Brilinta (Ticagrelor)
Medication information written by Dr. Conner Sheehy, PharmD, BCPS
Updated - November 18, 2020
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This prescription medication used in conjunction with low-dose aspirin to help prevent stroke and heart attacks in patients with heart problems.
It may also be used after specific heart surgeries like stent placements, coronary artery bypass grafts (CABG), and angioplasty.
This medicine works by preventing platelets from forming clots by blocking them from sticking together. An antiplatelet medication, it works to keep optimize and regulate steady blood flow throughout the body.
This medication can be taken with and without food, as directed by your physician, and should be taken regularly. Of note, the tablets may be crushed into a powder and drank with water for those who have difficulty swallowing pills. It is usually taken twice daily, as directed by your doctor.
To place an order and buy online with our Canadian Pharmacy a prescription is required to be submitted. The prescription can be sent in by fax, e-mail, or directly uploaded on our site.
The active medicinal ingredient is Ticagrelor and it is manufactured by AstraZeneca. It is available in the following dosages: 60 mg which is a round pink color film-coated tablet and 90 mg which is a young yellow color film-coated tablet. The pack sizes available are blisters of 56 or 60 tablets per box.
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For more information, click on the blue below to find more details on dosing, side effects, and precautions.
Brilinta (Ticagrelor) Medication Information
Uses
Brilinta attaches to platelets and stopped them from clumping together and forming clots. It is used in people with a history of acute coronary syndrome (ACS) or myocardial infarction (MI). It can also reduce stent thrombosis in patients who have received a stent to treat ACS.
ACS describes several conditions where blood flow to the heart is deceased. After experiencing ACS, you are at an increased risk for stroke, heart attack, and cardiovascular death.
Brilinta works by preventing the formation of clots that would cause these events.
Dosage
The first dose is 180 mg by mouth and is usually given in an acute care setting like a hospital.
After the first dose, take 90 mg by mouth twice daily for one year. After the first year, reduce the dose to 60 mg by mouth twice daily.
Brilinta should be used with 75-100 mg of aspirin every day.
Side Effects
Side effects of Brilinta may include:
- Angioedema
- Dizziness
- Dyspnea
- ECG abnormality
- Gout
- Hemorrhage
- Increased creatinine
- Increased uric acid
- Nausea
- Skin rash
Precautions
Aspirin can be used while taking Brilinta, but it must be dosed less than 100 mg per day. Doses higher than this can decrease the effectiveness of Brilinta.
Recently, Brilinta has been linked to an increased risk of central sleep apnea. Brilinta has also been associated with slow heart rate and second-degree and third-degree atrioventricular blocks.
Do not use Brilinta if you have a history of intracranial hemorrhage (ICH) or an ongoing active bleed.
Brilinta and other antiplatelet agents can significantly increase the risk of bleeding events. Risk factors for bleed include a history of GI bleed, liver impairment, advanced age, recent trauma, or the use of other medications that increase the risk of bleeding.
Interactions
Brilinta has many possible drug interactions, including:
- Amiodarone
- Aprepitant
- Carbamazepine
- Cyclosporine
- Digoxin
- Diltiazem
- Erythromycin
- Grapefruit
- Indinavir
- Itraconazole
- Ketoconazole
- Lovastatin
- Phenobarbital
- Phenytoin
- Posaconazole
- Rifampin
- Ritonavir
- Simvastatin
- St. John’s Wort
- Verapamil
- Voriconazole
Tell your doctor and pharmacist about all of the medications you are taking before starting Brilinta.
Storage
Store at room temperature, or approximately 25°C (77°F).
Pharmacist Tips
- Brilinta can be crushed or mixed with water instead of swallowed whole.
- People taking Brilinta can experience shortness of breath, which should go away within one week after stopping the medication.
- Avoid non-steroidal anti-inflammatory agents while taking Brilinta, except for aspirin 75-100 mg once daily.
Brilinta FAQs
If I have bleeding side effects, should I stop Brilinta?
When possible, your doctor should manage bleeding without stopping Brilinta because stopping increases the risk of cardiovascular events like heart attack, stroke, and death.
If I feel better, can I stop taking Brilinta?
No, do not stop taking the medication unless directed by your doctor. Typically it should be used for at least one year after ACS.
Should I take Brilinta with or without food?
You can take Brilinta with food or on an empty stomach.
Related Products
References
- Brilinta [package insert]. Wilmington, DE: AstraZeneca; 2016.
Author: Dr. Conor Sheehy, PharmD, BCPS
Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics. He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.
