Crestor vs. Lipitor: The Differences Explained

Category: Prescription Related Questions


Posted on November 17, 2023

Scott is passionate about health and wellness, and enjoys writing on various topic surrounding these fields. Scott lives in Seattle and spends his free time restoring old furniture and playing pickleball with his friends.

crestor vs lipitor

High cholesterol has been dubbed the "silent killer" since you can't feel you have it, and it shows no symptoms. Not until it's too late, that is. 

That's why getting an annual blood test and physical check-up is so important. Once you know you have high cholesterol, managing it is a critical aspect of cardiovascular health. 

Statins like Crestor (rosuvastatin) and Lipitor (atorvastatin) are commonly prescribed medications for this purpose. Both belong to the class of statins, but they have some differences that may influence the choice of medication for individuals.

Below, we'll explore the distinctions between Crestor vs Lipitor, shedding light on their similarities, unique characteristics, and considerations for cholesterol management.

1. Mechanism of Action

Crestor and Lipitor both work by inhibiting HMG-CoA reductase. This is an enzyme involved in cholesterol synthesis in the liver.

By blocking this enzyme, both medications reduce the production of cholesterol and promote the removal of LDL cholesterol from the bloodstream. However, there are differences in their potency and the specific ways they interact with the body.


Crestor is known for its high potency, meaning that lower doses of Crestor may achieve the same cholesterol-lowering effects as higher doses of other statins. It primarily targets LDL cholesterol but also has some impact on triglycerides and raises HDL cholesterol levels.


Lipitor is also a potent statin with a similar mechanism of action. It effectively reduces LDL cholesterol levels and has a moderate impact on triglycerides and HDL cholesterol.

2. Potency and Dosage

When you receive a prescription for either statin, you will also receive a recommended dosage range for each medication. They are very different for each statin and should be paid attention to.


Crestor is considered a highly potent statin. The recommended starting dose is often lower compared to other statins. Common doses range from 5 mg to 40 mg. Higher doses are reserved for individuals with specific cholesterol management needs.


Lipitor is also a potent statin but is generally considered slightly less potent than Crestor. Common doses of Lipitor range from 10 mg to 80 mg. The choice of dosage depends on the individual's cholesterol levels and overall health.

3. Effectiveness in Lowering Cholesterol

Both Crestor and Lipitor are effective in lowering cholesterol levels. However, studies have suggested some differences in their cholesterol-lowering capabilities.


Clinical trials have demonstrated that Crestor is highly effective in reducing LDL cholesterol levels. It is particularly known for its ability to achieve significant reductions in LDL cholesterol, even at lower doses.


Lipitor is also effective in lowering LDL cholesterol levels. However, studies have indicated that Crestor may have a slightly greater impact on LDL reduction, especially at higher doses.

4. Side Effects and Safety Profile

There are significant differences in the two statins' safety profiles and potential side effects. Make sure to learn about these differences from your doctor when consulting about statins.


Common side effects of Crestor include muscle pain, joint pain, and digestive issues. It has been associated with a slightly higher risk of developing diabetes compared to some other statins.

Crestor is generally considered safe. Individuals with liver problems or those taking certain medications should exercise caution.


Lipitor shares common side effects with Crestor, including muscle pain and digestive issues. Like Crestor, Lipitor has been associated with a risk of developing diabetes, though the overall risk is generally considered low. It is important for individuals with liver issues or those taking specific medications to consult their healthcare provider.

5. Cost and Availability

The cost and availability of medications can be significant factors in treatment decisions. You don't want the cost of your medication to become a deterring factor in getting better.


Crestor is available as a generic medication, rosuvastatin, which is generally more affordable than the brand-name version. Generic medications are often a cost-effective option for individuals looking to manage their cholesterol levels.


Lipitor is also available as a generic medication, atorvastatin. This makes it a more budget-friendly choice for those concerned about the cost of their medication. The availability of generic versions has contributed to increased affordability.

6. Drug Interactions

Both Crestor and Lipitor may interact with other medications. It's crucial to be aware of potential drug interactions to ensure safe and effective cholesterol management.


Crestor can interact with certain medications, including some blood pressure medications and antifungal drugs. It's important to inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.


Lipitor may interact with various medications, including certain antibiotics, antifungal medications, and drugs used to treat heart conditions. It's essential to disclose your complete medication list to your healthcare provider to prevent potential interactions.

7. Individual Response and Tolerability

Individual responses to medications can vary. Factors such as genetics, overall health, and lifestyle can influence how well a person tolerates a particular statin.

Just because your friend or loved one did well on a particular statin doesn't mean that you will have a good reaction as well. It's always important to consult with a medical professional before starting any long-term medication regimen. 

Crestor vs Lipitor - Which One Will You Choose?

The risk of heart attacks goes up with a high cholesterol level. That's why you need to do all you can to reduce it. 

Most people have to pick between Crestor vs Lipitor when making this important decision. The more information you have at hand, the easier it will be for you to choose.

In the United States, the prices of medications can be prohibitively expensive. If you are looking for a cheaper source, then consider PricePro Pharmacy. It's a Canadian online pharmacy that offers medication at discounts. 

Order with us today and ease your financial worries a bit. 


Sorrentino, S. (2023, September 18). National Cholesterol Education Month: Beware the "Silent Killer." Whittier Street Health Center.

S. (2023, June 4). What Medications Can You Order From a Canadian Online Pharmacy? PricePro Pharmacy.

Research, C. F. D. E. A. (2021, March 16). Generic Drugs: Questions & Answers. U.S. Food And Drug Administration.

S. (2023, September 8). Easy Prep, Big Reward: 9 Heart Healthy Recipes You're Sure to Love. PricePro Pharmacy.

How to Order Prescription Drugs Online from Canada | PricePro Pharmacy. (2021, June 14). PricePro Pharmacy.

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