PRANDIN comes as a tablet and is typically taken by mouth with meals.

If you skip a meal, skip your dose of PRANDIN. If you add a meal, take an extra dose.

Your doctor may start you on a low dose of this medicine and gradually increase it.

Follow the directions on your prescription label carefully. Don't take more or less than is prescribed.

PRANDIN Overdose

If you suspect an overdose, you should contact a poison-control center or emergency room immediately.

Missed Dose of PRANDIN

If you miss a dose of PRANDIN and you've just begun to eat a meal, take the missed dose as soon as you remember.

However, if you've finished eating your meal, skip the missed dose and continue on your regular dosing schedule.

Don't take extra medicine to make up for a missed dose.

Common Side Effects of PRANDIN

Tell your doctor if any of the following side effects become severe or don't go away:

• Headache
• Constipation
• Diarrhea
• Nasal congestion
• Sinus pain or pressure
• Joint pain
• Back pain

Serious Side Effects of PRANDIN

Seek medical assistance right away if you experience any of the symptoms listed in the Warning section or any of the following serious side effects:

• Signs of an allergic reaction, which may include rash; hives; difficulty breathing; or swelling of the mouth, face, lips, or tongue
• Chest pain
• Seizures
• Yellowing of the eyes or skin (jaundice)
• Dark-colored urine
• Fever, chills, or a persistent sore throat
• Unusual bleeding or bruising

You shouldn't take PRANDIN if you have type 1 diabetes (the body doesn't produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated).

Before taking this medicine, tell your doctor if you have or have ever had:

• Liver disease
• Kidney disease
• Adrenal or pituitary problems

Don't take PRANDIN if you are also taking NPH insulin or gemfibrozil (Lopid).

Tell your healthcare providers that you're taking PRANDIN before having any type of surgery, including a dental procedure.

PRANDIN should be used with caution in elderly people because they may be more sensitive to it.

Don't give this medicine to a child or anyone under 18 years old. Safety and effectiveness of PRANDIN in kids hasn't been established.

PRANDIN may cause changes in your blood sugar.

You should know the symptoms of high (hyperglycemic) or low (hypoglycemic) blood-sugar episodes and be prepared to treat them.

Low blood sugar is a common side effect of PRANDIN.

Symptoms can include headache, hunger, weakness, sweating, tremor or severe shaking, irritability, or trouble concentrating.

Drinking orange juice or eating a hard candy or glucose tablet can bring up blood sugar levels.

Tell your physician if you experience an illness, fever, injury, or unusual stress while taking PRANDIN, because these can change your blood sugar and the dosage you need.

PRANDIN controls diabetes, but it doesn't cure it. Continue to take it even if you feel well. Don't stop it without talking to your doctor.

Your doctor will probably want to frequently check your glucose levels while you are taking PRANDIN.

Always wear a diabetic ID bracelet to be sure you get proper treatment in case of an emergency.

Pregnancy and PRANDIN

This medicine is an FDA Pregnancy Category C drug, which means harm to an unborn baby can't be ruled out.

Tell your doctor if you're pregnant or plan to become pregnant while taking PRANDIN.

Your physician may recommend insulin during pregnancy to ensure that your blood sugar is well-controlled.

It's also not known if PRANDIN is found in breast milk. Don't breastfeed while taking this medicine without talking to your doctor first.

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Warning section or any of the following:

• Acetophenazine (Tindal)
• Arthritis drugs
• Aspirin
• Blood-pressure medicines
• Carbamazepine (Tegretol)
• Chloramphenicol (Chloromycetin)
• Chlorpromazine (Thorazine)
• Contraceptives (such as birth-control pills)
• Corticosteroids
• Erythromycin
• Estrogens
• Fluphenazine (Prolixin)
• Isoniazid (Nydrazid, Rifamate)
• Ketoconazole (Nizoral)
• Mesoridazine (Serentil)
• Perphenazine (Trilafon)
• Phenelzine (Nardil)
• Phenobarbital (Luminal)
• Phenytoin (Dilantin)
• Probenecid (Benemid)
• Prochlorperazine (Compazine)
• Promazine (Sparine)
• Promethazine (Phenergan)
• Rifampin (Rifadin, Rimactane, Rifamate)
• Thioridazine (Mellaril)
• Tranylcypromine (Parnate)
• Trifluoperazine (Stelazine)
• Triflupromazine (Vesprin)
• Trimeprazine (Temaril)
• Troglitazone (Rezulin)
• Warfarin (Coumadin)
• Water pills (diuretics)
• Vitamins

PRANDIN and Alcohol

Alcohol can cause a decrease in blood sugar.

Ask your doctor about consuming alcoholic beverages while you are taking PRANDIN.

PRANDIN and Other Interactions

You may experience dizziness while taking this medicine.

Don't drive or operate machinery until you know you can do so safely.

Like all medicines, Rapamune can have side effects. However, since Rapamune is taken in combination with other medicines, Rapamunemay not have been the cause of the side effects experienced.

If you get any side effects, do not stop taking Rapamune without first talking to your doctor.

Tell your doctor if you have any of these symptoms and they concern you:

Very common side effects (occur in 10% or more of patients) include:

• Abnormal healing
• Abnormal vision
• Acne
• Constipation
• Diarrhea
• Headache
• Insomnia
• Joint, bone or back pain
• Nausea or upset stomach
• Stomach pain
• Swelling of the hands, feet, ankles, or lower legs
• Shaking (tremor)
• Urinary tract infection
• Weakness

Common side effects (occur in 1% to 9% of patients) include:

• Abnormal bleeding or bruising
• Cold or flu-like symptoms (lung infection)
• Dizziness upon standing
• Feeling anxious
• Fever or chills
• Fluid accumulation/retention
• Increased heart rate or heart palpitations
• Kidney infection
• Leg pain or muscle pain
• Menstrual disorders (absence of menstrual period or abnormal heavy and prolonged menstrual period)
• Mouth ulcers or cold sores
• Nose bleed
• Ovarian Cysts
• Rash
• Shortness of breath
• Skin cancer
• Surgical wounds slow to heal
• Swollen abdomen

Uncommon or rare side effects (occur in less than 1% of patients) include:

• Melanoma (a type of skin cancer)
• Pancreatitis (inflammation of the pancreas)
• Severe allergic reaction including skin reaction

Unwanted side effects that you may not be aware of while taking your medicine include changes in levels of blood cells or substances in your blood (e.g. cholesterol, creatinine, or sugar). Your doctor may do blood tests to look for any changes.

Immunosupressive drugs may increase the risk of infections.

Immunosuppressive drugs like Rapamune may increase your risk of developing lymphoma (a type of cancer) or cancer of the skin. Contact your doctor immediately if you notice a lump in your neck, armpits, collarbone region, or groin, or unintended weight loss (may be signs of lymphoma). Talk to your doctor if you notice any new moles or any changes in the size, shape, or colour of moles you already have (may be a sign of skin cancer).

Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything that concerns you, even if you do not think the problem is connected with Rapamune or the problem is not listed in this leaflet.

Do NOT stop taking Rapamune without talking to your doctor.

BEFORE you use Rapamune talk to your doctor or pharmacist if any of the following situations apply to you:

• Allergies: Tell your doctor if you have any allergies to medicines or any other substances such as foods, preservatives, or dyes.

• Pregnancy: Women must avoid pregnancy while taking Rapamune as it may cause damage to the unborn baby. Women must use effective contraception methods before taking Rapamune, during treatment with Rapamune and for 12 weeks after treatment has stopped. If you are unsure, or think you may become pregnant, talk to your doctor or pharmacist.

• Breast-feeding: It is not known whether Rapamune passes into breast milk. Ask your doctor or pharmacist for advice before breast-feeding your baby.

• Liver problems: You should inform your doctor if you have any liver problems or have had a disease which may have affected your liver, as this may affect the dose of Rapamune that you receive.

• If you have high cholesterol or triglycerides (fat in blood). Your doctor may order blood tests for you.

• If you are going to have an operation, or if you still have a wound that hasn’t healed completely after a surgery, you should tell your doctor before receiving this medicine, as Rapamune may prevent these wounds from healing properly.

• Talk to your doctor before switching from the oral solution to the tablet, since your doctor may need to adjust the dose of Rapamuneyou receive.

• Limit your exposure to sunlight and UV light by wearing protective clothing and using a sunscreen with a high protection factor.

• Driving and operating machinery: No specific studies on the effects of Rapamune on the ability to drive and operate machines have been conducted. If you have any concerns please consult your doctor.

• Alcohol: Rapamune oral solution contains 1.5-2.5% ethanol. Each 2 mg dose contains up to 50 mg of alcohol, approximately the same amount of alcohol as half a teaspoon of a light beer. If you have any concerns please consult your doctor.

• Tell any other doctors, dentists, and pharmacists who are treating you that you are taking Rapamune.

With drugs: Some medicines and Rapamune may interfere with each other. Your doctor or pharmacist should know if you are taking, or have recently taken, other medicines, even those not prescribed for you, including non-prescription (over-the-counter) drugs and herbal preparations. Drugs that may interact with Rapamune include:

• Any other immunosuppressive agents.
• Antibiotics or antifungal medicines used to treat infection e.g. rifampicin, clarithromycin, erythromycin, telithromycin, troleandomycin, rifabutin, rifapentine, clotrimazole, fluconazole, itraconazole, ketoconazole, voriconazole.
• High blood pressure medicines or medicines for heart problems including nicardipine, verapamil and diltiazem.
• Anti-convulsant medicines including carbamazepine, phenobarbital, phenytoin.
• Cisapride (not marketed in Canada), metoclopramide, bromocriptine, cimetidine, danazol, protease inhibitors (eg, for HIV that include drugs such as ritonavir, indinavir, and hepatitis C drugs such as boceprevir, and telaprevir).
• Immunosuppressive drugs like Rapamune may alter the effectiveness of vaccinations. If you plan on being vaccinated, inform your doctor that you are taking Rapamune.
• Herbal preparations, such as St. John's Wort.

With food:

• Grapefruit juice

These medicines/foods may be affected by Rapamune or may affect how well Rapamune works.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

REBETOL is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product.

Take REBETOL with food.

Do not crush, chew, break, or open a REBETOL capsule. Swallow it whole. Tell your doctor if you have trouble swallowing the capsule.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Use REBETOL regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Drink extra fluids while you are taking REBETOL to keep from getting dehydrated, especially during exercise or in hot weather.

REBETOL can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking REBETOL, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.

Store REBETOL tablets or capsules at room temperature away from moisture, heat, and light.

Store REBETOL liquid (oral solution) in the refrigerator. Do not allow it to freeze.

Seek emergency medical attention or call the Poison Help line.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

REBETOL can cause anemia. In rare cases, this can lead to fatal heart problems. Get emergency medical attention if you have chest pain.

Call your doctor at once if you have:

• problems with your vision;
• severe pain in your upper stomach spreading to your back, nausea, vomiting, diarrhea;
• stabbing chest pain, wheezing, feeling short of breath;
• severe depression, thoughts about suicide, or thoughts about hurting someone else;
• signs of serious anemia--pale or yellowed skin, dark colored urine, confusion or weakness; or
• other signs of low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, easy bruising, unusual bleeding, feeling light-headed.

Common side effects may include:

• nausea, flu-like symptoms, tiredness;
• fever, chills or shaking;
• headache;
• mood changes, feeling irritable;
• muscle pain; or
• stomach pain, vomiting, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You should not use REBETOL if you have autoimmune hepatitis, severe kidney disease, or a hemoglobin blood cell disorder.

REBETOL is not effective when used alone. It must be used together with an interferon alfa product. You should not take REBETOL with didanosine.

REBETOL can cause birth defects or death in an unborn baby. Do not use this medicine if you are pregnant, or if you are a man and your sexual partner is pregnant. Use 2 forms of birth control to prevent pregnancy while either sexual partner is taking REBETOL, and for at least 6 months after treatment ends.

In rare cases, REBETOL can cause fatal heart problems. Get emergency medical attention if you have chest pain.

You should not take REBETOL if you are allergic to it, or if you have:

• a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia;
• autoimmune hepatitis;
• severe kidney disease;
• if you are also taking didanosine (Videx); or
• if you are pregnant, or if you are a man whose sexual partner is pregnant.

You should not take REBETOL with peginterferon alfa-2a if you have:

• autoimmune hepatitis; or
• severe liver disease (especially cirrhosis).

To make sure REBETOL is safe for you, tell your doctor if you have:

• heart disease;
• a blood cell disorder such as anemia (low red blood cells);
• breathing problems;
• vision problems;
• liver problems other than hepatitis C;
• a thyroid disorder;
• kidney disease;
• human immunodeficiency virus (HIV or AIDS);
• diabetes;
• a history of depression, mental illness, or suicide attempt;
• a history of organ transplant; or
• if you have ever received treatment for hepatitis C that did not work well.

REBETOL can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before taking this medicine and every month during your treatment.

• If you are a woman, do not take REBETOL if you are pregnant.
• If you are a man, do not take REBETOL if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking REBETOL.
• Use at least 2 effective forms of birth control to prevent pregnancy while either sexual partner is taking REBETOL. Keep using 2 forms of birth control for at least 6 months after treatment ends.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking REBETOL.

If a pregnancy occurs, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of REBETOL on the baby.

It is not known whether REBETOL passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

REBETOL is not approved for use by anyone younger than 3 years old.

REBETOL can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Avoid drinking alcohol. It may increase your risk of liver damage.

Using this medicine will not prevent you from passing hepatitis to other people. Follow your doctor's instructions about how to prevent passing the disease to another person.

Tell your doctor about all your current medicines and any you start or stop using, especially:

• azathioprine; or
• medicines to treat HIV or AIDS.

This list is not complete. Other drugs may interact with REBETOL, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

RECLAST is given as an injection into a vein. It's typically administered by a healthcare professional in a clinical setting.

Your dose will depend on your medical condition and response to treatment. Some people require an injection of RECLAST just once a year, while others may need more frequent doses.

Drink at least two glasses of water a few hours before your injection, to prevent dehydration. Follow your doctor's instructions about preparation and aftercare for your treatment.

RECLAST Overdose

If you suspect an overdose of RECLAST, contact a poison control center or emergency room immediately.

Missed Dose of RECLAST

Call your doctor for instructions if you miss an injection of RECLAST.

Common Side Effects of RECLAST

Tell your doctor if any of the following side effects become severe or don't go away:

• Diarrhea or constipation
• Nausea or vomiting
• Stomach pain
• Heartburn
• Loss of appetite or weight loss
• Vaginal discharge
• Swelling, redness, irritation, itching, or burning of the vagina
• Difficulty falling asleep or staying asleep
• Hair loss
• Redness, itching, pain, or swelling at the injection site
• Red, swollen, itchy, or teary eyes

Serious Side Effects of RECLAST

Tell your doctor right away if you experience any of the symptoms listed in the RECLAST Warnings section above, or any of the following serious side effects:

• Signs of an allergic reaction (may include rash, hives, itching, difficulty breathing or swallowing, or swelling of the face, eyes, lips, tongue, throat, hands, arms, feet, ankles, or lower legs)
• Hoarseness
• Irregular heartbeat
• Upper chest pain
• Signs of an infection, such as fever, chills, or cough
• Muscle spasms, twitches, or cramps
• Unusual pain in the thigh or groin
• Pale skin
• Painful or swollen gums
• Loosening of the teeth
• Numbness or heaviness in the jaw
• A sore in the mouth or jaw that doesn't heal
• Unusual bleeding or bruising
• Numbness or tingling around the mouth, or in the fingers or toes
• Little or no urination
• Painful or difficult urination
• Rapid weight gain
• Extreme fatigue

RECLAST may damage your kidneys.

This risk is greater if you also use other medicines that are harmful to the kidneys, such as chemotherapy drugs, arthritis or pain medicines, injectable antibiotics, antiviral drugs, drugs to treat a bowel disorder, or drugs to prevent organ transplant rejection.

Before taking RECLAST, tell your doctor if you have, or have ever experienced:

• Kidney disease
• Dark-colored urine
• Excessive sweating
• Decreased sweating
• Dry skin
• Diarrhea or vomiting
• Fever
• Infection
• Inability to drink enough fluids
• Other signs of dehydration

If you're dehydrated, your doctor may want to wait to give you this treatment. Your doctor may also tell you to drink extra fluids before receiving your treatment of RECLAST. Follow these instructions carefully.

RECLAST contains the same active ingredient as the brand-name medicine Zometa. You shouldn't take both of these drugs at the same time.

RECLAST may cause severe bone, muscle, or joint pain. These symptoms can begin within days of starting your treatment, or they may not show up for some time. Call your doctor right away if you experience severe pain while taking RECLAST.

You may also experience a reaction during the first few days after receiving your treatment of RECLAST. Symptoms of this reaction can include fever, headache, or chills.

Your doctor may tell you to take a fever-reducing medicine to prevent or treat these symptoms.

RECLAST can also cause bone loss in the jaw (osteonecrosis of the jaw).

Osteonecrosis is more likely to occur if you have dental surgery or treatments while using RECLAST; if you have cancer or certain blood disorders; or if you've been treated with chemotherapy, radiation, or steroids.

Be sure to brush your teeth and keep your mouth clean while using RECLAST. A dentist should examine your mouth and perform any necessary treatments before you start on the medicine.

Don't have any dental procedures while taking this drug without first talking to your doctor.

Before using RECLAST, tell your doctor if you have, or have ever had:

• Heart failure
• Anemia or another blood disorder
• Problems with your teeth, mouth, or gums
• An infection
• Asthma or wheezing (especially if it's caused by taking aspirin)
• Parathyroid disease
• Liver disease
• Low levels of calcium, magnesium, or potassium in your blood
• Surgery to remove part of your intestines
• Thyroid or parathyroid surgery
• Any condition that prevents your body from absorbing nutrients from food
• Allergies to medications

Also, let your doctor know if you've been treated with RECLAST or another bisphosphonate drug in the past.

Your doctor may tell you to take calcium or vitamin D while using this medicine. Follow your doctor's instructions.

Bisphosphonate drugs such as RECLAST may raise the risk of breaking your thigh bone. Talk to your doctor about this potential risk.

Your doctor may order frequent tests to monitor your body's response to RECLAST. Keep all appointments with your doctor's office and laboratory.

Pregnancy and RECLAST

RECLAST can harm an unborn baby. Don't take this medicine if you're pregnant or might become pregnant.

Use an effective form of birth control while receiving RECLAST.

Tell your doctor right away if you become pregnant during your treatment, or if you might become pregnant in the future.

The medicine passes into breast milk and may hurt a nursing baby. Don't breastfeed while taking RECLAST without first talking to your doctor.

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those mentioned in the RECLAST Warnings section above, and any of the following:

• Aminoglycoside antibiotics, such as Amikin (amikacin), Garamycin (gentamicin), Kantrex (kanamycin), Neo-Rx or Neo-Fradin (neomycin), Humatin (paromomycin), streptomycin, or Tobi or Nebcin (tobramycin)
• Aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) or Aleve (naproxen)
• Chemotherapy drugs for cancer
• Lanoxin or Digitek (digoxin)
• Diuretics (water pills), such as Bumex (bumetanide), Edecrin (ethacrynic acid), or Lasix (furosemide)
• Oral steroids, such as Decadron or Dexone (dexamethasone), Medrol (methylprednisolone), or Deltasone (prednisone)

RECLAST and Other Interactions

RECLAST may make you dizzy.

Don't drive or perform any activity that requires alertness until you know how this medicine affects you.

RECLAST and Alcohol

Alcohol may worsen certain side effects of RECLAST.

Talk to your doctor about how much alcohol is safe to drink while receiving this drug.

REGLAN comes as an oral tablet, dissolving tablet, and liquid to take by mouth. Follow your doctor's instructions carefully when taking this medication; don't take more or less of the drug than is prescribed.

If you take the disintegrating tablet, make sure you use dry hands to remove the tablet from the package. If the tablet breaks or crumbles, throw it away and remove a new tablet.

The following are typical dosage schedules:

For GERD: The typical dose of REGLAN for treating symptoms of GERD is 10-15 milligrams (mg), four times daily. Each dose is typically given 30 minutes before a meal.

For gastroparesis: The typical dose of REGLAN for treating gastroparesis is 10 mg, four times daily. Each dose is typically given 30 minutes before a meal and at bedtime.

REGLAN Overdose

If you suspect an overdose, contact a poison control center or emergency room immediately.

Missed Dose of REGLAN

If you miss a dose of REGLAN, take it as soon as you remember.

However, if it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Don't take extra doses to make up for a missed one.

Common Side Effects of REGLAN

You should tell your doctor if any of the following side effects are severe or don't go away:

• Excessive fatigue
• Drowsiness
• Weakness
• Headache
• Dizziness
• Diarrhea
• Nausea or vomiting
• Breast enlargement or discharge
• Decreased sexual ability
• Frequent urination or inability to control urination
• Missed menstrual periods

Serious Side Effects of REGLAN

You should call your doctor immediately if you experience any of the following serious side effects:

• Problems with speech
• Tightening of the muscles, especially in the jaw or neck
• Muscle stiffness
• Slow or stiff movements
• Uncontrollable shaking of a part of the body
• Depression or thoughts of harming/killing yourself
• Fever
• Confusion
• Agitation
• Slow, fast, or irregular heartbeat
• Sweating
• Restlessness, nervousness, pacing, foot tapping, or jitteriness
• Difficulty falling asleep or staying asleep
• Difficulty with balance
• Rash or hives
• Swelling of the face, eyes, lips, tongue, mouth, throat, arms, hands, feet, ankles, or lower legs
• Difficulty breathing or swallowing
• Sudden weight gain
• Vision trouble
• High-pitched sounds while breathing

REGLAN may be used to prevent vomiting in dogs, especially chronic vomiting caused by kidney problems or vomiting after surgery. It can also be used to treat symptoms of acid reflux in dogs.

You should talk to your veterinarian before using this medication for your pet.

REGLAN and Tardive Dyskinesia

Taking REGLAN may increase your risk of developing tardive dyskinesia. Symptoms of this disorder include restlessness and uncontrollable muscle movements in the lips, tongue, eyes, face, arms, or legs.

The risk of developing tardive dyskinesia is higher in older adults, women, patients taking medicines for mental illness, and people with diabetes. Your risk for this condition is also greater if you take REGLAN for a longer period of time. Your doctor will probably tell you not to take REGLAN for longer than 12 weeks.

You should tell your doctor immediately if you experience any uncontrollable body movements including lip smacking, chewing, mouth puckering, frowning, scowling, blinking, sticking out your tongue, eye movements, or shaking arms or legs.

Other REGLAN Warnings

Before taking REGLAN, you should tell your doctor if you have or have ever had:

• A blockage, bleeding, or tear in your stomach or intestines
• Seizures
• Pheochromocytoma (a tumor on the small gland near your kidneys)
• Parkinson's disease
• High blood pressure
• Breast cancer
• Asthma
• Depression
• Heart, liver, or kidney disease
• G-6PD deficiency or NADH cytochrome B5 reductase deficiency (inherited blood disorders)

You should continue to take REGLAN even if you feel well. Don't stop taking this medicine without first talking to your doctor.

You should tell your doctor you are taking REGLAN before having any type of surgery, including dental procedures.

If you take REGLAN to relieve gastroparesis, your symptoms will not improve all at once. Your nausea, vomiting, and loss of appetite may improve early on, but it may take longer for your feeling of fullness to go away.

Pregnancy and REGLAN

REGLAN is an FDA Pregnancy Category B drug, which means it's not expected to be harmful to an unborn baby. You should tell your doctor if you are pregnant or plan to become pregnant before taking REGLAN.

The drug can pass into breast milk and may harm a breastfeeding baby. You should talk to your doctor before breastfeeding while taking REGLAN.

You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

• Acetaminophen (Tylenol, others)
• Antihistamines
• Aspirin
• Atropine (in Lonox, in Lomotil)
• Cyclosporine (Gengraf, Neoral, Sandimmune)
• Barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal)
• Digoxin (Lanoxicaps, Lanoxin)
• Haloperidol (Haldol)
• Insulin
• Ipratropium (Atrovent)
• Lithium (Eskalith, Lithobid)
• Levodopa (in Sinemet, in Stalevo)
• Medications for anxiety, blood pressure, irritable bowel disease, motion sickness, nausea, Parkinson's disease, ulcers, or urinary problems
• Monoamine oxidase inhibitors (MAOIs) including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
• Narcotic medications for pain
• Sedatives
• Sleeping pills
• Tetracycline (Bristacycline, Sumycin)
• Tranquilizers

REGLAN and Alcohol

You shouldn't consume alcohol while taking this medication. Drinking alcohol can increase your risk for developing side effects.

REGLAN and Other Interactions

REGLAN may make you drowsy, so avoid driving or operating machinery until you know how this medicine affects you.