional right away if you have these or other symptoms.

    Warnings and Precautions

    Do not use Cymbalta if:

    You are younger than 18 years of age

    • You are allergic to any of the ingredients in CYMBALTA (please read “What are the ingredients in CYMBALTA?”, above)

    • You have a liver impairment or disorder. A liver disorder is when your liver can no longer carry out its normal function

    • You have severe kidney disease

    • You are taking or have just stopped taking any of these drugs in the last 14 days:

      • monoamine oxidase inhibitors (MAOI), such as phenelzine or moclobemide, to treat depression

      • linezolid to treat infection(s)

    • You have been given a dye called methylene blue during surgery in the last 14 days

    • You are on a drug or have been on a drug to manage psychosis (serious mental illness) called thioridazine

    • You are taking a medication to treat depression, like fluvoxamine, a potent CYP1A2 inhibitor

    • You are taking certain antibiotics, like ciprofloxacin or enoxacin

    Interactions with this medication

    The following may interact with Cymbalta:

    Medications for depression called monoamine oxidase inhibitors (MAOIs), like phenelzine and moclobemide

    • An antibiotic called linezolid

    • A dye called methylene blue used during surgery

    • A medication to manage psychosis (serious mental illness) called thioridazine

    • Some antibiotics, like ciprofloxacin or enoxacin

    • Other medications to treat depression such as:

      • selective serotonin reuptake inhibitors (SSRIs) or SNRIs like fluoxetine, venlafaxine and paroxetine,

      • tricyclics like amitriptyline and desipramine,

      • potent CYP1A2 inhibitors like fluvoxamine.

    • Medications used to treat schizophrenia like olanzapine and risperidone

    • Medications used to treat bipolar disorder like lithium

    • Medications that can affect blood clotting and increase bleeding such as:

      • oral anticoagulants like warfarin and dabigatran

      • acetylsalicylic acid or ASA

      • non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and fever like ibuprofen and naproxen

    • Some medications used to treat patients with irregular heartbeats like flecainide and encainide

    • Some medications that affect the chemical messenger serotonin, like

      • lithium

      • medications containing tryptophan, used to treat bipolar disorder

      • St. John’s Wort (also called Hypericum perforatum), an herbal product often used to treat depression

      • a group of medications called triptans used to treat migraines, like sumatriptan and rizatriptan

    • Some pain medications in a group of drugs called opioids, like fentanyl, tramadol, tapentadol, meperidine, methadone and pentazocine

    • Some medications used to treat cough, like dextromethorphan (a cough syrup)

    In general, drink only small amounts of alcohol while you are taking CYMBALTA.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.