Multaq (Dronedarone)

(℞) Prescription Required

    Multaq (Dronedarone) Dosage and Side Effects

    MULTAQ is a prescription medicine used in adults to help control abnormal heart rate and rhythm called atrial fibrillation.

    Warnings and Precautions

    BEFORE you use MULTAQ talk to your doctor or pharmacist if you are using:

    • Medicine for high blood pressure, chest pain, or other heart conditions, such as:
      • Verapamil, diltiazem, nifedipine, metoprolol, propranolol, atenolol, digoxin
      • Benazepril and captopril in a therapeutic class called ACE inhibitors
      • Losartan, and valsartan in a therapeutic class called ARBs
    • Any of these medicines:
      • Fexofenadine, a medicine for allergy or hay fever
      • A medicine to treat cancer (doxorubicin)
      • Statin medicine to lower blood cholesterol such as atorvastatin (LIPITOR) or simvastatin
      • Rifampicin used for tuberculosis
      • Erythromycin
      • Phenobarbital, carbamazepine, and phenytoin used for seizure disorders
      • St. John’s Wort herbal medicine for depression
      • Sirolimus and tacrolimus used for organ transplants
      • Anticoagulant medications such as: Warfarin (COUMADIN), other vitamin K antagonists, and dabigatran etexilate (PRADAXA)

    Tell your doctor about all your heart problems, including if you have a problem when your heart does not pump the blood through your body as well as it should (heart failure). You should call your doctor right away if any of the following signs appear or if you already had them and they worsen:

    • shortness of breath when moving around,
    • trouble breathing while lying down or sleeping,
    • swelling of your feet or legs,
    • weight increase.

    Tell your doctor about all your liver problems including life threatening liver failure. Your doctor will order blood tests to check your liver function before you start taking MULTAQ and during treatment. In some cases MULTAQ treatment may need to be stopped. You should call your doctor right away if any of the following signs and symptoms of liver problems appear:

    • loss of appetite, nausea, vomiting,
    • fever, feeling unwell, unusual tiredness,
    • itching,
    • yellowing of the skin or the whites of the eyes (jaundice),
    • unusual darkening of the urine,
    • right upper stomach area pain or discomfort.

    Tell your doctor about all your other health problems. Including:

    • any health problem that could lead to a low level of potassium or magnesium in your blood.

    Tell your doctor if:

    • you are pregnant, or planning to become pregnant.
    • you are breast-feeding a baby.

    Blood test and ECG while taking MULTAQ:

    While you are taking MULTAQ, your doctor may perform heart examination tests such as an ECG or/and may take blood tests to assess your medical condition and how you tolerate the treatment. The results of one of the blood tests for kidney function (blood creatinine) may be changed by MULTAQ and may lead your doctor to take into account another reference for the “normal” value. Please notify any other doctor you may consult for the first time about your new “normal” value for your blood creatinine.

    Interactions with this medication

    MULTAQ can interact with certain other medicines and cause serious side effects.

    Tell your doctor about all medicines you take. Keep a list of them with you at all times. Show it to your doctor and pharmacist each time you get a new medicine. Do not take any new medicines while you are taking MULTAQ unless you have talked with your doctor. Include all non-prescription medicines, vitamins, and herbal remedies. MULTAQ and certain other medicines can interact with each other, causing serious side effects. Sometimes the dose of other medicines must be changed when they are used with MULTAQ.

    Tell your doctor about:

    • Water pills for high blood pressure. They could lower your blood potassium and magnesium.
    • All heart medicines and blood pressure medicines
    • Medicines for hay fever, cancer, or high cholesterol
    • Medicines to treat infections, depression, or seizures
    • Medicines used in organ transplants
    • St. John’s Wort
    • Medication for fungal infections

    You should avoid:

    Drinking grapefruit juice or eating grapefruit.

    Proper Use of this medication

    Usual dose:

    Take MULTAQ as your doctor tells you at the same time each day. Take 1 MULTAQ tablet (400 mg) 2 times a day with meals.

    • Take the first MULTAQ tablet with your morning meal.
    • Take the second MULTAQ tablet with your evening meal.

    Keep taking MULTAQ even if you feel better. If you stop, your condition may get worse. Keep taking MULTAQ until your doctor tells you to stop. Make sure to observe all appointments with your doctor for check-ups.

    Overdose:

    In case of drug overdose, contact a heath care practitioner, hospital emergency department or Regional Poison Control Centre immediately, even if there are no symptoms.

    Taking too much MULTAQ can be dangerous. You may need medical care right away.

    Missed dose:

    If you miss a dose, wait and take your next dose at your regular time. Do not take 2 doses at the same time. Do not make up for a missed dose.

    Side Effects

    The common side effects are:

    • digestive disturbances such as diarrhea, nausea, vomiting, abdominal pain and indigestion
    • feeling tired and weak

    Other side effects may also be observed:

    • skin problems such as rash and itching, redness of skin, eczema, inflammation of the skin, abnormal sensitivity of the skin to sunlight
    • change in your sense of taste, loss of taste

    Talk with your doctor about any side effects that bother you. These are not all the side effects of MULTAQ. Your doctor and pharmacist have a more complete list.

     

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.