Axert (Almotriptan)

(℞) Prescription Required- Almotriptan is the Generic Equivalent for Axert

    Axert (Almotriptan) Dosage and Side Effects

    AXERT is used for acute treatment of migraines with or without aura in adults and adolescents aged 12-17 years. AXERT is not for use in children under 12 years of age.

    Warnings and Precautions

    BEFORE you use AXERT talk to your doctor or pharmacist if you:

    • Have past or present medical problems

    • Have a history of high blood pressure, chest pain, shortness of breath, strokes, or heart disease

    • Have risk factors for heart disease, such as:

      • High blood pressure or diabetes

      • High cholesterol

      • Obesity

      • Smoking

      • Family history of heart disease

      • You are a post-menopausal woman

      • You are a male over 40 years of age

    • Have or have had allergies

    • Have or have had allergic reactions to sulfonamides, also known as sulfa drugs (ask your doctor if you are not sure what sulfonamide drugs are)

    • Have kidney or liver disease

    • Plan to become or are already pregnant

    • Plan to breastfeed, or if you are already breastfeeding an infant

    • Plan to take or are taking drugs, including those obtained without a prescription, and those you normally take for a migraine.

    Do not use AXERT if you are pregnant, think you might be pregnant, are trying to become pregnant, or are not using adequate contraception, unless you have discussed this with your doctor.

    If you use AXERT too often, it may make your headaches worse. If this happens, your doctor may tell you to stop taking AXERT.

    Side Effects

    Like all prescription drugs, AXERT can cause side effects. In studies, AXERT was generally well tolerated. The side effects were usually mild and temporary. The following is not a complete list of side effects reported with AXERT. Do not rely on this leaflet alone for information about side effects. Ask your doctor to discuss with you the more complete list of side effects.

    In studies, the most common side effects reported were:

    • Nausea

    • Sleepiness

    • Dizziness

    • Tingling sensation

    • Headache

    • Dry mouth

    Other side effects that may rarely occur include: shortness of breath, wheeziness, heart throbbing, increased blood pressure, fast heart rate or irregular heart rate.

    If any of these occur, do not take any more AXERT and contact your doctor immediately.

    If you experience sleepiness after taking AXERT, you should not perform complex tasks such as driving or operating heavy machinery until you are sure you are no longer sleepy or drowsy.

    Call your doctor immediately if you feel tightness, pain, pressure or heaviness in your chest, throat, neck or jaw after taking AXERT. Do not take AXERT again until your doctor has checked you.

    Call your doctor immediately if you feel unwell or have any other symptoms that you do not understand or find distressing while taking AXERT.

    Call your doctor immediately if you experience any symptoms that suggest an allergic reaction (such as a rash or itching) after taking AXERT.

    This is not a complete list of side effects. For any unexpected effects while taking AXERT, contact your doctor or pharmacist.

    Interactions with this medication

    Drugs that may interact with AXERT include:

    • Other drugs in the same class

    • Ergotamine-type medications

    • Monoamine oxidase inhibitors (MAOIs)

    • Ketoconazole, itraconazole, ritonavir or erythromycin

    • Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)

    • Herbal products that contain St. John’s Wort (Hypericum perforatum)

    Do not take AXERT with any other drug in the same class within 24 hours, such as naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig).

    Do not take AXERT within 24 hours of taking ergotamine type medications such as ergotamine (Bellergal Spacetabs, Cafergot, Ergodryl), dihydroergotamine (Dihydroergotamine (DHE), Migranal), or methysergide (Sansert) to treat your migraine.

    Tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, such as phenelzine sulfate (Nardil), moclobemide (Manerix) or tranylcypromine sulfate (Parnate) for mental depression, or if it has been less than two weeks since you stopped taking a MAO inhibitor.

    Tell your doctor if you are taking ketoconazole (Nizoral, Apo-Ketoconazole, Novo-Ketoconazole), itraconazole (SPORANOX), ritonavir (Norvir), or erythromycin (Apo-Erythro, Diomycin, Erybid, Eryc, Erythrocin, Erythromid, Novo-Rythro Encap, PCE, PMS-Erythromycin), or if it has been less than one week since you stopped taking one of these drugs.

    Ask your doctor for instructions about taking AXERT if you are taking selective serotonin reuptake inhibitors (SSRIs) such as sertraline, escitalopram and fluoxetine or serotonin norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine or duloxetine for depression. A life-threatening condition called serotonin syndrome can happen when medicines called triptans, such as AXERT, and medicines used to treat depression and mood disorders called SSRIs or SNRIs are used together. Signs and symptoms of serotonin syndrome include the following: restlessness, diarrhea, hallucinations, coma, loss of coordination, nausea, fast heart beat, vomiting, increased body temperature, changes in blood pressure and overactive reflexes.

    Proper Use of this medication

    Usual dose:

    Your doctor has prescribed either a 6.25 mg or 12.5 mg dose of AXERT for your migraine attack. When you have a migraine headache, take your medication as directed by your doctor. If your headache comes back after your initial dose, you may take a second dose any time after 2 hours of administering the first dose. If you had no pain relief after the first dose, do not take a second dose without first consulting with your doctor. Do not take more than 25 mg of AXERT in a 24-hour period (for example, do not take more than two 12.5 mg tablets in 24 hours). If your condition worsens, seek medical attention.


    If you take more medication than you have been told to take, you should contact your doctor, hospital emergency department, or nearest poison control centre immediately, even if you do not feel sick.

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    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.