Xiidra’s Cost Explained: Why is This Dry Eye Medication So Pricey?

Category: Drug Information

Author

Posted on November 3, 2025

Scott is passionate about health and wellness, and enjoys writing on various topic surrounding these fields. Scott lives in Seattle and spends his free time restoring old furniture and playing pickleball with his friends.



Xiidra is expensive because it’s a prescription-only dry eye medication with specialized ingredients, complex manufacturing, and limited generic alternatives driving up its cost.

Dry eye disease (DED) is widespread in America, with the American Academy of Ophthalmology (AAO) offering statistics suggesting that over 16 million Americans have it. Such prevalence makes it one of the most widespread eye health problems nationwide.

If you’re struggling with dry eye, Xiidra is a popular prescription medication that can help manage your symptoms. However, in general, the cost of Xiidra tends to be higher than that of many alternative medications.

The high price tag might leave you wondering, “Why is Xiidra so expensive?” In this guide, we’ll explore Xiidra’s cost factors and budget-friendly ways to treat your eyes.

Why Are Xiidra Eye Drops So Expensive?

Xiidra (ophthalmic Lifitegrast solution) is currently only available as a brand-name drug. Brand-name drugs tend to be expensive because of their high initial costs. These costs usually cover research and development (R&D), patenting, marketing, and branding.

Once the patent for a brand-name drug expires, other manufacturers can produce generic versions. These generic drugs have the same active ingredients and offer the same benefits as brand-name drugs. However, they don’t have the exact high development costs, allowing manufacturers to sell them at lower prices.

Since Xiidra doesn’t have a generic version yet, the price still reflects the costs associated with its development. As such, they’re often still expensive to buy.

Is Xiidra Available in Canada as Xiidra or Otherwise?

Xiidra is currently marketed by Health Canada and approved for the treatment of dry eye disease symptoms in adults. However, whether Xiidra is available at individual pharmacies may depend on local supply and distribution, even when it is marketed.

When visiting, discuss with your pharmacist whether they have stock and how fast they can usually turn around a supply to avoid disappointment.

Why Is Xiidra So Expensive?

The prices of Xiidra can differ significantly depending on various factors. These include your insurance coverage, any manufacturer rebates or coupons, and where you purchase your medication from. Here’s a lowdown on some commonplace variables that may influence how much you’ll pay:

Will Insurance Pay for Xiidra?

Whether or not you have insurance coverage is another crucial consideration. The cost of Xiidra is generally lower with insurance than without insurance.

Some insurance plans might cover a greater share of the cost of Xiidra, while others might cover a smaller share. Check with your insurance provider to see how much they will pay and what your out-of-pocket costs will be.

Your Treatment Plan

Several different factors can cause dry eyes, and every person’s condition is unique. A tailored treatment plan is crucial to ensure the best patient outcomes, as it considers your specific symptoms.

The length and frequency of your treatment are key factors in the Xiidra price. If your doctor prescribes Xiidra for an extended period, your costs will be higher compared to a shorter treatment plan. Also, the dosage and how often you need to use it will affect your total expense.

Availability of Generic Alternatives

The FDA’s Drug Competition Action Plan aims to increase the availability of generic drugs and lower the prices of brand-name drugs.

However, there are many reasons they may not have approved a generic version of a drug yet, including the need for additional testing. Equally, patent protections and litigation are common ways that drug companies can continue to control access to their pharmaceuticals.

In conclusion, generic versions of Xiidra aren’t available yet. When they do eventually become available, they may be less expensive while still providing similar effectiveness. This fact can significantly reduce the cost of Xiidra medication for users on a tight budget.

However, at present, we would like to warn you about those who claim to sell “generic Xiidra,” as there is no FDA-approved equivalent.

You might instead discuss lower-cost alternatives with your clinician. They may be able to match your circumstances with other drugs that have a similar effect, whether they require a prescription or not.

The Pharmacy You Use

Xiidra’s prices can vary between different pharmacies, even within the same area. Some pharmacies may offer discounts or have special pricing agreements that make Xiidra more affordable. Shopping around and comparing prices at different pharmacies is a good idea to find the best deal.

Tips to Save Money on the Cost of Xiidra 

Managing dry eyes shouldn’t break the bank. If the cost of Xiidra medication is a significant concern, you can take steps to reduce the financial burden. The following are a few practical ways to make expensive dry eye treatments more affordable:

Sign Up for Pharmacy Loyalty Cards

Many pharmacies offer loyalty cards or programs that can help you save money on prescriptions. These programs often provide discounts, cashback, or points that you can redeem for future purchases. It’s a simple way to reduce the cost of your medication over time without much effort.

Look for Coupons

Coupons can significantly lower the cost of Xiidra. Check the official Xiidra website for any available coupons or discounts. You can also look at third-party coupon websites or ask your pharmacy if they know of any current deals. These discounts can make a big difference in your overall medication expenses.

Consider Less Expensive Xiidra Alternatives

If Xiidra is too expensive, ask your doctor about cheaper brand-name alternatives. There might be other medications that can effectively treat your dry eyes without the high price tag.

Exploring branded drug alternatives can help you find a more affordable solution without sacrificing quality. However, these might not be an option if your doctor writes “do not substitute” on the prescription.

Buy Online

Buying Xiidra online can often be cheaper than purchasing it at a local pharmacy. Many online pharmacies offer competitive prices and discounts. Just make sure to use a reputable source to ensure you’re getting the genuine product.

Additionally, some online pharmacies may offer bulk purchase options, further reducing costs.

Get a 90-Day Supply of Xiidra

Purchasing a 3-month supply of Xiidra can often be cheaper than buying a monthly supply. Many pharmacies offer discounts for bulk purchases, which can lower your overall costs. Speak with your pharmacist about your options in this matter, as there may be limits on what you can source at one time.

This approach also means fewer trips to the pharmacy, saving you time and effort.

Find an In-Network Pharmacy

If you have insurance coverage, using a pharmacy in your network can lower your costs. Pharmacies outside your network might charge higher prices, and your insurance may not cover as much of the cost.

Seek Financial and Insurance Assistance

There are various financial assistance programs and insurance plans that can help cover the cost of Xiidra, including drug discount cards. Check if you qualify for any patient assistance programs offered by the manufacturer or non-profit organizations.

Additionally, review your insurance plan to see whether your provider offers better coverage for your medication needs. These resources can significantly reduce your out-of-pocket expenses.

Frequently Asked Questions

Is Xiidra Being Taken Off the Market Any Time Soon?

As Health Canada currently lists Xiidra as marketable, rather than discontinued or canceled, you can expect Xiidra to remain on the market. However, keep an eye on the page for more information on its status in the future.

Temporary shortages may occur, but they do not imply that Canada is removing it from the market permanently. If you have difficulty finding it, speak with your pharmacist about the options available to you. They may be able to recommend generic alternatives to many drugs or suggest other methods for you to source the pharmaceutical itself.

Is Xiidra a Steroid Eye Drop?

Lifitegrast, the active ingredient in Xiidra, is not a steroid. While it is an eye drop solution, it is a “lymphocyte function-associated antigen-1 antagonist”.

Lymphocyte: The white blood cells that boost inflammation.

Function-associated antigen: A protein on the cell that helps it stick to irritated tissue. In this case, to the eye’s surface.

Antagonist: A blocker.

As such, they block white blood cells’ ability to adhere to the surface of the eye, thereby preventing inflammation.

Is It Safe to Buy Meds From Canadian Pharmacies?

In Canada, Health Canada is a government department responsible for maintaining the health of Canadians and helping educate the country’s citizens on how to look after their health. They oversee many local regulatory authorities, such as provinces and territories, which in turn license pharmacies.

These licenses ensure that the pharmacies maintain strict standards, making them broadly safe to use. However, if you have concerns about specific pharmacies, you should report them to the relevant authorities so they can investigate the issue and reach a conclusion.

Maximize Your Prescription Cost Savings with PricePro Pharmacy 

Why is Xiidra so expensive? Well, this is a common question for people with dry eyes. Knowing the answer can help you manage your condition without breaking the bank.

Looking to save big on your prescriptions? Look no further than PricePro Pharmacy! Our network of trusted international pharmacies and Canadian partners allows you to save up to 80% on your US prescriptions.

Don’t wait! Order Xiidra online now.