Migranal Nasal Spray (Dihydroergotamine Mesylate)

(℞) Prescription Required

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Migranal Nasal Spray 4mg/ml

Product of Canada
Manufactured by: Sterimax Inc
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Migranal Nasal Spray 4mg/ml
Product of Canada
Manufactured by Sterimax Inc
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Migranal Nasal Spray (Dihydroergotamine) Medication Information


Migranal is a nasal spray that is used to treat migraine headaches with or without aura.


The nasal spray contains 4 mg of Migranal in a 3.5 mL vial.

Side Effects

The most common side effects of Migranal include:

  • Sinusitis
  • Nausea
  • Vomiting
  • Dizziness
  • Somnolence
  • Fatigue 

Speak with your doctor for a full list of side effects that apply to you if you are taking Migranal.


There is a possibility of blood vessel spasms while taking Migranal, which can present as angina. IF this occurs, patients should be evaluated. 


The most common drug interactions with Migranal include:

  • Triptans
  • Beta blocker
  • Nicotine
  • SSRIs
  • Oral contraceptive

Speak with your doctor for more information and before starting a new medication with Migranal. 


Store below room temperature (77 ºF). Do not refrigerate or freeze. 

Pharmacist Tips

  • Migranal is to be used as a nasal spray, it should not be injected. 
  • Migranal has not been studied in patients for longer than a year
  • Migranal is dosed as one spray in each nostril, and then a second spray in each nostril 15 minutes later.

Dihydroergotamine FAQs

How much Migranal can you use?

There has been no benefit in using more than 2 mg of Migranal.


How long does it take Migranal to work?

Patients typically see relief within 30 minutes of using Migranal.


How many doses are in Migranal?

Each vial contains enough Migranal for 4 sprays, the initial one spray in each nostril, and enough to administer a second spray in each nostril.


How much does Migranal cost?

The average cost of Migranal is around $1000 for 8 vials of 4 sprays.


How often can you use Migranal?

Do not use more than the amount your doctor prescribes. 

Related Drugs


Migranal {package insert}. Bridgewater, NJ: Valcant Pharmaceuticals North America LLC; 2019.


PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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