7 Common Side Effects of Domperidone

Category: Prescription Related Questions


Posted on June 29, 2022

Scott is passionate about health and wellness, and enjoys writing on various topic surrounding these fields. Scott lives in Seattle and spends his free time restoring old furniture and playing pickleball with his friends.


In a recent year, Americans made 37.2 million doctor's office visits for stomach problems. 5.9% of all adults have stomach ulcers.

One of the drugs doctors prescribe for digestive issues is domperidone. Domperidone is an antiulcer drug used to treat gastroesophageal reflux disease.

It's great that the drug helps individuals manage their gastrointestinal disorders. But domperidone has common side effects that patients need to know about.

Are you taking domperidone and wondering about the possible side effects? If so, this is the perfect guide for you. Keep on reading to learn more about the common side effects of domperidone.

What Is Domperidone? 

You can buy domperidone from an online pharmacy in Canada. It's available as a generic drug and under the brand name Motilium. It is a prescription medication used to treat gastroparesis (abnormal stomach emptying).

Gastroparesis often accompanies gastritis and diabetes. It can also reduce stomach pain in patients undergoing palliative care. Doctors may prescribe it to patients suffering the side effects of Parkinson's medication.

Domperidone helps the stomach to empty faster. This reduces nausea and acid reflux symptoms. 

What Is the Recommended Dosage?

Your doctor will prescribe the correct dosage for you. This will vary from person to person.

You often take this medication before meals. Two tablets, three to four times per day is a common dosage. Domperidone is not usually prescribed for a long time.

How Domperidone Works

Domperidone is a type of dopamine antagonist. Dopamine helps to send signals to the brain. It is an important component of our gastric health.

It helps to regulate the transit of the contents of the gastrointestinal tract. When all is working well, dopamine prevents food from moving through too fast.

Dopamine antagonists like domperidone help to regulate dopamine levels. They turn down dopamine activity and this helps to reduce nausea and stop vomiting. They can also treat regurgitation - acid reflux.

Some doctors may prescribe domperidone to increase breast milk supply in breastfeeding women. It is not licensed for this in the United States. 

Drug Interactions

Domperidone can interact with other drugs. Tell your doctor if you are taking any of the following drugs:

  • Bepridil
  • Cisapride
  • Darunavir
  • Dronedarone
  • Fluconazole
  • Ketoconazole
  • Levoketoconazole
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

You are also advised against taking domperidone in conjunction with the following medications. If your doctor feels you need both, it's very important to remain under their supervision. Follow their instructions on how to take them.

  • Abametapir
  • Abiraterone Acetate
  • Alfuzosin
  • Alprazolam
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Amprenavir
  • Anagrelide
  • Apomorphine
  • Aprepitant
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Bicalutamide
  • Boceprevir
  • Buprenorphine
  • Buserelin
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Delavirdine
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Donepezil
  • Doxepin
  • Droperidol
  • Ebastine
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Famotidine
  • Fedratinib
  • Felbamate
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Fosnetupitant
  • Fosphenytoin
  • Fostemsavir
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Ginkgo Biloba
  • Glasdegib
  • Goldenseal
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Isoniazid
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Lithium
  • Lofexidine
  • Lopinavir
  • Lumefantrine
  • Macimorelin
  • Mefloquine
  • Methadone
  • Metronidazole
  • Miconazole
  • Mifepristone
  • Mirtazapine
  • Mizolastine
  • Mobocertinib
  • Moxifloxacin
  • Nafarelin
  • Nefazodone
  • Nelfinavir
  • Netupitant
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Pimavanserin
  • Pipamperone
  • Pitolisant
  • Ponesimod
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranitidine
  • Ranolazine
  • Ribociclib
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Selegiline
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Ticagrelor
  • Tolterodine
  • Toremifene
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vorinostat
  • Zuclopenthixol

Your doctor may tell you to avoid certain foods and drinks. This includes grapefruit juice.

Let your doctor know if you are allergic to domperidone. Also if you have bowel or stomach issues, brain tumors, or liver disease. 

Seven Common Side Effects of Domperidone

Domperidone is generally safe, but there are some medication side effects to consider. First, never take domperidone without talking to your doctor and obtaining and prescription. It could be dangerous for certain groups of people and may interact with other drugs.

Domperidone is not currently approved for marketing in the United States. 

Symptoms of Domperidone Overdose

If you have any of the following symptoms seek immediate medical help:

  • Speech difficulties
  • Confusion/disorientation
  • Dizziness
  • Irregular heartbeat
  • Light-headedness or fainting
  • Loss of muscle control
  • Loss of balance

People who have overdosed on domperidone may sometimes experience swelling of the mouth. In rare cases, they may experience a fast or irregular heartbeat or swelling of the face or lower limbs.

More common side effects include:

1. Dry Mouth

Dry mouth is the most common side effect of domperidone. This may be uncomfortable but is not serious for most people.

2. Headaches

Some people may find they experience more headaches after taking domperidone. If these persist or become severe, talk to your doctor immediately.

3. Diarrhea and Abdominal Cramping

Domperidone treats gastric discomfort. But some people may experience side effects of diarrhea and cramping. Talk to your doctor if this persists or gets worse. 

Serious Side Effects

The following are more serious side effects. Talk to your doctor immediately if you experience any of them.

4. Mood/Mental State Changes

Talk to your doctor if you begin to suffer from:

  • Low mood
  • Nervousness
  • Irritability

Do not change your dosage without talking to your doctor. 

5. Fatigue and Weakness

Most people will not experience a loss of energy when taking domperidone. If you do, talk to your doctor.

6. Changes in Periods or Sexual Ability

It is rare for domperidone to impact the reproductive system. But if you experience changes, talk to your doctor.

7. Changes in Breasts

Both men and women may experience changes in their breasts while taking domperidone. For women, this includes breast milk flowing from the nipples. 

Men may experience swelling of their breasts. Both men and women may experience pain in the breast area. 

The Bottom Line: The Side Effects of Domperidone

Are you experiencing gastric discomfort and acid reflux? Domperidone may be a good prescription medication for you.

Most users experience few side effects and the serious side effects are rare. Talk to your doctor about prescription drugs that could help you.

At PricePro Pharmacy, we supply prescription drugs at great prices. Click here to order Motilium (domperidone) or call us today at 1-855-776-0079.







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