Synvisc One (Hylan G-F 20)

(℞) Prescription Required

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Synvisc One 8mg/mL

Product of New Zealand
Manufactured by: Genzyme
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Synvisc One 8mg/mL
Product of New Zealand
Manufactured by Genzyme
Top Brand Choice
Top Generic Choice

Synvisc One 8mg/mL

Product of Canada
Manufactured by: Genzyme
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Synvisc One 8mg/mL
Product of Canada
Manufactured by Genzyme
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Synvisc-One (Hyaluronate) Medication Information


Synvisc-One is a hylan containing injection  that is used for osteoarthritic pain in patients that have responded unsuccessfully to analgesics and non-pharmacologic treatment. 


Synvisc-One comes  as a strength of 48mg/6ml. 

Side Effects

The most common side effects of Synvisc-One include:

  • arthralgia
  • joint effusion
  • arthritis 
  • arthropathy
  • injection site pain

Speak with your doctor for a full list of side effects that apply to you if you are taking the injection.


This medication should not be frozen or used if the package has been opened or damaged. It should be stored away from light in its original packaging. 

Caution should be exercised when using this injection in patients with lymphatic or venous stasis or lymphatic in the leg that will be receiving the injection. 

Synvisc-One has not been shown to be effective or safe other than osteoarthritis in the knee. 


There may be interactions with the COVID-19 vaccine, but there are no other known drug interactions with Synvisc-One. 


This medication should be stored at room temperature below  86°F and away from light. This medication should not be freezed. 

Pharmacist Tips

  • Patients should wait 48 hours post injection before participating in demanding activities such as sports or persistent weight-bearing activities. 
  • This medication is intended to be used immediately once it has been removed from packaging. 
  • Do not freeze this medication.
  • Avoid using the same syringe  to remove the synovial fluid and perform Synvisc-One injections.

Synvisc-One FAQs

How long does Synvisc-One last?  

Synvisc-One may provide relief of osteoarthritic knee pain up to 6 months.  


Is Synvisc-One a steroid? 

No, it is not a steroid. 


How quickly does Synvisc-One work?

Greatest relief from symptoms occur between 8-12 weeks after first injection.


Is Synvisc-One safe in pregnancy and breastfeeding?

There is not enough evidence to determine the safety and efficacy in patients that are pregnant or breastfeeding. 


Do Synvisc-One injections hurt? 

Synvisc-One injections may be painful, however they are typically tolerable. 


Related Drugs

Hyaluronate. Lexi-Drugs. Hudson, OH: Lexicomp, 2015. Updated July 27, 2015. Accessed March 3, 2021.

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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