Jentadueto (Linagliptin/Metformin) Dosage and Side Effects
JENTADUETO, is used along with diet and exercise to improve control of blood sugar in adults with type 2 diabetes.
Proper Use of this medication
Usual adult dose:
2.5/500 mg, or 2.5/850 mg, or 2.5/1000 mg twice daily taken with meals. Take JENTADUETO tablet with meals to lower the chance of having an upset stomach.
If you take more JENTADUETO tablets than you should or in case of drug overdose, contact your doctor or a poison control centre or go to the emergency room of the hospital near you.
- If you forget to take a dose of JENTADUETO, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
- Do not take a double dose to make up for a forgotten dose. Never take two doses of JENTADUETO at the same time.
The most common side effects of JENTADUETO include:
Stuffy nose or runny nose and sore throat (nasopharyngitis)
Diarrhea, nausea, and stomach upset, bloating, flatulence
Other side effects include:
Allergic (hypersensitivity) reactions: Allergic reactions such as rash, hives, and swelling of the face, lips, and throat, or coughing, wheezing, or shortness of breath may rarely occur. If you have these symptoms, stop taking JENTADUETO and call your doctor right away
Lactic Acidosis, a build-up of lactic acid in the blood that can cause death. You should stop taking JENTADUETO and call your doctor right away if you have any signs of lactic acidosis (see above Lactic Acidosis:). Lactic acidosis is a medical emergency and must be treated in the hospital.
Low blood sugar (hypoglycemia): If you take JENTADUETO with another medication that can cause low blood sugar, such as sulfonylureas, you have a higher risk of having low blood sugar. If you have symptoms of low blood sugar, you should check your blood sugar and treat it, then call your doctor. Symptoms of low blood sugar include: shaking, sweating, rapid heartbeat, change in vision, hunger, headache, and change in mood.
Warnings and Precautions
Serious Warnings and Precautions
JENTADUETO contains metformin which can rarely cause lactic acidosis. Lactic acidosis can cause death and must be treated in the hospital (see Lactic Acidosis: below). Therefore, you should not drink a lot of alcohol if you take JENTADUETO (see Lactic Acidosis: below).
Stop taking JENTADUETO and call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis:
- feel very weak or tired
- have unusual (not normal) muscle pain
- have trouble breathing
- have unusual sleepiness or sleep longer than usual
- have sudden stomach or intestinal problems with nausea and vomiting or diarrhea
- feel cold, especially in your arms and legs
- feel dizzy or lightheaded
- have a slow or irregular heartbeat
You have a higher chance of getting lactic acidosis if you:
- have kidney problems. People whose kidneys are not working properly should not take JENTADUETO.
- have liver problems
- have congestive heart failure that requires treatment with medicines
- drink alcohol very often, or drink a lot of alcohol in short-term (“binge” drinking)
- get dehydrated (lose a large amount of body fluids). This can happen if you are sick with a fever, vomiting, or diarrhea. Dehydration can also happen when you sweat a lot with activity or exercise and do not drink enough fluids
- have certain x-ray tests with dyes or contrast agents that are injected into your body
- have surgery
- have a heart attack, severe infection, or stroke
- are 80 years of age or older and have not been assessed for kidney function
BEFORE you use JENTADUETO talk to your doctor or pharmacist if you:
- are taking insulin because JENTADUETO is not approved for use with insulin
- have kidney problems
- have an injection of dye or contrast agents for an x-ray procedure
- have liver problems
- have pancreas problems, such as inflammation of the pancreas
- have any skin problems
- have had allergic reaction to any other medicines that you take to control the blood sugar
- have heart problems, including congestive heart failure
- drink alcohol very often, or drink a lot of alcohol in short term (“binge” drinking)
- have any other medical conditions
- are pregnant or planning to become pregnant
- are breast-feeding or plan to breast-feed
Interactions with this medication
Talk to your doctor or pharmacist about all the medicines you take. This includes prescription and non-prescription medicines, vitamins, and herbal supplements.
Some drugs may interact with JENTADUETO. Tell your doctor if you are taking:
- other diabetes drugs such as glyburide
- certain blood thinners (anticoagulants)
- cationic drugs (e.g. amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin)
- drugs that can increase the blood sugar include:
- thiazide and other diuretics (water pills)
- corticosteroids (e.g. Prednisone)
- thyroid products
- estrogens or estrogens plus progestogen
- oral contraceptives (birth control pills)
- nicotinic acid
- calcium channel blocking drugs
- angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors may lower blood glucose.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.