Glumetza (Metformin Hydrochloride)
Glumetza (Metformin Hydrochloride) Dosage and Side Effects
GLUMETZA extended-release tablets are used in addition to diet and exercise, to improve blood sugar levels in adults with type 2 diabetes.
Proper Use of this medication
Follow the directions provided by your doctor for using this medicine. Only take this medicine with food, and drink plenty of fluids while taking this medicine. Do not miss any doses. Swallow whole. Do not break or crush tablets.
Initial dose is 1000 mg with evening meal. Maximum daily dose is 2000 mg.
If an overdose is suspected, contact your local poison control centre or emergency immediately. Symptoms of overdose may include rapid breathing or trouble in breathing, nausea and vomiting followed by diarrhea, drowsiness, weakness, dizziness, and headache.
If a dose of this medication has been missed it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not double doses. If you do not feel well or your home glucose test shows higher levels, contact your physician.
Some common side effects include diarrhea, nausea and stomach upset. If they continue or are bothersome, check with your doctor.
After you are on the same dose for several days or weeks, if any of these symptoms come back, tell your doctor immediately. A late recurrence of stomach symptoms may be due to a serious medical condition (lactic acidosis).
This is not a complete list of side effects. For any unexpected effects while taking GLUMETZA contact your doctor or pharmacist.
Warnings and Precautions
Serious Warnings and Precautions
GLUMETZA may rarely be associated with a serious, life-threatening condition called lactic acidosis.
You should not drink a lot of alcohol if you take GLUMETZA
Before you use GLUMETZA, talk to your doctor or pharmacist if you have:
- a history of kidney disease
- are 80 years or older and you have NOT had your kidney function tested
- liver disease
- metabolic acidosis (e.g., diabetic ketoacidosis)
- recent heart attack
- recent stroke
- serious infection
- scheduled surgery
- scheduled x-ray or scanning procedures
- are pregnant, breast-feeding, or planning to become pregnant.
- vitamin B12 or folic acid deficiency
- drink alcohol
GLUMETZA therapy may rarely be associated with a serious, life-threatening condition called lactic acidosis.
Due to potential for lactic acidosis, you should talk to your doctor if you take GLUMETZA and if you:
- develop or experience a worsening of heart disease and particularly heart failure
- develop a serious medical condition, such as heart attack, severe infection, or a stroke
Signs and symptoms of lactic acidosis include: discomfort, muscle pain, difficult or fast breathing, extreme tiredness, weakness, upset stomach, stomach pain, feeling cold, low blood pressure or slow or irregular heartbeat.
If any of the above side effects occur, contact your doctor immediately.
Interactions with this medication
Always inform your doctor or pharmacist of all prescription over-the-counter, and herbal medicines that you are taking. Medicines which may require additional monitoring of your dose or condition include:
- other diabetes drugs, such as glyburide, insulin, and rosiglitazone;
- medications that may increase blood sugar levels such as “water pills” (diuretics), birth control pills, sympathomimetics (decongestants), thyroid medicines, prednisone (corticosteroid drugs), phenytoin, nicotinic acid, certain drugs which control high blood pressure (e.g., calcium channel blockers), and isoniazid;
- cationic drugs which may interfere with the elimination of metformin (e.g., cimetidine, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin);
- certain “blood thinners” (coumarin-type anticoagulants);
Interactions with herbal products have not been established.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.