Eliquis (apixaban) Dosage and Side Effects
ELIQUIS is used to prevent strokes and blood clots in people with atrial fibrillation (a condition characterized by an irregular heartbeat). This medicine is also given to treat or reduce the risk of developing deep vein thrombosis (DVT; a blood clot that usually develops in the leg) and pulmonary embolism (PE; a blood clot in the lung). In addition, Eliquis may be prescribed after hip or knee replacement surgery to help prevent DVT or PE.
Warnings and Precautions
ELIQUIS contains a black box warning because it may cause a higher risk of stroke when people with atrial fibrillation stop taking it.
Don't suddenly stop using this medicine without first talking to your doctor. Continue to take ELIQUIS even if you feel well, and don't miss any doses.
If you need to stop using ELIQUIS, your healthcare provider may prescribe another blood thinner to help prevent stroke.
ELIQUIS contains another black box warning because it may cause a serious blood clot around your spinal cord if you have an epidural, spinal anesthesia, or a spinal puncture while taking it.
This blood clot can lead to long-term or permanent paralysis.
Tell your doctor if you currently have, or have a history of having:
- Epidural catheters
- Spinal punctures
- A spinal deformity
- Spinal surgery
It's also important to let your healthcare provider know if you're taking any drugs that may affect how your blood clots, including:
- Aggrastat (tirofiban)
- Agrylin (anagrelide)
- Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen), Indocin or Tivorbex (indomethacin), ketoprofen, and Aleve, Anaprox, or Naprosyn (naproxen)
- Brilinta (ticagrelor)
- Coumadin or Jantoven (warfarin)
- Effient (prasugrel)
- Integrilin (eptifibatide)
- Persantine (dipyridamole)
- Plavix (clopidogrel)
- Pletal (cilostazol)
ELIQUIS may interact with certain medicines that are commonly used during a medical emergency.
It's important that you or a family member tells healthcare professionals that you're taking ELIQUIS, in case of an emergency.
Tell your doctor immediately if you experience any of the following symptoms while using this medicine:
- Muscle weakness, especially in the legs or feet
- Numbness or tingling, especially in the legs
- Back pain
- Loss of control of your bladder or bowels
Don't take ELIQUIS if you have an artificial heart valve or active bleeding.
This drug may cause you to bleed or bruise more easily.
Try to avoid activities that increase your risk of bleeding or injury while using ELIQUIS. Call your doctor right away if you injure yourself — especially if you hit your head.
Let your healthcare provider know you're using this medicine before having any type of medical or dental procedure.
Before starting treatment with ELIQUIS, tell your doctor if you have, or have ever had:
- Kidney disease
- Liver disease
- Bleeding problems
- A stroke
- Allergies to medicines
Also, let your doctor know if you're age 80 or older, or if you weigh 132 pounds or less.
Keep all appointments with your doctor and laboratory while being treated with ELIQUIS. Your healthcare provider will probably order frequent tests to check your body's response to this medicine.
Pregnancy and ELIQUIS
ELIQUIS isn't believed to harm an unborn baby if taken during pregnancy.
But it may increase the risk of bleeding during your pregnancy or delivery.
Tell your doctor if you're pregnant, or might become pregnant, while using ELIQUIS.
It's not known whether this drug passes into breast milk. Don't breastfeed a baby while taking ELIQUIS.
Serious Side Effects of Eliquis
Tell your doctor immediately if you experience any of the symptoms listed in the Eliquis Warnings section above, or the following serious side effects:
- Easy bruising
- Unusual bleeding or bleeding that won't stop, including nosebleeds and bleeding gums
- Heavy menstrual periods
- Pink, brown, or red urine
- Black or bloody stools
- Coughing up blood, or vomit that looks like coffee grounds
- Trouble breathing or wheezing
- Severe headache
- Dizziness or feeling like you might pass out
- Severe weakness
- Swelling or joint pain
- Chest pain or tightness
- Signs of anaphylaxis, which may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat
Interactions with this medication
Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Eliquis Warnings section above, and the following:
- Biaxin or Prevpac (clarithromycin)
- Carbatrol, Epitol, Equetro, Tegretol, or Teril (carbamazepine)
- Dilantin or Phenytek (phenytoin)
- Nizoral (ketoconazole)
- Norvir or Kaletra (ritonavir)
- Onmel or Sporanox (itraconazole)
- Rifadin, Rimactane, Rifadin, or Rifater (rifampin)
- Selective serotonin reuptake inhibitors (SSRIs), such as Celexa (citalopram); Prozac, Sarafem, Selfemra, or Symbyax (fluoxetine); Luvox (fluvoxamine); Brisdelle, Paxil, or Pexeva (paroxetine); or Zoloft (sertraline)
- Serotonin and norepinephrine reuptake inhibitors (SNRIs), such as Cymbalta (duloxetine), Khedezla or Pristiq (desvenlafaxine), Fetzima or Savella (milnacipran), or Effexor (venlafaxine)
- St. John's wort
Proper Use of this medication
ELIQUIS comes as a tablet to take by mouth, typically twice a day.
It may also be given through a feeding tube.
Your dose will depend on your condition and response to treatment.
Try to take ELIQUIS around the same time each day.
This medicine can be taken with or without food.
ELIQUIS is usually taken for 35 days after hip replacement surgery, and for 12 days after knee replacement surgery.
Follow the instructions on your prescription label carefully. Don't take more or less ELIQUIS than is recommended.
Symptoms of an ELIQUIS overdose may include:
- Unusual bleeding or bruising
- Coughing up blood or material that looks like coffee grounds
- Brown, pink, or red urine
- Black, red, or tarry stools
If you suspect an overdose, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center.
Missed Dose of ELIQUIS
If you miss a dose of ELIQUIS, take it on the same day you remember it.
Then, take your next dose at the regular time. Stay on your twice-a-day schedule.
Don't take extra medicine to make up for a missed dose.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.