Before taking DEMADEX, tell your doctor if you have, or have ever had:

• Fluid in your abdomen
• Diabetes
• Gout
• Hearing problems
• Problems with urination
• High blood uric acid levels
• A blood disorder
• Kidney disease
• Lupus
• A heart attack or heart disease
• Liver disease
• Allergies to medications

Taking too much DEMADEX can lead to serious water and mineral loss. Be sure to take this medicine exactly as your doctor prescribes.

Your doctor will want to monitor your condition while you're taking this medicine. Be sure to keep all appointments with your doctor's office and laboratory.

Let your doctor know if you're dehydrated, or easily get dehydrated, before taking DEMADEX. This medicine can raise your risk of becoming dehydrated, so you may need to avoid strenuous exercise and exposure to very hot weather.

Tell your doctor right away if you experience:

• Extreme thirst
• Dry mouth
• Confusion
• Muscle cramps or weakness

The drug may affect your blood glucose levels. If you have diabetes, be sure to monitor your blood glucose carefully, and talk to your healthcare provider before changing any doses of your diabetes medicines.

DEMADEX shouldn't be given to children because safety and effectiveness hasn't been confirmed in this age group.

Older adults may be more sensitive to certain side effects of DEMADEX. Talk to your doctor about this issue if you're over 65.

Be sure to tell your healthcare provider you're taking DEMADEX before having any type of surgery, including a dental procedure.

Your doctor may tell you to take a potassium supplement while you're taking DEMADEX. Follow these instructions carefully.

DEMADEX may make your skin more sensitive to sunlight. Avoid unnecessary sun exposure, sunlamps, and tanning booths. Wear sunscreen or protective clothing while outdoors.

Continue to take DEMADEX even if you feel well. Don't stop taking the medicine without first talking to your doctor.

Pregnancy and DEMADEX

DEMADEX isn't believed to harm a fetus. Still, talk to your doctor before taking this drug if you're pregnant or plan to become pregnant.

It's not known whether the medicine passes into breast milk or could hurt a nursing baby. Talk to your doctor before taking this medicine if you're breastfeeding.

Tell your doctor if any of the following side effects become severe or don't go away:

• Dizziness or lightheadedness when standing or sitting up
• Nausea
• Excessive urination
• Constipation
• Coughing
• Headache
• Nasal inflammation

Serious Side Effects of DEMADEX

Tell your doctor immediately if you experience any of the symptoms listed in the DEMADEX Warnings section above, or any of the following serious side effects:

• Chest pain
• Rapid or irregular heartbeat
• Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)
• Diarrhea
• Fever, chills, or a sore throat that doesn't go away
• Hearing loss or ringing in the ears
• Loss of appetite or rapid weight loss
• Red, swollen, or blistered skin
• Unusual bleeding or bruising
• Pain that begins in the stomach area, but may spread to the back
• Restlessness
• Unusual weakness or fatigue
• Muscle cramps
• Rectal bleeding
• Vomiting blood

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

• Aminoglycoside antibiotics, such as Amikin (amikacin), Garamycin (gentamicin), or Bethkis or Tobi (tobramycin)
• Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) or Aleve (naproxen)
• Corticosteroids, such as Celestone (betamethasone), Entocort (budesonide), Cortone (cortisone), Decadron, Dexpak, or Dexasone (dexamethasone), Florinef (fludrocortisone), Cortef or Hydrocortone (hydrocortisone), Medrol (methylprednisolone), Prelone (prednisolone), Rayos (prednisone), or Aristocort or Azmacort (triamcinolone)
• ACTH or H.P. Acthar Gel (corticotropin)
• Lanoxin (digoxin)
• Edecrin (ethacrynic acid)
• Indocin (indomethacin)
• Lithobid or Eskalith (lithium)
• Probalan (probenecid)
• Medications for high blood pressure or pain

Also, if you're taking Questran (cholestyramine), take it four hours before, or one hour after, taking DEMADEX.

DEMADEX and Other Interactions

Licorice and Korean (Asian) ginseng may interfere with how DEMADEX works in your body. Avoid these products while taking DEMADEX.

DEMADEX may cause dizziness, fainting, or drowsiness. Don't drive or perform activities that require alertness until you know how this medicine affects you.

DEMADEX and Alcohol

Alcohol may worsen certain side effects of DEMADEX. Avoid drinking alcohol while taking this medicine.

DEMADEX comes as an oral tablet. It's usually taken once a day, with or without food.

Try to take DEMADEX around the same time each day.

Follow the instructions on your prescription label carefully. Don't take more or less DEMADEX than your doctor recommends.

DEMADEX may cause you to urinate a greater amount, or more often, when you first start taking it. You may want to take it before 6 p.m. so that your nighttime sleep isn't disturbed.

DEMADEX Overdose

Symptoms of a DEMADEX overdose may include:

• Confusion
• Dizziness or lightheadedness
• Dry mouth
• Excessive urination, followed by a decrease in the amount of urine
• Rapid or irregular heartbeat
• Muscle weakness or cramps

If you suspect an overdose, contact a poison control center or emergency room immediately.

Missed Dose of DEMADEX

If you miss a dose of DEMADEX, take it as soon as you remember.

But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.

Don't take extra medicine to make up for a missed dose.

DEPO PROVERA may decrease the amount of calcium in your bones. Loss of calcium may lead to osteoporosis and could increase your risk of a bone fracture. This effect is greater the longer you use the drug and may not be completely reversible.

You shouldn't use DEPO PROVERA as a long-term birth control method (longer than two years) unless other methods are not suitable.

It's not known if using DEPO PROVERA during the teen years (when bone mass increases) will affect a woman's risk of developing osteoporosis later in life. You should talk to your doctor about this risk.

You should consume foods that are rich in vitamin D and calcium (or take supplements) while taking DEPO PROVERA to lower the risk of calcium bone loss.

Tell your doctor if you or anyone in your family has ever had osteoporosis, breast cancer, or diabetes before taking this medication.

If you are younger than 35 years of age and have received DEPO PROVERA in the last four to five years, you may be at a slightly increased risk for developing breast cancer. This medicine may also increase the chance of developing blood clots that move to your lungs or brain. Talk to your doctor about these risks.

You might not become pregnant for some time after your last injection of DEPO PROVERA . Tell your doctor if you wish to become pregnant in the near future.

Your menstrual periods will probably be different while taking DEPO PROVERA.   You may experience irregular periods, spotting between periods, or no periods at all. Your cycle will probably return to normal after you stop using this medicine.

Before taking DEPO PROVERA , you should tell your doctor if you have or have ever had the following:

• Any bone disease
• Anorexia nervosa
• Lumps in your breasts
• Bleeding from your nipples
• Excessive weight gain or fluid retention before menstruation
• Blood clots in the legs, brain, lungs, or eyes
• A stroke or mini-stroke
• Migraine headaches
• Seizures
• Depression
• Asthma
• High blood pressure
• A heart attack or heart disease
• Lung disease
• Kidney disease
• Unusual vaginal bleeding or very light menstrual periods
• An abnormal mammogram
• Fibrocystic breast disease

Also, alert your physician if you drink large amounts of alcohol, smoke frequently, or are undergoing any type of surgery.

DEPO PROVERA is effective at preventing pregnancy, but it doesn't protect you from sexually transmitted diseases.

Pregnancy and DEPO PROVERA 

DEPO PROVERA  may harm an unborn baby. You should call your doctor if you are pregnant, think you are pregnant, or plan to become pregnant while taking this drug.  This medicine may be safe to use while you are breastfeeding as long as your baby is at least 6 weeks old. You should talk to your doctor about receiving DEPO PROVERA while breastfeeding.

Before taking DEPO PROVERA, you should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

• Corticosteroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone)
• Medications for seizures such as carbamazepine (Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton)
• Aminoglutethimide (Cytadren)

The intramuscular injection is typically administered once every three months by a health care provider. It's usually injected into the buttocks or upper arm.

The subcutaneous injection is typically administered once every 12 to 14 weeks by a healthcare provider. This form is injected just under the skin, often in the abdomen or upper thigh.

To ensure that you aren't pregnant, you will receive your injection of DEPO PROVERA during the first five days of your menstrual period, during the first five days after you give birth, or during the sixth week after giving birth.

If you miss an injection of DEPO PROVERA, you should call your doctor and use a back-up form of birth control.

You might become pregnant if you don't receive your injection on a set schedule. The injection must be received once every 12 weeks to provide full protection.

Common Side Effects of DEPO PROVERA

You should tell your doctor if any of the following side effects are severe or don't go away:

• Weakness or fatigue
• Nervousness
• Difficulty falling asleep or staying asleep
• Depression
• Breast pain, swelling, or tenderness
• Hot flashes
• Leg cramps
• Stomach cramps or bloating
• Acne
• Joint or back pain
• Hair loss
• White vaginal discharge
• Redness, irritation, swelling, burning, or itching of the vagina
• Cold or flu-like symptoms
• Changes in sexual desire
• Pain, redness, irritation, lumping, or scarring at the site of injection

Progesterone-only forms of birth control such as DEPO PROVERA may cause weight gain.

Serious Side Effects of DEPO PROVERA

You should call your doctor right away if you experience any of the following serious side effects:

• Coughing up blood
• Severe headache
• Sudden shortness of breath
• Sudden crushing or sharp chest pain
• Nausea or vomiting
• Dizziness or fainting
• Change in vision, loss of vision, or double vision
• Bulging eyes
• Seizures
• Difficulty speaking
• Numbness or weakness in an arm or leg
• Pain, warmth, swelling, or redness in one leg only
• Menstrual bleeding that is heavier or lasts longer than usual
• Severe pain just below the waist
• Extreme fatigue
• Yellowing of the eyes or skin
• Rash, hives, or itching
• Difficulty swallowing or breathing
• Swelling of the hands, feet, ankles, or lower legs
• Painful, difficult, or frequent urination
• Constant pain, warmth, swelling, bleeding, or pus at the site of injection

Tell your doctor or pharmacist if:

• you are allergic to any of the ingredients listed above;

• you have abnormal vaginal bleeding;

• you have porphyria (congenital or acquired disorder of the biosynthesis of the red blood stain);

• you have malignant disease of the breast or genital organs, or if such a disease is suspected;

• you have an acute blood clot including inflammation of superficial veins (thrombophlebitis), a vascular occlusion (thormboembolic disorder), or a cerebral apoplexy, or if you have had such disease before;

• you are pregnant with a dead fetus (missed abortion);

• you are breast feeding;

• you have liver disease, epilepsy, heart or kidney problems, or are using any other vaginal product.

One application of CRINONE 8% (90 mg of progesterone) every day, starting the day of the transfer. In some cases, the dose can be increased to two applications of CRINONE 8% daily. If pregnancy occurs, treatment should be continued for up to 10 to 12 weeks.

CRINONE is to be applied directly from the specially designed applicator into the vagina. CRINONE coats the vaginal mucosa to provide long-lasting release of progesterone.

Each applicator contains a slightly larger amount of gel than actually released, as the rest of the product tends to adhere to the inside of the applicator. It is therefore quite normal for a little gel to be left inside the applicator.

Each applicator contains 1.45 g vaginal gel and is designed in such way that with each administration an exactly defined amount of gel (1.125 g) is delivered. Any content of gel remaining in the applicator after use must be discarded.

Each applicator is intended for single use only.

If you forget to use CRINONE on a normal dosage day then use it the following day and then continue as before. Do not administer double doses to make up for a forgotten single dose.

Typically the gel stays attached to the vaginal walls as the medicine absorbs. Do not be concerned if small globules appear as a discharge after several days of usage. It is common, not harmful, to have some gel residue build-up. Gel accumulation may be less likely to occur if the gel is applied in the morning because activities like walking may help spread the gel on the vaginal walls. Therefore, it is not necessary to remain lying down following administration of CRINONE. If gel accumulation becomes bothersome, talk to your doctor.

Remove the applicator from the sealed wrapper. DO NOT remove the twist-off cap at this time.

1. Grip the applicator by the thick end. Shake down like a thermometer to ensure that the contents are at the thin end.

2. Twist-off the tab and discard.

3. The applicator may be inserted into the vagina while you are in a sitting position or when lying on your back with your knees bent. Gently insert the thin end well into the vagina.

4. Press the thick end of the applicator firmly to deposit gel. Remove the applicator and discard into a waste container.

You should not use DARAPRIM if you have a blood cell disorder called megaloblastic anemia that has been caused by folate deficiency.

You should not use DARAPRIM if you are allergic to it, or if you have:

• a blood cell disorder called megaloblastic anemia that has been caused by folate (folic acid) deficiency.

To make sure DARAPRIM is safe for you, tell your doctor if you have:

• seizures (especially if you take phenytoin);
• liver disease;
• kidney disease;
• a history of alcoholism;
• if you are pregnant; or
• if you are malnourished.

FDA pregnancy category C. It is not known whether DARAPRIM will harm an unborn baby. Tell your doctor if you are pregnant, and avoid becoming pregnant while taking this medicine.

In some cases, DARAPRIM is given to pregnant women to treat toxoplasmosis. Talk with your doctor about the risks and benefits of using this medicine if you are pregnant.

DARAPRIM can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Stop using DARAPRIM and call your doctor at once if you have:

• sore throat, swelling in your tongue;
• pale skin, easy bruising, purple spots under your skin;
• the first sign of any skin rash, no matter how mild;
• blood in your urine;
• new or worsening cough, fever, trouble breathing;
• irregular heartbeats; or
• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• vomiting; or
• loss of appetite.

Other drugs may interact with DARAPRIM , including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

The DARAPRIM dose for treating toxoplasmosis is much higher than the dose for malaria. Follow your doctor's dosing instructions very carefully.

Your dosage and the length of time you take DARAPRIM will depend on the reason you are taking this medicine. In some cases, DARAPRIM is taken for several weeks.

Take with food if DARAPRIM upsets your stomach or affects your appetite.

Overdose symptoms may include stomach pain, severe vomiting, coughing up blood or vomit that looks like coffee grounds, feeling anxious or excited, seizure (convulsions), and weak or shallow breathing (breathing may stop).

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

You should not use DANTRIUM if you have liver disease such as hepatitis or cirrhosis.  Do not use DANTRIUM at a time when muscle tone is needed to assure safe balance and movement for certain activities.

DANTRIUM can cause life-threatening liver damage, especially if you take high doses or take the medicine long-term. You may be more likely to develop liver problems while taking DANTRIUM  if you are a woman, if you are older than 35, or if you also take other medications. Ask your doctor about your individual risk.

Call your doctor at once if you have signs of liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These side effects may be most likely to occur between 3 and 12 months of your treatment with DANTRIUM.

While using DANTRIUM, you may need frequent blood tests to check your liver function.

You should not take this medicine if you are allergic to DANTRIUM, or if you have liver disease such as hepatitis or cirrhosis. Do not use DANTRIUM  at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

DANTRIUM can cause life-threatening liver damage, especially if you take high doses or take the medicine long-term. You may be more likely to develop liver problems while taking DANTRIUM if you are a woman, if you are older than 35, or if you also take other medications.  Ask your doctor about your individual risk.

To make sure DANTRIUM is safe for you, tell your doctor if you have:

• a history of liver disease;
• a breathing disorder such as COPD (chronic obstructive pulmonary disease); or
• heart disease, or a history of heart attack.

FDA pregnancy category C. It is not known whether DANTRIUM will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

DANTRIUM can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Dantrolene should not be given to a child younger than 5 years old.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have signs of liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These side effects may be most likely to occur between 3 and 12 months of your treatment with DANTRIUM.

DANTRIUM can cause muscle weakness, which can affect your ability to swallow. Use caution to prevent choking while you are eating meals. Talk with your doctor if you are unable to eat because of this side effect.

Also call your doctor right away if you have:

• muscle weakness;
• severe drowsiness; or
• vomiting, severe diarrhea.

Common side effects may include:

• mild diarrhea;
• weakness, drowsiness;
• dizziness; or
• tired feeling.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of dantrolene.

Avoid exposure to sunlight or tanning beds. Dantrolene can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking dantrolene with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with dantrolene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using .

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take this medicine with a full glass of water. If you take DANTRUIM within 3 or 4 hours before surgery, use only enough water needed to swallow the pill.

While using DANTRIUM, you may need frequent blood tests to check your liver function.

Store at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Serious Warnings and Precautions

• Blood: Although infrequently reported and very rarely fatal, serious adverse effects affecting blood cell counts have been observed during the use of TEGRETOL. Other side effects include: low white blood cell count, bone marrow depression, hepatitis and signs of liver failure such as jaundice (yellowing of the skin or eyes). Contact your doctor immediately if you are experiencing any of these symptoms. Close clinical and frequent laboratory supervision with your doctor should be maintained throughout treatment with TEGRETOL in order to detect as early as possible any possible signs of a blood disorder. Your doctor should discontinue TEGRETOL, if there is significant evidence of a bone marrow depression.
• Skin: Serious and sometimes fatal skin reactions known as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson Syndrome (SJS), have been reported with TEGRETOL. Other serious skin reactions such as Drug Rash with Eosinophilia and Systemic Symptoms (DRESS), Acute Generalized Exanthematous Pustulosis (AGEP) and Maculopapular Rash have also been reported. Although very rare, serious forms of DRESS and AGEP may also lead to death. Some cases of these skin reactions have been genetically linked. Your doctor may recommend a blood test to determine if you belong to an at-risk population.
• Contact your doctor immediately if you are developing any combination of:
  • a rash or any serious skin reactions such as red skin, blistering of the lips, eyes or mouth, and skin peeling accompanied by fever
  • swollen lymph nodes
  • joint pain
  • enlargement of the liver and/or the spleen
  • problems related to the lungs, kidneys, pancreas, heart, bone marrow, thymus, and colon
• Your doctor will determine if it is indeed drug-related, and discontinue TEGRETOL in this case.
• Cancer: Long-term toxicity studies in rats have indicated a possible cancer risk associated with carbamazepine. Before taking TEGRETOL, discuss with your doctor the potential benefits and possible risks of this treatment for you.

BEFORE you use TEGRETOL talk to your doctor or pharmacist:

• About your medical conditions, especially if you have or have had any liver, kidney, heart or thyroid disease or blood disorders (including those caused by other drugs).
• If you have a history, or family history, of bone disease or have taken antiepileptics (such as phenobarbital, phenytoin, primidone, oxcarbazepine, lamotrignine, sodium valproate and/or carbamezepine) for a prolonged period of time.
• If you are taking delavirdine, a medicine used to treat HIV-1 infection.
• About any allergies you may have, especially if you have ever shown any unusual sensitivity (rash or other signs of allergy) to oxcarbazepine or other drugs used to treat your condition. It is important to note that if you are allergic to TEGRETOL(carbamazepine), there is an approximately 1 in 4 (25%) chance that you could also have an allergic reaction to oxcarbazepine (TRILEPTAL).
• If you are pregnant. Your doctor may recommend that you take folic acid before and during your pregnancy and vitamin K during the last weeks of pregnancy. Your doctor may also recommend that the newborn receive vitamin K and be observed for liver and gall bladder problems.
• If you are planning on becoming pregnant to discuss the potential benefits against any potential hazards of TEGRETOL.
• If you are a women taking hormonal contraceptive (birth control medicine). TEGRETOL may render this contraceptive ineffective. Therefore, you should use a different or additional non-hormonal method of contraception while you are taking TEGRETOL. This should help to prevent an unwanted pregnancy.
• If you get irregular vaginal bleeding or spotting.
• If you are breast-feeding. TEGRETOL is known to pass into breast milk. You must discuss with your doctor the benefits of breastfeeding against any possible risks to the infant. If you decide to breastfeed, the baby must be observed for liver and gall bladder problems, drowsiness, and allergic skin reactions.
• About any other medicines (prescription and non-prescription) you are taking.
• About your usual alcohol consumption.
• If you have increased pressure in the eye (glaucoma).
• If you have difficulty passing urine (urinary retention).
• If you were told by your physician that you suffer from mental problems, a mental disorder called psychosis that may be accompanied by confusion or agitation, or have thoughts about suicide.

If any of the following apply to you, tell your doctor.

• If an allergic reaction happens such as fever with lymph nodes swelling, rash or skin blistering, tell your doctor immediately or go to the emergency department at your nearest hospital.
• If you experience an increase in the number of seizures, tell your doctor immediately.
• If you experience any side effects such as drowsiness, headache, unsteadiness on the feet, double vision, dizziness, nausea or vomiting, consult your doctor.
• If, at any time, you have thoughts of harming or killing yourself. A small number of people being treated with antiepileptic drugs have reported having such thoughts or behavior. Should this happen to you, or to those in your care if you are a caregiver or guardian, talk to your doctor immediately. Close observation by a doctor is necessary in this situation. Do not discontinue your medication on your own.
• If you have kidney problems associated with low sodium blood level or if you have kidney problems and you are also taking certain medicines that lower sodium blood level (diuretics such as hydrochlorothiazide, furosemide).

TEGRETOL may affect male fertility or cause abnormal sperm.

Periodic eye examinations are recommended while taking TEGRETOL.

Do not drive a car or operate dangerous machinery until you are sure that TEGRETOL does not cause dizziness, drowsiness, sleepiness, blurred or double vision, affect your muscular coordination or affect your alertness.

Side effects may include:

• purple or reddish-purple bumps that may be itchy
• trembling, uncontrolled body movements, muscle spasm, loss of muscle coordination, weakness
• agitation or hostility (especially in the elderly), depression with restlessness, nervousness or other mood or mental changes, changes in behaviour, confusion, headache, memory loss
• blurred vision, double vision, itching with redness and swelling of the eye (conjunctivitis), uncontrolled eye movements
• difficulty speaking or slurred speech, taste disturbances, dry mouth, red and sore tongue, mouth sores
• ringing or other unexplained sounds in the ears, decreased hearing
• numbness, tingling in hands and feet
• unusual secretion of breast milk, breast enlargement in men, sexual disturbances (erectile dysfunction), male infertility
• increased sensitivity of the skin to sun, alterations in skin pigmentation, acne, increased sweating
• reactivation of herpes virus infection (can be serious when the immune system is depressed)
• complete loss of the nails, loss of hair, excessive body and facial hair
• vomiting, nausea, loss of appetite, constipation, diarrhea, abdominal pain
• dizziness, sleepiness, unsteadiness, drowsiness, fatigue
• weight gain
• aching joints or muscles

Long-term use of antiepileptics such as carbamazepine, phenobarbital, phenytoin, primidone, oxcarbazepine, lamotrigine and sodium valproate is associated with a risk of decreased bone mineral density that may lead to weakened or brittle bones, or fracture.

If any of these affects you severely, contact your doctor

TEGRETOL can cause abnormal blood test results. Your doctor will decide when to perform blood tests and will interpret the results.

Tell your doctor or pharmacist if you are taking or have recently taken any prescription, non-prescription medicines or natural health products. It is particularly important for TEGRETOL, since many other medicines interact with it.

You may need a change in your dose or, sometimes, to stop one of these other medicines.

Irregularity of the menstrual period may occur in women taking hormonal contraceptives (birth control medicines) and TEGRETOL. The hormonal contraceptive may become less effective and you should use another contraceptive method (non-hormonal).

• Avoid alcohol consumption when taking TEGRETOL.
• Do not drink grapefruit juice or eat grapefruit since this can increase the effect of TEGRETOL. Other juices, like orange juice or apple juice, do not have this effect.

Usual dose:

Dosage should be individualised. It is very important that you take TEGRETOL exactly as your doctor instructed.

• Never increase or decrease the recommended dose of TEGRETOL you are taking unless your doctor tells you to.
• If you are taking TEGRETOL, do not suddenly stop taking it without first checking with your doctor. Your doctor will tell you if and when you can stop taking this medicine.
• TEGRETOL Tablets, CHEWTABS and Suspension should be taken in 2-4 divided doses daily, with meals whenever possible.
• TEGRETOL CR tablets should be swallowed unchewed with a little liquid during or after a meal.
• Shake TEGRETOL Suspension well before you take it or else you may not receive the correct dose.

Adults and Children Over 12 Years of Age:

Initial dose 100 to 200 mg once or twice a day. Your doctor will decide the best dosage for you. Always follow your doctor’s instructions.

For the treatment of trigeminal neuralgia, the maximum dose is 1200 mg a day.

Children 6-12 Years of Age:

Initial dose 100 mg in divided doses on the first day. Your doctor will decide the best dosage for you. Always follow your doctor’s instructions.

Overdose:

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Missed dose:

If you miss a dose, take your TEGRETOL as soon as possible. However, if the time is close to the next dose, do not take the missed dose and return to your regular dosing schedule. Do not double the dose to make up for the forgotten dose.