Synjardy (Empagliflozin/Metformin)

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    Synjardy (Empagliflozin/Metformin) Dosage and Side Effects

    SYNJARDY is used along with diet and exercise to improve control of blood sugar in adults with type 2 diabetes.

    Proper Use of this medication

    Your doctor will tell you how much to take. The amount  that you take depends on your condition and the doses you currently take of metformin and/or individual tablets of empagliflozin and metformin. Take only the dose that has been prescribed to you. If you are not sure what your dose is, ask your doctor.

    Diet and exercise can help your body use its blood sugar better. It is important to stay on the diet and exercise program recommended by your doctor.

    Taking your dose with meals may lower your chance of having an upset stomach.

    Do not stop taking without first consulting your doctor. Your blood sugar levels may increase when you stop taking SYNJARDY.

    Usual adult dose:

    One tablet two times a day with food. Swallow the tablet whole with water.


    If you think you have taken too much , contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

    Missed dose:

    • If you forget to take a dose , take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
    • Do not take a double dose to make up for a forgotten dose. Never take two doses  at the same time.

    Side Effects

    These are not all the possible side effects you may feel. If you experience any side effects not listed here, contact your healthcare professional.

    Side Effects may include:

    • constipation;
    • dry mouth;
    • joint pain;
    • muscle spasms.

    Your doctor will tell you how to treat low blood sugar levels and what to do if you get any of the signs described below. If you have symptoms of low blood sugar, eat glucose tablets, a high sugar snack or drink fruit juice. Measure your blood sugar, if possible and rest.

    An urge to pass urine or more frequent urination may be due to the way this medicine works, but can also be a sign of urinary tract infection. If you note an increase in such symptoms, you should contact your doctor.

    Rare cases, including fatal cases, of diabetic ketoacidosis (DKA), a serious life-threatening condition requiring urgent hospitalization, have been reported.

    It can cause abnormal test results. It will cause your urine to test positive for sugar (glucose). You should use a different way to monitor your diabetes.

    This drug may cause changes in the amount of cholesterol or fats in your blood.

    From time to time, your doctor may test your eyes, heart, blood, liver, and kidneys. Your doctor will decide when to perform tests and will interpret the results.

    Warnings and Precautions

    You have a higher chance of getting lactic acidosis if you:

    • have any of the first five conditions from the bulleted list just above;

    • have certain x-ray tests with iodinated dyes or contrast agents that are injected into your body;

    • have surgery;

    • have a heart attack, severe infection, or stroke;

    • are 80 years of age or older and have not been assessed for kidney function.

    This medication increases the chance of getting a yeast infection of the penis or vagina. This is more likely in people who have had yeast infections in the past.

    Driving and using machines:

    It may cause dizziness or lightheadedness. Do not drive or use machines until you know how the medicine affects you.

    Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

    Interactions with this medication

    The following may interact:

    • diuretics, known as water pills, such as furosemide. They are used to remove excess water from the body;
    • medicines used to lower blood sugar levels, such as glyburide, gliclazide or glimepiride (sulfonylureas) or insulin. Taking SYNJARDY with any of these medicines can increase the risk of having low blood sugar (hypoglycemia);
    • medicines used to lower high blood pressure; such as angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors may lower blood glucose;
    • antibiotics used to treat tuberculosis, such as rifampin or isoniazid;
    • blood thinners, known as anticoagulants;
    • cationic drugs. For example, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin;
    • drugs that can increase the blood sugar include:
      • corticosteroids, an anti-inflammatory medicine such as prednisone. They are used to treat inflammation in diseases like asthma or arthritis;
      • tranquilizing drugs, such as phenothiazines. They are known as antipsychotics;
      • thyroid products. They are used to treat problems with the thyroid gland;
      • birth control pills;
      • drugs used to control seizures, such as phenytoin;
      • niacin, also known as vitamin B3 or nicotinic acid;
      • drugs used to treat angina. They are known as calcium channel blockers. An example is nifedipine;
      • bronchodilators, such as beta-2-agonists. They are used to treat asthma.


    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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