Xarelto 

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     Xarelto (rivaroxaban) Dosage and Side Effects FAQ

    What is Xarelto used for?

    • Xarelto is used to prevent blood clots in your brain and other blood vessels in those who have atrial fibrillation. Atrial fibrillation is form of irregular heart rhythm which can cause blood clots to develop and increase the risk of suffering from a stroke. It is also used to prevent blood clots after major surgery such as knee or hip surgery. Blood clots are dangerous as they travel to lungs and could pose a serious risk.

    How does Xarelto work?

    • Xarelto is an anticoagulant medication. It works by preventing blood clots from forming by directly blocking Factor-Xa, which is a clotting factor in the body.

    What the common Xarelto side effects?

    • Since Xarelto effects the clotting factors in the body, the common side effects are linked to signs of bruising or bleeding.

    How do you take Xarelto?

    • You should  try to take the tablet at the same time daily as a good reminder to ensure you don't miss a dose. The tablet should be swallowed with water.

    What is the Xarelto Dosage?

    • When you take Xarelto to prevent blood clots following major hip or knee surgery, the usual dose is 10mg once daily. Often the first dose is taken 6-10 hours following the surgery and continued till your doctor has prescribed you to stop the medication. For those that require Xarelto following major knee surgery, you typically require to continue Xarelto for 14 days and for those following major hip surgery would continue therapy for 35 days. For patients who have atrial fibrillation and are prescribed Xarelto, the usual dose is 20mg once a day. If there any issues concerning your kidneys then the doctor would typically prescribe a lower 15mg dose daily.  When treating and preventing blood clots in the lungs or legs then Xarelto is taken in treatment cycles. On Day 1 to 21: 15mg dose is taken twice daily and then on Day 22 and continuing would be 20mg once a day as directed by your doctor. The maximum recommended daily dosage is 20mg.

    What is the Xarelto Starter Pack?

    • Xarelto Starter Pack is used when treating a blood clot in the veins of your legs or lungs. The Starter Pack is for initial 28 days of the treatment which includes both Xarelto 15mg and 20mg tablets.

    Can you take Xarelto with food?

    • Xarelto 10mg can be taken with or without food, while Xarelto 15mg and 20mg should be taken with food.

    Xarelto vs Eliquis - how are they different?

    • Both Xarelto and Eliquis are anticoagulants. They both work to inhibit Factor-Xa, which prevents blood clots from forming. Xarelto is taken in most cases once daily while Eliquis is taken twice daily.

    Xarelto vs Warfarin - how are they different?

    • Both Xarelto and Warfarin are anticoagulants. They work differently in the body as Xarelto blocks Factor Xa while Warfarin stops the production of vitamin k clotting factors. There are other significant differences between these two medications. Warfarin requires regular bloodwork monitoring while Xarelto does not. Also there are dietary restrictions with Warfarin while with Xarelto there are no diet restrictions.

    Is a Xarelto coupon available?

    • PricePro Pharmacy offers even more discounts on the low Xarelto price with a Xarelto Coupon. Look on our Rx Coupon page for more details.

    Warnings and Precautions

    Do not stop taking XARELTO without first talking to your doctor. If you stop taking XARELTO, blood clots may cause a stroke or other complications. This can be fatal or lead to severe disability.

    As with other blood thinners, taking XARELTO may result in serious or life-threatening bleeding from any site, including internal organs.

    Take special care when using XARELTO:

    • if you have an increased risk of bleeding, as could be the case with conditions such as
      • bleeding disorders
      • very high blood pressure, not controlled by medical treatment
      • active ulcer or a recent ulcer of your stomach or bowel
      • a problem with the blood vessels in the back of your eyes (retinopathy)
      • recent bleeding in your brain (stroke, intracranial or intracerebral bleeding) problems with the blood vessels in your brain or spinal column
      • problems with the blood vessels in your brain or spinal column
      • a recent operation on your brain, spinal column or eye
      • a chronic disease of the airways in your lungs causing widening, damage and scarring (bronchiectasis), or a history of bleeding into your lungs
      • if you are older than 75 years of age

    For the treatment and prevention of blood clots in the veins of your legs or lungs, XARELTO is not recommended if your doctor determines that:

    • you are not able to maintain an adequate blood pressure
    • you are taking drugs to break down your blood clots
    • you have been scheduled for emergency surgical removal of blood clots from your lung

    Tell your doctor before you take XARELTO, if any of these apply to you. Your doctor may decide to keep you under closer observation.

    • If you are having surgery for any reason including an operation that involves a catheter or injection into your spinal column (e.g., for epidural or spinal anesthesia or pain reduction):
      • it is very important to take XARELTO before and after the procedure/injection or removal of a catheter exactly at the times you have been told by your doctor
      • tell your doctor immediately if you get numbness or weakness of your legs, or problems with your bowel or bladder after the end of anesthesia, because urgent care is necessary

    Lactose is a nonmedicinal ingredient in XARELTO. Do not take XARELTO if a doctor has told you that you have one of the following rare hereditary diseases:

    • Galactose intolerance
    • Lapp lactase deficiency
    • Glucose-galactose malabsorption

    XARELTO is not recommended if you have severe kidney disease. Your doctor will know how to determine your kidney function.

    XARELTO is not recommended if you have an artificial heart valve.

    XARELTO is not recommended in children younger than 18 years old.

    Pregnancy and breastfeeding:

    If there is a chance that you could become pregnant, use a reliable contraceptive while you are taking XARELTO. If you become pregnant while you are taking XARELTO, immediately tell your doctor, who will decide how you should be treated.

    Interactions with this medication

    Tell your doctor or pharmacist if you are taking:

    • anticoagulants (blood thinners) such as warfarin, heparin or low molecular weight heparin (LMWH) including enoxaparin, fondaparinux, bivalirudin, apixaban, dabigatran, or antiplatelet agents, such as clopidogrel, ticlopidine, prasugrel, ticagrelor
    • oral medications to treat fungal infections such as ketoconazole, itraconazole, posaconazole
    • medications for HIV/AIDS such as ritonavir [NORVIR] and lopinavir/ritonavir [KALETRA]
    • anti-inflammatory and pain relieving medicines including nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., naproxen [NAPROSYN] or acetylsalicylic acid [ASPIRIN])
    • some antibiotics such as clarithromycin
    • rifampicin
    • anticonvulsants (to control seizures or fits) such as phenytoin, carbamazepine, phenobarbital

    If you take XARELTO with NSAIDs or antiplatelet agents such as ASA or clopidogrel you are at an increased risk for bleeding. The use of XARELTO with prasugrel or ticagrelor is not recommended.

    Please tell your doctor or pharmacist if you are taking or have recently taken any other medication, including medications obtained without a prescription as well as vitamins and herbal supplements, such as St. John's Wort. Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.

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    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.