Otezla (Apremilast)

(℞) Prescription Required

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Otezla Starter Kit 10mg/20mg/30mg

Product of United Kingdom
Manufactured by: Celgene
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Otezla Starter Kit 10mg/20mg/30mg
Product of United Kingdom
Manufactured by Celgene
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Otezla 30mg

Product of Australia
Manufactured by: Amgen, Inc.
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Otezla 30mg
Product of Australia
Manufactured by Amgen, Inc.
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Otezla 30mg

Product of Canada
Manufactured by: Celgene
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Otezla 30mg
Product of Canada
Manufactured by Celgene
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Otezla Starter Kit 10mg/20mg/30mg

Product of Canada
Manufactured by: Celgene
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Otezla Starter Kit 10mg/20mg/30mg
Product of Canada
Manufactured by Celgene
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Apremilast 30mg

Product of India
Manufactured by: Glenmark
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Apremilast 30mg
Product of India
Manufactured by Glenmark
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Otezla (Apremilast) Medication Information

Uses

Otezla is a phosphodiesterase inhibitor that is used to treat plaque psoriasis and psoriatic arthritis. 

Dosage

The tablets come in several different strengths:

  • 10 mg
  • 20 mg
  • 30 mg

Side Effects

The most common side effects of Otezla include:

  • Diarrhea
  • Nausea
  • headache

Speak with your doctor for a full list of side effects that apply to you if you are taking Apremilast.

Precautions

There is a risk of depression while taking Otezla, patients should be monitored for changes in behavior while taking Otezla. 

There is a risk of weight decreases while taking Otezla, weight should be monitored regularly during treatment. 

Interactions

The most common drug interactions with Otezla include:

  • Ketoconazole
  • Rifampin
  • Phenobarbital
  • Carbamazepine
  • Phenytoin 

Speak with your doctor for more information and before starting a new medication with Apremilast. 

Storage

Store below room temperature (86 ºF). 

Pharmacist Tips

  • Otezla can cause diarrhea and vomiting, if this becomes severe you should seek medical attention.
  • Apremilast can cause weight loss, so it is important to monitor your weight regularly. 
  • To reduce stomach upset Otezla should be slowly titrated. 

Apremilast FAQs

What does Otezla do?

Otezla reduces the phosphodiesterase activity in cells which can reduce overactive inflammation in patients with psoriasis. 

 

Does Otezla reduce inflammation?

Yes, Apremilast reduces inflammation in patients with psoriasis. 

 

How long can you be on Otezla?

Otezla is a long term treatment and you should stay on it until your doctor says otherwise.

 

Can you take Otezla on an empty stomach?

Yes, you can take Otezla with or without food.

 

Does Otezla cure psoriasis?

No, Apremilast will not cure psoriasis, it will return of the medication is stopped.

 

Related Drugs

Reference:

Otezla {package insert}. Summit, NJ: Celegene Corporation 2017.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/205437s006lbl.pdf

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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