Gilotrif (Afatinib)

(℞) Prescription Required

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Giotrif 20mg

Product of Canada
Manufactured by: Boehringer Ingelheim
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Gilotrif is also marketed as Giotrif
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Giotrif 20mg
Product of Canada
Manufactured by Boehringer Ingelheim
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Giotrif 30mg

Product of Canada
Manufactured by: Boehringer Ingelheim
*Product image for reference use only.
Gilotrif is also marketed as Giotrif
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Giotrif 30mg
Product of Canada
Manufactured by Boehringer Ingelheim
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Top Generic Choice

Giotrif 40mg

Product of Canada
Manufactured by: Boehringer Ingelheim
*Product image for reference use only.
Gilotrif is also marketed as Giotrif
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Giotrif 40mg
Product of Canada
Manufactured by Boehringer Ingelheim
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Gilotrif (Afatinib) Dosage and Side Effects

GILOTRIF is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Warnings and Precautions

To make sure GILOTRIF is safe for you, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • heart disease;
  • breathing problems or lung disease other than cancer; or
  • vision problems, a history of very dry eyes, or if you wear contact lenses.

Do not use GILOTRIF if you are pregnant. It could harm the unborn baby. Tell your doctor right away if you become pregnant during treatment. Use effective birth control to avoid pregnancy while you are using this medication and for at least 2 weeks after your treatment ends.

It is not known whether GILOTRIF passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using GILOTRIF and call your doctor at once if you have:

  • severe skin reaction that causes blistering and peeling;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • eye problems--eye pain or redness, blurred vision, watery eyes, feeling like something is in your eye, increased sensitivity to light;
  • heart problems--pounding heartbeats or fluttering in your chest, shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • liver problems--nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • lung problems--fever, chest pain, dry cough, wheezing.

Common side effects may include:

  • mild diarrhea for 1 day or less;
  • nausea, vomiting, loss of appetite;
  • mouth sores;
  • acne, dry skin, mild itching or skin rash; or
  • redness, pain, swelling, or other signs of infection around your fingernails or toenails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Interactions with this medication

Avoid exposure to sunlight or tanning beds. GILOTRIF can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with GILOTRIF, especially:

  • St. John's wort; or
  • an antibiotic--erythromycin, rifampin; antifungal medicine--itraconazole, ketoconazole; HIV or AIDS medicine--nelfinavir, ritonavir, saquinavir; heart or blood pressure medication--amiodarone, quinidine, verapamil; medicine to prevent organ transplant rejection--cyclosporine, tacrolimus; seizure medication--carbamazepine, phenobarbital, phenytoin.

This list is not complete. Other drugs may interact with GILOTRIF, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Proper Use of this medication

Before you start treatment, your doctor may perform tests to make sure GILOTRIF is the best treatment for your type of lung cancer.

GILOTRIF is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take GILOTRIF on an empty stomach, at least 1 hour before or 2 hours after a meal.

GILOTRIF can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given medications to prevent or quickly treat diarrhea.

Your doctor may recommend you have an anti-diarrhea medicine such as loperamide (Imodium) available at all times while you are taking GILOTRIF. Take the anti-diarrhea medicine as directed on the label, or as prescribed by your doctor.

Call your doctor if you are sick with severe diarrhea, or diarrhea lasting longer than 2 days. You may need to stop taking GILOTRIF for a short time.

While using GILOTRIF, you may need frequent blood tests.

Store the tablets in their original container at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Throw away any GILOTRIF tablets not used before the expiration date on the medicine label.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.

Other related products

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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