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Motilium (Domperidone) Medication Information
Motilium can be prescribed for the short-term treatment of diabetic gastroparesis or nausea and vomiting that’s not treatable with other medications.
Diabetic gastroparesis is a long-term complication of diabetes where the gastrointestinal (GI) nerves become damaged from high levels of blood sugar. Motilium can be prescribed once you have gotten underlying diabetes under control with diet, exercise, and medication.
Domperidone works by blocking dopamine receptors in the GI tract. Dopamine receptors are involved in the contraction of muscles in the stomach and intestines. By blocking these receptors, Motilium improves the movement of food through the GI tract.
Domperidone is not approved by the Food and Drug Administration (FDA) for use or sale in the United States. However, it can be obtained by certain pharmacies and physicians who have completed the required paperwork for an expanded access Investigational New Drug application (IND).
The usual dose is 10 mg by mouth up to three times daily before meals. Take Motilium 15-30 minutes before meals.
The maximum dose of Motilium is 30 mg per day.
For acute nausea and vomiting, Motilium should be used for a maximum of one week.
For diabetic gastroparesis, Domperidone should not be used for longer than four weeks.
Common side effects of Motilium can include:
- Breast enlargement
- Breast pain
- Breast tenderness
- Irregular menstruation
- Loss of libido
Motilium is contraindicated in people with heart rhythm problems.
Motilium can cause gynecomastia (painful breast enlargement) in men and women. Your doctor should monitor your levels of prolactin if you take Motilium for an extended period.
Tell your doctor if you have a history of liver or kidney problems before starting Motilium.
Motilium has many potential drug-drug interactions. Tell your doctor and pharmacist about all of the drugs you are taking before starting Motilium. Common interacts include:
Store Motilium at or near room temperature between 15°C and 30°C.
- Make sure to take Motilium 15-30 minutes before meals for the full effect.
- Do not double up a missed dose. If a dose is missed, skip it and take the next scheduled dose.
- Do not drink grapefruit juice while taking Domperidone.
Can I take Motilium while pregnant or breastfeeding?
It is not recommended to take Motilium while pregnant or breastfeeding. Discuss the risks and benefits with your doctor.
Will Motilium affect my ability to drive?
Motilium can cause dizziness and drowsiness in some people. Do not drive or use heavy machinery until you know how Motilium affects you.
How long does it take Motilium to work?
For nausea and vomiting, it will start working in 1-3 days. For gastroparesis, it will start working in 1-2 weeks.
- Motilium [package insert]. Australia: Janssen; 2017.
Author: Dr. Conor Sheehy, PharmD, BCPS
Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics. He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.