Hyzaar (Losartan/HCTZ)

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Hyzaar (Losartan and Hydrochlorothiazide) Medication Information

Uses

Hyzaar is used to treat hypertension, and to reduce the risk of stroke in patients with left ventricular hypertrophy and hypertension. 

Dosage

The tablets are available in several different strengths:

  • 50-12.5 mg
  • 100-12.5 mg
  • 100-25 mg

Side Effects

The most common side effects of Hyzaar include:

  • Abdominal pain
  • Edema
  • Palpitations
  • Back pain
  • Dizziness
  • Cough
  • Rash 

Speak with your doctor or pharmacist for a full list of side effects that applies to you.

Precautions

All patients taking a thiazide should be observed for signs of fluid or electrolyte abnormalities. Warning signs of fluid and electrolyte abnormalities include: drowsiness, dry mouth, thirst, weakness, confusion, muscle pains or cramps, nausea, and vomiting.

A side effect of inhibiting the renin-angiotensin-aldosterone system, is changes in kidney function. In some patients, these changes in kidney function were reversible when the medication was stopped.

Interactions

Common medications that interact with Hyzaar are listed:

  • Rifampin
  • Ketoconazole
  • Fluconazole
  • Spironolactone
  • Potassium supplement
  • NSAIDs
  • Lithium
  • Alcohol
  • Corticosteroids
  • Muscle relaxants

Speak with your doctor or pharmacist for more information. 

Storage

Store at room temperature (77ºF). Protect from light.  

Pharmacist Tips

  • Do not take Hyzaar if you are pregnant or planning to become pregnant
  • If you miss a dose, take the dose as soon as possible, it if is close to your next scheduled dose, skip the missed dose. 
  • Your doctor may want to test your blood to check your electrolytes.

Hyzaar FAQs

Can you take Hyzaar at night?

This medication contains a diuretic, which increases your need to urinate. In order to avoid waking up in the middle of the night, it is recommended to take this medication at least 4 hours before bed. 

 

How long does it take for Hyzaar to work?

It can take a week or so to see the full effect of blood pressure medication, with the full effect seen in 3-6 weeks. 

 

What are the side effects of Hyzaar?

Common side effects with Hyzaar include: hypotension, dizziness, headache, cough, and fluid retention. 

 

What is Hyzaar used for?

Hyzaar is used to treat high blood pressure. 

 

Related Drugs

Reference:

Hyzaar {package insert}. Whitehouse Station, NJ: Merck & Co., Inc.; 2013.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020387s057lbl.pdf

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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