Enstilar Aerosal Foam (Calcipotriene/Betamethasone)

(℞) Prescription Required

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Enstilar Aerosol Foam 50mcg/g 0.5mg/g

Product of Canada
Manufactured by: Leo Pharma Inc.
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Enstilar is also marketed as Enstilar Aerosol Foam
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Enstilar Aerosol Foam 50mcg/g 0.5mg/g
Product of Canada
Manufactured by Leo Pharma Inc.
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Enstilar Aerosol Foam (Calcipotriene and Betamethasone dipropionate) Medication Information


Enstilar Foam contains the drugs calcipotriene and betamethasone dipropionate. It can be prescribed to treat psoriasis in adults 18 years and older.

Psoriasis is a genetic condition where skin cells replicate too fast. Sufferers experience red, scaly, itchy patches of skin. The patches sometimes have white scales and bumps. Psoriasis can happen anywhere on the body but is most common on the lower back, elbows, knees, and scalp. 

Calcipotriene is a vitamin D analog that is thought to regulate the growth and replication of skin cells. It slows down skin cell division, so the skin grows more normally.

Betamethasone dipropionate is a corticosteroid. All corticosteroids regulate the immune system to reduce inflammation, redness, swelling, itching, and other symptoms. 


Wash hands and shake the canister before use.

Apply Enstilar to the affected area for up to 4 weeks or as long as directed by the physician. Apply by gently rubbing the foam into the skin and stop using it when symptoms of psoriasis have resolved.

Do not use more than one can (60 grams) every four days.

Side Effects

The most common side effects of Enstilar include:

  • Application site pruritus
  • Exacerbation of psoriasis
  • Folliculitis
  • Hypercalcemia
  • Irritation
  • Skin hypopigmentation
  • Urticaria

Side effects of Enstilar are uncommon and only happen in about 1% of people who use the medication.


Enstilar should not be used on the face, groin, eyes, mouth, or armpits.

Enstilar can increase the amount of calcium in the blood or urine. Your doctor should monitor your calcium levels while taking Enstilar.

Topical steroids can lower your body’s steroid hormones if used over a large surface area, over a long time, in people with liver failure, or if the foam is covered in an occlusive dressing or bandage.


Enstilar does not interact with other medications because it doesn’t absorb into the bloodstream. However, do not apply it at the same time as other topical medications. Apply Enstilar, and then wait 15 minutes before using other lotions and creams.


Storage Enstilar between 20 - 25C (68 -77F). Enstilar is a pressurized foam canister, so do not expose it to heat or temperatures above 120°F (49°C). Do not freeze. Do not puncture the container.

Use Enstilar within six months after opening it.

Pharmacist Tips

  • Enstilar is flammable, so do not use it near open flames and do not smoke nearby during use.
  • Shake the can well before use.
  • Avoid exposure to the sun or artificial light while using Enstilar.

Enstilar FAQs

How long should I take this?

Enstilar is usually used until psoriasis symptoms are under control, and it should not be used for the long-term.


Do I have to hold the can in a specific orientation for it to work?

The canister may be held in any way except horizontally during use.


Can I cover the area with a bandage?

No, do not apply an occlusive dressing to the area unless instructed by your doctor.

Related Products


  1. Enstilar [package insert]. Parsippany, NJ: LEO Pharma Inc.; 2015.

Medication Review by a Clinical Pharmacist - PharmD

Author: Dr. Conor Sheehy, PharmD, BCPS

Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics.  He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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