Rexulti (Brexpiprazole)
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Medication information written by Dr. Patricia Weiser, Pharm.D
Updated - May 3, 2024
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Find Affordable Options for Your Rexulti Prescription
Finding low-cost medications at your local pharmacy can be a challenge. You shouldn't have to decide whether you fill your Rexulti prescription. Learn how you can save money on your monthly medication costs by filling your order with PricePro Pharmacy.
How to Save Money on Your Rexulti Prescription
Always Low Prices
While we're able to serve customers in Canada, the United States, and beyond, our pharmacy is based in Canada. Canadian citizens have access to universal healthcare and we can pass those benefits onto our customers regardless of their citizenship.
The Canadian Federal Government continually monitors the price of drugs and medications to ensure they're affordable. If the government deems them to be too expensive, pharmacies aren't able to sell those products. As a result, you'll find significantly reduced medications in our online store than you would find in your local pharmacy.
Generic Rexulti
Many patients opt for generic medications to save money. Generic prescriptions tend to be significantly less expensive than the name-brand alternative. Rexulti is a brand-name medication and at this time, there is no generic option available.
Rexulti Coupon
PricePro Pharmacy offers several coupon options to our customers. Use the code REX20 in your cart at checkout to save $20 on your Rexulti prescription.
We also offer two different coupons for your first order. You can save $10 or $20 depending on how much you spend on your order. Continually check our coupon page for new discounts that might become available.
Price Matching
We invite you to contact our customer support team if you find another pharmacy that has Rexulti in stock for a cheaper price than we do. We're happy to match or beat their price. Keep in mind that we can't match sales or special discounts the other pharmacy might be running.
FAQs
When Does Rexulti Start Working?
Most patients start to notice changes in their behavior, thoughts, and mood around one to two weeks after they start taking Rexulti. You will likely need to take the medication for around six to eight weeks before you begin noticing major changes.
Your provider will typically start you on a lower dose of Rexulti so you don't experience a lot of side effects. Your dosage may get slowly raised over the next few weeks until you reach the recommended dosage.
When Should I Take Rexulti?
There's no strict recommendation on whether you should take Rexulti in the morning or at night. The best time of day to take medication is when you're likely to remember. You want to take it at the same time each day.
You may want to start taking it at night if you start to experience tiredness or dizziness after taking your medication. Ask your doctor about any concerns you might have.
Keep Your Medication Cost Low With PricePro Pharmacy
Our team is available to provide you with more Rexulti information or assist you with processing your order. We make it easy to get your prescription filled. Get started filling your Rexulti prescription online or give us a call so we can walk you through it.
Rexulti (Brexpiprazole) Medication Information
Uses
Rexulti (brexpiprazole) is a prescription medication used to treat the following mental health disorders in adults:
- Major depressive disorder (MDD, commonly known as depression)
- Schizophrenia
MDD is a common but serious mood disorder that affects how you think, feel, and handle daily activities. If you experience at least two weeks of some of the following symptoms, you may have depression:
- Persistent sad or anxious mood
- Feelings of hopelessness, guilt, or worthlessness
- Loss of interest in activities once enjoyed
- Decreased energy levels or irritability
- Moving or talking slowly
- Trouble with concentration, memory, or making decisions
- Difficulty sleeping or oversleeping
- Changes in appetite
- Weight loss or gain
- Thoughts of death or suicide
Not everyone with depression experiences every symptom listed. If you think you have depression, speak with your healthcare provider about treatment options such as Rexulti. Rexulti (brexpiprazole) may be used along with other antidepressant medications and therapy.
Rexulti is also used to treat schizophrenia, a serious mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may show an altered sense of reality, abnormal thinking, and unusual behaviors. They may experience the world differently, which is often distressing to their friends and family. Medications such as Rexulti (brexpiprazole) may reduce the severity of schizophrenia symptoms.
Dosage
Rexulti is an oral tablet that comes in several strengths:
- 0.25 milligrams (mg)
- 0.5 mg
- 1 mg
- 2 mg
- 3 mg
- 4 mg
Rexulti is usually prescribed once daily. Be sure to take Rexulti according to your healthcare provider’s directions.
Precautions
Rexulti may not be safe for everyone. Be sure to discuss your past and current health conditions with your doctor. If you have any of the following conditions, they may still want you to take Rexulti if they feel that the benefits of this medication outweigh your risks, but they’ll likely monitor you more carefully.
- Dementia
- High cholesterol levels
- High blood sugar
- Seizures
- Low levels of white blood cells
- Low or high blood pressure
- Heart problems or past stroke
- Pregnant or plans to become pregnant
- Breastfeeding or plans to breastfeed
Side Effects
Like all medications, Rexulti may cause side effects. The most common side effects of Rexulti are mild, but severe side effects are also possible.
Common side effects may include:
- Weight gain
- Uncontrolled movements, such as fidgeting or rocking
- Restlessness (a frequent urge to move around)
Notify your doctor immediately if you experience the following symptoms of a rare but severe reaction called Neuroleptic Malignant Syndrome. These may include:
- High fever
- Stiff muscles
- Confusion
- Sweating
- Fast pulse or blood pressure
For more information about the side effects of Rexulti, talk to your doctor or pharmacist.
Interactions
Some potential drug interactions might cause harmful effects with Rexulti. A few examples include:
- Clarithromycin
- Fluoxetine
- Ketoconazole
- Paroxetine
- St. John’s Wort, an herb
- Rifampin
Talk to your doctor or pharmacist before taking any medications (including prescription and over-the-counter products) or herbal supplements with Rexulti.
Storage
Store Rexulti at room temperature between 68°F and 77°F (20°C and 25°C).
Pharmacists Tips
- If you miss a dose of Rexulti, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Do not take two doses of Rexulti at the same time.
- Take Rexulti exactly as prescribed by your doctor. Do not change your dose or stop taking this medication without first talking to your doctor.
Rexulti FAQs
What should I avoid while taking Rexulti?
Avoid driving or operating heavy machinery until you know how Rexulti affects you. Rexulti may make you feel sleepy. You should also take precautions so that you don’t become dehydrated or overheated while taking Rexulti. Do not over-exercise, limit your time in hot or humid conditions, and drink plenty of fluids.
Is it true that Rexulti can cause unusual behaviors, and what can I do if I experience them?
Some people taking Rexulti have had unusual compulsive behaviors, such as gambling, binge eating, impulsive spending, and sexual urges. If you or your family members notice that you have unusual urges or actions, talk to your doctor. They may advise you to change your dose or stop taking Rexulti.
Can Rexulti make me have suicidal thoughts?
Both antidepressant medications and mental illnesses can cause suicidal thoughts or actions. Suicidal thoughts are considered a rare side effect of Rexulti but are more likely at the start of treatment or after your dose has been changed. Pay close attention to any sudden changes in your mood, behaviors, or thoughts. Call your doctor right away if this occurs.
Related Drugs
References:
- Rexulti Prescribing Information. Rockville, MD. Otsuka America Pharmaceutical, Inc.; 2020. https://otsuka-us.com/sites/g/files/qhldwo2286/files/media/Rexulti-PI.pdf, Accessed February 14, 2021.
- National Institute of Mental Health. Depression; 2018. https://www.nimh.nih.gov/health/topics/depression/index.shtml, Accessed February 14, 2021.
- National Institute of Mental Health. Schizophrenia; 2020. https://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml, Accessed February 14, 2021.

Author: Dr. Patricia Weiser, PharmD
Patricia Weiser, PharmD, is a licensed pharmacist and medical writer. She has clinical experience in community and hospital pharmacy. Patricia is a 2007 graduate of the University of Pittsburgh. She resides in Pennsylvania with her husband and two daughters.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

