Mepron (Atovaquone)

You are allergic to atovaquone or to any of the ingredients in MEPRON.

Medicinal ingredients: Atovaquone

Nonmedicinal ingredients: Benzyl alcohol, flavour (tutti frutti), polaxamer 188, purified water, saccharin sodium, and xanthan gum

Talk to your doctor if you have any health conditions or problems you may have, including the following:

• currently have diarrhea
• have kidney problems
• are pregnant or are planning to become pregnant
• are breastfeeding or are planning to breastfeed

These are not all the possible side effects you may feel when taking MEPRON. If you experience any side effects not listed here, contact your healthcare professional.

Side effects may include:

• headache, fever
• nausea, vomiting, diarrhea, abdominal pain, constipation
• trouble sleeping, dizziness, feeling weak and achy
• sweating, rash, itching, hives
• thrush (yeast infection in the mouth)
• eye problems
• kidney problems

Side effects that may show up in a blood test:

• low levels of sodium in the blood (hyponatremia)
• changes in liver enzymes
• low numbers of red blood cells (anemia), which can cause tiredness, headaches and shortness of breath
• low numbers of white blood cells (neutropenia)
• high levels of amylase (an enzyme produced in the pancreas)
• high blood sugar levels (hyperglycemia)
• high levels of methemoglobin (a protein in the blood)
• low numbers of platelets in the blood

The following may interact with MEPRON:

• tetracycline, rifampicin, rifabutin, and cephalosporins, drugs used to treat bacterial infections
• metoclopramide, a drug used to treat symptoms of slowed stomach emptying
• acetaminophen, a drug used to relieve pain and reduce fever (also included in cold and flu remedies)
• benzodiazepines and opiates (like codeine), drugs used to treat anxiety and pain
• acyclovir, a drug used to treat herpes
• medicines used to treat diarrhea
• laxatives
• zidovudine and indinavir, drugs used to treat HIV infection/AIDS

It is important to drink MEPRON with a meal. This will help the medicine to work properly. Drink it with your morning meal and your evening meal. If you can eat only one meal a day, take your whole daily dose with your daily meal. Before you pour each dose, shake the bottle gently.

Usual adult dose:

Drink 5 mL (one teaspoonful) of MEPRON twice each day, with your meals. Take this medicine for 21 days.

If you can eat only one meal a day, drink 10 mL (two teaspoonfuls) of MEPRON once each day with your meal. Take this medicine for 21 days.

OVERDOSE:

If you think you have taken too much MEPRON, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

MISSED DOSE:

If you missed a dose of MEPRON, take it as soon as you remember (with a meal) and then take the next dose at the right time (again with a meal). Do not take more than 10 mL (two teaspoonfuls) a day in total.