Motilium (Domperidone)

(℞) Prescription Required - Domperidone is the Generic Equivalent of Motilium

    Motilium (Domperidone) Dosage and Side Effects

    Domperidone (dom-PER-i-done) is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

    Warnings and Precautions

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For domperidone the following should be considered:

    Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to domperidone.

    Pregnancy—Pregnancy—domperidone has not been studied in pregnant women. However, domperidone has not been shown to cause birth defects or other problems in animal studies.

    Breast-feeding— Breast-feeding—Domperidone passes into the breast milk, but it is not known if domperidone will cause unwanted effects in the newborn. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

    Children—Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of domperidone in children with use in other age groups.

    Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of domperidone in the elderly with use in other age groups.

    Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your doctor or pharmacist if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine, especially:

    • Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegilene [e.g., Eldepryl], tranylcypromine [e.g., Parnate])

    Other medical problems—The presence of other medical problems may affect the use of domperidone. Make sure you tell your doctor if you have any other medical problems, especially:

    • Bleeding from the stomach or other problems involving the bowels
    • Pituitary (brain) tumor
    • Liver disease
    • Medicine sensitivity to domperidone

    Interactions with this medication

    There may be an interaction between domperidone and any of the following:

    • alfuzosin
    • amantadine
    • amiodarone
    • anticholinergics (e.g., benztropine, dimenhydrinate, diphenhydramine, oxybutinin)
    • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
    • antipsychotic medications (e.g., haloperidol, risperidone, quetiapine)
    • apomorphine
    • aprepitant
    • "azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, voriconazole)
    • bicalutamide
    • boceprevir
    • bosutinib
    • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
    • chloral hydrate
    • chloroquine
    • cisapride
    • conivaptan
    • cyclosporine
    • dasatinib
    • disopyramide
    • dronedarone
    • famotidine
    • fingolimod
    • flecainide
    • formoterol
    • fusidic acid
    • galantamine
    • grapefruit juice
    • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
    • HIV protease inhibitors (e.g., indinavir, atazanavir, lopinavir, nelfinavir, ritonavir)
    • imatinib
    • indapamide
    • lapatinib
    • lithium
    • macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
    • maprotiline
    • methadone
    • metronidazole
    • mifepristone
    • monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine, nefazodone)
    • nilotinib
    • octreotide
    • oxytocin
    • paliperidone
    • pazopanib
    • peginterferon Alfa-2b
    • pentamidine
    • pimozide
    • procainamide
    • propafenone
    • romidepsin
    • quinidine
    • quinine
    • quinolone antibiotics (e.g., ciprofloxacin, moxifloxacin, levofloxacin)
    • selective serotonin reuptake inhibitors (SSRIS; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
    • serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
    • simeprevir
    • sotalol
    • sulfamethoxazole
    • sunitinib
    • tacrolimus
    • tamoxifen
    • telaprevir
    • tetrabenazine
    • tetracycline
    • thioridazine
    • trazodone
    • tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
    • trimethoprim
    • vardenafil
    • venlafaxine
    • vorinostat

    If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

    • stop taking one of the medications,
    • change one of the medications to another,
    • change how you are taking one or both of the medications, or
    • leave everything as is.

    An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

    Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also, tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

    Proper Use of this medication

    Dosing—The dose of domperidone will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of domperidone.If your dose is different, do not change it unless your doctor tells you to do so.

    The number of tablets of that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking domperidone.

    • For oral dosage form (tablets):
      • Treatment of gastrointestinal motility disorders:
        • Adults—10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily.
      • Nausea and vomiting:
        • Adults—20 milligrams (mg) three to four times daily.

    Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    Storage—To store this medicine:

    • Keep out of the reach of children.
    • Store away from heat and direct light.
    • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
    • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

    Side Effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Symptoms of overdose

    Get emergency help immediately if any of the following symptoms of overdose occur

    Difficulty in speaking; disorientation; dizziness; fainting; irregular heartbeat; light-headedness; loss of balance or muscle control

    Check with your doctor immediately if any of the following side effects occur:

    Less common

    Loss of balance or muscle control; swelling of the mouth


    Fast, irregular, pounding, or racing heartbeat or pulse; swelling of face, hands, lower legs, or feet

    . Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

    Less common

    Breast milk flowing from the nipple; dry mouth; swelling of the breast in the male; headache; hives; hot flashes; itching of skin; itching, redness, pain, or swelling of eye; menstrual irregularities; pain in the breast


    Change in need to urinate; change in appetite; constipation; diarrhea; burning, difficult, or painful urination; difficulty in speaking; dizziness; drowsiness; heartburn; irritability; lack or loss of strength; leg cramps; mental dullness; nervousness; palpitations; sluggishness; stomach cramps; thirst; tiredness; weakness

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.