BEFORE you use HYDREA talk to your doctor or pharmacist if:

• you have problems with your kidney because the dose of HYDREA may need to be adjusted
• you are breast-feeding. HYDREA can pass into your breast milk and harm your baby. Do not breast-feed if you are taking HYDREA.
• you have problems with low blood count or anemia
• you have received radiation therapy as this may increase your chances of developing redness of the skin if HYDREA is used with radiation treatment
• you are pregnant or planning on becoming pregnant. HYDREA can harm the fetus when given to a pregnant woman. Women should avoid becoming pregnant while undergoing treatment with HYDREA.
• you are a male contemplating conception.
• HYDREA may cause an absence or low amount of sperm in the semen (sometimes these events are reversible) and damage DNA in your sperm. Therefore you should seek advice on sperm conservation prior to treatment with HYDREA and use safe contraceptive measures during and at least 1 year after therapy ends.
• you have HIV/AIDS and are receiving treatment as this can increase your chances of developing pancreatitis (inflammation of the pancreas) and liver problems
• you are lactose intolerant
• you recently received a vaccination or are scheduled for any vaccination. Patients taking HYDREA should not receive live vaccines.
• you are receiving treatment with interferon. Inflammation of the blood vessels of the skin, sometimes leading to formation of ulcers or death of the blood vessels has been reported mostly in patients who have received or are currently receiving interferon treatment.

Along with their needed effects, medicines like HYDREA can sometimes cause unwanted effects such as blood problems and other side effects.

The following information describes the most important side effects of which you should be aware. It is not a comprehensive list of all side effects. You should report any unusual symptoms to your doctor.

Check with your doctor if any of the following side effects occur:

• Inflammation in or around the mouth.
• Loss of appetite.
• High fevers (≥40 degrees celcius).
• Nausea and vomiting.
• Diarrhea and constipation.
• Inflammation of the blood vessels of the skin, sometimes leading to formation of ulcers or death of the blood vessels has been reported mostly in patients who have received or are currently receiving interferon treatment.
• Rash, redness and ulceration in the face, skin or extremities. Any skin or nail changes.

Discontinue medication and check with your doctor if any of the following side effects occur:

• Lack of urination, severe muscle weakness, abnormal heartbeat, and seizures (symptoms of tumour lysis syndrome)
• Yellowing of skin and eyes, feeling tired, stomach ache, nausea, diarrhea, no appetite, fever, headaches (symptoms of Hepatitis)
• Clay-colored or white stools, dark urine, inability to digest certain foods, itching, nausea or vomiting, pain in the right upper part of the abdomen, yellow skin or eyes (symptoms of cholestasis).

Make sure you talk to your doctor about any other conditions you may have and all other medications you are taking, including prescription, non-prescription and herbal and/or natural products.

Concurrent use of hydroxyurea and other myelosuppressive agents or radiation therapy may increase the likelihood of bone marrow depression or other adverse events.

While you are using this medicine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.

Usual dose:

The dose of HYDREA will be different for different patients. The dose that is used may depend on a number of things, including what the medicine is being used for, your weight, and whether or not other medicines are also being taken. Follow your doctor's orders.

Depending on your condition, the usual dose could be 80 mg/kg, or 20-30 mg/kg given orally. The dose and frequency will vary with your disease. Please follow your doctor's orders.

Overdose:

If you think you may have taken more HYDREA than you should, talk to your doctor immediately or contact the Emergency room of the nearest hospital.

Missed dose:

It you miss a dose of this medicine check with your doctor.

Before taking URISPAS, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: stomach/intestinal blockage (e.g., pyloric/duodenal obstruction, ileus), bleeding from the stomach or intestines, bladder blockage.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., fast/irregular heartbeat, heart failure), a certain eye condition (glaucoma), kidney problems, a certain muscle disease (myasthenia gravis), enlarged prostate gland, stomach/intestinal problems (e.g., infection, acid-reflux disease, chronic constipation, ulcerative colitis), overactive thyroid (hyperthyroidism).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication can cause decreased sweating. To reduce the risk of a serious reaction to too much heat (heatstroke), avoid becoming overheated in hot weather, saunas, or during exercise or other strenuous activities.

Older adults may be more sensitive to the side effects of this drug, especially dizziness (more likely when standing up), drowsiness, constipation, trouble urinating, or confusion. Dizziness, drowsiness, and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Nausea, vomiting, dry mouth, headache, drowsiness, dizziness, blurred vision, and nervousness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated, consult your pharmacist for help in choosing a laxative (e.g., stimulant-type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion), eye pain.

Tell your doctor right away if any of these rare but very serious side effects occur: chest pain, fast/pounding heartbeat, signs of infection (e.g., fever, persistent sore throat), stomach/intestinal blockage (e.g., persistent nausea/vomiting, long-lasting constipation), difficult/painful urination.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medication because a very serious interaction may occur: pramlintide.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting URISPAS.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anticholinergic drugs (e.g., atropine, belladonna alkaloids, scopolamine, benztropine, trihexyphenidyl), antispasmodic drugs (e.g., clidinium, dicyclomine), bisphosphonate drugs (e.g., alendronate, etidronate, risedronate), potassium tablets/capsules.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Take this medication by mouth, usually 3-4 times a day or as directed by your doctor. Take with food if stomach upset occurs.

The dosage is based on your medical condition and response to therapy. Your doctor may lower your dose after your symptoms have improved. The length of treatment depends on the cause of the problem.

Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster, and the risk of side effects may be increased.

Tell your doctor if your condition persists or worsens.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. Symptoms of overdose may include: slow/shallow breathing, hallucination, seizures, loss of consciousness.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in that case.

This medication may relieve the symptoms of a bladder infection, urinary tract infection (UTI), or prostate infection. However, it does not treat an infection. An antibiotic may be needed if you have an infection.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

You should not take UROCIT-K tablets if you have problems with your esophagus, stomach, or intestines that make it difficult for you to swallow or digest pills.

Do not crush, chew, break, or suck on an extended-release tablet. Swallow the pill whole. Breaking or crushing the pill may cause too much of the drug to be released at one time. Sucking on a potassium tablet can irritate your mouth or throat.

Avoid lying down for at least 30 minutes after you take this medication.

Take this medication with a meal or bedtime snack, or within 30 minutes after a meal.

To be sure this medication is helping your condition, your blood may need to be tested often. Your heart rate may also be checked using an electrocardiograph or ECG (sometimes called an EKG) to measure electrical activity of the heart. This test will help your doctor determine how long to treat you with potassium. Do not miss any scheduled appointments.

Serious side effects of UROCIT-K include uneven heartbeat, muscle weakness or limp feeling, severe stomach pain, and numbness or tingling in your hands, feet, or mouth.

Do not stop taking this medication without first talking to your doctor. If you stop taking potassium suddenly, your condition may become worse.

You should not use this medication if you are allergic to it, or if you have certain conditions. Be sure your doctor knows if you have:

• high levels of potassium in your blood (hyperkalemia);
• kidney failure;
• a urinary tract infection;
• untreated or uncontrolled diabetes;
• Addison's disease (an adrenal gland disorder);
• a large tissue injury such as a severe burn;
• a peptic ulcer in your stomach;
• if you are severely dehydrated; or
• if you are taking a "potassium-sparing" diuretic (water pill) such as amiloride (Midamor, Moduretic), spironolactone (Aldactone, Aldactazide), triamterene (Dyrenium, Dyazide, Maxzide).

You should not take UROCIT-K tablets if you have problems with your esophagus, stomach, or intestines that make it difficult for you to swallow or digest pills.

Before using UROCIT-K, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• congestive heart failure, enlarged heart, or history of heart attack;
• other heart disease or high blood pressure;
• diabetes;
• a blockage in your stomach or intestines; or
• chronic diarrhea (such as ulcerative colitis, Crohn's disease).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take UROCIT-K.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether potassium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• confusion, anxiety, feeling like you might pass out;
• uneven heartbeat;
• extreme thirst, increased urination;
• leg discomfort;
• muscle weakness or limp feeling;
• numbness or tingly feeling in your hands or feet, or around your mouth;
• severe stomach pain, ongoing diarrhea or vomiting;
• black, bloody, or tarry stools; or
• coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

• mild nausea or upset stomach;
• mild or occasional diarrhea; or
• appearance of a UROCIT-K tablet in your stool.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Avoid lying down for at least 30 minutes after you take this medication.

Avoid taking potassium supplements or using other products that contain potassium without first asking your doctor. Salt substitutes or low-salt dietary products often contain potassium. If you take certain products together you may accidentally get too much potassium. Read the label of any other medicine you are using to see if it contains potassium.

While taking this medication, avoid strenuous exercise if you are not in proper condition for it.

The following drugs can interact with UROCIT-K. Tell your doctor if you are using any of these:

• eplerenone (Inspra);
• digoxin (digitalis, Lanoxin);
• candesartan (Atacand), losartan (Cozaar, Hyzaar), valsartan (Diovan), or telmisartan (Micardis);
• glycopyrrolate (Robinul);
• mepenzolate (Cantil);
• quinidine (Quinaglute, Quinidex, Quin-Release);
• atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
• a bronchodilator such as ipratroprium (Atrovent) or tiotropium (Spiriva);
• bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
• irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine);
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik); or
• any type of diuretic (water pill) such as bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), or torsemide (Demadex).

This list is not complete and there may be other drugs that can interact with UROCIT-K. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Do not crush, chew, break, or suck on an extended-release tablet. Swallow the pill whole. Breaking or crushing the pill may cause too much of the drug to be released at one time. Sucking on a potassium tablet can irritate your mouth or throat. Call your doctor if it feels like the tablet is getting stuck in your throat when you swallow it.

Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Liquid potassium should be mixed with at least 4 ounces (one-half cup) of cold water or fruit juice. Drink the mixture slowly, over 5 to 10 minutes in all. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Take this medication with a meal or bedtime snack, or within 30 minutes after a meal.

Your treatment may include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

To be sure this medication is helping your condition, your blood may need to be tested often. Your heart rate may also be checked using an electrocardiograph or ECG (sometimes called an EKG) to measure electrical activity of the heart. This test will help your doctor determine how long to treat you with potassium. Do not miss any scheduled appointments.

Do not stop taking this medication without first talking to your doctor. If you stop taking potassium suddenly, your condition may become worse.

Store UROCIT-K at room temperature away from moisture and heat. Keep the medication in a closed container.

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include heavy feeling in your arms or legs, muscle weakness, limp feeling, slow or uneven heartbeat, chest pain, or feeling like you might pass out.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

To make sure GILOTRIF is safe for you, tell your doctor if you have:

• kidney disease;
• liver disease;
• heart disease;
• breathing problems or lung disease other than cancer; or
• vision problems, a history of very dry eyes, or if you wear contact lenses.

Do not use GILOTRIF if you are pregnant. It could harm the unborn baby. Tell your doctor right away if you become pregnant during treatment. Use effective birth control to avoid pregnancy while you are using this medication and for at least 2 weeks after your treatment ends.

It is not known whether GILOTRIF passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using GILOTRIF and call your doctor at once if you have:

• severe skin reaction that causes blistering and peeling;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
• eye problems--eye pain or redness, blurred vision, watery eyes, feeling like something is in your eye, increased sensitivity to light;
• heart problems--pounding heartbeats or fluttering in your chest, shortness of breath (even with mild exertion), swelling, rapid weight gain;
• liver problems--nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• lung problems--fever, chest pain, dry cough, wheezing.

Common side effects may include:

• mild diarrhea for 1 day or less;
• nausea, vomiting, loss of appetite;
• mouth sores;
• acne, dry skin, mild itching or skin rash; or
• redness, pain, swelling, or other signs of infection around your fingernails or toenails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Avoid exposure to sunlight or tanning beds. GILOTRIF can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with GILOTRIF, especially:

• St. John's wort; or
• an antibiotic--erythromycin, rifampin; antifungal medicine--itraconazole, ketoconazole; HIV or AIDS medicine--nelfinavir, ritonavir, saquinavir; heart or blood pressure medication--amiodarone, quinidine, verapamil; medicine to prevent organ transplant rejection--cyclosporine, tacrolimus; seizure medication--carbamazepine, phenobarbital, phenytoin.

This list is not complete. Other drugs may interact with GILOTRIF, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Before you start treatment, your doctor may perform tests to make sure GILOTRIF is the best treatment for your type of lung cancer.

GILOTRIF is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take GILOTRIF on an empty stomach, at least 1 hour before or 2 hours after a meal.

GILOTRIF can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given medications to prevent or quickly treat diarrhea.

Your doctor may recommend you have an anti-diarrhea medicine such as loperamide (Imodium) available at all times while you are taking GILOTRIF. Take the anti-diarrhea medicine as directed on the label, or as prescribed by your doctor.

Call your doctor if you are sick with severe diarrhea, or diarrhea lasting longer than 2 days. You may need to stop taking GILOTRIF for a short time.

While using GILOTRIF, you may need frequent blood tests.

Store the tablets in their original container at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Throw away any GILOTRIF tablets not used before the expiration date on the medicine label.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.

Serious Warnings and Precautions

KAZANO contains metformin which can rarely cause lactic acidosis. Lactic acidosis can cause death and must be treated in the hospital. Since alcohol may increase the risk of lactic acidosis caused by metformin you should not drink a lot of alcohol if you take KAZANO.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor if you have any of the following side effects:

Stomach and intestinal side effects, such as nausea, diarrhea, stomach upset, abdominal bloating, gas and appetite loss, are very common with metformin—one of the active ingredients in KAZANO.

The Common side effects that may occur are:

• cold or flu-like symptoms such as sore throat, stuffy or blocked nose, feeling tired, fever, chills, body aches, dry cough

• shortness of breath

• pink eye: itchy and red eye(s), with or without discharge

• dry, itchy skin with or without hives, rash

• headache

• indigestion, heartburn

• abdominal pain

• swollen or irritated blood vessels in the anus and rectum (hemorrhoids)

• gallstones

• kidney stones

• bruise

• back pain

• joint pain

• muscle and/or bone pain (including of the chest)

• cramp

• difficulty sleeping

• a metallic taste in your mouth

• stomach pain

• constipation

• nausea

• toothache

• vomiting

• tiredness (fatigue)

• swelling of extremities

• sensation of “pins and needles” or numbness (paresthesia)

• pain, weakness, numbness, or tingling in the leg (sciatica)

• coughing, wheezing shortness of breath, difficulty breathing, with or without fever

• high blood pressure (hypertension)

The Uncommon side effects that may occur are:

• allergic reaction (including severe rash, facial swelling and hives)

• upper abdominal pain that radiates into the back, with or without vomiting, due to a swelling of the pancreas (pancreatitis)

In very rare cases, metformin, one of the medicines in KAZANO can cause a serious side effect called lactic acidosis. This is caused by a buildup of lactic acid in your blood. This build-up can cause serious damage. You should also stop using KAZANO and call your physician right away if you have signs of lactic acidosis. Lactic acidosis is a medical emergency that must be treated in a hospital.

The Unknown side effects that may occur are:

• serious rash, involving skin reddening, pain, swelling of lips, eyes or mouth, skin peeling and flu-like symptoms (Stevens-Johnson Syndrome)

• liver problems

KAZANO CAN CAUSE ABNORMAL BLOOD TEST RESULTS. YOUR DOCTOR WILL DECIDE WHEN TO PERFORM TESTS AND WILL INTERPRET THE RESULTS.

Tell your doctor about all the medicines you take, have recently taken or might take including prescription and nonprescription medicines, vitamins, and herbal supplements.

In particular tell your doctor or pharmacist if you are taking any of the following:

• hydrocortisone and prednisolone (corticosteroids) used to treat diseases that involve inflammation like asthma and arthritis

• other diabetes drugs such as glyburide

• furosemide

• nifedipine

• cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin)

• other drugs tend to produce hyperglycemia (high blood sugar) and may lead to a loss of blood sugar control. Some example of drugs that can increase the blood sugar include:

  • thiazide and other diuretics (water pills)

  • corticosteroids

  • phenothiazines

  • thyroid products

  • estrogens or estrogens plus progestogen

  • oral contraceptives

  • phenytoin

  • nicotinic acid

  • sympathomimetics

  • calcium channel blocking drugs

  • isoniazid

• cimetidine, used to treat stomach problems

• bronchodilators (beta-2 agonists) which are used to treat asthma

• ramipril, lisinopril and enalapril (ACE inhibitors) used to treat high blood pressure

• iodinated contrast agents or medicines containing alcohol

You are allergic to atovaquone or to any of the ingredients in MEPRON.

Medicinal ingredients: Atovaquone

Nonmedicinal ingredients: Benzyl alcohol, flavour (tutti frutti), polaxamer 188, purified water, saccharin sodium, and xanthan gum

Talk to your doctor if you have any health conditions or problems you may have, including the following:

• currently have diarrhea
• have kidney problems
• are pregnant or are planning to become pregnant
• are breastfeeding or are planning to breastfeed

These are not all the possible side effects you may feel when taking MEPRON. If you experience any side effects not listed here, contact your healthcare professional.

Side effects may include:

• headache, fever
• nausea, vomiting, diarrhea, abdominal pain, constipation
• trouble sleeping, dizziness, feeling weak and achy
• sweating, rash, itching, hives
• thrush (yeast infection in the mouth)
• eye problems
• kidney problems

Side effects that may show up in a blood test:

• low levels of sodium in the blood (hyponatremia)
• changes in liver enzymes
• low numbers of red blood cells (anemia), which can cause tiredness, headaches and shortness of breath
• low numbers of white blood cells (neutropenia)
• high levels of amylase (an enzyme produced in the pancreas)
• high blood sugar levels (hyperglycemia)
• high levels of methemoglobin (a protein in the blood)
• low numbers of platelets in the blood

The following may interact with MEPRON:

• tetracycline, rifampicin, rifabutin, and cephalosporins, drugs used to treat bacterial infections
• metoclopramide, a drug used to treat symptoms of slowed stomach emptying
• acetaminophen, a drug used to relieve pain and reduce fever (also included in cold and flu remedies)
• benzodiazepines and opiates (like codeine), drugs used to treat anxiety and pain
• acyclovir, a drug used to treat herpes
• medicines used to treat diarrhea
• laxatives
• zidovudine and indinavir, drugs used to treat HIV infection/AIDS

It is important to drink MEPRON with a meal. This will help the medicine to work properly. Drink it with your morning meal and your evening meal. If you can eat only one meal a day, take your whole daily dose with your daily meal. Before you pour each dose, shake the bottle gently.

Usual adult dose:

Drink 5 mL (one teaspoonful) of MEPRON twice each day, with your meals. Take this medicine for 21 days.

If you can eat only one meal a day, drink 10 mL (two teaspoonfuls) of MEPRON once each day with your meal. Take this medicine for 21 days.

OVERDOSE:

If you think you have taken too much MEPRON, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

MISSED DOSE:

If you missed a dose of MEPRON, take it as soon as you remember (with a meal) and then take the next dose at the right time (again with a meal). Do not take more than 10 mL (two teaspoonfuls) a day in total.