Celebrex (Celecoxib)

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    Celebrex (Celecoxib) Dosage and Side Effects

    Celebrex, also referred to by its generic name, Celecoxib, is a COX-2 specific inhibitor and a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of inflammation, like pain and swelling in patients who suffer from arthritis, acute pain, and menstrual pain/discomfort.

    The drug works by blocking the enzymes in the body that produce prostaglandins, ultimately reducing pain and swelling. Celebrex is taken orally with a tall glass of water. It’s suggested that patients do not lie down for at least 10 minutes after taking Celebrex. For certain conditions like arthritis, it may take upwards of 2 weeks for Celebrex to deliver its full benefits, and is best taken when the first signs of pain occur.

    Warnings and Precautions

    As a precaution prior to beginning to take Celebrex, patients should discuss their medical history with their doctor. Of note, patients should divulge if they’re allergic to aspirin, other NSAIDs such as Ibuprofen, other COX-2 inhibitors, or have another medication allergies. Celebrex may contain inactive ingredients that can trigger allergic reactions and other medical issues. Celebrex can also cause stomach bleeding, which may be increased as a result of daily alcohol and/or tobacco use when combined with celecoxib.

    People with a medical history of asthma should discuss their medical history with their doctor or pharmacist as well, as should patients with a history of liver disease, stomach/intestine/oesophagus problems like bleeding,ulcers, and recurring heartburn. Patients should also disclose whether they have medical histories that include heart diseases like angina or heart attack, high blood pressure, stroke, blood disorders like anemia, clotting/bleeding problems, and growths in the nose (nasal polyps).

    Before you use Celebrex talk to your doctor or pharmacist if you have any of the following:

    • Disease of the heart or blood vessels (also called cardiovascular disease, including uncontrolled high blood pressure, congestive heart failure, established ischemic heart disease, or peripheral arterial disease)

    • Risk factors for cardiovascular disease (see above) such as high blood pressure, abnormally high levels of fat (cholesterol, triglycerides) in your blood

    • Diabetes mellitus or on a low sugar diet

    • Atherosclerosis

    • Poor circulation to your extremities

    • Smoker or ex-smoker

    • Kidney disease or urine problems

    • Previous ulcer or bleeding from the stomach or gut

    • Previous bleeding in the brain

    • Bleeding problems

    • Family history of allergy to sulfonamide drugs

    • Family history of allergy to NSAIDs, such as acetylsalicylic acid (ASA), celecoxib, diclofenac, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, rofecoxib, sulindac, tenoxicam, tiaprofenic acid, tolmetin, or valdecoxib (NOT a complete list)

    • Family history of asthma, nasal polyp, long-term swelling of the sinus (chronic sinusitis) or hives

    • Gastrointestinal problems (problems with your stomach and/or intestine)

    • Any other medical problem

    Fertility may be decreased. The use of Celebrex is not recommended in women who have difficulty conceiving.

    Also, before taking this medication, tell your health care provider if you are planning to get pregnant.

    While taking this medication:

    • tell any other doctor, dentist, pharmacist or other health care professional that you see, that you are taking this medication, especially if you are planning to have heart surgery;

    • do NOT drink alcoholic beverages while taking this medication because you would be more likely to develop stomach problems;

    • If you have cardiovascular disease or risks for cardiovascular disease, your doctor will periodically re-evaluate whether you should continue treatment with Celebrex. Patients with these conditions should not receive doses of Celebrex higher than 200 mg per day.

    If, at any time while taking Celebrex you experience any signs or symptoms of problems with your heart or blood vessels such as chest pain, shortness of breath, weakness, or slurring of speech, seek emergency medical treatment immediately.

    Side Effects

    CELEBREX may cause some side effects, especially if used for a long time or in large doses. When these side effects occur, you may require medical attention. Report all symptoms or side effects to your health care provider.

    CELEBREX may cause you to become drowsy or tired. Be careful about driving or participating in activities that require you to be alert. If you become drowsy, dizzy or light-headed after taking CELEBREX, do NOT drive or operate machinery.

    CELEBREX may cause you to become more sensitive to sunlight. Any exposure to sunlight or sunlamps may cause sunburn, skin blisters, skin rash, redness, itching or discolouration, or vision changes. If you have a reaction from the sun, check with your health care provider.

    Check with your health care provider IMMEDIATELY if you develop chills, fever, muscle aches or pains, or other flu-like symptoms occur, especially if they occur before or together with a skin rash. These symptoms may be the first signs of a SERIOUS ALLERGIC REACTION to this medication.

    Interactions with this medication

    Talk to your health care provider and pharmacist if you are taking any other medication (prescription or non-prescription) such as any of the following (NOT a complete list):

    • Acetylsalicylic acid (ASA) or other NSAIDs (e.g. diclofenac, ibuprofen, indomethacin, ketorolac, meloxicam, naproxen)

    • Antacids or proton pump inhibitors (omeprazole)

    • Antidepressants [Selective serotonine receptor uptake inhibitor (SSRIs) (e.g. citalopram, paroxetine, fluoxetine, sertraline)]

    • Blood pressure medications, such as ACE (angiotensin converting enzyme) inhibitors (e.g. enalapril, lisinopril, perindopril, ramipril), ARBs (angiotensin II receptor blockers) (e.g. candesartan, irbesartan, losartan, valsartan), beta blockers (e.g. metoprolol)

    • Blood thinners (to prevent blood clots), such as warfarin, apixaban, rivaroxaban, dabigatran, ASA, clopidogrel

    • Corticosteroids (including glucocorticoids) e.g. prednisone

    • Cyclosporin

    • Digoxin

    • Diuretics such as furosemide, hydrochlorothiazide

    • Fluconazole

    • Lithium

    • Dextromethorphan (found in some cough medications)

    • Tacrolimus

    Using CELEBREX with a blood thinner such as warfarin increases the risk of bleeding, which can be fatal, especially in older patients.

    Your health care provider may prescribe low dose ASA (acetylsalicylic acid) as a blood thinner for the prevention of having a heart attack or stroke while you are taking CELEBREX. Take only the amount of ASA prescribed by your health care provider. You are more likely to upset or damage your stomach if you take both CELEBREX and ASA than if you take CELEBREX alone.

    How to Take Celebrex

    Celebrex is specifically geared towards treating:

    • Rheumatoid Arthritis
    • Rheumatic Disease causing pain and stiffness in backbone
    • Painful periods
    • Joint Inflammation Disease in adults and children
    • Gout
    • Acute pain following surgery
    • Joint damage causing pain and loss of basic function

    Take Celebrex only as directed by your health care provider. Do NOT take more of it, do NOT take it more often and do NOT take it for a longer period of time than your health care provider recommended. If possible, you should take the lowest dose of this medication for the shortest time period. Taking too much Celebrex may increase your chances of unwanted and sometimes dangerous side effects, especially if you are elderly, have other diseases or take other medications.

    If you will be using Celebrex for more than 7 days, see your health care provider regularly to discuss whether this medicine is working for you and if it is causing you any unwanted effects.

    This medication has been prescribed specifically for you. Do NOT give it to anyone else. It may harm them, even if their symptoms seem to be similar to yours.

    Celebrex is NOT recommended for patients under 18 year of age since safety and effectiveness have NOT been established.

    Celebrex can be taken with or without food.

    Missed dose:

    Take the dose you missed as soon as you remember, then take the next dose at the scheduled time.


    If you take more than the prescribed dose, contact your health care provider immediately.

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    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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