Kazano (Alogliptin/Metformin)

(℞) Prescription Required

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Kazano 12.5MG/1000MG

Product of United Kingdom
Manufactured by: Takeda Pharmaceutical Co.
*Product image for reference use only.
Kazano is also marketed as Vipdomet
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Kazano 12.5MG/1000MG
Product of United Kingdom
Manufactured by Takeda Pharmaceutical Co.
Top Brand Choice
Top Generic Choice

Kazano 12.5mg/500mg

Product of Australia
Manufactured by: Takeda Pharmaceutical Co.
*Product image for reference use only.
Kazano is also marketed as Vipdomet
Select Quantity
Kazano 12.5mg/500mg
Product of Australia
Manufactured by Takeda Pharmaceutical Co.
Select your dosage

Kazano (Alogliptin/Metformin) Dosage and Side Effects

KAZANO is used along with diet and exercise to improve control of blood sugar in adults with type 2 diabetes.

KAZANO is used when your blood sugar cannot be adequately controlled by diet, exercise and other antidiabetic medicines such as metformin alone; insulin alone; or metformin and medicines known as thiazolidinediones (e.g. pioglitazone) taken together.

Warnings and Precautions

Serious Warnings and Precautions

KAZANO contains metformin which can rarely cause lactic acidosis. Lactic acidosis can cause death and must be treated in the hospital. Since alcohol may increase the risk of lactic acidosis caused by metformin you should not drink a lot of alcohol if you take KAZANO.

KAZANO with alcohol:

Do not take this medicine with alcohol as you could be at greater risk of developing lactic acidosis, a serious complication which must be treated in a hospital.

Lactic Acidosis:

Stop taking KAZANO if you get the following symptoms of lactic acidosis:

  • You feel very weak and tired.

  • You have unusual (not normal) muscle pain.

  • You have trouble breathing.

  • You have stomach pain with nausea and vomiting, or diarrhea.

  • You feel cold, especially in your arms and legs.

  • You feel dizzy or lightheaded.

  • You have a slow or irregular heart beat.

  • Your medical condition suddenly changes.

You have a higher chance of getting lactic acidosis if you:

  • have kidney problems.

  • have congestive heart failure that requires treatment with medicines.

  • drink a lot of alcohol (very often or short-term “binge” drinking).

  • get dehydrated (lose a large amount of body fluids). This can happen if you are sick with a fever, vomiting, or diarrhea. Dehydration can also happen when you sweat a lot with activity or exercise and don’t drink enough fluids.

  • have certain x-ray tests with injectable dyes or contrast agents used.

  • have surgery.

  • have a heart attack, severe infection, or stroke.

  • are 80 years of age or older and have not had your kidney function tested.

  • are pregnant or planning to become pregnant.

  • are breast-feeding.

 Before you take KAZANO, tell your doctor if you:

  • have any allergies, especially to the ingredients in KAZANO.

  • have type 1 diabetes (your body does not produce insulin).

  • are taking KAZANO with insulin. Your doctor may want to reduce your dose of insulin when you take it together with KAZANO in order to avoid too low blood sugar.

  • are going to have an operation under general, spinal or epidural anesthetic. You may need to stop taking this medicine for a couple of days before and after the procedure.

During treatment with KAZANO, your doctor will check your kidney function at least once a year and more frequently if you are elderly or if your kidney function is borderline or at risk of worsening.

Pregnancy and breast-feeding:

If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. You should not use KAZANO in pregnancy.

Do not breast-feed while taking KAZANO since metformin passes into breast milk.

Driving and using machines:

KAZANO has no known influence on the ability to drive and use machines.

Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor if you have any of the following side effects:

Stomach and intestinal side effects, such as nausea, diarrhea, stomach upset, abdominal bloating, gas and appetite loss, are very common with metformin—one of the active ingredients in KAZANO.

The Common side effects that may occur are:

  • cold or flu-like symptoms such as sore throat, stuffy or blocked nose, feeling tired, fever, chills, body aches, dry cough

  • shortness of breath

  • pink eye: itchy and red eye(s), with or without discharge

  • dry, itchy skin with or without hives, rash

  • headache

  • indigestion, heartburn

  • abdominal pain

  • swollen or irritated blood vessels in the anus and rectum (hemorrhoids)

  • gallstones

  • kidney stones

  • bruise

  • back pain

  • joint pain

  • muscle and/or bone pain (including of the chest)

  • cramp

  • difficulty sleeping

  • a metallic taste in your mouth

  • stomach pain

  • constipation

  • nausea

  • toothache

  • vomiting

  • tiredness (fatigue)

  • swelling of extremities

  • sensation of “pins and needles” or numbness (paresthesia)

  • pain, weakness, numbness, or tingling in the leg (sciatica)

  • coughing, wheezing shortness of breath, difficulty breathing, with or without fever

  • high blood pressure (hypertension)

The Uncommon side effects that may occur are:

  • allergic reaction (including severe rash, facial swelling and hives)

  • upper abdominal pain that radiates into the back, with or without vomiting, due to a swelling of the pancreas (pancreatitis)

In very rare cases, metformin, one of the medicines in KAZANO can cause a serious side effect called lactic acidosis. This is caused by a buildup of lactic acid in your blood. This build-up can cause serious damage. You should also stop using KAZANO and call your physician right away if you have signs of lactic acidosis. Lactic acidosis is a medical emergency that must be treated in a hospital.

The Unknown side effects that may occur are:

  • serious rash, involving skin reddening, pain, swelling of lips, eyes or mouth, skin peeling and flu-like symptoms (Stevens-Johnson Syndrome)

  • liver problems

KAZANO CAN CAUSE ABNORMAL BLOOD TEST RESULTS. YOUR DOCTOR WILL DECIDE WHEN TO PERFORM TESTS AND WILL INTERPRET THE RESULTS.

Interactions with this medication

Tell your doctor about all the medicines you take, have recently taken or might take including prescription and nonprescription medicines, vitamins, and herbal supplements.

In particular tell your doctor or pharmacist if you are taking any of the following:

  • hydrocortisone and prednisolone (corticosteroids) used to treat diseases that involve inflammation like asthma and arthritis

  • other diabetes drugs such as glyburide

  • furosemide

  • nifedipine

  • cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin)

  • other drugs tend to produce hyperglycemia (high blood sugar) and may lead to a loss of blood sugar control. Some example of drugs that can increase the blood sugar include:

    • thiazide and other diuretics (water pills)

    • corticosteroids

    • phenothiazines

    • thyroid products

    • estrogens or estrogens plus progestogen

    • oral contraceptives

    • phenytoin

    • nicotinic acid

    • sympathomimetics

    • calcium channel blocking drugs

    • isoniazid

  • cimetidine, used to treat stomach problems

  • bronchodilators (beta-2 agonists) which are used to treat asthma

  • ramipril, lisinopril and enalapril (ACE inhibitors) used to treat high blood pressure

  • iodinated contrast agents or medicines containing alcohol

Proper Use of this medication

 Usual dose:

The usual dose is one tablet twice a day.

Swallow your tablet(s) whole with water. You should take this medicine with food to reduce your chance of an upset stomach.

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Your doctor will tell you exactly how much KAZANO you need to take. The amount of KAZANO will vary depending on your condition and the doses you currently take of metformin alone, metformin in combination with pioglitazone, insulin and/or individual tablets of alogliptin and metformin.

Overdose:

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Missed dose:

If you forget to take a dose, take it as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose. Do not take a double dose (two doses at the same time) to make up for a forgotten dose.

Other related products

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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