Xifaxan (Rifaximin)

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    Xifaxan (Rifaximin) Dosage and Side Effects

    This medication is used to treat travelers' diarrhea that's caused by Escherichia coli (E. coli). Rifaximin is an antibiotic that works by killing bacteria and preventing their growth.

    Proper Use of this medication

    Your dose will depend on your medical condition and response to treatment.

    The drug comes as a tablet to take by mouth.

    Follow your doctor's instructions carefully when using this medicine. Don't take more or less than is recommended.

    The typical dose for people with travelers' diarrhea is one 200 milligram (mg) tablet three times a day for three days.

    The usual dose for people with hepatic encephalopathy is one 550 mg tablet two times a day.

    You can take with or without food.


    If you suspect an overdose, contact a poison control center or emergency room immediately.

    Missed Dose

    If you miss a dose, take it as soon as you remember.

    However, skip the missed dose if it's almost time for your next dose.

    Don't take extra medicine to make up for a missed dose.

    Side Effects

    Common Side Effects

    Tell your doctor if any of the following side effects are severe or don't go away:

    • Stomach pain or nausea
    • Headache
    • Dizziness
    • Swelling of the hands, feet, or midsection
    • Flatulence or gas
    • Feeling like your bowel isn't completely empty
    • Feeling like you need to empty your bowel urgently

    Serious Side Effects

    Tell your doctor immediately if you experience any of the following serious side effects:

    • Diarrhea that's watery or bloody
    • Fever
    • Signs of an allergic reaction, which may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat

    Warnings and Precautions

    This medicine, and the generic versions, isn't effective for all forms of traveler's diarrhea. Your healthcare provider will decide if this medication is right for you.

    Before taking, tell your doctor if you have:

    • Diarrhea with fever
    • Watery or bloody diarrhea
    • Liver disease
    • Allergies to any medications

    This drug won't treat viral infections such as the common cold or flu.

    Call your physician if your symptoms don't improve or worsen after 24 hours.

    Antibiotics such as this medication may increase your risk of developing Clostridium difficile-associated diarrhea, a serious form of infectious colitis caused by C. diff bacteria.

    Tell your doctor if your diarrhea continues after you stop using this drug.

    Take this medicine for the entire amount of time that your doctor prescribes it. Your symptoms might improve before your infection clears.

    Don't give to a child who is younger than 12.


    It's not known whether this medicine will harm an unborn baby.

    Tell your doctor if you're pregnant or might become pregnant before using this medicine.

    It's also uncertain if the drug passes into breast milk or could hurt a breastfeeding baby. You shouldn't breastfeed while taking Rifaximin.

    Interactions with this medication

    Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking before taking, especially:

    • Antifungal medicines such as Sporanox (itraconazole) or Nizoral (ketoconazole)
    • Heart or blood pressure medicines such as Capoten (captopril), Cardizem (diltiazem), Cordarone (amiodarone), Coreg (carvedilol), Covera-HS (verapamil), Multaq (dronedarone), Plendil (felodipine), Quinidex (quinidine), or Ranexa (ranolazine)
    • Kaletra (lopinavir and ritonavir)
    • Sandimmune (cyclosporine)
    • Other antibiotics such as Z-Pak (azithromycin), Biaxin (clarithromycin), or E-Mycin (erythromycin)

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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