Dexilant (Dexlansoprazole)

(℞) Prescription Required

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    Dexilant 60mg

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    Dexilant (Dexlansoprazole) Dosage and Side Effects

    Dexilant is used to reduce acid production and therefore help treat acid reflux and gastroesophageal reflux disease. It is available in both 30mg and 60mg capsules which are manufactured by Takeda.

    Proper Use of this medication

    Once you begin taking DEXILANT, don’t stop taking it or change the dose without first consulting your doctor.

    The recommended dose of DEXILANT for those with erosive esophagitis is 60 milligrams (mg) once a day for up to eight weeks, and 30 mg once a day to maintain the healing thereafter. If you have liver problems, your doctor may adjust this dose.

    The recommended dose for those with GERD-associated heartburn is 30 mg once a day for four weeks.

    You can take DEXILANT with or without food, but if your symptoms occur after a meal, your doctor may tell you to take it before the same meal to get the best results. Don’t crush the capsule or chew it, just swallow it.

    In the event you have problems swallowing, open the capsule and sprinkle the contents into one tablespoon of applesauce and swallow it right away without chewing it. Never prepare the mixture ahead of time, since it may destroy the drug’s effectiveness.

    Ask your doctor for detailed instructions if you are using a syringe or if you have a stomach tube.

    It’s best to take antacids 30 to 60 minutes before DEXILANT. If you are using sucralfate (Carafate), take DEXILANT at least 30 minutes beforehand.

    If you believe you may have overdosed on DEXILANT go to the emergency room right away or contact a poison control.

    If you miss a dose of DEXILANT, take it as soon as you remember. If it’s almost time for your next dose, wait until your next schedule dose. Don’t “double up” to make up for your missed dose.

    Warnings and Precautions

    DEXILANT is designed to treat those 18 and over. It’s unknown if this drug is safe or effective in those under 18.

    DEXILANT can cause a serious allergic reaction. If you are using DEXILANT and develop a rash, throat tightness, difficulty breathing, or notice that your face is swelling, you need to let your doctor know right away.

    DEXILANT may increase your risk of severe diarrhea. Let your physician know immediately if you have stomach pain, a watery stool, or a fever that doesn’t go away.

    Taking multiple daily doses of a proton pump inhibitor like DEXILANT for a year or longer, may increase your risk of hip, wrist, or spine fractures. In addition, people who take this medicine may experience low magnesium levels.

    If your heartburn is accompanied by unexplained weight loss, lightheadedness, sweating or dizziness as well as chest, jaw, arm and shoulder pain — especially in conjunction with shortness of breath or unusual sweating — see your doctor right away.

    Be sure to tell your doctor if you have a history of liver disease. You should also mention any products you are taking that contain iron, ketoconazole, tacrolimus or methotrexate, as well as drugs like ampicillin (Principen), atazanavir (Reyataz), erlotinib (Tarceva) and digoxin (Digox and Lanoxin).

    If you are currently using warfarin (Jantoven or Coumadin) and DEXILANT together, you may need to be monitored closely since serious problems could occur.

    It’s unknown how this medication affects pregnant or breastfeeding women, so tell your doctor if you are pregnant or breastfeeding or plan to become pregnant or breastfeed.

    Side Effects

    Common Side Effects of DEXILANT

    • Diarrhea
    • Stomach pain
    • Nausea
    • Vomiting
    • Gas

    Serious Side Effects of DEXILANT

    If you are taking DEXILANT and have symptoms like chest pain, fast or pounding heartbeats, severe stomach pain, or worsening heartburn, call your doctor immediately.

    Other problems that require immediate attention:

    • Low magnesium levels signaled by dizziness
    • Confusion
    • Jerky muscle movements
    • Muscle cramps or weakness
    • Irregular heartbeats
    • Feeling jittery or limp
    • Cough or choking feeling
    • Seizures

    Get emergency help right away if you have hives, difficulty breathing, or swelling of your face, lips, tongue, or throat since these could be signs of a severe allergic reaction.

    Interactions with this medication

    One substance that could interact with DEXILANT is methotrexate (Trexall), particularly if you are using high doses.

    Some medications require stomach acid to work properly and DEXILANT decreases your stomach acid, so it could change the way your other medicines work. Products that fall into this category include:

    • Itraconazole (Onmel, Sporanox)
    • Ketoconazole (Xolegel, Extina, Nizoral)
    • Posaconazole (Noxafil)
    • Ampicillin (Principen)
    • Atazanavir (Reyataz)
    • Erlotinib (Tarceva)
    • Nelfinavir (Viracept)
    • Rilpivirine (Edurant)

    Do not use medications containing lansoprazole such as lansoprazole (Prevacid) while taking DEXILANT since the two are very similar.

    If you are undergoing medical tests, be sure the laboratory technician and your doctor are aware of the fact that you are taking DEXILANT, since it could cause false test results.

    DEXILANT should be accompanied by lifestyle and dietary changes, including eating smaller portions and avoiding fatty, spicy, or acidic foods as well as chocolate, mint, coffee, and other caffeinated beverages, carbonated drinks, and alcohol. Quitting smoking is also advised.

    In addition, it’s recommended that you elevate the head of your bed to relieve the symptoms of GERD.

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.