Saphris (Asenapine)

Saphris (Asenapine) Medication Information

Uses

Saphris is an atypical antipsychotic that is used to treat schizophrenia and bipolar disorder. 

Dosage

The tablets are available in several different strengths:

• 2.5 mg
• 5 mg
• 10 mg

Side Effects

The most common side effects of Saphris include:

• Nausea
• Dizziness
• Tremor
• Parkinsonism
• Akathisia
• Somnolence

Speak with your doctor for a full list of side effects that apply to you if you are taking Saphris.

Precautions

Saphris can cause movement disorders that in some cases are not reversible. If you notice movements that are unvoluntary report them to your doctor right away.

Saphris, like other antipsychotics can cause an increase in blood sugar, which can lead to diabetes, or worsening of glucose control in those who have diabetes. 

In elderly patients with dementia, Saphris can cause cardiovascular events which can lead to death.

Interactions

The most common drug interaction with Saphris included:

• Alcohol
• Antihypertensive medications
• Levodopa/carbidopa
• Cimetidine
• Clozapine
• Fluoxetine
• Paroxetine

Speak with your doctor for more information and before starting a new medication with Saphris. 

Storage

Store at room temperature (68-77ºF). 

Pharmacist Tips

• Saphris can cause a drop in blood pressure with posture changes, especially when initiating treatment. 
• Saphris can affect motor movement, if changes occur let your doctor know immediately. 
• When taking Saphris, eating and drinking should be avoided for at least 10 minutes following taking the tablet. 

Asenapine FAQs

Does Saphris work immediately?

It can take up to 6 weeks to see the full effect of Saphris.

How does Saphris make you feel?

Some of the common side effects seen with Saphris include dizziness, drowsiness, numbness of the mouth, and weight.

What happens if you stop taking Saphris?

If you stop taking Saphris, you can experience withdrawal symptoms like nausea, vomiting, headache, dizziness, and fever. 

Can you take Saphris as needed?

No, Saphris can not be taken as needed. 

Does Saphris help you sleep?

One of the most common side effects with Saphris is drowsiness, so it can help you sleep.

Related Drugs

• Abilify
• Geodon
• Invega
• Latuda
• Risperdal
• Seroquel
• Seroquel XR
• Zyprexa

Reference:

Saphris {package insert}. Irvine, CA: Allergan USA, Inc.; 2017.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022117s020s021lbl.pdf