This medicine is usually applied 1 to 3 times daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. DIPROSONE topical is for use only on the skin.

Wash your hands before and after using DIPROSONE topical, unless you are using the medicine to treat the skin on your hands.

Apply a small amount to the affected area and rub it gently into the skin. Do not apply DIPROSONE topical over a large area of skin.

Do not cover the treated skin area unless your doctor tells you to. Covering the skin that is treated with DIPROSONE topical can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

When treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers.

Use DIPROSONE topical regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Call your doctor if your skin condition does not improve after several days of treatment, or if it gets worse while using DIPROSONE topical.

If you use this medicine long-term, you may need frequent medical tests at your doctor's office.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line if anyone has accidentally swallowed the medication.

An overdose of DIPROSONE topical is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body. Stop using DIPROSONE topical and call your doctor if you have:

• blurred vision, or seeing halos around lights;
• uneven heartbeats;
• sleep problems (insomnia);
• weight gain, puffiness in your face; or
• tired feeling.

Also stop using DIPROSONE topical and call your doctor at once if you have:

• severe skin irritation where the medicine was applied; or
• signs of skin infection (swelling, redness, warmth, oozing).

Common side effects may include:

• increased hair growth;
• burning or itching of treated skin;
• skin dryness or irritation;
• acne, skin rash;
• folliculitis (redness or crusting around your hair follicles);
• lightened color of treated skin;
• stretch marks; or
• white or "pruned" appearance of the skin (caused by leaving wound dressings on for long periods of time).

You should not use DIPROSONE topical if you are allergic to it.

To make sure DIPROSONE topical is safe for you, tell your doctor if you have:

• any type of skin infection.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

It is not known whether DIPROSONE topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether DIPROSONE topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not use DIPROSONE topical on a child without a doctor's advice. Children can absorb larger amounts of this medication through the skin and may be more likely to have side effects. Steroid medicine can also affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medicine.

Avoid getting this medicine in your eyes. If contact does occur, rinse with water. Do not use DIPROSONE topical on broken or infected skin. Also avoid using this medicine in open wounds.

Avoid applying DIPROSONE topical to the skin of your face, underarms, or groin area without your doctor's instruction.

Do not use DIPROSONE topical to treat any condition that has not been checked by your doctor.

It is not likely that other drugs you take orally or inject will have an effect on topically applied DIPROSONE. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

The effectiveness of ROCALTROL therapy is based on the assumption that each patient is receiving an adequate daily intake of calcium.

To ensure that you receive an adequate daily intake of calcium, your doctor may either prescribe a calcium supplement or instruct appropriate dietary measures. Your doctor may monitor your blood levels of calcium and phosphorus.

Be sure to drink plenty of fluids to maintain good hydration, important during ROCALTROL treatment.

Usual adult dose:

Dosage is based on your medical condition and response to therapy. Your doctor may start you on a low dose and adjust the dose slowly to find the best dose for you. Follow your doctor's directions carefully.

Overdose:

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Missed dose:

Take your missed dose as soon as you remember. Skip taking the missed dose if it is almost time for the next scheduled dose. No extra medicine should be taken to make up the missed dose.

The most common side effect of ROCALTROL is hypercalcemia—high calcium levels in the blood (see Serious Side Effects Table below for symptoms). Common side effects include nausea, vomiting, stomach cramps, itching and sleeplessness.

Other side effects include agitation, sleeplessness, lack of feeling, weakness, constipation, upper abdominal pain, redness or itching of the skin, excessive thirst, fever and joint pain. If these side effects become bothersome or persist, contact your doctor.

BEFORE you use ROCALTROL talk to your doctor or pharmacist if:

• you are allergic to vitamin D or other forms of vitamin D products or to any ingredient of ROCALTROL.
• you have a history of kidney disease.
• you are undergoing dialysis.
• you have a history of heart disease.
• you are using cardiac glycosides (e.g. digitalis).
• you are pregnant or planning to become pregnant during treatment.
• you are breastfeeding or planning to breastfeed. ROCALTROL may be released in human breast milk. Discuss with your doctor.
• you are taking any other drugs including non-prescription drugs, other vitamin D products, or other forms of vitamin D or any other vitamins or supplements.

Drugs that may interact with ROCALTROL include: digitalis, bile acid sequestrants (including cholestyramine and sevelamer) and mineral oil, anticonvulsants (e.g. phenytoin, phenobarbital), calcium supplements, corticosteroids, ketoconazole, magnesium-containing drugs (e.g. some antacids), thiazides.

It's very important that ROCEPHIN is taken in the exact amounts and duration prescribed to avoid developing a new illness that is resistant to antibiotics.

Your doctor will determine the appropriate dosage for you and/or your child, most likely administering it in a hospital or clinical setting.

It's possible that you might be shown how to inject the drug yourself so that you can do it at home.

Do not inject yourself unless you know how to do it, and be sure to dispose of the needles and other used items properly.

Never mix ROCEPHIN in the same injection with other antibiotics, or with any diluent that contains calcium. If you are injecting other drugs, be sure to flush the catheter thoroughly before using a new medicine.

If you think there is any chance that you might have overdosed, go to the emergency room or call the poison help line.

In most cases your doctor will administer this drug. If you are doing it yourself and forget, give yourself an injection as soon as you remember.

However, if it's almost time for the next dose, you must skip it. Never take extra or "double dose" to make up for a missed dose.

All drugs have side effects. In the case of ROCEPHIN, some of the more common problems reported include swelling, redness, pain, or soreness at the injection site.

While not frequent, the medication has been known to cause a loss of appetite, vomiting, headache, diarrhea or nausea. If any of these symptoms continue or get worse, let your doctor know right away.

ROCEPHIN might also produce serious problems like a fast, pounding or irregular heartbeat, seizures, yellowing of the skin or eyes, dark urine, or changes in urination.

Other symptoms could include bruising or bleeding more easily, chest pain, trouble breathing, mood changes like confusion, or unusual tiredness or weakness.

On some occasions, taking ROCEPHIN may cause a severe intestinal infection known as Clostridium difficile-associated diarrhea.

Contact your doctor right away if you have persistent diarrhea, abdominal or stomach pain/cramping, and/or blood or mucus in your stool. Don't attempt to treat these symptoms on your own unless your healthcare provider tells you to do so.

In addition, if you use ROCEPHIN for long periods of time or repeat its use frequently, you could develop a vaginal yeast infection or notice fungus accumulating on the lining of your mouth (thrush).

Let your doctor know if you see white patches in your mouth or experience a change in vaginal discharge.

Severe allergic reactions (anaphylaxis) are not common.

If you get a rash, experience severe dizziness, have trouble breathing, develop itching or swelling of the face, tongue or throat, seek medical help right away.

Never give any calcium-containing products by vein to a newborn under one month of age if the infant is also being given ROCEPHIN. Doing so could cause serious damage to the baby's vital organs.

ROCEPHIN is also not recommended for newborns with high bilirubin levels.

Before starting ROCEPHIN, it's key that you determine whether you might be allergic to it or similar antibiotics including:

• Cefuroxime axetil (Ceftin)
• Cefprozil (Cefzil)
• Cefaclor (Raniclor)
• Cefazolin (Ancef)
• Cefadroxil (Duricef)
• Cefditoren (Spectracef)
• Cefpodoxime (Vantin)
• Ceftibuten (Cedax)
• Cephalexin (Keflex)
• Cephradine (Velosef)
• Cefdinir (Omnicef)

If you're allergic to penicillin, it's possible that you will have an allergic reaction to ROCEPHIN.

Never use this medication if there is any chance of an allergic reaction without speaking to your doctor or pharmacist first.

A few months after you receive the last shot of ROCEPHIN you may get diarrhea or colitis.

If you get diarrhea while taking this medicine and you notice that it is watery or contains blood, call your doctor right away. Do not stop taking any medication without first speaking to your physician.

You might also develop hemolytic anemia, which destroys your red blood cells and could affect your blood's clotting time. Your doctor may monitor your blood clotting time while you're using this drug.

Taking ROCEPHIN could also cause gallbladder problems, which are usually temporary and reverse once treatment ends. Your pancreas might also become inflamed (pancreatitis), especially in you have underlying biliary problems.

Never stop taking ROCEPHIN until you have completed your entire dosing regimen. Quitting or stopping prematurely could put you at risk of a serious or life-threatening infection that might be resistant to antibiotics.

To help your doctor decide if ROCEPHIN is right for you, it's key that you give him/her a complete medical history, including the following conditions:

• Liver disease
• Kidney disease
• Gallbladder disease
• Diabetes
• Stomach or intestinal disorder
• Colitis
• Inflamed colon
• Anemia

You should also tell your doctor about any blood clotting problems as well as whether you are malnourished.

ROCEPHIN and Pregnancy

It's unknown how ROCEPHIN affects pregnant women, so it's extremely important that you let your doctor know if you're pregnant or might become pregnant while on this medication.

If you take this medication while breastfeeding it will pass into your breast milk, so be sure to let your doctor know if you plan to breastfeed while using ROCEPHIN.

A number of drugs are known to interact with ROCEPHIN, changing the way it works or increasing the possibility of serious side effects.

That's why it's key that you provide your physician with a complete list of all prescription and over-the-counter medications, including vitamins, herbal supplements, and illegal or recreational drugs.

Aminoglycoside antibiotics like tobramycin (Tobi or Tobrex) and gentamicin (Gentak or Garamycin) are known to interact with ROCEPHIN.

Blood thinners like warfarin (Jantoven or Coumadin) are also known to produce interactions along with live bacterial vaccines, and calcium-containing IV fluids.

In addition, some antibiotics are known to decrease the effectiveness of hormonal birth control. Talk to your doctor about whether you might want to switch to another type of birth control while using ROCEPHIN.

You should be aware that the medication could affect your urine glucose test as well as other laboratory diagnostics so be sure to tell all lab personnel and doctors that you are taking ROCEPHIN.

There are no specific foods that you have to avoid while using this medicine.

However, ROCEPHIN could impact your ability to drive or operate machinery safely. You should hold off on doing both until you know how this drug will affect you.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Before and during your treatment with RIFATER (isoniazid, pyrazinamide, and rifampin), your doctor may perform tests to make sure your tuberculosis is not resistant to this medicine. During treatment you may need frequent blood tests to check your liver function, and eye examinations to check your vision.

Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal. Take each dose with a full glass of water.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. RIFATER (isoniazid, pyrazinamide, and rifampin) will not treat a viral infection such as the common cold or flu.

This medication can also cause unusual results with certain lab urine tests, and may cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking RIFATER (isoniazid, pyrazinamide, and rifampin).

Your doctor may have you take extra vitamin B6 while you are taking RIFATER (isoniazid, pyrazinamide, and rifampin). Take only the amount of vitamin B6 that your doctor has prescribed.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line. An overdose of RIFATER (isoniazid, pyrazinamide, and rifampin) can be fatal, especially when this medicine is combined with alcohol.

The first signs of an overdose may include nausea, vomiting, stomach pain, lack of energy, headache, and itching. Later symptoms may include severe stomach pain, yellowing of your skin or eyes, brown or red-orange colored body fluids (tears, sweat, saliva, urine, stools), swelling in your face, fast heartbeats, seizures (convulsions) or loss of consciousness.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

RIFATER (isoniazid, pyrazinamide, and rifampin) can cause severe liver symptoms, especially in people who are 35 and older. Call your doctor at once if you have any of these early signs of liver damage: nausea, vomiting, upper stomach pain, tired feeling, or loss of appetite.

Also tell your doctor right away if you have:

• signs of liver or pancreas problems--dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), severe pain in your upper stomach spreading to your back;
• side effects on the brain or nervous system--vision problems, pain behind your eyes, unusual thoughts or behavior, seizure (convulsions);
• blood cell disorders--fever, chills or other flu symptoms, pale skin, confusion or weakness, easy bruising, unusual bleeding;
• joint pain or swelling;
• severe skin rash;
• little or no urinating;
• diarrhea that is watery or bloody; or
• shortness of breath, feeling like you might pass out.

Common side effects may include:

• numbness, tingling, or burning pain in your hands or feet;
• mild nausea or decreased appetite;
• mild rash or itching; or
• mild joint or muscle pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You should not use this medication if you have severe liver disease, an attack of gout, a history of fever/chills and joint pain or stiffness when taking isoniazid, or if you also take certain antiviral medicines to treat HIV.

Serious and sometimes fatal liver problems may occur during treatment with isoniazid, pyrazinamide, and rifampin or after you stop taking this medication, even months after stopping. The risk of liver problems is highest in adults between the ages of 35 and 65. Your liver function may need to be checked every month while you are taking this medicine.

Call your doctor right away if you have: nausea, upper stomach pain, loss of appetite, and feeling weak or tired.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking this medicine.

You should not use this medication if you are allergic to isoniazid, pyrazinamide, or rifampin, or if you have:

• severe liver disease;
• an attack of gout;
• a history of fever, chills, and joint pain or stiffness caused by taking isoniazid; or
• if you also take certain antiviral medicines--atazanavir, darunavir, fosamprenavir, tipranavir, or saquinavir.

To make sure isoniazid, pyrazinamide, and rifampin is safe for you, tell your doctor if you have:

• liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
• gout;
• diabetes;
• kidney disease;
• if you take phenytoin (Dilantin); or
• if you take antiviral medication to treat HIV or hepatitis.

FDA pregnancy category C. In animal studies, this medicine caused birth defects. However, it is not known whether these effects would occur in people. Taking this medicine during the last few weeks of pregnancy may increase your risk of bleeding during delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

This medicine can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking this medicine.

Isoniazid, pyrazinamide, and rifampin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking this medicine.

Avoid taking an antacid within 1 hour before or after you take RIFATER (isoniazid, pyrazinamide, and rifampin). Some antacids can make it harder for your body to absorb RIFATER (isoniazid, pyrazinamide, and rifampin).

Do not wear soft contact lenses while taking RIFATER (isoniazid, pyrazinamide, and rifampin). This medicine may turn certain body fluids a red color (including tears, saliva, urine, and sweat). While this is a harmless side effect, it may permanently stain contact lenses.

Avoid foods that are high in tyramine or histamine, listed below. Tyramine or histamine can interact with this medication and cause unpleasant side effects. These foods include:

• beer (alcoholic and nonalcoholic), wine (especially red wine);
• cheese, especially aged or processed cheeses (American, blue, brie, cheddar, gruyere, mozzarella, parmesan, romano, Swiss, and others);
• sour cream and yogurt;
• tuna, skipjack, pickled or smoked fish, anchovies, dried fish, herring, caviar, shrimp paste, or other tropical fish;
• soy sauce, miso soup, bean curd, fava beans; or
• yeast extracts.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking RIFATER (isoniazid, pyrazinamide, and rifampin) and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Many drugs can interact with RIFATER (isoniazid, pyrazinamide, and rifampin). Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with RIFATER (isoniazid, pyrazinamide, and rifampin), especially:

• antifungal medication--fluconazole, itraconazole, ketoconazole, voriconazole;
• birth control pills or hormone replacement therapy;
• a blood thinner (warfarin, Coumadin) or other medication to prevent blood clots (clopidogrel, dabigatran, Plavix, Pradaxa, rivaroxaban, ticagrelor, and others);
• vitamin D; or
• steroids (prednisone and others) or thyroid medication.

This list is not complete and many other drugs can interact with RIFATER (isoniazid, pyrazinamide, and rifampin). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.