Kombiglyze XR (Saxagliptin/Metformin)

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Kombiglyze XR 2.5mg/1000mg

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Manufactured by: AstraZeneca
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Kombiglyze XR 2.5mg/1000mg
Product of Australia
Manufactured by AstraZeneca
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Kombiglyze XR 5mg/1000mg

Product of Australia
Manufactured by: AstraZeneca
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Kombiglyze XR 5mg/1000mg
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Manufactured by AstraZeneca
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Kombiglyze XR 5mg/500mg

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Manufactured by: AstraZeneca
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Manufactured by AstraZeneca
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Kombiglyze XR 5mg/1000mg

Product of India
Manufactured by: Bristol-Myers Squibb
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Kombiglyze XR 5mg/1000mg
Product of India
Manufactured by Bristol-Myers Squibb
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Kombiglyze XR 5mg/500mg

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Manufactured by: AstraZeneca
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Buy Kombiglyze XR Online

Kombiglyze XR is the brand name of the drug that is a combination of two active medicinal ingredients named Saxagliptin and Metformin. Doctors normally recommend this tablet together with diet and exercise to control blood sugar in adults (at least 18 years old) who are facing problems with type-2 diabetes mellitus. 

If you have diabetes and your medical doctor recommends this tablet for you, and you are worried about the cost, you have come to the right place. PricePro Pharmacy is here to deliver you affordable prescription medication at discount prices.

PricePro Pharmacy is providing you the opportunity to order from the comforts of your home. You can visit our user-friendly website by typing www.pricepropharmacy.com on your browser address bar and it will direct you to a number of options we have by which you can place your order easily. You can contact us by phone call dialing toll-free number 1-855-776-0079 and request to talk to our customer service team, who will guide you through the steps by which you can successfully place your order. 

Please bear in mind that, Kombiglyze XR is available for sale by prescription only. If you want to place an order you will need to submit a valid prescription, which can be uploaded online to your account. You can email or fax your Rx, or connect us with your doctor to speed up your order process.

Available Products

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The following dosages are available to order:

  • Kombiglyze XR 2.5mg/10000 mg (2.5mg Saxagliptin and 1000mg Metformin)
  • Kombiglyze XR 5mg/1000mg (5mg Saxagliptin and 1000mg Metformin)
  • Kombiglyze XR 5mg/500mg (5mg Saxagliptin and 500mg Metformin)

The brand medication is produced by AstraZeneca. The pack sizes are varied from one dose to another. For 2.5mg/1000mg dose, the pack size comes of 56, 112 and 168 tablets; while for 5mg/1000mg and 5mg/500mg doses have the pack size made of 28, 56 and 84 tablets.

There is no generic Kombiglyze XR currently available on the market.

Kombiglyze XR Price Comparison

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The average retail price of Kombiglyze XR 2.5mg/1000mg in the United States is:

  • $508.00 for 60 tablets

At PricePro Pharmacy, the cost-savings are clear:

  • $145.00 for 56 tablets

Why pay more when you don't have to with our discount prices available. You can save up to 70% compared to your US pharmacy plus no need to worry about coupons or insurance coverage.

You can also maximize your savings when you order 3-month supply of medication.

Shipping Times

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The estimated delivery time for your order will vary depending on the option selected:

  • Product of Australia - 10 to 18 business days
  • Product of India and Turkey - 10 to 21 business days

The standard shipping cost is $9.95 for all orders. You will receive an email notification with tracking details when your order has been dispensed and shipped from the licensed pharmacy.

Prescription Refill Reminder

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PricePro Pharmacy has been working hard to earn your trust and be a leader amongst other online pharmacies. We believe we can ensure this reliability if we can provide user-friendly services to our customers. Our commitment to your care is that that you will be kindly reminded of the optimal time to place a refill order to ensure you won't go without your meds. We will have an email or phone update as for the best time to place your next order.

You can also sign into your online pharmacy account and view previous orders and place a re-order directly if you have an active prescription on file.

We make it simple to manage your medications.

Kombiglyze XR (Saxagliptin and Metformin Extended-Release) Medication Information


Kombiglyze XR is a prescription medication for type 2 diabetes that contains two medicines in one pill: saxagliptin (Onglyza) and metformin extended-release (Glucophage XR). 

It is prescribed to reduce blood sugar levels in adults with type 2 diabetes along with a healthy diet and exercise.

In type 2 diabetes, your blood sugar (glucose) becomes too high.  Insulin is a hormone made by the pancreas that typically helps sugar get into your cells. But, if your body doesn’t recognize insulin properly, too much sugar stays in your blood.  Over time, high blood sugar can lead to many health problems and increase your risk of having a heart attack or stroke. 

The good news is you can take control of your diabetes by eating healthy foods, exercising, and taking your medications as prescribed.


Kombiglyze XR (saxagliptin/metformin ER) oral tablets are available in three combination strengths: 5 mg/500 mg, 5 mg/1,000 mg, and 2.5 mg/1,000 mg.  

Your doctor may prescribe a low starting dose, then gradually increase it.  This gradual approach helps to prevent or reduce stomach side effects.  Stomach upset is a common (but usually temporary) side effect after starting or stepping up the metformin dose.

Kombiglyze XR is taken once daily with a meal.  Your doctor will decide the dosage that is best for you.


Kombiglyze XR may not be safe for people with the following medical history or conditions:

  • Kidney or liver problems
  • Heart disease
  • Pancreas problems
  • Drink alcohol often, or occasionally drink large amounts of alcohol (“binge drink”)
  • Age 80 years or older (due to reduced kidney function with older age)
  • Pregnant or plan to become pregnant
  • Breastfeeding
  • Type 1 diabetes
  • History of an allergic reaction to Kombiglyze XR, saxagliptin (Onglyza), or metformin

Side Effects

Like all medications, Kombiglyze XR may cause side effects.  The most common side effects of Kombiglyze XR are mild, but severe side effects are also possible.  The most common side effects are stomach-related and go away after one to two weeks for most people.  

Common side effects may include:

  • Diarrhea
  • Nausea and vomiting
  • Headache
  • Cold-like symptoms (runny nose, stuffy nose, or sore throat)
  • Upper respiratory tract infections
  • Urinary tract infections

Serious side effects can rarely occur with Kombiglyze XR.  These side effects require emergency medical care and may include:

  • Lactic acidosis (build-up of acid in the blood)
  • Pancreatitis (inflammation of the pancreas)
  • Heart failure (heart doesn’t pump blood well)
  • Kidney damage
  • Dehydration
  • Joint pain
  • Low blood levels of vitamin B12
  • Skin reaction involving skin blisters 
  • Allergic reaction

Your doctor will prescribe Kombiglyze XR if the benefits of treatment outweigh your risks for serious side effects.  For more information about the side effects, talk with your doctor or pharmacist.


Some potentially harmful drug interactions can happen with Kombiglyze XR. A few examples include:

  • Acetazolamide
  • Cimetidine
  • Clarithromycin
  • Digoxin
  • Diuretics (water pills)
  • Insulin or other medicines that lower blood sugar
  • Ketoconazole
  • Nefazodone
  • Ranolazine 
  • Ritonavir
  • Topiramate
  • Zonisamide

Talk with your doctor or pharmacist before taking any other medications or herbal supplements with Kombiglyze XR.


Store Kombiglyze XR at room temperature between 68°F and 77°F (20°C and 25°C).

Pharmacist Tips

  • Take each dose of Kombiglyze XR with a meal to reduce stomach upset.  
  • If you miss a dose, take it with food as soon as possible.  If it is almost time for your next dose, skip the missed dose.  Don’t take two doses at the same time.
  • Swallow Kombiglyze XR tablets whole; Don’t crush, chew, or cut in half.

Kombiglyze XR FAQs

Can I drink alcohol with Kombiglyze XR?

Drinking alcohol can increase the risk of dangerous side effects of Kombiglyze XR.  Talk with your doctor to decide if modest alcohol use is safe for you while taking Kombiglyze XR.   


I noticed Kombiglyze XR tablets in my stool.  Should I be concerned?

No.  The inactive (“filler”) ingredients of Kombiglyze XR tablets sometimes don’t completely dissolve.  If you notice the tablets intact in your stool, there is no need to worry.  Your body is still absorbing the active ingredients (saxagliptin and metformin ER).


What should I do if Kombiglyze XR upsets my stomach?

At first, Kombiglyze can cause diarrhea or nausea until your body gets used to it.   You can prevent or lessen stomach upset by always taking Kombiglyze with a meal, and don’t skip any doses.  If your symptoms become severe or don’t go away within two weeks, talk with your doctor.

Related Medication


  1. Kombiglyze XR Prescribing Information.  Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2019. https://www.azpicentral.com/kombiglyzexr/kombiglyzexr.pdf#page=1 Accessed November 20, 2020.
  2. Goyal R, Jialal I. Diabetes Mellitus Type 2. Treasure Island, FL: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK513253/ Accessed November 20, 2020.

PharmD Medical Writer

Author: Dr. Patricia Weiser, PharmD

Patricia Weiser, PharmD, is a licensed pharmacist and medical writer.  She has clinical experience in community and hospital pharmacy.  Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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